Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

Author : Anonim
Publisher : Academic Press
Page : 564 pages
File Size : 53,8 Mb
Release : 2020-08-26
Category : Science
ISBN : 9780128210185

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Quadruplex Nucleic Acids As Targets For Medicinal Chemistry by Anonim Pdf

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Annual Reports in Medicinal Chemistry series

Author : Stephen Neidle,Shankar Balasubramanian
Publisher : Royal Society of Chemistry
Page : 301 pages
File Size : 42,5 Mb
Release : 2007-10-31
Category : Science
ISBN : 9781847555298

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Quadruplex Nucleic Acids by Stephen Neidle,Shankar Balasubramanian Pdf

Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and stability. The biology of quadruplexes and G-rich genomic regions and G-quartets in supramolecular chemistry and nanoscience are also considered. Surveying the current state of knowledge, and with contributions from leading experts, this is the first comprehensive review of this rapidly growing area. Quadruplex Nucleic Acids is ideal for researchers interested in areas related to chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology.

Author : Stephen Neidle
Publisher : Academic Press
Page : 210 pages
File Size : 40,9 Mb
Release : 2012
Category : Business & Economics
ISBN : 9780123751386

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Therapeutic Applications of Quadruplex Nucleic Acids by Stephen Neidle Pdf

"Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. [4] of cover.

Author : Lihe Zhang,Xinjing Tang,Zhen Xi,Jyoti Chattopadhyaya
Publisher : John Wiley & Sons
Page : 564 pages
File Size : 47,5 Mb
Release : 2023-01-05
Category : Science
ISBN : 9781119692744

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Nucleic Acids in Medicinal Chemistry and Chemical Biology by Lihe Zhang,Xinjing Tang,Zhen Xi,Jyoti Chattopadhyaya Pdf

Nucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field. Readers will also find: A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry Comprehensive explorations of the methods used to determine the development of nucleic acid drugs Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistry Perfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.

Author : Amanda L. Garner
Publisher : Springer
Page : 259 pages
File Size : 50,9 Mb
Release : 2017-09-26
Category : Science
ISBN : 9783319680910

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RNA Therapeutics by Amanda L. Garner Pdf

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Author : Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski
Publisher : Springer Science & Business
Page : 599 pages
File Size : 49,6 Mb
Release : 2014-04-22
Category : Science
ISBN : 9783642544521

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Chemical Biology of Nucleic Acids by Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barciszewski Pdf

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.

Author : Lihe Zhang,Zhen Xi,Jyoti Chattopadhyaya
Publisher : John Wiley & Sons
Page : 477 pages
File Size : 54,8 Mb
Release : 2011-08-10
Category : Medical
ISBN : 9781118092811

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Medicinal Chemistry of Nucleic Acids by Lihe Zhang,Zhen Xi,Jyoti Chattopadhyaya Pdf

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

Author : Julius A. Vida,Maxwell Gordon,American Chemical Society. Division of Medicinal Chemistry
Publisher : Unknown
Page : 296 pages
File Size : 42,6 Mb
Release : 1984
Category : Medical
ISBN : UOM:39015018156953

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Conformationally Directed Drug Design by Julius A. Vida,Maxwell Gordon,American Chemical Society. Division of Medicinal Chemistry Pdf

Author : Carmen Avendaño,J. Carlos Menéndez
Publisher : Elsevier
Page : 1062 pages
File Size : 42,5 Mb
Release : 2023-04-28
Category : Science
ISBN : 9780128196526

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Medicinal Chemistry of Anticancer Drugs by Carmen Avendaño,J. Carlos Menéndez Pdf

This third edition of Medicinal Chemistry of Anticancer Drugs, provides an updated resource for students and researchers from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. This new edition includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theranostic anticancer agents, and pre-mRNA processing in cancer. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a unique and valuable perspective from the point of view of medicinal chemistry and drug design. It will be useful to undergraduate and postgraduate students of medicinal chemistry, pharmacology, biological chemistry, pharmacy and other health sciences. Researchers and practitioners will find a comprehensive treatment of the topic and a large number of references to reviews and the primary literature. Provides a resource that is organized consistently based on targets and mechanisms of action from a molecular point-of-view Focuses on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, providing a rationalization on the action of these type of drugs and the design of new active structures Features a large number of color figures which give information in a clear-and-concise way Includes extensive references to review articles and primary literature Includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theragnostic anticancer agents, and pre-mRNA processing in cancer

Author : Jonathan B. Chaires,David Graves
Publisher : Springer
Page : 0 pages
File Size : 44,7 Mb
Release : 2013-03-16
Category : Science
ISBN : 3642347428

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Quadruplex Nucleic Acids by Jonathan B. Chaires,David Graves Pdf

Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay, by Christine E. Kaiser, Vijay Gokhale, Danzhou Yang and Laurence H. Hurley.- Higher-Order Quadruplex Structures, by Luigi Petraccone.- Investigation of Quadruplex Structure Under Physiological Conditions Using In-Cell NMR, by Robert Hänsel, Silvie Foldynová-Trantírková, Volker Dötsch and Lukás Trantírek.- Circular Dichroism of Quadruplex Structures, by Antonio Randazzo, Gian Piero Spada and Mateus Webba da Silva.- Molecular Crowding and Hydration Regulating of G-Quadruplex Formation, by Daisuke Miyoshi, Takeshi Fujimoto and Naoki Sugimoto.- Visualizing the Quadruplex: From Fluorescent Ligands to Light-Up Probes, by Eric Largy, Anton Granzhan, Florian Hamon, Daniela Verga and Marie-Paule Teulade-Fichou.- Calculation of Hydrodynamic Properties for G-Quadruplex Nucleic Acid Structures from in silico Bead Models, by Huy T. Le, Robert Buscaglia, William L. Dean, Jonathan B. Chaires and John O. Trent.- Energetics of Ligand Binding to G-Quadruplexes, Concetta Giancola and Bruno Pagano.- Tetramolecular Quadruplex Stability and Assembly, by Phong Lan Thao Tran, Anne De Cian, Julien Gros, Rui Moriyama and Jean-Louis Mergny.

Author : Li-He Zhang,Zhen Xi,Jyoti Chattopadhyaya
Publisher : John Wiley & Sons
Page : 477 pages
File Size : 44,8 Mb
Release : 2011-08-30
Category : Medical
ISBN : 9780470596685

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Medicinal Chemistry of Nucleic Acids by Li-He Zhang,Zhen Xi,Jyoti Chattopadhyaya Pdf

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

Author : Stephen Neidle,Mark Sanderson
Publisher : Academic Press
Page : 456 pages
File Size : 45,8 Mb
Release : 2021-10-15
Category : Science
ISBN : 9780128196786

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Principles of Nucleic Acid Structure by Stephen Neidle,Mark Sanderson Pdf

Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA). This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results. Completely updated, with an expanded section on protein-nucleic acid interactions that reflects major increases in our knowledge Defines technical terms for novices Includes a complete list of resources, including relevant online databases and software, as well as useful websites

Author : Danzhou Yang,Clement Lin
Publisher : Humana
Page : 437 pages
File Size : 44,8 Mb
Release : 2020-09-07
Category : Medical
ISBN : 1493996681

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G-Quadruplex Nucleic Acids by Danzhou Yang,Clement Lin Pdf

This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and cutting-edge, G-Quadruplex DNA: Methods and Protocols is a valuable resource for both novice and experienced researchers who work in biophysics, structural biology, computational biology, biochemistry, and molecular and cell biology, and who want to learn more about the potential roles and effects of G-quadruplex in these fields.

Author : Anonim
Publisher : Elsevier
Page : 4609 pages
File Size : 43,9 Mb
Release : 2017-06-03
Category : Technology & Engineering
ISBN : 9780128032015

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Comprehensive Medicinal Chemistry III by Anonim Pdf

Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Author : Sapna Malviya,Neelesh Malviya
Publisher : CRC Press
Page : 294 pages
File Size : 55,8 Mb
Release : 2023-10-03
Category : Health & Fitness
ISBN : 9781000923131

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Medicinal Plants and Cancer Chemoprevention by Sapna Malviya,Neelesh Malviya Pdf

Cancer is the second leading cause of death globally. Medicinal Plants and Cancer Chemoprevention provides information on the use of various herbal plants used as anticancer agents. It discusses the traditional system of medicine and focuses on plant-derived compounds for cancer therapy with integrated approaches. Chapters present information on various medicinal plants that covers background and history, ethnomedical considerations, morphology, phytochemistry, and pharmacological properties. The book presents a scientific investigation on medicinal plants in managing cancer, reported mechanisms of action as anticancer activity, as well as covering the toxicological aspects of certain plants. KEY FEATURES: · Details information on plant-derived compounds for cancer therapy. · Features information on methods of extraction and isolation of various phytoconstituents responsible for anticancer activity. · Discusses herbal formulations and alternative approaches used for the management and treatment of cancer. · Demonstrates the importance of alternative approaches including yoga, acupuncture, and dietary supplements to be effective in the management of cancer. This book is helpful to botanists, researchers and practitioners in alternative and complementary medicine, and the herbal medicine research community.