Novel Therapeutic Approaches Targeting Oxidative Stress

Author : Pawan Kumar Maurya,Imteyaz Qamar
Publisher : Academic Press
Page : 294 pages
File Size : 48,5 Mb
Release : 2022-02-18
Category : Science
ISBN : 9780323909068

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Novel Therapeutic Approaches Targeting Oxidative Stress by Pawan Kumar Maurya,Imteyaz Qamar Pdf

Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored. The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives. Explores oxidative stress in a variety of diseases, including neurological disorders, cardiovascular diseases, age-related diseases, and cancer Covers a range of therapeutic approaches to target oxidative stress Includes chapters on the application of novel drug delivery systems and diagnostic biosensors to oxidative stress Features case studies illustrating the targeting of oxidative stress

Author : Touqeer Ahmed,Nady Braidy
Publisher : Frontiers Media SA
Page : 193 pages
File Size : 42,5 Mb
Release : 2023-09-01
Category : Science
ISBN : 9782832534106

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From Oxidative Stress to Cognitive Decline - Towards Novel Therapeutic Approaches by Touqeer Ahmed,Nady Braidy Pdf

Oxidative stress plays multiple roles in the pathobiology of several neurodegenerative disorders and Alzheimer’s disease in particular. Increased oxidative stress in the brain is suggested to be associated with aging, greater amounts of easily oxidizable unsaturated fatty acids, higher utilization of oxygen by the brain, mitochondrial-derived free radicals, calcium homeostasis, and glutamate-induced excitotoxicity. Moreover, environmental chemicals/toxins, heavy metals, and an imbalanced diet might increase oxidative stress potentially leading to a decrease in cognitive functions. Cellular health is also dependent on the levels of nicotinamide adenine dinucleotide (NAD+). It has been well documented that NAD+ is an important coenzyme for over 400 different oxidoreductases and turns out to be a relevant factor to the oxidative stress in the brain. Since the last two decades, NAD+ has been shown to be more than a mere regulator of metabolism, but rather may play a key role in the aging process. NAD+ along with sirtuins are important for various neurophysiological functions, and depletion of NAD+ may be associated with compromised physiological and cognitive functions. To protect the brain from oxidative stress, a modest endogenous protective system works in the brain through dedicated enzymatic machinery. Key enzymes are superoxide dismutase and catalase, which provide protection against oxidative stress. Aging, various neurological disorders, and chronic inflammation might also affect the levels of these protective enzymes and reduce their levels. Natural compounds, including polyphenols, can offer protection through NAD+ and various other mechanisms. Based on these factors it is becoming more and more clear that oxidative stress and its devastating effects on cognitive decline represents a major health issue in neurobiology. There is a need to identify potential compounds and therapeutic targets for mitigating oxidative stress and/or to strengthen the protective endogenous mechanisms. Novel approaches aiming to support and provide protective mechanisms in the brain will represent a great success in therapeutics. We welcome all article types focusing on the analysis and investigation of oxidative stress - originated from different sources - and its impairing effects on the brain. We will also accept studies investigating naturally occurring compounds, standard medications, and nutraceuticals that have an impact on oxidative stress, NAD+ metabolism and medical and health applications. For this, the aim of this Research Topic is to provide novel insights on oxidative stress (induced by any mechanism) impact on brain health, and on the strengthening of brain-protective mechanisms, supporting cognitive functions.

Author : Monica Dinu,Chiara Nediani
Publisher : Mdpi AG
Page : 224 pages
File Size : 47,6 Mb
Release : 2022-06-02
Category : Electronic
ISBN : 3036543635

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Oxidative Stress and Inflammation as Targets for Novel Preventive and Therapeutic Approaches in Non-Communicable Diseases II by Monica Dinu,Chiara Nediani Pdf

Non-communicable diseases are chronic non-infectious pathologies that represent the leading cause of death and disability for the general population. Oxidative stress and inflammation induce and modulate several signaling pathways that play a crucial role in the pathophysiology and progression of these diseases. Therefore, they represent a good target for the development of different therapeutic strategies and open new strategies for assessment and intervention. This book focuses on different approaches to investigate the underlying pathogenesis and treatment mechanisms of conditions related to oxidative stress and inflammation. Particular attention is given to biomarkers specific to these features that can detail the pathogenesis and evolution of kidney disease, cardiovascular disease, obesity, breast cancer, and idiopathic pulmonary fibrosis. In addition, the potential medicinal and beneficial effects of plant compounds such as oleuropein, columbianadin, and rebaudioside A are addressed.

Author : Sajal Chakraborti
Publisher : Springer Nature
Page : 4078 pages
File Size : 45,9 Mb
Release : 2022-09-28
Category : Medical
ISBN : 9789811654220

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects by Sajal Chakraborti Pdf

This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​

Author : Sajal Chakraborti,Naranjan S Dhalla,Nirmal K Ganguly,Madhu Dikshit
Publisher : Springer Nature
Page : 596 pages
File Size : 49,5 Mb
Release : 2019-11-06
Category : Science
ISBN : 9789811382734

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Oxidative Stress in Heart Diseases by Sajal Chakraborti,Naranjan S Dhalla,Nirmal K Ganguly,Madhu Dikshit Pdf

This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

Author : Thomas Dziubla,D Allan Butterfield
Publisher : Academic Press
Page : 404 pages
File Size : 43,6 Mb
Release : 2016-05-31
Category : Technology & Engineering
ISBN : 9780128032701

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Oxidative Stress and Biomaterials by Thomas Dziubla,D Allan Butterfield Pdf

Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of “meso-compatibility, a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction. Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death Brings together the two fields of biomaterials and the biology of oxidative stress Provides approaches for the design of biomaterials with improved biocompatibility

Author : Kenneth Maiese
Publisher : Academic Press
Page : 472 pages
File Size : 45,9 Mb
Release : 2016-02-21
Category : Medical
ISBN : 9780128027554

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Molecules to Medicine with mTOR by Kenneth Maiese Pdf

Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin. Covers the role of mTOR by internationally recognized expert contributors in the field. Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels. Includes analysis of the role of mTOR and in both health and disease. Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.

Author : Loutfy H. Madkour
Publisher : Academic Press
Page : 782 pages
File Size : 53,7 Mb
Release : 2020-06-27
Category : Medical
ISBN : 9780128224960

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Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms by Loutfy H. Madkour Pdf

Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS?mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals?induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions. Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences. Covers the ecotoxicology of environmental heavy metal ions and the interactions between specific heavy metals?induced cell responses and oxidative stress Provides a better understanding of the mechanism of nanomaterial-induced toxicity as a first defense for hazard prevention Covers recent advances in new nanomedication technologies for the effects of NPs on oxidative stress, ROS and ER stress Discusses the effects of interactions between antioxidant defense therapy, ROS and strategies for treatment

Author : Henning Willers,Iris Eke
Publisher : Springer Nature
Page : 370 pages
File Size : 49,7 Mb
Release : 2020-08-10
Category : Medical
ISBN : 9783030497019

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Molecular Targeted Radiosensitizers by Henning Willers,Iris Eke Pdf

Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.

Author : George Edward Billman
Publisher : John Wiley & Sons
Page : 610 pages
File Size : 40,6 Mb
Release : 2010-01-07
Category : Medical
ISBN : 9780470261002

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Novel Therapeutic Targets for Antiarrhythmic Drugs by George Edward Billman Pdf

PROFILES POTENTIAL TREATMENT APPROACHES FOR CARDIAC ARRHYTHMIAS Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrhythmias alongside comprehensive presentations of basic cardiac physiology and pharmacology. Written by leading experts in their research areas, this invaluable resource offers both practitioners and researchers a one-stop guide that brings together previously dispersed information. The text consists of four sections: Section One comprehensively reviews basic cardiac electrophysiology, the mechanisms responsible for arrhythmias in the setting of ischemia, and basic pharmacology of antiarrhythmic drugs. Section Two addresses safety pharmacology, including the concept of "repolarization reserve," safety challenges, and regulatory issues for the development of novel antiarrhythmic drugs. Section Three describes several novel pharmacological targets for antiarrhythmic drugs, including both ion channel and non-ion channel targets. Section Four describes promising non-pharmacological antiarrhythmic interventions including selective cardiac neural disruption or nerve stimulation, aerobic exercise training, and diet (omega-3 fatty acids). Offering an unparalleled look at the current state and future direction of cardiac arrhythmia treatment, Novel Therapeutic Targets for Antiarrhythmic Drugs provides an important resource to advanced students, working researchers, and busy professionals alike.

Author : Sajal Chakraborti,Tapati Chakraborti,Salil Kumar Das,Dhrubajyoti Chattopadhyay
Publisher : Springer Nature
Page : 491 pages
File Size : 51,5 Mb
Release : 2019-08-31
Category : Science
ISBN : 9789811384134

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Oxidative Stress in Lung Diseases by Sajal Chakraborti,Tapati Chakraborti,Salil Kumar Das,Dhrubajyoti Chattopadhyay Pdf

This first volume of the comprehensive, two-volume work on oxidative stress in lung disease introduces the molecular mechanisms, and the role of oxidants in the progression of different lung diseases. The lungs of humans and animals are under constant threat from oxidants from either endogenous (e.g. in situ metabolic reactions) or exogenous sources (e.g. air pollutants). Further, oxidative stress causes the oxidation of proteins, DNA and lipids, which in turn generates secondary metabolic products. The book consists of sections, each focusing on different aspects of oxidant-mediated lung diseases. As such it is a unique reference resource for postgraduate students, biomedical researchers and also for the clinicians who are interested in studying and understanding oxidant-mediated lung diseases. The second volume will incorporate other aspects of oxidant-mediated lung diseases, including prevention and therapeutics.

Author : Mohinder Bansal,Naveen Kaushal
Publisher : Springer
Page : 167 pages
File Size : 51,5 Mb
Release : 2014-10-17
Category : Science
ISBN : 9788132220329

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Oxidative Stress Mechanisms and their Modulation by Mohinder Bansal,Naveen Kaushal Pdf

Research over the years has demonstrated that free radicals mediated oxidative stress lies at the helm of almost all patho-physiological phenomena. These findings emphasize on the need to understand the underlying molecular mechanism(s) and their critical role in the pathogenesis. This book aims to focus on these areas to provide readers a comprehensive outlook about the major redox sensitive pathways and networks involved in various disease conditions. In the first chapter of the book, basic information about the oxidative stress, its generation, its biomarkers and its role in body are discussed. In the next three chapters, the role of oxidative stress in various pathologies ranging from neurological disorders, to cardiovascular diseases, cancers, metabolic diseases and ageing have been described. Chapter 5 cumulatively describes the most important molecular signaling pathways that are affected by reactive oxygen species (ROS). These are the mechanisms which are common denominators in various pathological states. In the next part of the book, various antioxidant strategies to target and mitigate ROS have been discussed with details on the mechanisms. Selenium, being the research focus and interest of the authors for years, the role of selenium as an antioxidant as part of selenoproteins has been included in the book. Finally, the book culminates with authors’ perspective on the future of the redox biology field. Throughout the book, efforts have been made to use simplified language and suitable figures for ease to understand the contents. Although the authors have tried to touch on all the different aspects of oxidative stress in detail, the fact that it is a continuously growing field with updates coming every day, there might be some areas which might not be described in depth. This book is designed for students, young scientists to get acquainted with the redox biology. Overall, this book is a reference to understand the redox regulation of cellular signaling pathways involved in pathogenesis.

Author : David R. Riddle
Publisher : CRC Press
Page : 408 pages
File Size : 52,5 Mb
Release : 2007-04-19
Category : Medical
ISBN : 1420005529

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Brain Aging by David R. Riddle Pdf

Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Author : Ian S. Zagon,Patricia J. McLaughlin
Publisher : Unknown
Page : 137 pages
File Size : 54,9 Mb
Release : 2017
Category : Electronic
ISBN : 0994438133

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Multiple Sclerosis by Ian S. Zagon,Patricia J. McLaughlin Pdf

Author : Magdalena M. Gorska
Publisher : Springer Nature
Page : 337 pages
File Size : 55,8 Mb
Release : 2022-06-30
Category : Medical
ISBN : 9781071623640

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Asthma by Magdalena M. Gorska Pdf

This volume details a collection of laboratory protocols to study asthma in mice and humans. Chapters cover animal models of asthma, methods to measure asthma-related molecules, protocols to detect, isolate, culture and stimulate cells that contribute to asthma in mice and humans, methods to deplete these cells in vivo and study responses of intact airway tissues ex vivo. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Asthma: Methods and Protocols aims to be a foundation for future studies and to be a source of inspiration for new investigations in the field.