Oecd Guidelines For The Testing Of Chemicals Oecd Series On Testing And Assessment Guidance Document On The Recognition Assessment And Use Of Clinical Signs As Human Endpoints For Experimental Animals Used In Safety Evaluation

Author : OECD
Publisher : OECD Publishing
Page : 39 pages
File Size : 52,6 Mb
Release : 2002-05-10
Category : Electronic
ISBN : 9789264078376

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OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on the Recognition, Assessment and Use of Clinical Signs as Human Endpoints for Experimental Animals Used in Safety Evaluation by OECD Pdf

The purpose of this Guidance Document is to apply the principles of the Three Rs to the use of animals in regulatory toxicity tests.

Author : Organisation for Economic Co-operation and Development
Publisher : Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
Page : 128 pages
File Size : 51,8 Mb
Release : 1981
Category : Chemical industry
ISBN : 9264122214

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OECD Guidelines for Testing of Chemicals by Organisation for Economic Co-operation and Development Pdf

Author : OECD
Publisher : OECD Publishing
Page : 27 pages
File Size : 47,8 Mb
Release : 2016-07-29
Category : Electronic
ISBN : 9789264264885

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 489: In Vivo Mammalian Alkaline Comet Assay by OECD Pdf

The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.

Author : OECD
Publisher : OECD Publishing
Page : 156 pages
File Size : 45,9 Mb
Release : 2014-09-03
Category : Electronic
ISBN : 9789264221475

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OECD Series on Testing and Assessment Guidance Document 116 on the Conduct and Design of Chronic Toxicity and Carcinogenicity Studies, Supporting Test Guidelines 451, 452 and 453 Second edition by OECD Pdf

This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453.

Author : OECD
Publisher : OECD Publishing
Page : 13 pages
File Size : 53,5 Mb
Release : 2023-07-04
Category : Electronic
ISBN : 9789264185333

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 405: Acute Eye Irritation/Corrosion by OECD Pdf

This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is ...

Author : OECD
Publisher : OECD Publishing
Page : 15 pages
File Size : 41,5 Mb
Release : 2018-06-27
Category : Electronic
ISBN : 9789264071186

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 451: Carcinogenicity Studies by OECD Pdf

The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses of a test substance by an appropriate route of ...

Author : OECD
Publisher : OECD Publishing
Page : 20 pages
File Size : 54,8 Mb
Release : 2018-06-27
Category : Electronic
ISBN : 9789264071223

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies by OECD Pdf

The objective of a combined chronic toxicity/carcinogenicity study is to identify carcinogenic and the majority of chronic effects, and to determine dose-response relationships following prolonged and repeated exposure. The rat is typically used for ...

Author : OECD
Publisher : OECD Publishing
Page : 217 pages
File Size : 49,9 Mb
Release : 2004-11-01
Category : Electronic
ISBN : 9789264078857

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OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Background Review of the Uterotrophic Bioassay by OECD Pdf

This detailed background review paper provides a summary of the relevant literature (up to September 2001) relevant to the standardisation and validation of the rodent uterotrophic bioassay.

Author : OECD
Publisher : OECD Publishing
Page : 27 pages
File Size : 54,5 Mb
Release : 2009-09-08
Category : Electronic
ISBN : 9789264076037

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OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects Test No. 436: Acute Inhalation Toxicity – Acute Toxic Class Method by OECD Pdf

The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according to the Globally Harmonized System of ...

Author : OECD
Publisher : OECD Publishing
Page : 20 pages
File Size : 55,7 Mb
Release : 2024-06-25
Category : Electronic
ISBN : 9789264070608

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 403: Acute Inhalation Toxicity by OECD Pdf

This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...

Author : Thangaraj Parimelazhagan
Publisher : Springer
Page : 188 pages
File Size : 50,5 Mb
Release : 2015-12-29
Category : Medical
ISBN : 9783319268118

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Pharmacological Assays of Plant-Based Natural Products by Thangaraj Parimelazhagan Pdf

This volume provides information on how to select and screen plants for their medicinal properties. It describes phytopharmacological techniques for extracting and qualitatively and quantitatively analyzing a plant’s phytochemicals. After a detailed in vitro investigation including nutritional and anti-nutritional analyses, medicinal properties were tested with various in vivo models for anti-inflammatory, analgesic, anti-pyretic, anticancer and anti-diabetic properties, as well as wound healing, neurodegenerative diseases, etc. Compound identification and purification techniques include, among others, TLC and column chromatography, as well as molecular docking with specific proteins.

Author : OECD
Publisher : OECD Publishing
Page : 249 pages
File Size : 52,8 Mb
Release : 2002-05-10
Category : Electronic
ISBN : 9789264078475

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OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures by OECD Pdf

This document sets out the objectives, organisational context, and plan for a Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures.

Author : OECD
Publisher : OECD Publishing
Page : 7 pages
File Size : 42,5 Mb
Release : 2017-10-09
Category : Electronic
ISBN : 9789264070585

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 402: Acute Dermal Toxicity by OECD Pdf

This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ...

Author : OECD
Publisher : OECD Publishing
Page : 112 pages
File Size : 51,7 Mb
Release : 2002-12-12
Category : Electronic
ISBN : 9789264078499

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OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Notes for Analysis and Evaluation of Chronic Toxicity and Carcinogenicity Studies by OECD Pdf

These Guidance Notes outline core concepts in order to obviate the need to consult large numbers of text books, while still pointing the reader to sources of more detailed or specific information.

Author : OECD
Publisher : OECD Publishing
Page : 60 pages
File Size : 46,7 Mb
Release : 2017-04-13
Category : Electronic
ISBN : 9789264274761

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OECD Series on Testing and Assessment Overview on genetic toxicology TGs by OECD Pdf

Following a general update of the Genetic Toxicology TGs in 2015, the present Document was written to provide succinct and useful information to individuals unfamiliar with genetic toxicology testing, as well as experienced individuals wishing to obtain an overview of the recent changes that ...