Ubiquitin Proteasome System

Author : Matthew Summers
Publisher : BoD – Books on Demand
Page : 228 pages
File Size : 49,7 Mb
Release : 2019-06-19
Category : Science
ISBN : 9781838804909

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Ubiquitin Proteasome System by Matthew Summers Pdf

The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

Author : Aldrin V. Gomes
Publisher : Nova Medicine & Health
Page : 0 pages
File Size : 53,6 Mb
Release : 2018
Category : Central nervous system
ISBN : 1536135186

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Ubiquitin Proteasome System by Aldrin V. Gomes Pdf

Over the last decade, major advancements in our understanding of the ubiquitin-proteasome system (UPS) have occurred. This book focuses on recent trends in the UPS. The UPS is possibly the most complex of all intracellular pathways as close to 7% of all genes in the human genome make up part of the UPS. This complex system serves as an essential role in intracellular protein degradation, and because of its critical function, improper functioning of the UPS is associated with nearly all know diseases, including cancer, cardiovascular disease, and neurological diseases. The proteolytic component of the UPS is the proteasome, a multicatalytic complex found in the nucleus and cytoplasm. Another form of the proteasome, the immunoproteasome, is less abundant than the constitutive proteasome, but is important in immune response and degradation of oxidized proteins, and recent research suggests that it may be important in longevity. The articles in this book discuss recent findings which indicate that mutations in proteins involved with the UPS are associated with genetic diseases such as familial dilated cardiomyopathy, Nakajo syndrome, and spinal muscular atrophy (X-linked). Some chapters also discuss recent results which suggest that the UPS is heavily regulated by post-translational modifications such as phosphorylation, acetylation, and methylation. The UPS is also heavily regulated by ubiquitination itself. This book contains a research article using PubMed bibliometric data to present current research trends in the UPS. Articles are written so that no one tissue is emphasized to allow readers from any discipline to benefit from this information.

Author : R. John Mayer,Aaron J. Ciechanover,Martin Rechsteiner
Publisher : John Wiley & Sons
Page : 252 pages
File Size : 50,5 Mb
Release : 2008-06-25
Category : Science
ISBN : 9783527620296

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Cell Biology of the Ubiquitin-Proteasome System by R. John Mayer,Aaron J. Ciechanover,Martin Rechsteiner Pdf

The third of four volumes discusses the role of ubiquitin-mediated protein breakdown in cellular regulation and physiology. Required reading for molecular biologists, cell biologists and physiologists with an interest in the topic.

Author : R. John Mayer,Aaron J. Ciechanover,Martin Rechsteiner
Publisher : John Wiley & Sons
Page : 300 pages
File Size : 42,7 Mb
Release : 2008-06-25
Category : Science
ISBN : 9783527620364

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The Ubiquitin-Proteasome System by R. John Mayer,Aaron J. Ciechanover,Martin Rechsteiner Pdf

The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation. Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

Author : Cam Patterson,Douglas M. Cyr
Publisher : Springer Science & Business Media
Page : 376 pages
File Size : 46,8 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781592598953

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Ubiquitin-Proteasome Protocols by Cam Patterson,Douglas M. Cyr Pdf

A collection of cutting-edge techniques for studying ubiquitin-dependent protein degradation via the proteasome. The topics covered range broadly from basic biochemistry to cellular assays to discovery techniques using mass spectrometric analysis. These biochemical and cellular methods are necessary to explore the ubiquitin-proteasome system and ubiquitin-proteasome-dependent functions. State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols offers novice and experienced bench scientists alike a thorough compendium of readily reproducible techniques that will accelerate discovery, enhance productivity, and permit manipulation of the system for varied research purposes.

Author : Anonim
Publisher : BoD – Books on Demand
Page : 126 pages
File Size : 46,8 Mb
Release : 2020-12-09
Category : Science
ISBN : 9781838804329

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Ubiquitin by Anonim Pdf

The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases.

Author : R. John Mayer,Aaron J. Ciechanover,Martin Rechsteiner
Publisher : John Wiley & Sons
Page : 258 pages
File Size : 53,8 Mb
Release : 2008-06-25
Category : Science
ISBN : 9783527620302

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The Ubiquitin-Proteasome System and Disease by R. John Mayer,Aaron J. Ciechanover,Martin Rechsteiner Pdf

This final volume in the series focuses on malfunctions of the ubiquitin-proteasome system and their role in human disease. The editors and authors represent unmatched expertise, comprising virtually all the top scientists in the field, including the pioneers of protein degradation research. From the contents: * Ubiquitin and cancer * Ubiquitin and liver cancer * Muscle atrophy * Aggresomes and human disease * Parkin and neurodegeneration * Chronic neurodegenerative diseases * Parkinson's disease * Ubiquitin and viruses * Druggability of the ubiquitin-proteasome system Required reading for molecular and cell biologists, as well as physiologists with an interest in the topic.

Author : Milton J. Schlesinger,Avram Hershko
Publisher : Cold Spring Harbor Laboratory Press
Page : 218 pages
File Size : 55,6 Mb
Release : 1988
Category : Science
ISBN : MINN:31951000430545P

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The Ubiquitin System by Milton J. Schlesinger,Avram Hershko Pdf

Author : Zheng-Hong Qin
Publisher : Springer Nature
Page : 727 pages
File Size : 51,9 Mb
Release : 2019-11-27
Category : Science
ISBN : 9789811506024

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Autophagy: Biology and Diseases by Zheng-Hong Qin Pdf

This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.

Author : Matthew Summers
Publisher : Unknown
Page : 226 pages
File Size : 47,9 Mb
Release : 2019
Category : Microbiology
ISBN : 1838804919

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Ubiquitin Proteasome System - Current Insights into Mechanism Cellular Regulation and Disease by Matthew Summers Pdf

The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

Author : R. John Mayer,Aaron J. Ciechanover,Martin Rechsteiner
Publisher : Wiley-VCH
Page : 252 pages
File Size : 54,6 Mb
Release : 2006-10-27
Category : Science
ISBN : 3527314350

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Protein Degradation by R. John Mayer,Aaron J. Ciechanover,Martin Rechsteiner Pdf

Annotation. The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation. Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

Author : Thibault Mayor,Gary Kleiger
Publisher : Unknown
Page : 413 pages
File Size : 51,8 Mb
Release : 2018
Category : Biochemistry
ISBN : 1493987062

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The Ubiquitin Proteasome System by Thibault Mayor,Gary Kleiger Pdf

This volume explores numerous techniques used to study the ubiquitin proteasome system. The chapters in this book are organized into five parts and cover topics such as determining the mechanisms of action for E2s, E3s, and DUB enzymes; the latest advances to study the formation of poly-ubiquitin chains as well as their linkage types; the binding partners of proteins in the UPS; methods for structure determination by x-ray crystallography, cryo electron microscopy and SAXS; screening assays to select for degrons or modulators of E3s and DUBs; proteomics approaches in the ubiquitin field and methods to study 26S proteasome function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and authoritative, The Ubiquitin Proteasome System: Methods and Protocols is a valuable resource for both experienced and novice scientists who are interested in expanding their knowledge in this field.

Author : Rosa Barrio,James D. Sutherland,Manuel S. Rodriguez
Publisher : Springer Nature
Page : 350 pages
File Size : 54,9 Mb
Release : 2020-04-09
Category : Science
ISBN : 9783030382667

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Proteostasis and Disease by Rosa Barrio,James D. Sutherland,Manuel S. Rodriguez Pdf

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Author : Jan-Michael Peters,J. Robin Harris,Daniel Finley
Publisher : Springer Science & Business Media
Page : 498 pages
File Size : 49,8 Mb
Release : 1998-05-31
Category : Science
ISBN : 9780306456497

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Ubiquitin and the Biology of the Cell by Jan-Michael Peters,J. Robin Harris,Daniel Finley Pdf

The last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart the role of ubi quit in in their particular experimental systems, and this integration of the field into cell biology as a whole continues at a remarkable pace. We hope that for active researchers in the field as well as for newcomers and those on the fence, this book will prove helpful for its breadth, historical perspective, and practical tips. Structural data are now available on many of the components of the ubiquitin pathway. The structures have provided basic insights into the unusual biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. Because high-speed computer graphics can convey structures more effectively than print media, we have supplemented the figures of the book with a Worldwide Web site that can display the structures in a flexible, viewer-controlled format.

Author : Mario Di Napoli,Cezary Wójcik
Publisher : Nova Biomedical Books
Page : 552 pages
File Size : 49,9 Mb
Release : 2009-07-01
Category : Medical
ISBN : 1607416948

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The Ubiquitin Proteasome System in the Central Nervous System by Mario Di Napoli,Cezary Wójcik Pdf

The ubiquitin-proteasome field has experienced a breathtaking development from obscure origins in the late 1970s and early 1980s, through a maturing but a well circumscribed field in the 1990s, into a huge, and ever growing interdisciplinary area in the 2000s. Nearly 7% of all genes encoded by the human genome comprise elements of the ubiquitin-proteasome system (UPS), making it the most complex of all biochemical pathways. This complexity depends mostly on its hierarchical organisation, where the 20S proteasome is the common machinery mediating total or partial degradation of practically any protein in our body. Proteolysis via the UPS is a rapid and effective method of degrading a specific protein at a specific time, and in many cases a protein is degraded only in response to a particular cellular signal or event. Controlling where and when a protein is degraded can enhance the specificity and timing of proteolysis, generate asymmetry and maintain sub-compartments. The 24 articles of this updated collection describe the authors' research, from medical and academic research facilities world-wide, on various aspects of the UPS in nervous system. The articles discuss research of the UPS in connection with many important aspects of nervous system development, physiology and diseases, ranging from basic sciences to more specific topics useful for both basic neuroscientists and active clinical neurologists in an attempt to present in one place a cross-field, translational reference in a format accessible to a practising neurologist as well as to a neuroscientist. Due to the inherent nature of the topic, the book has crossed over discipline barriers, engaging an amazing international team of specialists from disparate fields to conduct the readers across the principal avenues of the UPS physiology and pathology in the nervous system.