The Organic Chemistry Of Enzyme Catalyzed Reactions

Author : Richard B. Silverman
Publisher : Academic Press
Page : 737 pages
File Size : 48,7 Mb
Release : 2002-02-28
Category : Science
ISBN : 9780126437317

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Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition- by Richard B. Silverman Pdf

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style

Author : Richard B. Silverman
Publisher : Unknown
Page : 717 pages
File Size : 50,6 Mb
Release : 2012
Category : Enzymes
ISBN : 9381269793

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The Organic Chemistry of Enzyme-catalyzed Reactions by Richard B. Silverman Pdf

Author : Dennis Piszkiewicz
Publisher : Unknown
Page : 262 pages
File Size : 47,6 Mb
Release : 1977
Category : Electronic
ISBN : 8210379456XXX

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Kinetics of Chemical and Enzyme-Catalyzed Reactions by Dennis Piszkiewicz Pdf

Author : Chi-Huey Wong,Whitesides
Publisher : Elsevier
Page : 392 pages
File Size : 54,7 Mb
Release : 1994-07
Category : Science
ISBN : 0080359418

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Enzymes in Synthetic Organic Chemistry by Chi-Huey Wong,Whitesides Pdf

Covering the recent development in enzymatic organic synthesis, this text focuses on the use of isolated enzymes. It includes a discussion of the characteristics of enzymes as catalysts and different types of chemical transformations.

Author : Vicente Gotor,Ignacio Alfonso,Eduardo García-Urdiales
Publisher : John Wiley & Sons
Page : 348 pages
File Size : 47,9 Mb
Release : 2008-03-31
Category : Science
ISBN : 3527318259

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Asymmetric Organic Synthesis with Enzymes by Vicente Gotor,Ignacio Alfonso,Eduardo García-Urdiales Pdf

Perfect for biochemists, synthetic and organic chemists, this book covers all important reactions, including C-C coupling reactions, oxidation reactions and many more. Divided into two parts, the first section on methodology presents new innovative methods for enzymatic catalysis optimization, including such new trends as medium engineering, directed evolution and computer-aided prediction of enantioselectivity. The second and main section deals with applications to synthesis, showing important reaction types and their applications. Only those reactions with very high selectivity are presented, allowing readers to improve their own reaction yields.

Author : Soundar Divakar
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 49,7 Mb
Release : 2012-12-18
Category : Science
ISBN : 9788132208730

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Enzymatic Transformation by Soundar Divakar Pdf

Transformations using enzymes have been extensively investigated in the last two decades and the results promise great potential for this growing field, especially in the area of synthetic organic chemistry mainly due to of its many advantages. Accordingly, this book has attempted to bring out the advantages of using enzymes involving complex underivatized and unprotected substrates in non-polar media under homogenous and heterogeneous reaction conditions. Merits and demerits of using enzymes in terms of yields and selectivity/specificity are presented without any prejudice. Almost all the reactions dealt with are from the author’s laboratory comprising diverse substrates, and the catalysis involves two important hydrolyzing enzymes, extensively examined for the reverse reactions. Thus, esterification involving lipses and glycosylation involving glycosidases were investigated with respect to various strategies like optimization of reaction conditions, response surface methodology and kinetics, carrying out reactions under solvent, non-solvent and super critical carbon dioxide conditions. In short, the work presented is to ensure the comprehension of the problems faced by the researchers in this area so as to work out further efficient strategies for carrying out enzymatic transformations in the laboratory successfully with better yields and specificity.

Author : Daniel L. Purich
Publisher : Elsevier
Page : 920 pages
File Size : 45,7 Mb
Release : 2010-06-16
Category : Science
ISBN : 9780123809254

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Enzyme Kinetics: Catalysis and Control by Daniel L. Purich Pdf

Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. Historical analysis of kinetic principles including advanced enzyme science Provides both theoretical and practical measurements tools Coverage of single molecular kinetics Examination of force generation mechanisms Discussion of organic and inorganic enzyme reactions

Author : Charles John Gray
Publisher : Van Nostrand Reinhold Company
Page : 384 pages
File Size : 40,6 Mb
Release : 1971
Category : Science
ISBN : MINN:31951000464531Y

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Enzyme-catalysed Reactions by Charles John Gray Pdf

Author : Paul Flowers,Richard Langely,William R. Robinson,Klaus Hellmut Theopold
Publisher : Unknown
Page : 0 pages
File Size : 48,8 Mb
Release : 2019-02-14
Category : Chemistry
ISBN : 194717262X

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Chemistry 2e by Paul Flowers,Richard Langely,William R. Robinson,Klaus Hellmut Theopold Pdf

Chemistry 2e is designed to meet the scope and sequence requirements of the two-semester general chemistry course. The textbook provides an important opportunity for students to learn the core concepts of chemistry and understand how those concepts apply to their lives and the world around them. The book also includes a number of innovative features, including interactive exercises and real-world applications, designed to enhance student learning. The second edition has been revised to incorporate clearer, more current, and more dynamic explanations, while maintaining the same organization as the first edition. Substantial improvements have been made in the figures, illustrations, and example exercises that support the text narrative. Changes made in Chemistry 2e are described in the preface to help instructors transition to the second edition.

Author : Gavin Williams,Mélanie Hall
Publisher : Royal Society of Chemistry
Page : 594 pages
File Size : 47,6 Mb
Release : 2018-05-31
Category : Science
ISBN : 9781788014533

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Modern Biocatalysis by Gavin Williams,Mélanie Hall Pdf

The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current ‘hot’ topics in biocatalysis, where recent advances in research are defining new grounds in enzyme-catalyzed processes. With contributions from leading academics around the world, this book makes a ground-breaking contribution to this progressive field and is essential reading for graduates and researchers investigating (bio)catalysis, enzyme engineering, chemical biology, and synthetic biology.

Author : Karlheinz Drauz,Herbert Waldmann
Publisher : Unknown
Page : 704 pages
File Size : 48,6 Mb
Release : 2002
Category : Catalysis
ISBN : UOM:39015051562737

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Enzyme Catalysis in Organic Synthesis by Karlheinz Drauz,Herbert Waldmann Pdf

Author : Perry A. Frey,Adrian D. Hegeman
Publisher : Oxford University Press
Page : 848 pages
File Size : 50,7 Mb
Release : 2007-01-27
Category : Science
ISBN : 9780199880744

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Enzymatic Reaction Mechanisms by Perry A. Frey,Adrian D. Hegeman Pdf

Books dealing with the mechanisms of enzymatic reactions were written a generation ago. They included volumes entitled Bioorganic Mechanisms, I and II by T.C. Bruice and S.J. Benkovic, published in 1965, the volume entitled Catalysis in Chemistry and Enzymology by W.P. Jencks in 1969, and the volume entitled Enzymatic Reaction Mechanisms by C.T. Walsh in 1979. The Walsh book was based on the course taught by W.P. Jencks and R.H. Abeles at Brandeis University in the 1960's and 1970's. By the late 1970's, much more could be included about the structures of enzymes and the kinetics and mechanisms of enzymatic reactions themselves, and less emphasis was placed on chemical models. Walshs book was widely used in courses on enzymatic mechanisms for many years. Much has happened in the field of mechanistic enzymology in the past 15 to 20 years. Walshs book is both out-of-date and out-of-focus in todays world of enzymatic mechanisms. There is no longer a single volume or a small collection of volumes to which students can be directed to obtain a clear understanding of the state of knowledge regarding the chemicals mechanisms by which enzymes catalyze biological reactions. There is no single volume to which medicinal chemists and biotechnologists can refer on the subject of enzymatic mechanisms. Practitioners in the field have recognized a need for a new book on enzymatic mechanisms for more than ten years, and several, including Walsh, have considered undertaking to modernize Walshs book. However, these good intentions have been abandoned for one reason or another. The great size of the knowledge base in mechanistic enzymology has been a deterrent. It seems too large a subject for a single author, and it is difficult for several authors to coordinate their work to mutual satisfaction. This text by Perry A. Frey and Adrian D. Hegeman accomplishes this feat, producing the long-awaited replacement for Walshs classic text.

Author : Cheanyeh Cheng
Publisher : John Wiley & Sons
Page : 719 pages
File Size : 55,8 Mb
Release : 2022-02-03
Category : Science
ISBN : 9781118995150

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Enzyme-Based Organic Synthesis by Cheanyeh Cheng Pdf

Enzyme-Based Organic Synthesis An insightful exploration of an increasingly popular technique in organic chemistry In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice. The distinguished author provides a single point of access for enzymatic methods applicable to organic synthesis and focuses on enzyme catalyzed organic synthesis with six different classes of enzyme. This book serves as a link between enzymology and biocatalysis and serves as an invaluable reference for the growing number of organic chemists using biocatalysis. Enzyme-Based Organic Synthesis provides readers with multiple examples of practical applications of the main enzyme classes relevant to the pharmaceutical, medical, food, cosmetics, fragrance, and health care industries. Readers will also find: A thorough introduction to foundational topics, including the discovery and nature of enzymes, enzyme structure, catalytic function, molecular recognition, enzyme specificity, and enzyme classes Practical discussions of organic synthesis with oxidoreductases, including oxidation reactions and reduction reactions Comprehensive explorations of organic synthesis with transferases, including transamination with aminotransferases and phosphorylation with kinases In-depth examinations of organic synthesis with hydrolases, including the hydrolysis of the ester bond Perfect for organic synthetic chemists, chemical and biochemical engineers, biotechnologists, process chemists, and enzymologists, Enzyme-Based Organic Synthesis is also an indispensable resource for practitioners in the pharmaceutical, food, cosmetics, and fragrance industries that regularly apply this type of synthesis.

Author : Animesh Goswami,Jon D. Stewart
Publisher : Academic Press
Page : 438 pages
File Size : 44,9 Mb
Release : 2015-09-06
Category : Science
ISBN : 9780124115422

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Organic Synthesis Using Biocatalysis by Animesh Goswami,Jon D. Stewart Pdf

Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules. Provides a concise background of the application of biocatalysis for the synthesis of organic compounds Expert contributors present recipes for carrying out biocatalytic reactions, including subject worthy discussions on biocatalysis in organic synthesis, biocatalysis for selective organic transformation, enzymes as catalysis for organic synthesis, biocatalysis in Industry, including pharmaceuticals, and more Contains detailed, separate chapters that describe the application of biocatalysis

Author : T. D. H. Bugg
Publisher : John Wiley & Sons
Page : 310 pages
File Size : 40,5 Mb
Release : 2012-05-29
Category : Science
ISBN : 9781118348994

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Introduction to Enzyme and Coenzyme Chemistry by T. D. H. Bugg Pdf

Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry. The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.