Nuclear Chromosomal And Genomic Architecture In Biology And Medicine

Author : Malgorzata Kloc,Jacek Z. Kubiak
Publisher : Springer Nature
Page : 657 pages
File Size : 45,8 Mb
Release : 2022-11-08
Category : Science
ISBN : 9783031065736

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Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine by Malgorzata Kloc,Jacek Z. Kubiak Pdf

This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.

Author : Anja Weise,Philipp G. Maass,Ron Hochstenbach
Publisher : Frontiers Media SA
Page : 94 pages
File Size : 49,8 Mb
Release : 2021-04-16
Category : Science
ISBN : 9782889666812

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Chromosome Biology as a Key to Understand Disease Mechanisms, Genome Architecture and Evolution by Anja Weise,Philipp G. Maass,Ron Hochstenbach Pdf

This topic has been realized, and is in collaboration with Dr. Constanze Pentzold, Post Doctoral Researcher at the Institute of Human Genetics, University Hospital Jena.

Author : Mark C. Leake
Publisher : Springer Nature
Page : 332 pages
File Size : 41,7 Mb
Release : 2022-05-30
Category : Science
ISBN : 9781071622216

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Chromosome Architecture by Mark C. Leake Pdf

This detailed new edition collects cutting-edge laboratory protocols, techniques, and applications in use by some of the leading international experts in the broad field of chromosome architecture. The book emphasizes the increasing physiological relevance of chromosome architecture investigation, manifest both through application of more complex bottom-up assays in vitro as well as through maintaining the native physiological context through the investigation of living, functional cells. In addition, the chapters reflect the dramatic improvement in the length scale of precision by utilizing single-molecule approaches, both for imaging the DNA content of chromosome and proteins that bind to DNA as well as using methods that can controllably manipulate single DNA molecules, and the use of advanced computational methods and mathematical analysis is also featured. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Chromosome Architecture: Methods and Protocols, Second Edition is an ideal guide for researchers working in this dynamic area of study.

Author : Sergey V. Razin
Publisher : Unknown
Page : 195 pages
File Size : 42,5 Mb
Release : 1997-01-01
Category : Chromosomes
ISBN : 3540624554

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The Nuclear Matrix and Spatial Organization of Chromosomal DNA Domains by Sergey V. Razin Pdf

This is the first monograph giving an all-round description of different aspects of the eukaryotic genome functional architecture. It focuses on how the spatial organization of a genome within a eukaryotic cell nucleus fulfills the specific needs of the genome functioning. This volume presents an integral view of eukaryotic cell nuclei functional compartmentalization with special emphasis on the genome spatial organization and the functional significance of this organization.

Author : G. Tiana,Giorgetti Luca
Publisher : CRC Press
Page : 370 pages
File Size : 45,8 Mb
Release : 2021-03-31
Category : Genomics
ISBN : 0367780453

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Modeling the 3D Conformation of Genomes by G. Tiana,Giorgetti Luca Pdf

This book provides a timely summary of physical modeling approaches applied to biological datasets that describe conformational properties of chromosomes in the cell nucleus. The coverage ranges from introductory chapters to modeling aspects related to polymer physics, and data-driven models for genomic domains, and predicting 3D genome structur

Author : Anonim
Publisher : Academic Press
Page : 1350 pages
File Size : 50,8 Mb
Release : 2012-10-30
Category : Science
ISBN : 9780123822284

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Genomic and Personalized Medicine by Anonim Pdf

Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Author : Geoffrey E. Hill
Publisher : Oxford University Press, USA
Page : 315 pages
File Size : 55,9 Mb
Release : 2019-04-30
Category : Science
ISBN : 9780198818250

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Mitonuclear Ecology by Geoffrey E. Hill Pdf

This novel text provides a concise synthesis of how the interactions between mitochondrial and nuclear genes have played a major role in shaping the ecology and evolution of eukaryotes. The foundation for this new focus on mitonuclear interactions originated from research in biochemistry and cell biology laboratories, although the broader ecological and evolutionary implications have yet to be fully explored. The imperative for mitonuclear coadaptation is proposed to be a major selective force in the evolution of sexual reproduction and two mating types in eukaryotes, in the formation of species, in the evolution of ornaments and sexual selection, in the process of adaptation, and in the evolution of senescence. The book highlights the importance of mitonuclear coadaptation to the evolution of complex life and champions mitonuclear ecology as an important subdiscipline in ecology and evolution.

Author : Henry H. Heng
Publisher : Academic Press
Page : 556 pages
File Size : 47,7 Mb
Release : 2019-05-25
Category : Medical
ISBN : 9780128136362

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Genome Chaos by Henry H. Heng Pdf

Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine Gathers the most pressing questions in genomic and cytogenomic research Offers alternative explanations to timely puzzles in the field Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 54,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : J. Zlatanova,S. H. Leuba
Publisher : Gulf Professional Publishing
Page : 546 pages
File Size : 42,7 Mb
Release : 2004
Category : Medical
ISBN : 0444515941

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Chromatin Structure and Dynamics by J. Zlatanova,S. H. Leuba Pdf

Biological processes that replicate, preserve and use the genetic information encoded in DNA must operate in the context of chromatin, a highly organized complex of DNA and proteins. These proteins do not merely package the DNA in the tiny volume of the nucleus, but impart the structure the ability to change according to the requirements of the specific process the DNA is involved in. Moreover, chromatin structure is used by the cell to control the activity of DNA. In this volume the basics of chromatin structure and dynamics are presented by established experts in the field.

Author : Dhavendra Kumar,Charis Eng
Publisher : Oxford Monographs on Medical G
Page : 853 pages
File Size : 48,9 Mb
Release : 2014-10-15
Category : Medical
ISBN : 9780199896028

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Genomic Medicine by Dhavendra Kumar,Charis Eng Pdf

Preceded by Genomics and clinical medicine / edited by Dhavendra Kumar. [First edition]. 2008.

Author : John P. Gearhart,Ranjiv Mathews
Publisher : Springer Science & Business Media
Page : 276 pages
File Size : 45,6 Mb
Release : 1999-07-31
Category : Medical
ISBN : 0306461285

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The Exstrophy—Epispadias Complex by John P. Gearhart,Ranjiv Mathews Pdf

This book contains the most up-to-date scientific information on the anatomy, physiology, and pathophysiology of the bladder muscle, nerves, and collagen in the patient with bladder exstrophy. In addition, this book covers the most modern surgical treatment of the infant born with bladder exstrophy and those who fail initial reconstruction. Chapters are contributed by major children's centers throughout the world. The aims of this book are to familiarize both the resident and the experienced practitioner with the most modern methods for the treatment for bladder exstrophy and epispadias. This book deals with the function, innervation, and pathophysiology of the bladder muscle in the patient born with bladder exstrophy. New concepts from leading laboratories around the world regarding the function of the bladder are discussed. In addition, experts offer their advice, expertise, and thoughts concerning the management of the patient born with bladder exstrophy. This book is intended for researchers who are interested in both the innervation, structure and function of bladder muscle and for pediatricians, pediatric surgeons, pediatric orthopedic surgeons, and both adult and pediatric urologists who deal with patients from birth until adult life who are born with bladder exstrophy. This is the first book to deal specifically with the basic science of bladder exstrophy and the clinical management of the bladder exstrophy-epispadias complex.

Author : Alexey V. Pindyurin,Veniamin Fishman
Publisher : Frontiers Media SA
Page : 248 pages
File Size : 53,5 Mb
Release : 2022-11-11
Category : Science
ISBN : 9782832505298

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The Role of High-Order Chromatin Organization in Gene Regulation by Alexey V. Pindyurin,Veniamin Fishman Pdf

Author : Mark C. Leake
Publisher : Humana
Page : 0 pages
File Size : 51,7 Mb
Release : 2016-06-10
Category : Medical
ISBN : 1493936298

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Chromosome Architecture by Mark C. Leake Pdf

This volume details a valuable collection of protocols and reviews, such as emerging experimental and theoretical approaches. These approaches have resulted in a substantial improvement in the understanding of chromosome architecture. Chromosome Architecture: Methods and Protocols guides readers through cutting-edge interdisciplinary methods which allow for an understanding of architecture of chromosomes with exceptionally enhanced resolution, both in terms of space and time. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chromosome Architecture: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Author : Ivan Iourov,Svetlana Vorsanova,Yuri Yurov
Publisher : Springer Nature
Page : 184 pages
File Size : 46,8 Mb
Release : 2021-01-29
Category : Medical
ISBN : 9783030625320

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Human Interphase Chromosomes by Ivan Iourov,Svetlana Vorsanova,Yuri Yurov Pdf

This second edition focuses on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and behavior of the human genome in interphase nuclei at chromosomal level has been repeatedly shown to play a significant role in almost all basic biological processes involved in the processing and inheritance of genetic information within and between species. Accordingly, post-genomic bioscience appeals to basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation opens new horizons for basic and applied bioscience Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze interphase nuclei are closely associated with application of these techniques in diagnostic and research practices to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This second edition serves as a source of updated valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology.