Optical Imaging Of Neocortical Dynamics

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Optical Imaging of Neocortical Dynamics

Bruno Weber,Fritjof Helmchen
Optical Imaging of Neocortical Dynamics Book PDF

Author : Bruno Weber,Fritjof Helmchen
Publisher : Unknown
Page : 296 pages
File Size : 55,7 Mb
Release : 2014
Category : Biomedicine
ISBN : 1627037853

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Optical Imaging of Neocortical Dynamics by Bruno Weber,Fritjof Helmchen Pdf

The application of optical methods for investigating neocortical circuit dynamics has greatly expanded in recent years, providing novel insights into the fascinating world of brain function. Optical Imaging of Neocortical Dynamics presents a guide to these indispensible tools, which cover a broad range of spatiotemporal scales and a large variety of signaling aspects, ranging from voltage changes to metabolic states. This detailed volume specifically explores methods that are applied in experiments on living brains (in vivo) and that relate to functional properties on the spatial scale of cortical circuits. Beginning with an introductory section that focuses on physical fundamentals of optical imaging as well as molecular tools used for in vivo optical imaging and optogenetic control, the book continues with the most relevant methods and their applications to investigate changes in neuronal and glial activity states as well as optical imaging methods probing metabolic states. Written for the Neuromethods series, this volume contains the kind of detail and key implementation advice that ensures successful results in the lab. Practical and easy to use, Optical Imaging of Neocortical Dynamics serves as an ideal guide for researchers who aim to apply these highly valuable tools to their own neuroscientific studies.

Imaging the Brain with Optical Methods

Anna W. Roe
Imaging the Brain with Optical Methods Book PDF

Author : Anna W. Roe
Publisher : Springer Science & Business Media
Page : 271 pages
File Size : 44,5 Mb
Release : 2009-11-11
Category : Medical
ISBN : 9781441904522

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Imaging the Brain with Optical Methods by Anna W. Roe Pdf

Monitoring brain function with light in vivo has become a reality. The technology 33 of detecting and interpreting patterns of reflected light has reached a degree of 34 maturity that now permits high spatial and temporal resolution visualization at both 35 the systems and cellular levels. There now exist several optical imaging methodolo- 36 gies, based on either hemodynamic changes in nervous tissue or neurally induced 37 light scattering changes, that can be used to measure ongoing activity in the brain. 38 These include the techniques of intrinsic signal optical imaging, near-infrared optical 39 imaging, fast optical imaging based on scattered light, optical imaging with voltage 40 sensitive dyes, and two-photon imaging of hemodynamic signals. The purpose of 41 this volume is to capture some of the latest applications of these methodologies to 42 the study of cerebral cortical function. 43 This volume begins with an overview and history of optical imaging and its use 44 in the study of brain function. Several chapters are devoted to the method of intrin- 45 sic signal optical imaging, a method used to record the minute changes in optical 46 absorption due to hemodynamic changes that accompanies cortical activity. Since the 47 detected hemodynamic changes are highly localized, this method has excellent 48 spatial resolution (50–100 μm ), a resolution sufficient for visualization of fundamen- 49 tal modules of cerebral cortical function.

Optical Imaging of Neocortical Dynamics

Bruno Weber,Fritjof Helmchen
Optical Imaging of Neocortical Dynamics Book PDF

Author : Bruno Weber,Fritjof Helmchen
Publisher : Humana
Page : 0 pages
File Size : 41,5 Mb
Release : 2016-09-24
Category : Medical
ISBN : 1493959700

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Optical Imaging of Neocortical Dynamics by Bruno Weber,Fritjof Helmchen Pdf

The application of optical methods for investigating neocortical circuit dynamics has greatly expanded in recent years, providing novel insights into the fascinating world of brain function. Optical Imaging of Neocortical Dynamics presents a guide to these indispensible tools, which cover a broad range of spatiotemporal scales and a large variety of signaling aspects, ranging from voltage changes to metabolic states. This detailed volume specifically explores methods that are applied in experiments on living brains (in vivo) and that relate to functional properties on the spatial scale of cortical circuits. Beginning with an introductory section that focuses on physical fundamentals of optical imaging as well as molecular tools used for in vivo optical imaging and optogenetic control, the book continues with the most relevant methods and their applications to investigate changes in neuronal and glial activity states as well as optical imaging methods probing metabolic states. Written for the Neuromethods series, this volume contains the kind of detail and key implementation advice that ensures successful results in the lab. Practical and easy to use, Optical Imaging of Neocortical Dynamics serves as an ideal guide for researchers who aim to apply these highly valuable tools to their own neuroscientific studies.

In Vivo Optical Imaging of Brain Function, Second Edition

Ron D. Frostig
In Vivo Optical Imaging of Brain Function Second Edition Book PDF

Author : Ron D. Frostig
Publisher : CRC Press
Page : 428 pages
File Size : 52,6 Mb
Release : 2009-05-06
Category : Science
ISBN : 9781420076851

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In Vivo Optical Imaging of Brain Function, Second Edition by Ron D. Frostig Pdf

These are exciting times for the field of optical imaging of brain function. Rapid developments in theory and technology continue to considerably advance understanding of brain function. Reflecting changes in the field during the past five years, the second edition of In Vivo Optical Imaging of Brain Function describes state-of-the-art techniques and their applications for the growing field of functional imaging in the live brain using optical imaging techniques. New in the Second Edition: Voltage-sensitive dyes imaging in awake behaving animals Imaging based on genetically encoded probes Imaging of mitochondrial auto-fluorescence as a tool for cortical mapping Using pH-sensitive dyes for functional mapping Modulated imaging Calcium imaging of neuronal activity using 2-photon microscopy Fourier approach to optical imaging Fully updated chapters from the first edition Leading Authorities Explore the Latest Techniques Updated to reflect continuous development in this emerging research area, this new edition, as with the original, reaches across disciplines to review a variety of non-invasive optical techniques used to study activity in the living brain. Leading authorities from such diverse areas as biophysics, neuroscience, and cognitive science present a host of perspectives that range from a single neuron to large assemblies of millions of neurons, captured at various temporal and spatial resolutions. Introducing techniques that were not available just a few years ago, the authors describe the theory, setup, analytical methods, and examples that highlight the advantages of each particular method.

Observed Brain Dynamics

Partha Mitra,Hemant Bokil
Observed Brain Dynamics Book PDF

Author : Partha Mitra,Hemant Bokil
Publisher : Oxford University Press, USA
Page : 408 pages
File Size : 44,6 Mb
Release : 2007-11-05
Category : Medical
ISBN : 9780199884360

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Observed Brain Dynamics by Partha Mitra,Hemant Bokil Pdf

The biomedical sciences have recently undergone revolutionary change, due to the ability to digitize and store large data sets. In neuroscience, the data sources include measurements of neural activity measured using electrode arrays, EEG and MEG, brain imaging data from PET, fMRI, and optical imaging methods. Analysis, visualization, and management of these time series data sets is a growing field of research that has become increasingly important both for experimentalists and theorists interested in brain function. Written by investigators who have played an important role in developing the subject and in its pedagogical exposition, the current volume addresses the need for a textbook in this interdisciplinary area. The book is written for a broad spectrum of readers ranging from physical scientists, mathematicians, and statisticians wishing to educate themselves about neuroscience, to biologists who would like to learn time series analysis methods in particular and refresh their mathematical and statistical knowledge in general, through self-pedagogy. It may also be used as a supplement for a quantitative course in neurobiology or as a textbook for instruction on neural signal processing. The first part of the book contains a set of essays meant to provide conceptual background which are not technical and shall be generally accessible. Salient features include the adoption of an active perspective of the nervous system, an emphasis on function, and a brief survey of different theoretical accounts in neuroscience. The second part is the longest in the book, and contains a refresher course in mathematics and statistics leading up to time series analysis techniques. The third part contains applications of data analysis techniques to the range of data sources indicated above (also available as part of the Chronux data analysis platform from http://chronux.org), and the fourth part contains special topics.

Optical Imaging in Human Disease and Biological Research

Xunbin Wei,Bobo Gu
Optical Imaging in Human Disease and Biological Research Book PDF

Author : Xunbin Wei,Bobo Gu
Publisher : Springer Nature
Page : 309 pages
File Size : 50,5 Mb
Release : 2021-05-29
Category : Medical
ISBN : 9789811576270

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Optical Imaging in Human Disease and Biological Research by Xunbin Wei,Bobo Gu Pdf

The book introduces readers to the basic principle of optical imaging technologies. Focusing on human disease diagnostics using optical imaging methods, it provides essential information for researchers in various fields and discusses the latest trends in optical imaging. In recent decades, there has been a huge increase in imaging technologies and their applications in human diseases diagnostics, including magnetic resonance imaging, x-ray computed tomography, and nuclear tomographic imaging. This book promotes further developments to extend optical imaging to a wider range of disease diagnostics. It is a valuable resource for researchers and students in the field of biomedical optics, as well as for clinicians.

Handbook of Neuroengineering

Nitish V. Thakor
Handbook of Neuroengineering Book PDF

Author : Nitish V. Thakor
Publisher : Springer Nature
Page : 3686 pages
File Size : 52,5 Mb
Release : 2023-02-02
Category : Technology & Engineering
ISBN : 9789811655401

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Handbook of Neuroengineering by Nitish V. Thakor Pdf

This Handbook serves as an authoritative reference book in the field of Neuroengineering. Neuroengineering is a very exciting field that is rapidly getting established as core subject matter for research and education. The Neuroengineering field has also produced an impressive array of industry products and clinical applications. It also serves as a reference book for graduate students, research scholars and teachers. Selected sections or a compendium of chapters may be used as “reference book” for a one or two semester graduate course in Biomedical Engineering. Some academicians will construct a “textbook” out of selected sections or chapters. The Handbook is also meant as a state-of-the-art volume for researchers. Due to its comprehensive coverage, researchers in one field covered by a certain section of the Handbook would find other sections valuable sources of cross-reference for information and fertilization of interdisciplinary ideas. Industry researchers as well as clinicians using neurotechnologies will find the Handbook a single source for foundation and state-of-the-art applications in the field of Neuroengineering. Regulatory agencies, entrepreneurs, investors and legal experts can use the Handbook as a reference for their professional work as well.​

Molecular Imaging: Basic Principles And Applications In Biomedical Research (3rd Edition)

Markus Rudin
Molecular Imaging Basic Principles And Applications In Biomedical Research 3rd Edition Book PDF

Author : Markus Rudin
Publisher : World Scientific
Page : 801 pages
File Size : 43,8 Mb
Release : 2020-04-04
Category : Technology & Engineering
ISBN : 9781786346865

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Molecular Imaging: Basic Principles And Applications In Biomedical Research (3rd Edition) by Markus Rudin Pdf

The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied.The third edition has been extended considerably. This holds for the chapter on imaging modalities, which now includes sections on intravital microscopy and mass spectrometric imaging. All chapters have been updated and a new chapter on the challenges of translating molecular imaging solutions for clinical use has been added.

Cortico-cortical Communication Dynamics

Gustavo Deco,Per E. Roland,Claus C. Hilgetag
Cortico cortical Communication Dynamics Book PDF

Author : Gustavo Deco,Per E. Roland,Claus C. Hilgetag
Publisher : Frontiers E-books
Page : 134 pages
File Size : 49,8 Mb
Release : 2014-10-17
Category : Biological psychiatry
ISBN : 9782889192885

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Cortico-cortical Communication Dynamics by Gustavo Deco,Per E. Roland,Claus C. Hilgetag Pdf

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Neural Signal Estimation in the Human Brain

Christopher W. Tyler,Clare Howarth,Lora T. Likova
Neural Signal Estimation in the Human Brain Book PDF

Author : Christopher W. Tyler,Clare Howarth,Lora T. Likova
Publisher : Frontiers Media SA
Page : 144 pages
File Size : 54,7 Mb
Release : 2016-09-06
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
ISBN : 9782889199235

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Neural Signal Estimation in the Human Brain by Christopher W. Tyler,Clare Howarth,Lora T. Likova Pdf

The ultimate goal of functional brain imaging is to provide optimal estimates of the neural signals flowing through the long-range and local pathways mediating all behavioral performance and conscious experience. In functional MRI (Magnetic Resonance Imaging), despite its impressive spatial resolution, this goal has been somewhat undermined by the fact that the fMRI response is essentially a blood-oxygenation level dependent (BOLD) signal that only indirectly reflects the nearby neural activity. The vast majority of fMRI studies restrict themselves to describing the details of these BOLD signals and deriving non-quantitative inferences about their implications for the underlying neural activity. This Frontiers Research Topic welcomed empirical and theoretical contributions that focus on the explicit relationship of non-invasive brain imaging signals to the causative neural activity. The articles presented within this resulting eBook aim to both highlight the importance and improve the non-invasive estimation of neural signals in the human brain. To achieve this aim, the following issues are targeted: (1) The spatial limitations of source localization when using MEG/EEG. (2) The coupling of the BOLD signal to neural activity. Articles discuss how animal studies are fundamental in increasing our understanding of BOLD fMRI signals, analyze how non-neuronal cell types may contribute to the modulation of cerebral blood flow, and use modeling to improve our understanding of how local field potentials are linked to the BOLD signal. (3) The contribution of excitatory and inhibitory neuronal activity to the BOLD signal. (4) Assessment of neural connectivity through the use of resting state data, computational modeling and functional Diffusion Tensor Imaging (fDTI) approaches.

Biomedical Optical Imaging

James G. Fujimoto,Daniel Farkas
Biomedical Optical Imaging Book PDF

Author : James G. Fujimoto,Daniel Farkas
Publisher : Oxford University Press
Page : 440 pages
File Size : 44,5 Mb
Release : 2009-04-22
Category : Science
ISBN : 9780190287788

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Biomedical Optical Imaging by James G. Fujimoto,Daniel Farkas Pdf

Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques and applications. A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this technology with exogenous chromophores can selectively enhance contrast for molecular targets as well as supply functional information on processes such as nerve transduction. Novel techniques integrate microscopy with state-of-the-art optics technology, and these include spectral imaging, two photon fluorescence correlation, nonlinear nanoscopy; optical coherence tomography techniques allow functional, dynamic, nanoscale, and cross-sectional visualization. Moving to the macroscopic scale, spectroscopic assessment and imaging methods such as fluorescence and light scattering can provide diagnostics of tissue pathology including neoplastic changes. Techniques using light diffusion and photon migration are a means to explore processes which occur deep inside biological tissues and organs. The integration of these techniques with exogenous probes enables molecular specific sensitivity.

Membrane Potential Imaging in the Nervous System and Heart

Marco Canepari,Dejan Zecevic,Olivier Bernus
Membrane Potential Imaging in the Nervous System and Heart Book PDF

Author : Marco Canepari,Dejan Zecevic,Olivier Bernus
Publisher : Springer
Page : 516 pages
File Size : 40,8 Mb
Release : 2015-08-03
Category : Medical
ISBN : 9783319176413

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Membrane Potential Imaging in the Nervous System and Heart by Marco Canepari,Dejan Zecevic,Olivier Bernus Pdf

This volume discusses membrane potential imaging in the nervous system and in the heart and modern optical recording technology. Additionally, it covers organic and genetically-encoded voltage-sensitive dyes; membrane potential imaging from individual neurons, brain slices, and brains in vivo; optical imaging of cardiac tissue and arrhythmias; bio-photonics modelling. This is an expanded and fully-updated second edition, reflecting all the recent advances in this field. Twenty chapters, all authored by leading names in the field, are cohesively structured into four sections. The opening section focuses on the history and principles of membrane potential imaging and lends context to the following sections, which examine applications in single neurons, networks, large neuronal populations and the heart. Topics discussed include population membrane potential signals in development of the vertebrate nervous system, use of membrane potential imaging from dendrites and axons, and depth-resolved optical imaging of cardiac activation and repolarization. The final section discusses the potential – and limitations – for new developments in the field, including new technology such as non-linear optics, advanced microscope designs and genetically encoded voltage sensors. Membrane Potential Imaging in the Nervous System and Heart is ideal for neurologists, electro physiologists, cardiologists and those who are interested in the applications and the future of membrane potential imaging.

Brain Dynamics

H. Haken
Brain Dynamics Book PDF

Author : H. Haken
Publisher : Springer Science & Business Media
Page : 266 pages
File Size : 42,8 Mb
Release : 2002
Category : Mathematics
ISBN : 3540430768

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Brain Dynamics by H. Haken Pdf

This book addresses a large variety of models in mathematical and computational neuroscience. It is written for the experts as well as for graduate students wishing to enter this fascinating field of research. The author studies the behaviour of large neural networks composed of many neurons coupled by spike trains. He devotes the main part to the synchronization problem. He presents neural net models more realistic than the conventional ones by taking into account the detailed dynamics of axons, synapses and dendrites, allowing rather arbitrary couplings between neurons. He gives a complete stabile analysis that goes significantly beyond what has been known so far. He also derives pulse-averaged equations including those of the Wilson--Cowan and the Jirsa-Haken-Nunez types and discusses the formation of spatio-temporal neuronal activity pattems. An analysis of phase locking via sinusoidal couplings leading to various kinds of movement coordination is included.

Brain Dynamics

Hermann Haken
Brain Dynamics Book PDF

Author : Hermann Haken
Publisher : Springer Science & Business Media
Page : 333 pages
File Size : 53,7 Mb
Release : 2007-12-22
Category : Science
ISBN : 9783540752387

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Brain Dynamics by Hermann Haken Pdf

This is an excellent introduction for graduate students and nonspecialists to the field of mathematical and computational neurosciences. The book approaches the subject via pulsed-coupled neural networks, which have at their core the lighthouse and integrate-and-fire models. These allow for highly flexible modeling of realistic synaptic activity, synchronization and spatio-temporal pattern formation. The more advanced pulse-averaged equations are discussed.

Neurophotonics and Brain Mapping

Yu Chen,Babak Kateb
Neurophotonics and Brain Mapping Book PDF

Author : Yu Chen,Babak Kateb
Publisher : CRC Press
Page : 669 pages
File Size : 41,8 Mb
Release : 2017-06-14
Category : Medical
ISBN : 9781315355740

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Neurophotonics and Brain Mapping by Yu Chen,Babak Kateb Pdf

Understanding how the brain works and developing effective therapeutics are important in advancing neuroscience and improving clinical patient care. Neurophotonics and Brain Mapping covers state-of-the-art research and development in optical technologies and applications for brain mapping and therapeutics. It provides a comprehensive overview of various methods developed using light, both microscopic and macroscopic techniques. Recent developments in minimally-invasive endoscopic imaging of deep brain structure and function, as well as light-based therapy are also reviewed.