Novel Delivery Systems For Transdermal And Intradermal Drug Delivery

Author : Ryan F. Donnelly,Thakur Raghu Raj Singh
Publisher : John Wiley & Sons
Page : 290 pages
File Size : 45,7 Mb
Release : 2015-09-28
Category : Science
ISBN : 9781118734513

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Novel Delivery Systems for Transdermal and Intradermal Drug Delivery by Ryan F. Donnelly,Thakur Raghu Raj Singh Pdf

This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.

Author : Ryan F. Donnelly,Thakur Raghu Raj Singh
Publisher : Wiley
Page : 296 pages
File Size : 42,9 Mb
Release : 2015-08-18
Category : Science
ISBN : 1118734467

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Novel Delivery Systems for Transdermal and Intradermal Drug Delivery by Ryan F. Donnelly,Thakur Raghu Raj Singh Pdf

Author : Ryan F. Donnelly,Thakur Raghu Raj Singh,Desmond I. J. Morrow,A. David Woolfson
Publisher : John Wiley & Sons
Page : 238 pages
File Size : 55,8 Mb
Release : 2012-01-17
Category : Medical
ISBN : 9781119959663

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Microneedle-mediated Transdermal and Intradermal Drug Delivery by Ryan F. Donnelly,Thakur Raghu Raj Singh,Desmond I. J. Morrow,A. David Woolfson Pdf

Microneedles can be used for delivery of a wide range of drug substances for practically any medical condition and present a real opportunity for vaccines and medicines that are unsuitable for oral administration or conventional patch delivery. Microneedle-mediated Transdermal and Intradermal Drug Delivery covers the major aspects relating to the use of microneedle arrays in enhancing drug delivery applications. It provides an overview of the various methods employed to design and produce microneedles, from the different materials involved to the importance of application methods. It carefully and critically reviews ongoing transdermal and intradermal delivery research using microneedles and includes the outcomes of in vivo animal and human studies. Importantly, it also discusses the safety and patient acceptability studies carried out to date. Finally, the book reviews the recent patents in microneedle research and describes the ongoing developments within industry that will determine the future of microneedle-mediated transdermal and intradermal drug delivery. By an expert author team with practical experience in the design and development of drug delivery systems this is the only text that provides a comprehensive review of microneedle research in transdermal and intradermal drug delivery.

Author : Ryan F. Donnelly,Thakur Raghu Raj Singh,Eneko Larrañeta,Maeliosa T.C. McCrudden
Publisher : John Wiley & Sons
Page : 349 pages
File Size : 44,5 Mb
Release : 2018-08-20
Category : Science
ISBN : 9781119305149

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Microneedles for Drug and Vaccine Delivery and Patient Monitoring by Ryan F. Donnelly,Thakur Raghu Raj Singh,Eneko Larrañeta,Maeliosa T.C. McCrudden Pdf

Provides comprehensive coverage of microneedles for delivering and monitoring patient drugs and vaccines Microneedles are an incredibly active research area and have the potential to revolutionize the way many medicines and vaccines are delivered. This comprehensive research book covers the major aspects relating to the use of microneedle arrays in enhancing both transdermal and intradermal drug delivery and provides a sound background to the use of microneedle arrays in enhanced delivery applications. Beginning with a history of the field and the various methods employed to produce microneedles from different materials, Microneedles for Drug and Vaccine Delivery and Patient Monitoring discusses the penetration of the stratum corneum by microneedles and the importance of application method and force and microneedle geometry (height, shape, inter-needle spacing). Transdermal and intradermal delivery research using microneedles is comprehensively and critically reviewed, focusing on the outcomes of in vivo animal and human studies. The book describes the important topics of safety and patient acceptability studies carried out to date. It also covers in detail the growing area for microneedle use in the monitoring of interstitial fluid contents. Finally, it reviews translational and regulatory developments in the microneedles field and describes the work ongoing in industry. The only book currently available on microneedles Filled with tables, graphs, and black and white images (photographs, micrographs) Authored by four experts in pharmaceutics Microneedles for Drug and Vaccine Delivery and Patient Monitoring is an ideal source for researchers in industry and academia working on drug delivery and transdermal delivery in particular, as well as for advanced students in pharmacy and pharmaceutical sciences.

Author : Ajay K Banga
Publisher : CRC Press
Page : 309 pages
File Size : 49,9 Mb
Release : 2011-05-16
Category : Medical
ISBN : 9781439805107

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Transdermal and Intradermal Delivery of Therapeutic Agents by Ajay K Banga Pdf

Skin, once thought to be an impenetrable barrier, is an extremely active organ capable of interacting with its environment. Advancements in science combined with the need for diverse drug delivery modalities have introduced a variety of transdermal and intradermal products for existing drugs at a fraction of the cost of new drug development. Commercialization of transdermal drug delivery requires technology from many disciplines beyond pharmaceutical sciences, such as polymer chemistry, adhesion sciences, mass transport, web film coating, printing, and medical technology. A comprehensive discussion of these technologies and practices, Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies covers: Commercial development of devices and products based on transdermal physical enhancement technologies Selecting optimal enhancement technology for a specific drug molecule using case studies Physicochemical properties and practical commercial considerations related to cost, unmet clinical needs, marketing, or intellectual property protection Technologies such as microneedles, iontophoresis, electroporation, and sonophoresis, with examples for delivery of small molecules, cosmeceuticals, proteins, and vaccines Practical information on experimental procedures and challenges related to skin irritation and safety issues Up-to-date and accessible to researchers and industry experts, this book provides a comprehensive discussion of the physical approaches and practical considerations for the laboratory and marketplace.

Author : Jonathan Hadgraft
Publisher : CRC Press
Page : 400 pages
File Size : 41,7 Mb
Release : 2002-10-29
Category : Medical
ISBN : 9780203909683

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Transdermal Drug Delivery Systems by Jonathan Hadgraft Pdf

Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulator

Author : Nayan A. Gujarathi,Juliana Palma Abriata,Raj Kumar Keservani,Anil K. Sharma
Publisher : CRC Press
Page : 353 pages
File Size : 47,6 Mb
Release : 2023-02-06
Category : Medical
ISBN : 9781000577648

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Topical and Transdermal Drug Delivery Systems by Nayan A. Gujarathi,Juliana Palma Abriata,Raj Kumar Keservani,Anil K. Sharma Pdf

Topical and transdermal drug delivery systems (TDDs) have several advantages over traditional drug delivery methods, as they can be less invasive, more sanitary, more cost-effective, and may result in better patient compliance. TDDs play a significant role in therapeutics with a variety of preparations and approaches designed by expert formulation scientists. This volume integrates a wide variety of case studies, research, and theories to reveal their diversity and capture the novel approaches of transdermal and topical drug delivery employed by developers and content experts in the field. It provides an abundance of important information and state-of-the-art research on topical and transdermal drug delivery systems and addresses the basics of drug delivery systems, strategies to enhance permeation across membranes, and formulation and evaluation of diverse dosage forms. The volume presents an evaluation of the pros and cons of conventional drug delivery systems against TDDs and discusses the nuances of micro- and nano-systems in TDDs. The extraordinary packages of nano systems (vesicular systems, polymeric nanoparticles, nanoemulsion and dendrimers) are broadly discussed, and their applications are reviewed through a transdermal route. The book looks at TDDs and the main nanoparticles used in skin diseases and lesions of the aging, such as psoriasis, vitiligo, cancer, lesions of the aging and others. Chapters also discuss polymeric micelles in topical and transdermal delivery; microneedles; emulsion, nanoemulsion and microemulsion; TDDs in pulmonary drug delivery systems; nanoencapsulated nasal drug delivery systems; skin sensitivity and irritation testing for transposing transdermal drug delivery systems; and regulatory aspects of drug development for dermal products. Topical and Transdermal Drug Delivery Systems: Applications and Prospects will be a valuable resource for pharmaceutical scientists and researchers, industry professionals, and academicians and students of the pharmaceutical and biomedical sciences.

Author : Sudhakar Yajaman & Jayaveera K.N.
Publisher : S. Chand Publishing
Page : 128 pages
File Size : 53,6 Mb
Release : 2014
Category : Medical
ISBN : 9788121942577

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Novel Drug Delivery Systems and Regulatory Affairs by Sudhakar Yajaman & Jayaveera K.N. Pdf

Novel Drug Delivery Systems | Transdermal Drug Delivery Systems | Mucoadhesive Drug Delivery Systems | Targeted Drugdelivery Systems | Regulatory Agencies | Quality Assurance | Good Manufacturing Practices | Validation

Author : Kevin Ita
Publisher : Academic Press
Page : 324 pages
File Size : 55,9 Mb
Release : 2020-06-12
Category : Business & Economics
ISBN : 9780128225516

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Transdermal Drug Delivery by Kevin Ita Pdf

Transdermal Drug Delivery: Concepts and Application provides comprehensive background knowledge and documents the most recent advances made in the field of transdermal drug delivery. It provides comprehensive and updated information regarding most technologies and formulation strategies used for transdermal drug delivery. There has been recent growth in the number of research articles, reviews, and other types of publications in the field of transdermal drug delivery. Research in this area is active both in the academic and industry settings. Ironically, only about 40 transdermal products with distinct active pharmaceutical ingredients are in the market indicating that more needs to be done to chronicle recent advances made in this area and to elucidate the mechanisms involved. This book will be helpful to researchers in the pharmaceutical and biotechnological industries as well as academics and graduate students working in the field of transdermal drug delivery and professionals working in the field of regulatory affairs focusing on topical and transdermal drug delivery systems. Researchers in the cosmetic and cosmeceutical industries, as well as those in chemical and biological engineering, will also find this book useful. Captures the most recent advancements and challenges in the field of transdermal drug delivery Covers both passive and active transdermal drug delivery strategies Explores a selection of state-of-the-art transdermal drug delivery systems

Author : Heather A. E. Benson,Adam C. Watkinson
Publisher : John Wiley & Sons
Page : 393 pages
File Size : 42,6 Mb
Release : 2012-02-03
Category : Medical
ISBN : 9781118140499

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Topical and Transdermal Drug Delivery by Heather A. E. Benson,Adam C. Watkinson Pdf

Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how these principles are put into practice in the design and development of new drug products. Drawing together and reviewing the latest research findings, the book focuses on practical, tested, and proven approaches that are backed by industry case studies and the authors' firsthand experience. Moreover, the book emphasizes the mechanistic information that is essential for successful drug product development. Topical and Transdermal Drug Delivery: Principles and Practice is divided into two parts: Part One, Current Science, Skin Permeation, and Enhancement Approaches, offers readers a fundamental understanding of the underlying science in the field. It describes the principles and techniques needed to successfully perform experimental approaches, covering such issues as skin permeation, enhancement, and assessment. Part Two, Topical and Transdermal Product Development, guides readers through the complete product development process from concept to approval, offering practical tips and cautions from experts in the field. This part also discusses regulations that are specific to the development of dermal drug products. The final chapter explores current and future trends, forecasting new development techniques and therapeutics. Throughout the book, the authors clearly set forth the basic science and experimental procedures, making it possible for researchers to design their own experimental approaches and accurately interpret their results. With contributions from experienced drug researchers, this text is highly recommended for all researchers involved in topical and transdermal product development who need to know both the state of the science and the standards of practice.

Author : Vitthal S. Kulkarni
Publisher : Elsevier
Page : 328 pages
File Size : 48,9 Mb
Release : 2009-12-31
Category : Medical
ISBN : 0815520263

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Handbook of Non-Invasive Drug Delivery Systems by Vitthal S. Kulkarni Pdf

With the improvements in formulation science and certain transdermal delivery technologies, the non-invasive mode of drug delivery is now ready to compete with traditional methods of oral and injectible routes of drug delivery. The Handbook of Non-Invasive Drug Delivery Systems encompasses the broad field of non-invasive drug delivery systems that include drug delivery via topical, transdermal-passive, transdermal-active (device- aided enhanced penetration), trans-mucosal membrane, trans-ocular membrane as well as delivery via alveolar membrane from inhaled medication. Patient compliance has been found to be much higher when administrated by non-invasive routes and therefore they are considered to be a preferred mode of drug delivery. The book includes both science and technological aspects of new drug delivery systems. Its unique focus is that it is on new drug delivery systems that are considered to be "non-invasive". Other unique features include a chapter on Regulatory Aspects of non-invasive systems and one on FDA guidance for topical nano-drug delivery. Two chapters covering market trends and perspectives, as well as providing guidance to those marketing such systems are also included.

Author : Tapash K. Ghosh,William Pfister,Su Il Yum
Publisher : CRC Press
Page : 736 pages
File Size : 52,8 Mb
Release : 1997-06-30
Category : Medical
ISBN : 1574910418

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Transdermal and Topical Drug Delivery Systems by Tapash K. Ghosh,William Pfister,Su Il Yum Pdf

Advances in the pharmaceutical and cosmetic sciences have propelled the development of transdermal and topical therapeutic systems into a technologically revolutionary phase. This book offers an authoritative guide to the development of delivery systems. Discussions by research and industry experts include methods for clinical assessment, percutaneous permeation enhancers, and formulation approaches to topical drug delivery. It also addresses IND, ANDA, NDA, and PLA filings for transdermal products with the FDA. The book contains practical information, step-by-step guidance, numerous references, and a complete index to help readers quickly locate the information they need. Features

Author : Richa Mishra,T.K. Bhattacharyya
Publisher : CRC Press
Page : 243 pages
File Size : 50,9 Mb
Release : 2023-12-11
Category : Technology & Engineering
ISBN : 9781003823414

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MEMS-based Transdermal Drug Delivery by Richa Mishra,T.K. Bhattacharyya Pdf

This book introduces transdermal drug delivery and the developments that have taken place in various transdermal drug delivery techniques including the system-level design approach of a novel miniaturized medical device to offer precise and painless drug delivery via a skin-based transdermal route. It discusses the microelectromechanical systems (MEMS)-based fabrication technique and the design, fabrication and characterization of different MEMS-based components like microneedles and micropumps. It further includes a MEMS-based component micropump with design, analysis, fabrication and characterization of the transdermal drug delivery device and challenges encountered in the design improvements. Features: Summarizes transdermal drug delivery systems especially with a focus on MEMS and microneedles, including theoretical concepts Emphasizes system integration by describing simulation and design techniques as well as experimental fabrication Discusses system-level integration for miniaturized therapeutic devices Includes working simulation models covering microneedles and micropump analysis Explores future direction in development of pertinent devices. The book is aimed at researchers, professionals, and graduate students in biomedical engineering, microelectronics, micro-electro-mechanical-systems, and drug delivery.

Author : Ryan F. Donnelly,Thakur Raghu Raj Singh
Publisher : John Wiley & Sons
Page : 296 pages
File Size : 55,5 Mb
Release : 2015-09-21
Category : Science
ISBN : 9781118734490

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Novel Delivery Systems for Transdermal and Intradermal Drug Delivery by Ryan F. Donnelly,Thakur Raghu Raj Singh Pdf

This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.

Author : Kewal K. Jain
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 53,8 Mb
Release : 2008-03-07
Category : Science
ISBN : 9781588298911

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Drug Delivery Systems by Kewal K. Jain Pdf

In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.