Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 453 Combined Chronic Toxicity Carcinogenicity Studies

Author : OECD
Publisher : OECD Publishing
Page : 20 pages
File Size : 47,6 Mb
Release : 2018-06-27
Category : Electronic
ISBN : 9789264071223

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies by OECD Pdf

The objective of a combined chronic toxicity/carcinogenicity study is to identify carcinogenic and the majority of chronic effects, and to determine dose-response relationships following prolonged and repeated exposure. The rat is typically used for ...

Author : OECD
Publisher : OECD Publishing
Page : 16 pages
File Size : 45,5 Mb
Release : 2018-06-27
Category : Electronic
ISBN : 9789264071209

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies by OECD Pdf

The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both ...

Author : OECD
Publisher : OECD Publishing
Page : 12 pages
File Size : 47,7 Mb
Release : 2006-09-11
Category : Electronic
ISBN : 9789264035447

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OECD Guidelines for the Testing of Chemicals / Section 4: Health Effects Summary of Considerations in the Report from the OECD Expert Groups on Short Term and Long Term Toxicology by OECD Pdf

Author : OECD
Publisher : OECD Publishing
Page : 15 pages
File Size : 48,7 Mb
Release : 2018-06-27
Category : Electronic
ISBN : 9789264071186

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 451: Carcinogenicity Studies by OECD Pdf

The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses of a test substance by an appropriate route of ...

Author : OECD
Publisher : OECD Publishing
Page : 156 pages
File Size : 52,7 Mb
Release : 2014-09-03
Category : Electronic
ISBN : 9789264221475

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OECD Series on Testing and Assessment Guidance Document 116 on the Conduct and Design of Chronic Toxicity and Carcinogenicity Studies, Supporting Test Guidelines 451, 452 and 453 Second edition by OECD Pdf

This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453.

Author : OECD
Publisher : OECD Publishing
Page : 112 pages
File Size : 44,9 Mb
Release : 2002-12-12
Category : Electronic
ISBN : 9789264078499

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OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Notes for Analysis and Evaluation of Chronic Toxicity and Carcinogenicity Studies by OECD Pdf

These Guidance Notes outline core concepts in order to obviate the need to consult large numbers of text books, while still pointing the reader to sources of more detailed or specific information.

Author : OECD
Publisher : OECD Publishing
Page : 20 pages
File Size : 47,5 Mb
Release : 2024-06-25
Category : Electronic
ISBN : 9789264070608

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 403: Acute Inhalation Toxicity by OECD Pdf

This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 ...

Author : OECD
Publisher : OECD Publishing
Page : 15 pages
File Size : 47,5 Mb
Release : 2018-06-27
Category : Electronic
ISBN : 9789264070806

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 413: Subchronic Inhalation Toxicity: 90-day Study by OECD Pdf

This revised Test Guideline has been designed to fully characterize test article toxicity by the inhalation route for a subchronic duration (90 days), and to provide robust data for quantitative inhalation risk assessments. Groups of 10 male and 10 ...

Author : OECD
Publisher : OECD Publishing
Page : 27 pages
File Size : 54,8 Mb
Release : 2009-09-08
Category : Electronic
ISBN : 9789264076037

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OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects Test No. 436: Acute Inhalation Toxicity – Acute Toxic Class Method by OECD Pdf

The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according to the Globally Harmonized System of ...

Author : OECD
Publisher : OECD Publishing
Page : 9 pages
File Size : 53,8 Mb
Release : 1981-05-12
Category : Electronic
ISBN : 9789264070769

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 411: Subchronic Dermal Toxicity: 90-day Study by OECD Pdf

This study relates to the analysis, via dermal application, of the health hazards of solid or liquid test substance. It may be carried out after initial information obtained by acute testing. This method is composed of the main test and the limit ...

Author : Aibo Wu
Publisher : Springer Nature
Page : 169 pages
File Size : 42,6 Mb
Release : 2019-11-08
Category : Technology & Engineering
ISBN : 9789813290389

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Food Safety & Mycotoxins by Aibo Wu Pdf

Mycotoxins are increasingly attracting attention at thegovernmental, public and academic level worldwide, due to more frequent and serious contaminations of food and feedstuffs, which pose a serious threat to human health and animal production. This book reviews the latest research on mycotoxins that directly concern food safety, and especially focuses on detection technologies, risk assessment and control strategiescurrently being used in China. Gathering contributions from over 20 respected researchers, the book will benefit graduatestudents, researchers and management groups from various disciplines, including food science and technology, analytical chemistry, plant pathology, public health, etc.

Author : OECD
Publisher : OECD Publishing
Page : 9 pages
File Size : 53,7 Mb
Release : 1998-09-21
Category : Electronic
ISBN : 9789264070721

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 409: Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents by OECD Pdf

This method provides information on health hazard likely to arise from short-term exposure to test substance. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been ...

Author : Ambrus Arpad,Hamilton Denis J
Publisher : World Scientific
Page : 568 pages
File Size : 47,9 Mb
Release : 2017-01-05
Category : Technology & Engineering
ISBN : 9781786341709

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Food Safety Assessment Of Pesticide Residues by Ambrus Arpad,Hamilton Denis J Pdf

Pesticides are now accepted as an integral part of modern agricultural production. This book provides analysis of the steps taken by national and international bodies working towards a cohesive global strategy for evaluating the safety of residues in food that result from approved pesticide uses. Also described is the role of the UN Food and Agriculture Organization (FAO), World Health Organization (WHO) and Codex Alimentarius in developing standards that protect the health of the consumers and ensure fair practices in the food trade. It goes on to look at the promotion of good agricultural practice in the use of pesticides and the need for control in their practical use. These include sampling, testing the compliance of marketed products against legal limits and verifying the effectiveness of the safety-based regulatory measures. This is a specialist book for those looking to go into the field of international food safety, for students and lecturers studying the topic, for policy makers working on public health and agricultural issues, and personnel responsible for taking samples and performing the analysis of pesticide formulations and residues.

Author : OECD
Publisher : OECD Publishing
Page : 14 pages
File Size : 48,8 Mb
Release : 2002-02-08
Category : Electronic
ISBN : 9789264070943

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure by OECD Pdf

A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...

Author : OECD
Publisher : OECD Publishing
Page : 19 pages
File Size : 55,8 Mb
Release : 2016-07-29
Category : Electronic
ISBN : 9789264264403

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test by OECD Pdf

This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance. It has been updated with endocrine disruptor endpoints, in particular measure of anogenital distance and male nipple retention in pups and thyroid examination.