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Author : Gianluigi Giannelli,Erica Villa,Maria L. Martinez Chantar
Publisher : Frontiers Media SA
Page : 151 pages
File Size : 54,8 Mb
Release : 2022-01-31
Category : Medical
ISBN : 9782889742615
Author : David Kerr,Rebecca Johnson
Publisher : Springer
Page : 252 pages
File Size : 47,5 Mb
Release : 2017-01-02
Category : Medical
ISBN : 9783319430638
This book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy. Starting by introducing concepts of modern immunology, the clinical applications of immunotherapy are then discussed. The reader will learn about the three broad classes of immune therapeutic agents: cell-based treatment; antibody therapy; cytokine application and the key effector cells and mechanisms which might cause tumour rejection. The reverse side of this equation, the genetic and molecular mechanisms which the tumour can use to escape immune control and regulation, is also discussed. Through reviewing the most up-to-date evidence, this volume provides an overview of the important scientific lessons learned from past failure of immunotherapeutics in the clinic and highlights more positive recent data, coupled to practical guidelines for clinical usage. Written by a team of worldwide experts, this is an indispensable guide for medical oncologists, surgical oncologists, radiation therapists, pharmacists, oncology nurse specialists.
Author : Vamsidhar Velcheti,Salman R Punekar
Publisher : Elsevier Health Sciences
Page : 355 pages
File Size : 49,9 Mb
Release : 2021-01-28
Category : Medical
ISBN : 9780323672993
Early recognition and management of adverse effects of cancer treatments are essential for optimal care of patients with cancer, and drastically different approaches are required for different physiologic reactions. Handbook of Cancer Treatment-Related Symptoms and Toxicities is a focused, one-stop resource that enables clinicians to quickly find up-to-date, reliable information needed at the point of care. The high-yield approach prioritizes the most common toxicities associated with cancer treatment, and concise, templated chapters offer fast access to information needed in day-to-day practice. Presents a user-friendly overview of cancer treatment-related symptoms and toxicities management in a practical, easy-to-use format, allowing you to quickly find information in one convenient, concise resource. Covers systemic and radiation therapies, including chemotherapy, immunotherapy, targeted therapies, and radiation therapy, detailing symptoms of each toxicity to confirm your diagnosis. Overviews pharmacologic and non-pharmacologic approaches to symptom management. Offers recommendations for mitigating toxicities in high-risk patients. Discusses key topics such as management of infusion reactions, when the need for biopsy is warranted, and the unique challenges posed by novel immunotherapies.
Author : Brendan Jenkins
Publisher : Elsevier
Page : 370 pages
File Size : 43,8 Mb
Release : 2021-07-23
Category : Science
ISBN : 9780323855631
Research and Clinical Applications of Targeting Gastric Neoplasms provides a comprehensive overview of gastrointestinal cancers, covering preclinical research and clinical findings related to risk factors, current treatment regimens (including immunotherapy), screening/detection methods, etiology of disease, precision medicine and future perspectives. Gastrointestinal cancers rank among the most lethal and common worldwide, and as such, there is intense research into their diverse causes and treatment options. This reference provides a consolidation of the research, making it a perfect resource for basic science and clinical researchers as well as oncologists who work in gastroenterology and GI tract cancer fields. Provides comprehensive coverage of preclinical research and the clinical aspects of gastric cancer Presents future perspectives from leading researchers in the field who provide the potential for furthering research topics Combines the expertise of researchers in GI tracts, cancer, immunity, immunology, infectious disease and microbiology for an interdisciplinary approach
Author : Ganji Purnachandra Nagaraju,Sujatha Peela
Publisher : Springer Nature
Page : 259 pages
File Size : 51,6 Mb
Release : 2020-10-01
Category : Medical
ISBN : 9789811554711
This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.
Author : Fumito Ito,Marc Ernstoff
Publisher : Elsevier Health Sciences
Page : 400 pages
File Size : 45,5 Mb
Release : 2018-09-03
Category : Medical
ISBN : 9780323549509
Get a quick, expert overview of the latest clinical information and guidelines for cancer checkpoint inhibitors and their implications for specific types of cancers. This practical title by Drs. Fumito Ito and Marc Ernstoff synthesizes the most up-to-date research and clinical guidance available on immune checkpoint inhibitors and presents this information in a compact, easy-to-digest resource. It’s an ideal concise reference for trainee and practicing medical oncologists, as well as those in research. Discusses the current understanding of how to best harness the immune system against different types of cancer at various stages. Helps you translate current research and literature into practical information for daily practice. Presents information logically organized by disease site. Covers tumor immunology and biology; toxicities associated with immune checkpoint inhibitors; and future outlooks. Consolidates today’s available information on this timely topic into one convenient resource.
Author : Zequn Li,Kui Zhang,Qun Zhang,Huashan Shi,Dongshi Chen
Publisher : Frontiers Media SA
Page : 467 pages
File Size : 51,6 Mb
Release : 2023-11-17
Category : Medical
ISBN : 9782832538982
Significant changes in diet, environment, and population increase gastrointestinal cancer morbidity. A growing number of novel biomarkers and underlying mechanisms are being elucidated, some of which may even conflict with assumptions of past decades. Therefore, collecting recent findings on novel diagnostic/prognostic factors, biomarkers, and/or risk factors in gastrointestinal cancers is a prerequisite for a better understanding of the disease. Despite remarkable progressions in surgical treatments and chemotherapies, the prognosis of gastrointestinal cancer is far from satisfactory due to the high occurrence of drug resistance. Based on the identification of novel biomarkers as well as their underlying mechanisms, targeted drug development will provide significant complementary therapeutic effects to conventional chemoradiotherapies. High-throughput methods such as next-generation sequencing on RNA level and mass spectrometry on protein/lipid/metabolite level serve as efficient strategies for biomarker identification and drug development. This Research Topic aims at presenting recent advances on gastrointestinal cancer biomarkers and their underlying functional mechanisms, providing a better understanding of carcinogenesis, tumor progression, tumor relapse, as well as drug resistance. This will subsequently contribute to the development of novel therapeutic interventions targeting gastrointestinal cancers, thus improving patients' outcomes.
Author : Manju Rawat Singh,Deependra Singh,Jagat Kanwar,Nagendra Singh Chauhan
Publisher : Academic Press
Page : 657 pages
File Size : 50,5 Mb
Release : 2020-04-07
Category : Business & Economics
ISBN : 9780128199183
Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents provides sound data on the utility of biological and plant-based drugs and describes challenges faced in all aspects offering indispensable strategies to use in the development of bioactive medicines. Bioactive based medications are commonly used throughout the world and have been recognized by physicians and patients for their therapeutic efficacy. Bioactive formulations, including their subordinates and analogs, address 50% of all medicines in clinical practice. Novel bioactive medicine transporters can cure many disorders by both spatial and transitory approaches and have various justifications in medicinal potential. This book presents information on the utility of natural, plant, animal and bioengineered bioactive materials. It is a fundamental source of information and data for pharmacognosists, pharmaceutical analysts, drug transport scientists and pharmacologists working in bioactive medications. Advances information on various bioactive based medications, their sources, clinical consequences and transport strategies Illustrates diverse transport systems for bioactives and derivatives, novel techniques for formulations, targeting strategies and fundamental qualities of developed bioactive carriers, and their safety concerns and standardization Discusses distinctive transport systems, stability, upgraded dissolvability, and enhanced bioavailability of bioactives
Author : Chi Chun Wong,Yantao Tian,Chenyu Sun,Qun Zhao,Ganesan Ramamoorthi,Ping’An Ding
Publisher : Frontiers Media SA
Page : 204 pages
File Size : 47,6 Mb
Release : 2024-03-13
Category : Medical
ISBN : 9782832544440
Currently, the treatment options for gastrointestinal malignancies mainly include surgery, chemotherapy, radiotherapy, and molecular targeted therapy, etc. Drug therapy is one of the main treatments for patients with advanced stages, but the efficacy of chemotherapy seems to have reached a plateau, and the progress of traditional molecular targeted therapy is relatively slow. In addition, the benefits of the current chemotherapy combined with targeted therapy for patients with advanced stages of gastrointestinal malignancies are still not satisfactory. Tumor immunotherapy is an emerging therapeutic approach and is a current research hotspot, and there are hopes that immunotherapy can help further improve the prognosis and quality of life for patients with gastrointestinal malignancies. At the same time, potential targets of immunotherapeutic drugs and prognostic biomarkers for gastrointestinal malignancies have been less studied than other common cancers, such as lung cancer. Prognostic biomarker studies are the beginning of exploring new drug targets and revealing potential mechanisms of tumor progression. Immunotherapies, particularly PD1 or PD-L1 antagonists, have demonstrated effective therapeutic efficacy against various types of cancer. To date, many PD1 drugs are available for cancer treatment, and more than 100 PD1 drugs are in clinical trials. However, the question of how to screen sensitive patients and predict the efficacy of immunotherapy remains unresolved. In addition, predictive biomarkers and treatment guidelines for immunotherapy of gastrointestinal malignancies have hardly been studied.
Author : Cho Chi-hin
Publisher : World Scientific
Page : 460 pages
File Size : 40,6 Mb
Release : 2017-04-20
Category : Medical
ISBN : 9789813148581
This unique book deals with both inflammation and cancer in a single source of publication. They are seldom grouped together although it has been known that both diseases are closely associated, particularly in the gastrointestinal tract and liver. As the book touches on two such major areas of diseases in humans, it should be of interest to a wider audience of researchers and readers. It is noted that the book combines the effort of both basic scientists and clinicians from different countries with extensive experiences in molecular biology and clinical practice to unveil the most updated picture of the pathogenesis and therapeutic strategies in the treatment of inflammation and cancer in the digestive tract. In this regard, potential pathogenic modulators and also therapeutic options are widely discussed. These types of information would definitely broaden our knowledge in better understanding these diseases. Contents:General Introduction to Inflammation and Cancer in the Digestive Tract (Ming Xing Li and Chi Hin Cho)Inflammation and Therapeutics in the Digestive Tract:Brain–Gut Relationship on Mucosal Inflammation in the Gastrointestinal Tract (Klara Gyires and Ágnes Fehér)Nesfatin-1: The Novel Appetite Peptide with Therapeutic Efficacy to Prevent Acute Hemorrhagic Gastric Lesions and Accelerate Gastric Ulcer Healing (Aleksandra Szlachcic, Jolanta Majka, and Tomasz Brzozowski)Chemoprophylaxis in Inflammatory Bowel Disease (Nikola Mitrev, Aladdin Alswaifi, and Rupert W Leong)Targeting the Nuclear Receptor HNF4α as a Potential Therapy for Gut Inflammation and Cancer (Jean-Philippe Babeu and François Boudreau)Established Therapies and New Therapeutic Strategies in Alcoholic Liver Disease (Helmut Karl Seitz and Sebastian Mueller)Carcinogenesis and Therapeutic Targets in the Gastrointestinal Tract:Targets of Tumor Epigenetics and Its Microenvironment in Gastrointestinal Cancer (Ssu-Yin Yen, Hong-Meng Chuang, Mao-Hsuan Huang, Sheng-Feng Tsai, Tzyy-Wen Chiou, Hong-Lin Su, Li-Ing Ho, Shinn-Zong Lin, and Horng-Jyh Harn)Esophageal Cancer: From Bench to Bedside (Gang Ma and Zhihua Liu)Angiogenesis and Lymphangiogenesis in Gastric MALT Lymphoma: Relation of VEGF and VASH2 (Masahiko Nakamura, Anders Øverby, and Hidenori Matsui)NF-κB as a Potential Molecular Target for Therapy of Gastrointestinal Cancers (Nathan Palmer, Muthu K Shanmugam, Gautam Sethi, and Philipp Kaldis)Hypoxia-Inducible Factor-1κ Modulation in Colorectal Carcinogenesis (Francesco Mariani, Stefano Mancini, Paola Sena, and Luca Roncucci)Therapeutic Approaches Targeting the Serrated Pathway of Colorectal Cancer Characterized by Mutation in the BRAF Gene and Overexpression of GTPase Rac1b (Paulo Matos, Vânia Gonçalves, and Peter Jordan)The "Yin" and "Yang" of Target-Oriented Anticancer Phytochemicals Derived from Herbal Medicines (Kathy K Auyeung and Joshua K S Ko)The Degradation System of Prostaglandin E2 in Gastrointestinal Cancer (Tetsuya Tanigawa, Toshio Watanabe, Shogo Takeda, Hiroshi Tatsuwaki, Masatsugu Shiba, Kazunari Tominaga, Yasuhiro Fujiwara, and Tetsuo Arakawa)Prostaglandin and Its Receptors: Potential Targets for Gastrointestinal Inflammation and Cancer (Vivian Y Shin and Ava Kwong)Autophagy and microRNAs as the Therapeutic Targets in Gastrointestinal Cancers:Modulation of Autophagy as a Potential Therapeutic Target for Gastrointestinal Cancers: Promises and Uncertainties (Li Ma)microRNAs as Therapeutic Targets for Gastric Cancer (Takatsugu Ishimoto and Hideo Baba)microRNA-based Novel Therapeutic Development in Gastrointestinal Cancer (Andrew Fesler and Jingfang Ju)Unraveling the Relationship between Autophagy and microRNA in Gastrointestinal Cancer (Yuanyuan Yin, Peiqi Wang, Yaxin Zheng, Yi Chen, and Jinhui Wang) Readership: Basic and clinical researchers in the fields of inflammation, hepatology, pathology, pharmacology, oncology and gastroenterology. Can be used as a reference for their research and clinical practice in academic and industrial sectors.
Author : Marnix Jansen,Nicholas A. Wright
Publisher : Springer
Page : 486 pages
File Size : 47,8 Mb
Release : 2016-08-29
Category : Medical
ISBN : 9783319413884
This book is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathology of early esophageal squamous cell carcinoma, therapeutic modalities for esophageal squamous cell carcinoma, pathology of Barrett’s esophagus, screening, early detection and novel diagnostic tools for Barrett's esophagus, clonal evolution of Barrett’s esophagus, endoscopic therapeutic modalities of early esophageal cancer, pathology of early gastric cancer, and experimental models for gastric cancer. Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract is an integrative text on both the current state of translational research on every cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike. Springer’s Advances in Experimental Medicine and Biology series presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research.
Author : Nima Rezaei
Publisher : Springer Nature
Page : 405 pages
File Size : 41,8 Mb
Release : 2024-01-01
Category : Medical
ISBN : 9783031483714
Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.
Author : Vita Golubovskaya,Sripathi Sureban
Publisher : Frontiers Media SA
Page : 139 pages
File Size : 46,7 Mb
Release : 2022-11-28
Category : Medical
ISBN : 9782832507308
Author : Manmohan Singh,Maya Salnikova
Publisher : Academic Press
Page : 520 pages
File Size : 53,9 Mb
Release : 2014-12-30
Category : Medical
ISBN : 9780124166615
Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies
Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation,Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials
Publisher : National Academies Press
Page : 102 pages
File Size : 54,5 Mb
Release : 2006-01-03
Category : Medical
ISBN : 9780309180689
Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.