Optical Imaging Of Brain Function And Metabolism 2

Author : Arno Villringer,Ulrich Dirnagl
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 55,8 Mb
Release : 2013-11-21
Category : Science
ISBN : 9781489900562

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Optical Imaging of Brain Function and Metabolism 2 by Arno Villringer,Ulrich Dirnagl Pdf

This volume covers the latest developments in optical imaging of the brain which is becoming an increasingly important functional neuroimaging method. Optical intrinsic signals offer unrivaled temporal and spatial resolution of functional measurements of the exposed brain cortex in animals and humans. Near-infrared spectroscopy and imaging ap proaches permit the noninvasive functional assessment of the human brain at bedside. Main advantages of these optical techniques are the biochemical specificity of the meas urements and the potential of measuring correlates of intracellular and intravascular oxy genation simultaneously. Recent data indicate that one may also measure a more direct correlate of neuronal activity associated with changes in light scattering. In this volume, recent technical progress of the optical method is covered as well as the physiological basis of the measurements. In simultaneous studies, near-infrared spec troscopy measurements are directly compared to other functional methods, especially PET and fMRI and examples are given for new applications of the NIRS-method. Based on re sults obtained with optical methods and other functional techniques the latest in our under standing of the coupling of neuronal activity and cerebral blood flow response is reviewed. This is an important basis for a better understanding of all functional neuroi maging methods which rely on neurovascular coupling such as PET, SPET and fMRI. Fi nally the optical method is put into the perspective of presently available functional neuroimaging methods including fMRI, PET, MEG and EEG.

Author : Arno Villringer,Ulrich Dirnagl
Publisher : Unknown
Page : 264 pages
File Size : 41,7 Mb
Release : 2014-09-01
Category : Electronic
ISBN : 1489900578

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Optical Imaging of Brain Function and Metabolism 2 by Arno Villringer,Ulrich Dirnagl Pdf

Author : Ulrich Dirnagl,K.M. Einhäupl,Arno Villringer
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 46,8 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781489924681

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Optical Imaging of Brain Function and Metabolism by Ulrich Dirnagl,K.M. Einhäupl,Arno Villringer Pdf

• . . . . At last the doctor will be freed from the tedious interpretation of screens and photographs. Instead, he will examine and scan through his patient directly. Wearing optical-shutter spectacles and aiming a pulsed laser torch, he will be able to peer at the beating heart, study the movement of a joint or the flexing of a muscle, press on suspect areas to see how the organs beneath respond, check that pills have been correctly swallowed or that an implant is savely in place, and so on. A patient wearing white cotton or nylon clothes that scatter but hardly absorb light, may not even have to undress . . . . •. David Jones, Nature (1990) 348:290 Optical imaging of the brain is a rapidly growing field of heterogenous techniques that has attracted considerable interest recently due to a number of theoretical advantages in comparison with other brain imaging modalities: it uses non ionizing radiation, offers high spatial and temporal resolution, and supplies new types of metabolic and functional information. From a practical standpoint it is important that bedside examinations seem feasible and that the implementations will be considerably less expensive compared with competing techniques. In October 1991, a symposium was held at the Eibsee near Garmisch, Germany to bring together the leading scientists in this new field.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 52,6 Mb
Release : 19??
Category : Electronic
ISBN : OCLC:312957341

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Optical Imaging of Brain Function and Metabolism by Anonim Pdf

Author : Ron D. Frostig
Publisher : CRC Press
Page : 428 pages
File Size : 53,7 Mb
Release : 2009-05-06
Category : Science
ISBN : 9781420076851

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In Vivo Optical Imaging of Brain Function, Second Edition by Ron D. Frostig Pdf

These are exciting times for the field of optical imaging of brain function. Rapid developments in theory and technology continue to considerably advance understanding of brain function. Reflecting changes in the field during the past five years, the second edition of In Vivo Optical Imaging of Brain Function describes state-of-the-art techniques and their applications for the growing field of functional imaging in the live brain using optical imaging techniques. New in the Second Edition: Voltage-sensitive dyes imaging in awake behaving animals Imaging based on genetically encoded probes Imaging of mitochondrial auto-fluorescence as a tool for cortical mapping Using pH-sensitive dyes for functional mapping Modulated imaging Calcium imaging of neuronal activity using 2-photon microscopy Fourier approach to optical imaging Fully updated chapters from the first edition Leading Authorities Explore the Latest Techniques Updated to reflect continuous development in this emerging research area, this new edition, as with the original, reaches across disciplines to review a variety of non-invasive optical techniques used to study activity in the living brain. Leading authorities from such diverse areas as biophysics, neuroscience, and cognitive science present a host of perspectives that range from a single neuron to large assemblies of millions of neurons, captured at various temporal and spatial resolutions. Introducing techniques that were not available just a few years ago, the authors describe the theory, setup, analytical methods, and examples that highlight the advantages of each particular method.

Author : Anna W. Roe
Publisher : Springer Science & Business Media
Page : 271 pages
File Size : 50,6 Mb
Release : 2009-11-11
Category : Medical
ISBN : 9781441904522

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Imaging the Brain with Optical Methods by Anna W. Roe Pdf

Monitoring brain function with light in vivo has become a reality. The technology 33 of detecting and interpreting patterns of reflected light has reached a degree of 34 maturity that now permits high spatial and temporal resolution visualization at both 35 the systems and cellular levels. There now exist several optical imaging methodolo- 36 gies, based on either hemodynamic changes in nervous tissue or neurally induced 37 light scattering changes, that can be used to measure ongoing activity in the brain. 38 These include the techniques of intrinsic signal optical imaging, near-infrared optical 39 imaging, fast optical imaging based on scattered light, optical imaging with voltage 40 sensitive dyes, and two-photon imaging of hemodynamic signals. The purpose of 41 this volume is to capture some of the latest applications of these methodologies to 42 the study of cerebral cortical function. 43 This volume begins with an overview and history of optical imaging and its use 44 in the study of brain function. Several chapters are devoted to the method of intrin- 45 sic signal optical imaging, a method used to record the minute changes in optical 46 absorption due to hemodynamic changes that accompanies cortical activity. Since the 47 detected hemodynamic changes are highly localized, this method has excellent 48 spatial resolution (50–100 μm ), a resolution sufficient for visualization of fundamen- 49 tal modules of cerebral cortical function.

Author : Hyder Fahmeed
Publisher : Humana Press
Page : 0 pages
File Size : 48,8 Mb
Release : 2014-11-03
Category : Medical
ISBN : 1627038817

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Dynamic Brain Imaging by Hyder Fahmeed Pdf

If a picture is worth a thousand words, then dynamic images of brain activity certainly warrant many, many more. This book will help users learn to decipher the dynamic imaging data that will be critical to our future understanding of complex brain functions. In recent years, there have been unprecedented methodological advancements in the imaging of brain activity. These techniques allow the measurement of everything from neural activity (e.g., membrane potential, ion ?ux, neurotransmitter ?ux) to energy metabolism (e.g., glucose consumption, oxygen consumption, creatine kinase ?ux) and functional hyperemia (e.g., blood ?ow, volume, oxygenation). This book deals with a variety of magnetic resonance, electrophysiology, and optical methods that are often used to measure some of these dynamic processes. All chapters were written by leading experts, spanning three continents, specializing in state-of-the-art methods. Brie?y, the book has ?ve sections. In the introductory section, there are two chapters; the ?rst one contains a brief pre- ble to dynamic brain imaging and the other presents a novel, analytical approach to processing of dynamically acquired data. The second section has four chapters and delves into a wide range of optical imaging methods. I am privileged to include a chapter from Lawrence B. Cohen, considered by many to be the authority on optical imaging and spectroscopy, both in vitro and in vivo [Cohen LB (1973) Physiol Rev.

Author : Bruno Weber,Fritjof Helmchen
Publisher : Humana Press
Page : 296 pages
File Size : 47,5 Mb
Release : 2014-01-24
Category : Medical
ISBN : 1627037861

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Optical Imaging of Neocortical Dynamics by Bruno Weber,Fritjof Helmchen Pdf

The application of optical methods for investigating neocortical circuit dynamics has greatly expanded in recent years, providing novel insights into the fascinating world of brain function. Optical Imaging of Neocortical Dynamics presents a guide to these indispensible tools, which cover a broad range of spatiotemporal scales and a large variety of signaling aspects, ranging from voltage changes to metabolic states. This detailed volume specifically explores methods that are applied in experiments on living brains (in vivo) and that relate to functional properties on the spatial scale of cortical circuits. Beginning with an introductory section that focuses on physical fundamentals of optical imaging as well as molecular tools used for in vivo optical imaging and optogenetic control, the book continues with the most relevant methods and their applications to investigate changes in neuronal and glial activity states as well as optical imaging methods probing metabolic states. Written for the Neuromethods series, this volume contains the kind of detail and key implementation advice that ensures successful results in the lab. Practical and easy to use, Optical Imaging of Neocortical Dynamics serves as an ideal guide for researchers who aim to apply these highly valuable tools to their own neuroscientific studies.

Author : Yu Chen,Babak Kateb
Publisher : CRC Press
Page : 669 pages
File Size : 40,9 Mb
Release : 2017-06-14
Category : Medical
ISBN : 9781315355740

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Neurophotonics and Brain Mapping by Yu Chen,Babak Kateb Pdf

Understanding how the brain works and developing effective therapeutics are important in advancing neuroscience and improving clinical patient care. Neurophotonics and Brain Mapping covers state-of-the-art research and development in optical technologies and applications for brain mapping and therapeutics. It provides a comprehensive overview of various methods developed using light, both microscopic and macroscopic techniques. Recent developments in minimally-invasive endoscopic imaging of deep brain structure and function, as well as light-based therapy are also reviewed.

Author : Steen J. Madsen
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 43,9 Mb
Release : 2012-11-13
Category : Science
ISBN : 9781461449782

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Optical Methods and Instrumentation in Brain Imaging and Therapy by Steen J. Madsen Pdf

This book provides a comprehensive up-to-date review of optical approaches used in brain imaging and therapy. It covers a variety of imaging approaches including diffuse optical imaging, laser speckle imaging, photoacoustic imaging and optical coherence tomography. A number of laser-based therapeutic techniques are reviewed, including photodynamic therapy, fluorescence guided resection and photothermal therapy. Fundamental principles and instrumentation are discussed for each imaging and therapeutic approach.

Author : S.R. Benbadis,R.G. Beran,A.T. Berg,J. Engel, Jr.,A.S. Galanopoulou,P.W. Kaplan,M. Koutroumanidis,S.L. Moshe,D.R. Nordli, Jr.,J.M. Serratosa,S.M. Sisodiya,W.O. Tatum,T. Valeta,A. Wilner
Publisher : Springer Science & Business Media
Page : 1966 pages
File Size : 44,8 Mb
Release : 2010-09-20
Category : Medical
ISBN : 9781848821279

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Atlas of Epilepsies by S.R. Benbadis,R.G. Beran,A.T. Berg,J. Engel, Jr.,A.S. Galanopoulou,P.W. Kaplan,M. Koutroumanidis,S.L. Moshe,D.R. Nordli, Jr.,J.M. Serratosa,S.M. Sisodiya,W.O. Tatum,T. Valeta,A. Wilner Pdf

Atlas of Epilepsies is a landmark, all-encompassing, illustrated reference work and hands-on guide to the diagnosis, management and treatment of epilepsy in all its forms and across all age groups. The premier text in the field with over one thousand images, the Atlas’s highly illustrative approach tackles the difficult subject of epileptic seizures and epileptic syndromes, accompanied by sequential photographs of each management step. Intraoperative photographs are accompanied by detailed figure legends describing nuances, subtleties, and the thought processes involved in each step, providing a fuller understanding of each procedure. The Atlas draws on the expertise of over 300 internationally-renowned experts, and is liberally interspersed with clinical insights and personal vignettes that offer helpful tips, technical advice and critical knowledge to the clinician and scholar. The thorough and complete table of contents includes dedicated sections or chapters on important topics such as neonatal and pediatric seizures; imitators of epilepsy; EEG and neuroimaging; psychiatric and quality of life aspects of epilepsy; and a complete guide to treatment options including current and up-to-date chapters on pharmaceuticals, surgical procedures, and additional and alternative treatments. No other publication addresses epilepsies as thoroughly and completely as the Atlas of Epilepsies. Exhaustive and illustrative, convenient and current, this reference is sure to be the premier text on epilepsy for many years to come.

Author : Anna Devor,David Boas
Publisher : Frontiers E-books
Page : 218 pages
File Size : 41,6 Mb
Release : 2012-02-01
Category : Electronic
ISBN : 9782889190140

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Neurovascular Imaging by Anna Devor,David Boas Pdf

Recent technological advances are significantly enhancing ones ability to image the interplay of neuronal activity, metabolism, and the associated vascular response with high spatial and temporal resolution. This Research Topic will cover these recent technological advances as well as the impact they have had on understanding the coupling of neuronal, metabolic, and vascular responses. We invite contributions to highlight new original research and to provide a forum for discussion of hot neurovascular topics. Potential contributions include, but are not limited by the following examples: - Development and application of novel optical technologies for imaging of neuronal, metabolic and vascular activity. Examples include 2-Photon Microscopy, Optical Coherence Tomography, and Second Harmonic Microscopy. - Intravital imaging of metabolites such as NADH and flavoproteins - Application of optical methods for manipulation of neuroglial circuits and vascular architectonics - Development of novel Magnetic Resonance contrasts for noninvasive imaging of blood flow, volume, and oxygen consumption. - Application of imaging tools for studying of neurovascular dysfunctions such as stroke, vascular dementia and Alzheimer’s Disease - Hypotheses, Perspectives, Commentaries and Opinions with regards to the body of recent publications that utilize imaging tools for investigation of neurogliovascular communication and the regulation of cerebral blood flow

Author : Francesco S. Pavone,Shy Shoham
Publisher : CRC Press
Page : 439 pages
File Size : 43,6 Mb
Release : 2020-05-10
Category : Science
ISBN : 9780429530906

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Handbook of Neurophotonics by Francesco S. Pavone,Shy Shoham Pdf

The Handbook of Neurophotonics provides a dedicated overview of neurophotonics, covering the use of advanced optical technologies to record, stimulate, and control the activity of the brain, yielding new insight and advantages over conventional tools due to the adaptability and non-invasive nature of light. Including 32 colour figures, this book addresses functional studies of neurovascular signaling, metabolism, electrical excitation, and hemodynamics, as well as clinical applications for imaging and manipulating brain structure and function. The unifying theme throughout is not only to highlight the technology, but to show how these novel methods are becoming critical to breakthroughs that will lead to advances in our ability to manage and treat human diseases of the brain. Key Features: Provides the first dedicated book on state-of-the-art optical techniques for sensing and imaging across at the cellular, molecular, network, and whole brain levels. Highlights how the methods are used for measurement, control, and tracking of molecular events in live neuronal cells, both in basic research and clinical practice. Covers the entire spectrum of approaches, from optogenetics to functional methods, photostimulation, optical dissection, multiscale imaging, microscopy, and structural imaging. Includes chapters that show use of voltage-sensitive dye imaging, hemodynamic imaging, multiphoton imaging, temporal multiplexing, multiplane microscopy, optoacoustic imaging, near-infrared spectroscopy, and miniature neuroimaging devices to track cortical brain activity.

Author : National Research Council,Division on Behavioral and Social Sciences and Education,Board on Behavioral, Cognitive, and Sensory Sciences,Division on Engineering and Physical Sciences,Standing Committee for Technology Insight--Gauge, Evaluate, and Review,Committee on Military and Intelligence Methodology for Emergent Neurophysiological and Cognitive/Neural Science Research in the Next Two Decades
Publisher : National Academies Press
Page : 215 pages
File Size : 47,8 Mb
Release : 2008-12-06
Category : Medical
ISBN : 9780309118941

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Emerging Cognitive Neuroscience and Related Technologies by National Research Council,Division on Behavioral and Social Sciences and Education,Board on Behavioral, Cognitive, and Sensory Sciences,Division on Engineering and Physical Sciences,Standing Committee for Technology Insight--Gauge, Evaluate, and Review,Committee on Military and Intelligence Methodology for Emergent Neurophysiological and Cognitive/Neural Science Research in the Next Two Decades Pdf

Emerging Cognitive Neuroscience and Related Technologies, from the National Research Council, identifies and explores several specific research areas that have implications for U.S. national security, and should therefore be monitored consistently by the intelligence community. These areas include: neurophysiological advances in detecting and measuring indicators of psychological states and intentions of individuals the development of drugs or technologies that can alter human physical or cognitive abilities advances in real-time brain imaging breakthroughs in high-performance computing and neuronal modeling that could allow researchers to develop systems which mimic functions of the human brain, particularly the ability to organize disparate forms of data. As these fields continue to grow, it will be imperative that the intelligence community be able to identify scientific advances relevant to national security when they occur. To do so will require adequate funding, intelligence analysts with advanced training in science and technology, and increased collaboration with the scientific community, particularly academia. A key tool for the intelligence community, this book will also be a useful resource for the health industry, the military, and others with a vested interest in technologies such as brain imaging and cognitive or physical enhancers.

Author : Jason S. Lewis,Kayvan R. Keshari
Publisher : Springer
Page : 331 pages
File Size : 52,8 Mb
Release : 2017-09-25
Category : Medical
ISBN : 9783319614014

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Imaging and Metabolism by Jason S. Lewis,Kayvan R. Keshari Pdf

This book presents advanced molecular imaging techniques used to assess metabolic function. Covering state-of-the art modalities, it discusses the evaluation of a wide range of diseases that have a metabolic component, including cancer, inflammatory conditions, diabetes, neurodegeneration, and cardiovascular disorders. Imaging provides a quantitative perspective to the assessment of metabolic function and complements genetic analysis of disorders related to disrupted metabolism. Organized into four parts, the book highlights basic principles in molecular imaging techniques; metabolic imaging approaches, including magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and hybrid modalities; metabolic diseases; and future perspectives. Featuring contributions from leading authorities in radiology, oncology, cardiology, and neurology, Imaging and Metabolism is a pioneering exploration of the role of imaging modalities in assessing the physiological status of abnormal cells and diagnosing disease.