Chromosome Architecture

Author : Mark C. Leake
Publisher : Springer Nature
Page : 332 pages
File Size : 50,6 Mb
Release : 2022-05-30
Category : Science
ISBN : 9781071622216

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Chromosome Architecture by Mark C. Leake Pdf

This detailed new edition collects cutting-edge laboratory protocols, techniques, and applications in use by some of the leading international experts in the broad field of chromosome architecture. The book emphasizes the increasing physiological relevance of chromosome architecture investigation, manifest both through application of more complex bottom-up assays in vitro as well as through maintaining the native physiological context through the investigation of living, functional cells. In addition, the chapters reflect the dramatic improvement in the length scale of precision by utilizing single-molecule approaches, both for imaging the DNA content of chromosome and proteins that bind to DNA as well as using methods that can controllably manipulate single DNA molecules, and the use of advanced computational methods and mathematical analysis is also featured. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Chromosome Architecture: Methods and Protocols, Second Edition is an ideal guide for researchers working in this dynamic area of study.

Author : Mark C. Leake
Publisher : Humana
Page : 0 pages
File Size : 53,7 Mb
Release : 2016-06-10
Category : Medical
ISBN : 1493936298

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Chromosome Architecture by Mark C. Leake Pdf

This volume details a valuable collection of protocols and reviews, such as emerging experimental and theoretical approaches. These approaches have resulted in a substantial improvement in the understanding of chromosome architecture. Chromosome Architecture: Methods and Protocols guides readers through cutting-edge interdisciplinary methods which allow for an understanding of architecture of chromosomes with exceptionally enhanced resolution, both in terms of space and time. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chromosome Architecture: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Author : Anja Weise,Philipp G. Maass,Ron Hochstenbach
Publisher : Frontiers Media SA
Page : 94 pages
File Size : 53,5 Mb
Release : 2021-04-16
Category : Science
ISBN : 9782889666812

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Chromosome Biology as a Key to Understand Disease Mechanisms, Genome Architecture and Evolution by Anja Weise,Philipp G. Maass,Ron Hochstenbach Pdf

This topic has been realized, and is in collaboration with Dr. Constanze Pentzold, Post Doctoral Researcher at the Institute of Human Genetics, University Hospital Jena.

Author : Bernard John,Kenneth Roderick Lewis
Publisher : Unknown
Page : 188 pages
File Size : 41,9 Mb
Release : 1975
Category : Chromosomes
ISBN : UCAL:B4344442

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Chromosome Hierarchy by Bernard John,Kenneth Roderick Lewis Pdf

Introduction - Nuleus and chromosome; Chromosome architecture; Epigenetic activities; Phylogenetic functions; Conclusion - the chromosome as a genetic mechanism.

Author : Malgorzata Kloc,Jacek Z. Kubiak
Publisher : Springer Nature
Page : 657 pages
File Size : 55,6 Mb
Release : 2022-11-08
Category : Science
ISBN : 9783031065736

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Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine by Malgorzata Kloc,Jacek Z. Kubiak Pdf

This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.

Author : Kirti Prakash
Publisher : Springer
Page : 152 pages
File Size : 40,7 Mb
Release : 2017-02-20
Category : Science
ISBN : 9783319521831

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Chromatin Architecture by Kirti Prakash Pdf

This book sheds new light on the current state of knowledge concerning chromatin organization. Particular emphasis is given to the new imaging potential offered by super-resolution microscopy, which allows DNA imaging with a very high labeling density. From the early work on chromosomes by Walther Flemming in the nineteenth century to recent advances in genomics, the history of chromatin research now spans more than a century. The various milestones, such as the discovery of the double helix structure, the sequencing of the human genome, and the recent description of the genome in 3D space, show that understanding chromatin and chromosome function requires a clear understanding of its structure. Presenting cutting-edge data from super-resolution single molecule microscopy, the book demonstrates that chromatin manifests several levels of folding, from nucleosomes to chromosomes. Chromatin domains emerge as a new fundamental building block of chromatin architecture, with functions possibly related to gene regulation. A detailed description of chromatin folding in the pachytene stage of meiosis serves as a model for exploring this functionality, showing the apparent interplay between structure, function, and epigenetic regulation. Lastly, the book discusses possible new avenues of innovation to describe chromatin’s organization and functions. Gathering essential insights on chromatin architecture, the book offers students an introduction to microscopy and its application to chromatin organization, while also providing advanced readers with new ideas for future research.

Author : Eeva Therman,Millard Susman
Publisher : Springer Science & Business Media
Page : 392 pages
File Size : 49,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468405293

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Human Chromosomes by Eeva Therman,Millard Susman Pdf

This book, like the two previous editions, was written as an introduction to human cytogenetics, but it could also be used as a text for a general cytogenetics course, since chromosome structure and behavior are similar in all eukaryotes. Many examples in this book are from organisms other than humans, reflecting our combined backgrounds of molecular and bacterial genetics, and plant and animal cytogenetics. In the rapidly expanding field of human cytogenetics, certain subjects, for instance clinical and cancer cytogenetics, are now covered in recently published, thousand-page volumes. In this book, such subjects are presented only in outline. The enormous growth of information has also made the choice of topics and of examples to illustrate them even more arbitrary and subjective than in the previous editions. Apart from a few pages here and there, the text has been rewritten. Major parts, especially those on molecular matters, have been added. This book would not exist without the dedicated participation of Mrs. Barbara Susman. She has been involved in the project from the planning stages to the final proofreading. She has done the extensive literature research, designed most of the tables and illustrations, and edited and typed the text. For discussions and suggestions we are indebted to many colleagues. We wish especially to mention Drs. Lassi Alvesalo, Evelyn M. Kuhn, and Renata Laxova, who have critically read selected parts of the book, and Dr. Carter Denniston, who has read the whole text.

Author : Ivan Iourov,Svetlana Vorsanova,Yuri Yurov
Publisher : Springer Nature
Page : 184 pages
File Size : 41,9 Mb
Release : 2021-01-29
Category : Medical
ISBN : 9783030625320

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Human Interphase Chromosomes by Ivan Iourov,Svetlana Vorsanova,Yuri Yurov Pdf

This second edition focuses on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and behavior of the human genome in interphase nuclei at chromosomal level has been repeatedly shown to play a significant role in almost all basic biological processes involved in the processing and inheritance of genetic information within and between species. Accordingly, post-genomic bioscience appeals to basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation opens new horizons for basic and applied bioscience Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze interphase nuclei are closely associated with application of these techniques in diagnostic and research practices to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This second edition serves as a source of updated valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology.

Author : Karsten Rippe
Publisher : John Wiley & Sons
Page : 597 pages
File Size : 55,7 Mb
Release : 2011-12-19
Category : Science
ISBN : 9783527326983

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Genome Organization And Function In The Cell Nucleus by Karsten Rippe Pdf

By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin structure, epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come.

Author : Anonim
Publisher : ScholarlyEditions
Page : 311 pages
File Size : 41,6 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464924682

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Chromosome Structures: Advances in Research and Application: 2011 Edition by Anonim Pdf

Chromosome Structures: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chromosome Structures. The editors have built Chromosome Structures: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chromosome Structures in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chromosome Structures: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : John Kaisermann
Publisher : Cambridge Stanford Books
Page : 75 pages
File Size : 47,8 Mb
Release : 2024-06-27
Category : Science
ISBN : 8210379456XXX

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Organization of human chromosomes by John Kaisermann Pdf

Since 2012, thousands of human genomes have been completely sequenced, and many more have been mapped at lower levels of resolution. The resulting data is used worldwide in biomedical sciences, anthropology, forensic medicine and other branches of science. Recent results suggest that most of the vast amounts of non-coding DNA within the genome have associated biochemical activities, including regulation of gene expression, organization of chromosome architecture and signals that control epigenetic inheritance. Summary of the contents of this book: Organization of human chromosomes Nuclear organization and rearrangements in pluripotent cells Organization of the human genome Repetitive elements and human disorders Mitochondrial DNA Cell division The cell cycle The phases of mitosis The human karyotype Karyotype analysis Types of staining Meiosis Cytokinesis The Second Meiotic Division (Meiosis II)

Author : Günter Kahl
Publisher : Unknown
Page : 540 pages
File Size : 45,8 Mb
Release : 1988
Category : Cytogenetics
ISBN : UOM:39015013577690

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Architecture of Eukaryotic Genes by Günter Kahl Pdf

Author : Anonim
Publisher : ScholarlyEditions
Page : 397 pages
File Size : 44,6 Mb
Release : 2012-12-26
Category : Science
ISBN : 9781464993800

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Advances in Chromatin Research and Application: 2012 Edition by Anonim Pdf

Advances in Chromatin Research and Application / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chromatin. The editors have built Advances in Chromatin Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chromatin in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Chromatin Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Oswaal Editorial Board
Publisher : Oswaal Books
Page : 449 pages
File Size : 49,6 Mb
Release : 2023-11-27
Category : Study Aids
ISBN : 9789359580463

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Oswaal CBSE LMP Last Minute Preparation System Class 12 Science Stream (Physics, Chemistry, Mathematics, Biology & English Core) With board Additional Practice questions For 2024 Board Exams #WinTheBoards by Oswaal Editorial Board Pdf

Description of the product: • Revision Notes to fill learning gaps • Mind Maps & Mnemonics for crisp recall. • Concept Videos for Visual Learnings • Board Additional Practice Papers 1 & 2 for Exam Practice

Author : M. Schmid,Indrajit Nanda
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 45,5 Mb
Release : 2004-02-29
Category : Medical
ISBN : 140200091X

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Chromosomes Today by M. Schmid,Indrajit Nanda Pdf

Chromosomes Today volume 14 records the plenary proceedings of the 14th International Chromosome Conference, presenting an overview of the current concerns in plant, animal and human cytogenetics. This volume provides up-to-date information regarding relevant aspects on structure, function and evolution of chromosomes, meiosis, sex chromosomes, and cancer cytogenetics. It contains invited contributions from some of the world's leading experts in the field.