Oligomerization In Health And Disease From Enzymes To G Protein Coupled Receptors

Author : Anonim
Publisher : Academic Press
Page : 348 pages
File Size : 54,6 Mb
Release : 2020-01-31
Category : Science
ISBN : 9780128179291

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Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors by Anonim Pdf

Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors, Volume 169 in the Progress in Molecular Biology and Translational Science series, provides in-depth reviews on topics of exceptional scienti?c importance. Topics of note in this new release include Computational prediction and re-design of aberrant oligomerization, Oligomerization of G protein-coupled receptors: an historical overview, Prediction and targeting of GPCR oligomer interfaces, GPCR Oligomerization dynamics: Functional consequences, GPCR heteromerization in neuropsychiatric disorders, Structural basis of regulation and oligomerization of human cystathionine ?-synthase, and Oligomerization of Porphobilinogen Synthase. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field of molecular biology

Author : Anonim
Publisher : Academic Press
Page : 656 pages
File Size : 40,8 Mb
Release : 2013-05-07
Category : Science
ISBN : 9780123869500

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Oligomerization in Health and Disease by Anonim Pdf

This special volume of Progress in Molecular Biology and Translational Science focuses on oligomerization in health and disease. Contributions from leading authorities Informs and updates on all the latest developments in the field

Author : Anonim
Publisher : Academic Press
Page : 480 pages
File Size : 53,6 Mb
Release : 2013-01-24
Category : Science
ISBN : 9780123918734

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G Protein Coupled Receptors by Anonim Pdf

This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high throughput assays for identification of pharmacoperone drugs. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers G protein coupled receptors Contains chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high-throughput assays for identifying pharmacoperone drugs

Author : Anonim
Publisher : Academic Press
Page : 350 pages
File Size : 54,5 Mb
Release : 2020-01-16
Category : Science
ISBN : 9780128179307

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Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors by Anonim Pdf

Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors, Volume 169 in the Progress in Molecular Biology and Translational Science series, provides in-depth reviews on topics of exceptional scienti?c importance. Topics of note in this new release include Computational prediction and re-design of aberrant oligomerization, Oligomerization of G protein-coupled receptors: an historical overview, Prediction and targeting of GPCR oligomer interfaces, GPCR Oligomerization dynamics: Functional consequences, GPCR heteromerization in neuropsychiatric disorders, Structural basis of regulation and oligomerization of human cystathionine ß-synthase, and Oligomerization of Porphobilinogen Synthase. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field of molecular biology

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 49,9 Mb
Release : 2009
Category : Cellular signal transduction
ISBN : OCLC:424556114

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G Protein-coupled Receptors in Health and Disease by Anonim Pdf

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 43,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Antonino Belfiore,Derek LeRoith
Publisher : Springer
Page : 0 pages
File Size : 54,6 Mb
Release : 2018-02-08
Category : Medical
ISBN : 3319446746

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Principles of Endocrinology and Hormone Action by Antonino Belfiore,Derek LeRoith Pdf

This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.

Author : Graeme Milligan,Ikuo Kimura
Publisher : Springer
Page : 0 pages
File Size : 42,9 Mb
Release : 2018-07-13
Category : Medical
ISBN : 3319844644

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Free Fatty Acid Receptors by Graeme Milligan,Ikuo Kimura Pdf

This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.

Author : Jesus Avila,Naruhiko Sahara
Publisher : Frontiers E-books
Page : 114 pages
File Size : 46,5 Mb
Release : 2014-08-18
Category : Medicine (General)
ISBN : 9782889192618

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Tau oligomers by Jesus Avila,Naruhiko Sahara Pdf

Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.

Author : Matthew Summers
Publisher : BoD – Books on Demand
Page : 228 pages
File Size : 53,8 Mb
Release : 2019-06-19
Category : Science
ISBN : 9781838804909

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Ubiquitin Proteasome System by Matthew Summers Pdf

The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

Author : Senthilkumar Rajagopal,Murugavel Ponnusamy
Publisher : Springer
Page : 76 pages
File Size : 44,9 Mb
Release : 2018-11-19
Category : Medical
ISBN : 9789811315718

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Metabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases by Senthilkumar Rajagopal,Murugavel Ponnusamy Pdf

This book will provide current understandings about two ubiquitously expressed metabotropic GPCRs, G-coupled purinoreceptor type 2 (P2Y) and Takeda G-protein-coupled bile acid receptor 5 (TGR5). G protein coupled receptors (GPCRs) are the largest family of proteins implicated in majority of cellular responses. The two receptor sub-families play a central role in many physiological functions as well as in many pathological conditions. This book offers up-to-date information on the physiological functions, signaling pathways and regulatory mechanisms of P2Y and TGR5 receptors. In addition, this book provides a comprehensive overview about the abnormalities of P2Y/TGR5 receptors and their contribution in the development and progression of pathological conditions. It also covers the currently available natural, chemical and pharmacological agents targeting these two receptor families and their therapeutic implications in P2Y and TGR5 associated disorders. This book is a valuable source for beginners and researchers to follow the rapidly progressing field of these two GPCR subfamily members.

Author : Anonim
Publisher : Academic Press
Page : 644 pages
File Size : 51,9 Mb
Release : 2015-04-30
Category : Science
ISBN : 9780128021934

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Membrane Proteins – Engineering, Purification and Crystallization by Anonim Pdf

Membrane Proteins – Engineering, Purification and Crystallization, a volume of Methods In Enzymology, encompasses chapters from the leading experts in the area of membrane protein biology. The chapters provide a brief overview of the topics covered and also outline step-by-step protocol for the interested audience. Illustrations and case example images are included wherever appropriate to help the readers understand the schematics and general experimental outlines. Volume of Methods In Enzymology Contains a collection of a diverse array of topics in the area of membrane protein biology ranging from recombinant expression, isolation, functional characterization, biophysical studies and crystallization

Author : Kjell Fuxe,Luigi F. Agnati
Publisher : Springer Science & Business Media
Page : 577 pages
File Size : 52,6 Mb
Release : 2013-03-13
Category : Computers
ISBN : 9781468454154

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Receptor-Receptor Interactions by Kjell Fuxe,Luigi F. Agnati Pdf

Author : Amitabha Chattopadhyay
Publisher : CRC Press
Page : 224 pages
File Size : 45,6 Mb
Release : 2007-05-17
Category : Science
ISBN : 1420005758

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Serotonin Receptors in Neurobiology by Amitabha Chattopadhyay Pdf

A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from leading experts in their fields, the book explores serotonin receptors from a broad-based, multidisciplinary approach. The approaches described vary from molecular biological techniques to fluorescence microscopy and imaging, to genetic manipulation in animal models, providing a wide range of tools to study serotonergic phenomena. While each of these approaches has its own advantages and limitations, the synthesis of information and knowledge achieved from studies using multiple approaches will result in a comprehensive understanding of the underlying complex phenomena involved in serotonergic signaling and its implications in health and disease. The book provides an overall understanding of these receptors based on currently used methodologies and techniques. It describes specific experimental procedures that will be of use to researchers interested in addressing similar problems involving other G-protein-coupled receptor signaling systems.

Author : J. Robin Harris,Jon Marles-Wright
Publisher : Springer Nature
Page : 580 pages
File Size : 40,8 Mb
Release : 2020-11-30
Category : Science
ISBN : 9783030589714

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Macromolecular Protein Complexes III: Structure and Function by J. Robin Harris,Jon Marles-Wright Pdf

This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.