Opportunities And Challenges Of The Therapies Targeting Cns Regeneration

Author : H.D. Perez,B. Mitrovic,A. Baron Van Evercooren
Publisher : Springer Science & Business Media
Page : 200 pages
File Size : 45,8 Mb
Release : 2007-01-19
Category : Medical
ISBN : 9783540276265

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Opportunities and Challenges of the Therapies Targeting CNS Regeneration by H.D. Perez,B. Mitrovic,A. Baron Van Evercooren Pdf

The therapeutic options for the treatment of Multiple Sclerosis (MS) and other neurodegenerative and traumatic diseases such as spinal cord injury, Alzheimer's, Parkinson's disease, etc. have experienced enormous progress over recent years. Despite these encouraging developments, available therapies are only partially effective, and the ultimate goal is still far from being attained. Improved understanding of the cellular and molecular mechanisms of the pathogenesis of neurodegeneration and demyelination has led to a variety of new therapeutic targets and approaches. In addition to modulation of the inflammatory process (MS) and classical neuroprotection (stroke, AD), therapeutic approaches focusing on active remyelinization and neuronal regeneration have become increasingly important. Based on current concepts, this book summarizes new therapeutic approaches.

Author : H.D. Perez,B. Mitrovic,A. Baron Van Evercooren
Publisher : Springer
Page : 186 pages
File Size : 48,5 Mb
Release : 2009-09-02
Category : Medical
ISBN : 3540806040

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Opportunities and Challenges of the Therapies Targeting CNS Regeneration by H.D. Perez,B. Mitrovic,A. Baron Van Evercooren Pdf

Author : John Morser,S. -I. Nishikawa
Publisher : Springer Science & Business Media
Page : 160 pages
File Size : 50,8 Mb
Release : 2005-07-06
Category : Science
ISBN : 3540234810

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The Promises and Challenges of Regenerative Medicine by John Morser,S. -I. Nishikawa Pdf

Melanocyte system for studying stem cell niche -- Establishment and maniupulation of monkey and human embryonic stem cell lines for biomedical research -- Human embryonic stem cell derivation -- In search of the elusive epidermal stem cell -- Corneal cells for regeneration -- Polycomb gene product Bmi-l -- Directed differentiation of neural and sensory tissues from embryonic stem cells in vitro -- Stem cell biology for vascular regeneration.

Author : Stefania Mondello,Anwarul Hasan,Deborah Shear
Publisher : Frontiers Media SA
Page : 281 pages
File Size : 51,6 Mb
Release : 2020-02-03
Category : Electronic
ISBN : 9782889634491

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Developing Successful Neuroprotective Treatments for TBI: Translational Approaches, Novel Directions, Opportunities and Challenges by Stefania Mondello,Anwarul Hasan,Deborah Shear Pdf

Author : M. A. Lewis,M. Dietel,P. Scriba,W.K. Raff
Publisher : Springer Science & Business Media
Page : 183 pages
File Size : 42,5 Mb
Release : 2007-05-24
Category : Medical
ISBN : 9783540378617

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Biologie und Epidemiologie der Hormonersatztherapie - Biology and Epidemiology of Hormone Replacement Therapy by M. A. Lewis,M. Dietel,P. Scriba,W.K. Raff Pdf

This volume contains an advanced level discussion on the appropriateness of hormone replacement therapy (HRT) in modern postmenopausal women on the basis of evidence provided by recent epidemiological studies. It addresses all aspects of benefits and risks associated with HRT. It focuses, however, on cancer risk and on risk of breast cancer in particular. The book advocates further epidemiological studies which incorporate pathobiological assessments.

Author : William M. Reichert
Publisher : CRC Press
Page : 296 pages
File Size : 51,5 Mb
Release : 2007-12-17
Category : Science
ISBN : 1420009303

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Indwelling Neural Implants by William M. Reichert Pdf

Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment examines many of these challenges, paying particular attention to how the healing of tissues surrounding an implant can impact the intended use of a device. The contributions are divided into four sections · Part one examines wound healing from the initial insertion trauma through the inflammatory and repair process, explaining how the action of healing varies throughout different areas of the body. · Part two considers various performance issues specific to particular implant components, including those that arise from the chemical, mechanical, thermal, and electrical impact on surrounding tissues. It discusses challenges that result from chronic tissue stimulation and heat effects that occur with on-chip and telemetric processing. · Part three presents both in vitro and in vivo approaches to assessing wound healing response to materials. It includes the contribution of the developer of a chronic hollow fiber membrane implant who explains how an in vivo model is used to assess molecular transport in brain tissue surrounding the implant. · The final section evaluates molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between the electrode surface and the surrounding tissue. It also presents novel approaches to nerve regeneration and repair. This seminal work provides researchers with an up-to-date account of the progress in the field that they can build upon to bring us closer to realizing the full value of neural implants in combating otherwise intractable human health problems.

Author : Shelley L. Berger,O. Nakanishi,Bernhard Haendler
Publisher : Springer Science & Business Media
Page : 223 pages
File Size : 40,8 Mb
Release : 2007-01-19
Category : Science
ISBN : 9783540376330

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The Histone Code and Beyond by Shelley L. Berger,O. Nakanishi,Bernhard Haendler Pdf

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

Author : P.A. Schubiger,L. Lehmann,M. Friebe
Publisher : Springer Science & Business Media
Page : 348 pages
File Size : 44,9 Mb
Release : 2007-01-19
Category : Science
ISBN : 9783540495277

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PET Chemistry by P.A. Schubiger,L. Lehmann,M. Friebe Pdf

Personalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of ?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious therapeutic drugs and a selective imaging probe for identi?cation of potential responders as well as therapy monitoring for an early bene?t assessment. Molecular imaging (MI) is based on the selective and speci?c interaction of a molecular probe with a biological target which is visualized through nuclear, magnetic resonance, near infrared or other methods. Therefore it is the method of choice for patient selection and therapy monitoring as well as for speci?c e- point monitoring in modern drug development. PET (positron emitting tomography), a nuclear medical imaging modality, is ideally suited to produce three-dimensional images of various targets or processes. The rapidly increasing demand for highly selective probes for MI strongly pushes the development of new PET tracers and PET chemistry. ‘PET chemistry’ can be de?ned as the study of positron-emitting compounds regarding their synthesis, structure, composition, reactivity, nuclear properties and processes and their properties in natural and - natural environments. In practice PET chemistry is strongly in?uenced by the unique properties of the radioisotopes used (e. g. , half-life, che- cal reactivity, etc. ) and integrates scienti?c aspects of nuclear-, organic-, inorganic- and biochemistry.

Author : J. Venitz,W. Sittner
Publisher : Springer Science & Business Media
Page : 224 pages
File Size : 49,8 Mb
Release : 2007-03-06
Category : Medical
ISBN : 9783540495291

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Appropriate Dose Selection - How to Optimize Clinical Drug Development by J. Venitz,W. Sittner Pdf

Optimal dose individualization has become more important in improving clinical efficacy and safety. This is due in part to the variability in drug response. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. This book reviews innovative methods, tools and examples of rational drug development strategies, particularly for novel oncological agents.

Author : Stefan Jaroch,Hilmar Weinmann
Publisher : Springer Science & Business Media
Page : 179 pages
File Size : 41,7 Mb
Release : 2007-05-26
Category : Science
ISBN : 9783540376354

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Chemical Genomics by Stefan Jaroch,Hilmar Weinmann Pdf

Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.

Author : John Morser,S. -I. Nishikawa,H.R. Schoeler
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 51,8 Mb
Release : 2007-01-19
Category : Medical
ISBN : 9783540314370

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Stem Cells in Reproduction and in the Brain by John Morser,S. -I. Nishikawa,H.R. Schoeler Pdf

Expectations of the potential of regenerative medicine have risen recently because of exciting research results. This book contains contributions from leading researchers who describe their successes and the problems that remain in converting the hopes into concrete therapies. The focus of the book is on the role of stem cells in two main areas -- reproduction and the brain -- described from molecular, cellular, in vivo and clinical perspectives.

Author : Hiroaki Naritomi,D. W. Krieger
Publisher : Karger Medical and Scientific Publishers
Page : 162 pages
File Size : 42,7 Mb
Release : 2013
Category : Medical
ISBN : 9783318023084

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Clinical Recovery from CNS Damage by Hiroaki Naritomi,D. W. Krieger Pdf

A compilation of innovative findings and new directions in neurological recovery After decades of focusing on how to alleviate and prevent recurrence of acute CNS injuries, the emphasis has finally shifted towards repairing such devastating events and rehabilitation. This development has been made possible by substantial progress in understanding the scientific underpinnings of recovery as well as by novel diagnostic tools, and most importantly, by emerging therapies awaiting clinical trials. In this publication, several international experts introduce novel areas of neurological reorganization and repair following CNS damage. Principles and methods to monitor and augment neuroplasticity are explored in depth and supplemented by a critical appraisal of neurological repair mechanisms and possibilities to curtail disability using computer or robotic interfaces. Rather than providing a textbook approach of CNS restoration, the editors selected topics where progress is most imminent in this labyrinthine domain of medicine. Moreover, the varied background and origins of the contributors lend this book a truly global perspective on the current state of affairs in neurological recovery.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 93 pages
File Size : 50,9 Mb
Release : 2019-12-01
Category : Medical
ISBN : 9780309495844

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Advancing Gene-Targeted Therapies for Central Nervous System Disorders by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

On April 23 and 24, 2019 the Forum on Neuroscience and Nervous System Disorders convened a workshop titled "Advancing Gene-Targeted Therapies for Central Nervous System Disorders" in Washington, DC. This public workshop brought together experts and key stakeholders from academia, government, industry, philanthropic foundations, and disease/patient-focused nonprofit organizations to explore approaches for advancing the development of gene-targeted therapies for central nervous system (CNS) disorders, and implications of developing these therapies. Participants explored lessons learned from both successful and unsuccessful clinical development programs; new knowledge about the genetic underpinnings of brain disorders; the current status and future potential of gene-targeted therapies for CNS disorders; challenges and potential solutions for translating preclinical findings to approved therapies; and patient and caregiver perspectives. They also discussed what will be needed to develop these therapies for common disorders such as Alzheimer's and Parkinson's disease, as well as neuropsychiatric and neurodevelopmental disorders such as schizophrenia and autism. The workshop included approaches that target both DNA and RNA, as well as gene products using viral vectors, antisense oligonucleotides, and RNA interference. This publication summarizes the presentations and discussion of the workshop.

Author : António Salgado
Publisher : Elsevier
Page : 712 pages
File Size : 44,5 Mb
Release : 2020-06-10
Category : Medical
ISBN : 9780128180853

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Handbook of Innovations in Central Nervous System Regenerative Medicine by António Salgado Pdf

Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance Discusses the limitations of present therapies used in the clinics Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path

Author : R. Numerof,Charles A. Dinarello,Khusru Asadullah
Publisher : Springer Science & Business Media
Page : 209 pages
File Size : 45,9 Mb
Release : 2007-01-19
Category : Medical
ISBN : 9783540376736

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Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases by R. Numerof,Charles A. Dinarello,Khusru Asadullah Pdf

Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development. This book summarizes the findings of the 56th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".