Free Radicals In Human Health And Disease

Author : Vibha Rani,Umesh Chand Singh Yadav
Publisher : Springer
Page : 430 pages
File Size : 42,7 Mb
Release : 2014-11-14
Category : Science
ISBN : 9788132220350

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Free Radicals in Human Health and Disease by Vibha Rani,Umesh Chand Singh Yadav Pdf

The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pathogenesis of human diseases, biomarkers of oxidative damage, antioxidants, phytonutrients and other related health concerns of modern society. The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress.

Author : Kaïs Hussain Al-Gubory,Ismail Laher
Publisher : Springer
Page : 553 pages
File Size : 48,5 Mb
Release : 2018-03-10
Category : Medical
ISBN : 9783319676258

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Nutritional Antioxidant Therapies: Treatments and Perspectives by Kaïs Hussain Al-Gubory,Ismail Laher Pdf

This book offers a collection of expert reviews on the use of plant-based antioxidant therapies in disease prevention and treatment. Topics discussed include the uses of plant and nutritional antioxidants in the contexts of reproductive health and prenatal development, healthcare and aging, noncommunicable chronic diseases, and environmental pollution. The text is complemented by a wealth of color figures and summary tables.

Author : Barry Halliwell,John M. C. Gutteridge
Publisher : OUP Oxford
Page : 896 pages
File Size : 44,7 Mb
Release : 2015-08-21
Category : Science
ISBN : 9780191026980

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Free Radicals in Biology and Medicine by Barry Halliwell,John M. C. Gutteridge Pdf

Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.

Author : Silvana Andreescu,Maria Hepel
Publisher : ACS Symposium
Page : 0 pages
File Size : 51,6 Mb
Release : 2016-08
Category : Science
ISBN : 0841231001

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Oxidative Stress by Silvana Andreescu,Maria Hepel Pdf

This book provides a comprehensive overview of the oxidative stress related mechanisms in biological systems and the involvement of reactive oxygen and nitrogen species (ROS and RNS), the damage of DNA, proteins, and lipids caused by oxidative stress, the protection of cells and tissues against free radicals, the relation of the oxidative stress to aging and human diseases including cancer and neurological disorders, and the development of new therapeutic approaches to modulate oxidative stress. The current state-of-the-art methodologies including the development of sensors and biosensors for the detection of ROS/RNS and of biomarkers of oxidative stress are also discussed. The book is organized in three overlapping parts, starting with general considerations of the oxidative stress, homeostasis pathways, and ROS mechanisms, followed by chapters discussing the involvement of ROS in particular diseases and concluding with analytical aspects of oxidative stress monitoring. The book provides a solid background on oxidative stress and ROS/RNS generation for novice learners while also offering scientists and practitioners already involved in this field a wealth of information covering the most recent developments in the study of oxidative stress, the role of radical species, novel antioxidant therapies, and methods for assessing free radicals and oxidative stress.

Author : Lester Packer,Midori Hiramatsu,Toshikazu Yoshikawa
Publisher : Elsevier
Page : 511 pages
File Size : 40,6 Mb
Release : 1999-03-16
Category : Technology & Engineering
ISBN : 0080527280

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Antioxidant Food Supplements in Human Health by Lester Packer,Midori Hiramatsu,Toshikazu Yoshikawa Pdf

Antioxidant Food Supplements in Human Health discusses new discoveries in the areas of oxygen and nitric oxide metabolism and pathophysiology, redox regulation and cell signaling, and the identification of natural antioxidants and their mechanisms of action on free radicals and their role in health and disease. An essential resource for researchers, students, and professionals in food science and nutrition, gerontology, physiology, pharmacology, and related areas. Health effects of antioxidant nutrients Nutrients of vitamins C and E, selenium, alpha-lipoic acid, coenzyme Q10, carotenoids, and flavonoids Natural source antioxidants, including pine bark, ginko biloba, wine, herbs,uyaku, and carica papaya

Author : Balz Frei
Publisher : Academic Press
Page : 588 pages
File Size : 43,8 Mb
Release : 2012-12-02
Category : Technology & Engineering
ISBN : 9780080571683

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Natural Antioxidants in Human Health and Disease by Balz Frei Pdf

This book serves as a comprehensive overview of the current scientific knowledge on the health effects of dietary and supplemental antioxidants (such as vitamins C and E). Chapters integrate information from basic research and animal studies, epidemiologic studies, and clinical intervention trials. The popular media has taken great interest in antioxidants, with numerous articles emphasizing their role in preventing disease and the possible slowing of the aging process. These antioxidant vitamins may be important in preventing not only acute deficiency symptoms, but also chronic disorders such as heart disease and certain types of cancer. This book, therefore, is not only for scientists and doctors, but also for health writers, journalists, and informed lay people. The text focuses on several human conditions for which there is now good scientific evidence that oxidation is an important etiological component. Specifically, antioxidants may prevent or slow down the progression of: Cancer, Cardiovascular disease, Immune system disorders, Cataracts, Neurological disorders, Degeneration due to the aging process.

Author : Shamim I. Ahmad
Publisher : CRC Press
Page : 543 pages
File Size : 50,6 Mb
Release : 2017-12-19
Category : Science
ISBN : 9781498735469

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Reactive Oxygen Species in Biology and Human Health by Shamim I. Ahmad Pdf

Unlike other narrowly focused books, Reactive Oxygen Species in Biology and Human Health provides a comprehensive overview of ROS. It covers the current status of research and provides pointers to future research goals. Additionally, it authoritatively reviews the impact of reactive oxygen species with respect to various human diseases and discusses antioxidants and other compounds that counteract oxidative stress. Comprised of seven sections, the first section describes the introduction, detection, and production of ROS, emphasizing phenolic compounds and vitamin E for their abilities to act as antioxidants. This section also highlights the role of lipoprotein-associated oxidative stress. Section two addresses the importance of iron accumulation in the brain resulting in the development of a group of neurodegenerative disorders (NDs) and identifies several causative genes for neurodegeneration with brain iron accumulation (NBIA) associated with Parkinsonism-related disorders. The third section discusses a number of NDs, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Huntington's disease (HD), epilepsy, and multiple sclerosis (MS). Section four addresses autoimmune diseases caused by ROS, including asthma, autoimmune liver diseases, rheumatoid arthritis, thyroid disease, primary biliary cirrhosis, and systemic lupus. Section five analyzes a number of different cancers, including lung cancer, breast cancer, and melanoma, along with possible treatment regimens. Section six discusses cardiovascular diseases (CVDs) induced by ROS, presents the ROS-associated complex biochemical processes inducing inflammation as an important cause of CVDs, and explains the roles carotenoids play in preventing CVDs. The final section addresses other human diseases induced by oxidative stress, including sickle cell disease, nonalcoholic steatohepatitis, retinopathy, fibromyalgia, chronic obstructive pulmonary disease, asthma, pulmonary hypertension, infertility, and aging of human skin.

Author : Anonim
Publisher : BoD – Books on Demand
Page : 140 pages
File Size : 47,9 Mb
Release : 2020-08-26
Category : Science
ISBN : 9781838801250

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Glutathione System and Oxidative Stress in Health and Disease by Anonim Pdf

The imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses determines a state known as oxidative stress. Higher levels of pro-oxidants compared to antioxidant defenses may generate oxidative damage, which, in turn, may lead to modifications in cellular proteins, lipids, and DNA, reducing functional capacity and increasing the risk of diseases. Nevertheless, the clearance of harmful reactive chemical species is achieved by the antioxidant defense systems. These protection systems are referred to as the first and second lines of defense and comprise the classic antioxidants, enzymatic and nonenzymatic defenses, including glutathione. This book presents and discusses the advancement of research on health and diseases and their underlying mechanisms, exploring mainly aspects related to the glutathione antioxidant system.

Author : Joe Marwah,Anumantha Kanthasamy
Publisher : Unknown
Page : 337 pages
File Size : 40,5 Mb
Release : 2001
Category : Electronic
ISBN : 0966899725

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Antioxidants and free radicals in health and disease by Joe Marwah,Anumantha Kanthasamy Pdf

Author : Toshiki Asao,Md Asaduzzaman
Publisher : BoD – Books on Demand
Page : 220 pages
File Size : 47,9 Mb
Release : 2018-11-07
Category : Science
ISBN : 9781789843774

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Phytochemicals by Toshiki Asao,Md Asaduzzaman Pdf

Phytochemicals provides original research work and reviews on the sources of phytochemicals, and their roles in disease prevention, supplementation, and accumulation in fruits and vegetables. The roles of anthocyanin, flavonoids, carotenoids, and taxol are presented in separate chapters. Antioxidative and free radicle scavenging activity of phytochemicals is also discussed. The medicinal properties of Opuntia, soybean, sea buckthorn, and gooseberry are presented in a number of chapters. Supplementation of plant extract with phytochemical properties in broiler meals is discussed in one chapter. The final two chapters include the impact of agricultural practices and novel processing technologies on the accumulation of phytochemicals in fruits and vegetables. This book mainly focuses on medicinal plants and the disease-preventing properties of phytochemicals, which will be a useful resource to the reader.

Author : R.C. Cutler,L. Packer,J. Bertram,A. Mori
Publisher : Birkhäuser
Page : 393 pages
File Size : 43,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783034873376

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Oxidative Stress and Aging by R.C. Cutler,L. Packer,J. Bertram,A. Mori Pdf

Oxidative stress and aging Over the past several years there has been an extraordinarily rapid growth in our knowledge of free radical chemistry and its possible involvement in both normal essential biology and age related disease and dysfunction. Much of this growth in the traditionally separate sciences of chemistry and molecular gerontology occurred independently, with little interaction or communi cation between the scientists working in these two fields. In view of the growing maturity of the two fields and the potential importance of advancing our knowledge in the area of oxidative stress and aging, we perceived a critical need to organize an international conference the "First Inter national Conference on Oxidative Stress and Aging" in Hawaii in 1994 to bring together the world's leading scientists in the fields of reactive oxygen species and molecular gerontology. The objective of this conference was to provide a unique opportunity for scholars working in these two related and rapidly growing fields to participate in the exchange, integration, and synthesis of new concepts and ideas, to engage in constructive criticism and to initiate new collaborative research projects. The conference focused on the molecular and cellular aspects of aging as related to oxidative stress. It was one of the largest and most comprehensive international conferences held in molecular gerontology. At this conference a call was made for submission of papers to be used in the publication of a book covering the major contributions of the meeting.

Author : Donald Armstrong,Robert D. Stratton
Publisher : John Wiley & Sons
Page : 600 pages
File Size : 41,7 Mb
Release : 2016-01-14
Category : Science
ISBN : 9781118832400

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Oxidative Stress and Antioxidant Protection by Donald Armstrong,Robert D. Stratton Pdf

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

Author : Antonis Zampelas,Renata Micha
Publisher : CRC Press
Page : 387 pages
File Size : 44,6 Mb
Release : 2015-06-09
Category : Health & Fitness
ISBN : 9781000219029

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Antioxidants in Health and Disease by Antonis Zampelas,Renata Micha Pdf

Antioxidant use in health promotion and disease prevention either through dietary intake or supplementation is controversial. This book reviews the latest evidence-based research in the area, principally through prospective cohort studies and randomized controlled trials. It assesses major dietary antioxidants and discusses their use in diseases such as cancer, diabetes, stroke, coronary heart disease, HIV/AIDS, and neurodegenerative and immune diseases. The use of antioxidants in health is also discussed along with common adverse effects associated with antioxidant use.

Author : Nina Pegg
Publisher : Unknown
Page : 242 pages
File Size : 49,5 Mb
Release : 2020-09-15
Category : Medical
ISBN : 1632418312

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Antioxidants in Human Health and Disease by Nina Pegg Pdf

Living organisms require oxygen for survival, but it is also a highly reactive molecule that can damage organisms by producing reactive oxygen species. Oxidation is the chemical reaction that produces free radicals and thereby leads to chain reactions with the potential to damage the cells of organisms. Antioxidants inhibit oxidation. Ascorbic acid or thiols are antioxidants that can terminate these chain reactions. Organisms have a complex system of antioxidant metabolites and enzymes that work in tandem to prevent oxidative damage to DNA, proteins and lipids. However, reactive oxygen species have useful cellular functions as well, such as redox signaling. Antioxidant systems therefore do not remove oxidants completely but keep them at an optimum level. The role of oxidative stress in degenerative diseases, such as diabetes, kidney disease, neurological disorders, obesity, cancer and aging is understood. This makes antioxidant dietary supplements a potential strategy to overcome these conditions. This book provides comprehensive insights into antioxidants and their role in human health and disease. It will also provide interesting topics for research, which interested readers can take up. With state-of-the-art inputs by acclaimed experts of this field, this book targets students and professionals.

Author : Anonim
Publisher : BoD – Books on Demand
Page : 302 pages
File Size : 49,7 Mb
Release : 2021-10-06
Category : Science
ISBN : 9781839688379

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Vitamin E in Health and Disease by Anonim Pdf

Vitamin E is a group of fat-soluble compounds found in a wide variety of foods. Daily requirements of vitamin E can be met with a balanced diet. High-dose supplementation may be hazardous rather than beneficial. Vitamin E serves as an antioxidant, participates in anti-inflammatory processes, inhibits platelet aggregation, and enhances immunity. Vitamin E supplementation can be beneficial against coronary artery disease, eye disorders, cognitive decline, cancer, and skin aging. This book will mainly focus on the diverse functions of vitamin E, importance of vitamin E status to provide a healthy lifespan, and the interaction between vitamin E and several pathological conditions. Readers will receive a general overview of the importance of vitamin E in health and different pathological conditions.