Oxidative Stress In Cancer Biology And Therapy

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Oxidative Stress in Cancer Biology and Therapy

Douglas R. Spitz,Kenneth J. Dornfeld,Koyamangalath Krishnan,David Gius
Oxidative Stress in Cancer Biology and Therapy Book PDF

Author : Douglas R. Spitz,Kenneth J. Dornfeld,Koyamangalath Krishnan,David Gius
Publisher : Springer Science & Business Media
Page : 462 pages
File Size : 52,8 Mb
Release : 2011-11-25
Category : Science
ISBN : 1617793973

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Oxidative Stress in Cancer Biology and Therapy by Douglas R. Spitz,Kenneth J. Dornfeld,Koyamangalath Krishnan,David Gius Pdf

During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observations have led to the realization that free radical biology and cancer biology are two integrally related fields of investigation that can greatly benefit from cross fertilization of theoretical constructs. The current volume of scientific papers was assembled under the heading of Oxidative Stress in Cancer Biology and Therapy in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications. The chapters contained in this volume provide highly informative emerging perspectives on how that selective enhancement of oxidative stress in cancerous tissues can be used as a target for enhancing therapeutic outcomes as well as how selective inhibition of oxidative stress could spare normal tissue damage and inhibit carcinogenesis. In this regard, the book represents an outstanding resource for both basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.

Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

Sajal Chakraborti
Handbook of Oxidative Stress in Cancer Therapeutic Aspects Book PDF

Author : Sajal Chakraborti
Publisher : Springer Nature
Page : 4078 pages
File Size : 48,6 Mb
Release : 2022-09-28
Category : Medical
ISBN : 9789811654220

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects by Sajal Chakraborti Pdf

This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​

Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

Sajal Chakraborti,Bimal K. Ray,Susanta Roychoudhury
Handbook of Oxidative Stress in Cancer Mechanistic Aspects Book PDF

Author : Sajal Chakraborti,Bimal K. Ray,Susanta Roychoudhury
Publisher : Springer
Page : 2675 pages
File Size : 55,9 Mb
Release : 2022-02-01
Category : Medical
ISBN : 9811594104

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Handbook of Oxidative Stress in Cancer: Mechanistic Aspects by Sajal Chakraborti,Bimal K. Ray,Susanta Roychoudhury Pdf

This comprehensive, up-to-date reference work compiles the scientific research on the relationship between various forms of cancer and reactive oxygen species (ROS). It is well known that ROS play a key role in the various steps leading to malignancy, this includes increase in DNA mutation rates. The book brings together exciting reviews, written by leading experts all over the world. The book is divided into four broad sections. Each section describes the role of oxidative stress and underlying mechanisms and pathways, at various stages of cancer, including its role in carcinogenesis, cancer progression and metastasis. Further, the book describes how the reactive oxygen species (ROS) modulate gene expression and signal transduction pathways in cancer. The book discusses the ways to interfere with the cancer progression, and design of anti-cancer drugs. The book provides an integrated approach for better understanding of the development phases of oxidative stress-induced cancers, and mainly the current perspectives about mechanistic aspects of cancer initiation, progression and metastasis. It is a highly resourceful book and would be extremely important to clinicians, students and researchers in the field of cancer genetics, therapeutics and oncology.

Free Radical Research in Cancer

Ana Čipak Gašparović
Free Radical Research in Cancer Book PDF

Author : Ana Čipak Gašparović
Publisher : MDPI
Page : 192 pages
File Size : 52,6 Mb
Release : 2020-06-18
Category : Science
ISBN : 9783039360888

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Free Radical Research in Cancer by Ana Čipak Gašparović Pdf

Cancer is a great challenge to efficient therapy due to biological diversity. Disturbed oxidative homeostasis in cancer cells certainly contributes to differential therapy response. Further, one of the hallmarks of cancer cells is adaptation which includes fine tuning of the cellular metabolic and signalling pathways as well as transcription profiles. There are several factors which contribute to the tumor diversity and therapy response, and oxidative stress is certainly one of them. Changes in oxygen levels due to hypoxia/reoxygenation during tumor growth modulate antioxidative patterns finally supporting increased cell diversity and adaptation to stressing conditions. Additionally, cancer chemotherapy based on ROS production can also induce also adaptation. To counteract these negative effects natural products are often used for their antioxidant activities as well as photodynamic therapy supported by novel chemosensitizers. Understanding of possible pathways which can trigger antioxidant defence at a certain time during cancer development can also provide possible strategies in fighting cancer.

Inflammation and Cancer

Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Inflammation and Cancer Book PDF

Author : Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta
Publisher : Springer
Page : 490 pages
File Size : 43,6 Mb
Release : 2014-05-12
Category : Medical
ISBN : 9783034808378

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Inflammation and Cancer by Bharat B. Aggarwal,Bokyung Sung,Subash Chandra Gupta Pdf

This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.

Redox and Cancer

Anonim
Redox and Cancer Book PDF

Author : Anonim
Publisher : Academic Press
Page : 338 pages
File Size : 40,6 Mb
Release : 2014-06-25
Category : Science
ISBN : 9780124201767

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Redox and Cancer by Anonim Pdf

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics — Volume 122 explores subjects related to redox, including: redox homeostasis in epithelial-derived cancers; reactive oxygen species in normal and tumor stem cells; and gamma-glutamyl transpeptidase and redox regulation. Provides information on cancer research Outstanding and original reviews Suitable for researchers and students

Cancer

Victor R. Preedy
Cancer Book PDF

Author : Victor R. Preedy
Publisher : Academic Press
Page : 308 pages
File Size : 49,7 Mb
Release : 2014-03-01
Category : Medical
ISBN : 9780124055247

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Cancer by Victor R. Preedy Pdf

Cancer: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in cancer and then the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component of this. Oncologists, cancer researchers, and nutritionists are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While oncologists and cancer researchers may study the underlying pathogenesis of cancer, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of oncology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of cancer. Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams Nutritionists and dietitians will gain an understanding of cell signaling, and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods

Oxidative Stress

Canhua Huang,Yuanyuan Zhang
Oxidative Stress Book PDF

Author : Canhua Huang,Yuanyuan Zhang
Publisher : Springer Nature
Page : 323 pages
File Size : 53,5 Mb
Release : 2021-05-27
Category : Science
ISBN : 9789811605222

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Oxidative Stress by Canhua Huang,Yuanyuan Zhang Pdf

This book offers a systematic review of the cutting-edge knowledge in stress medicine. Cellular redox imbalance, resulting from overproduction of reactive oxide species (ROS), leads to oxidative stress and subsequent occurrence and development of many diseases, such as cancer, diabetes, pain, etc. In addition, ROS can induce post-translational modification of proteins and play roles through redox signaling pathways. In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing. This book serves as a reference to graduate students and researchers in this growing field.

Redox-Active Therapeutics

Ines Batinić-Haberle,Júlio S. Rebouças,Ivan Spasojević
Redox Active Therapeutics Book PDF

Author : Ines Batinić-Haberle,Júlio S. Rebouças,Ivan Spasojević
Publisher : Springer
Page : 694 pages
File Size : 43,9 Mb
Release : 2016-10-13
Category : Science
ISBN : 9783319307053

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Redox-Active Therapeutics by Ines Batinić-Haberle,Júlio S. Rebouças,Ivan Spasojević Pdf

This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neglected diseases (e.g., leishmaniasis). It encompasses several major classes of redox-active experimental therapeutics, which include porphyrins, salens, nitrones, and most notably metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with nanomaterials and quantum dots. Numerous illustrations, tables and figures enhance and complement the text; extensive references to relevant literature are also included. Redox-Active Therapeutics is an invaluable addition to Springer’s Oxidative Stress in Applied Basic Research and Clinical Practice series. It is essential reading for researchers, clinicians and graduate students interested in understanding and exploring the Redoxome—the organism redox network—as an emerging frontier in drug design, redox biology and medicine.

Novel Therapeutic Approaches Targeting Oxidative Stress

Pawan Kumar Maurya,Imteyaz Qamar
Novel Therapeutic Approaches Targeting Oxidative Stress Book PDF

Author : Pawan Kumar Maurya,Imteyaz Qamar
Publisher : Academic Press
Page : 294 pages
File Size : 49,5 Mb
Release : 2022-02-18
Category : Science
ISBN : 9780323909068

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Novel Therapeutic Approaches Targeting Oxidative Stress by Pawan Kumar Maurya,Imteyaz Qamar Pdf

Novel Therapeutic Approaches Targeting Oxidative Stress investigates the role of oxidative stress in disease and explores the latest methods and approaches to targeting oxidative stress for treatment and diagnosis. The book begins with an introduction to oxidative stress and its significance. Subsequent sections cover biochemical methods for detecting free radicals and novel therapeutic approaches for targeting oxidative stress in a number of different diseases. This includes age-related illnesses, neuropsychiatric disorders such as schizophrenia and bipolar disorder, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Novel approaches for targeting oxidative stress in cancer and cardiovascular diseases are also explored. The book then moves on to discuss advances in drug delivery systems and detecting oxidative stress biomarkers using biosensors. It concludes with case studies that illustrate the targeting of oxidative stress and future perspectives. Explores oxidative stress in a variety of diseases, including neurological disorders, cardiovascular diseases, age-related diseases, and cancer Covers a range of therapeutic approaches to target oxidative stress Includes chapters on the application of novel drug delivery systems and diagnostic biosensors to oxidative stress Features case studies illustrating the targeting of oxidative stress

Oxidative Stress and Antioxidant Protection

Donald Armstrong,Robert D. Stratton
Oxidative Stress and Antioxidant Protection Book PDF

Author : Donald Armstrong,Robert D. Stratton
Publisher : John Wiley & Sons
Page : 600 pages
File Size : 40,6 Mb
Release : 2016-01-14
Category : Science
ISBN : 9781118832370

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Oxidative Stress and Antioxidant Protection by Donald Armstrong,Robert D. Stratton Pdf

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.

Stress Response Pathways in Cancer

Georg T. Wondrak
Stress Response Pathways in Cancer Book PDF

Author : Georg T. Wondrak
Publisher : Springer
Page : 446 pages
File Size : 53,5 Mb
Release : 2014-11-07
Category : Medical
ISBN : 9789401794213

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Stress Response Pathways in Cancer by Georg T. Wondrak Pdf

It is now established that dysregulated cell stress response pathways play a critical role in tumorigenesis, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit cancer patients in the near future. Coauthored by recognized leaders in cancer research from five continents, this novel book provides a comprehensive perspective on cell stress response pathways and therapeutic opportunities. Focusing on the role of genotoxic, proteotoxic, oxidative, metabolic, and inflammatory stress in tumorigenesis, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in cancer and therapeutic development.

Redox and Metabolic Circuits in Cancer

Salvatore Rizza,Andrea Rasola,Danyelle M. Townsend,Giuseppe Filomeni
Redox and Metabolic Circuits in Cancer Book PDF

Author : Salvatore Rizza,Andrea Rasola,Danyelle M. Townsend,Giuseppe Filomeni
Publisher : Frontiers Media SA
Page : 183 pages
File Size : 47,8 Mb
Release : 2018-12-21
Category : Electronic
ISBN : 9782889456352

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Redox and Metabolic Circuits in Cancer by Salvatore Rizza,Andrea Rasola,Danyelle M. Townsend,Giuseppe Filomeni Pdf

Living cells require a constant supply of energy for the orchestration of a variety of biological processes in fluctuating environmental conditions. In heterotrophic organisms, energy mainly derives from the oxidation of carbohydrates and lipids, whose chemical bonds breakdown allows electrons to generate ATP and to provide reducing equivalents needed to restore the antioxidant systems and prevent from damage induced by reactive oxygen and nitric oxide (NO)-derived species (ROS and RNS). Studies of the last two decades have highlighted that cancer cells reprogram the metabolic circuitries in order to sustain their high growth rate, invade other tissues, and escape death. Therefore, this broad metabolic reorganization is mandatory for neoplastic growth, allowing the generation of adequate amounts of ATP and metabolites, as well as the optimization of redox homeostasis in the changeable environmental conditions of the tumor mass. Among these, ROS, as well as NO and RNS, which are produced at high extent in the tumor microenvironment or intracellularly, have been demonstrated acting as positive modulators of cell growth and frequently associated with malignant phenotype. Metabolic changes are also emerging as primary drivers of neoplastic onset and growth, and alterations of mitochondrial metabolism and homeostasis are emerging as pivotal in driving tumorigenesis. Targeting the metabolic rewiring, as well as affecting the balance between production and scavenging of ROS and NO-derived species, which underpin cancer growth, opens the possibility of finding selective and effective anti-neoplastic approaches, and new compounds affecting metabolic and/or redox adaptation of cancer cells are emerging as promising chemotherapeutic tools. In this Research Topic we have elaborated on all these aspects and provided our contribution to this increasingly growing field of research with new results, opinions and general overviews about the extraordinary plasticity of cancer cells to change metabolism and redox homeostasis in order to overcome the adverse conditions and sustain their “individualistic” behavior under a teleonomic viewpoint.

Cancer

Victor R Preedy,Vinood B. Patel
Cancer Book PDF

Author : Victor R Preedy,Vinood B. Patel
Publisher : Academic Press
Page : 592 pages
File Size : 40,5 Mb
Release : 2021-01-14
Category : Medical
ISBN : 9780128195635

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Cancer by Victor R Preedy,Vinood B. Patel Pdf

Cancer: Oxidative Stress and Dietary Antioxidants, Second Edition, covers the science of oxidative stress in cancer and the potentially therapeutic usage of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor-mediated responses. This approach recognizes that diseases are often multifactorial and that oxidative stress is a single component. Other sections cover new organ site tumors—skin and liver cancer, the role of polymorphisms, cytochrome p450s, COX gene, fatty acids, apoptosis, T cells and mitochondria, prevention/protection with anthocyanins, esculetin, nanoparticles, and more. This book is a valuable resource for cancer researchers, oncologists, nutritionists and other members of the biomedical field who are interested in enhancing treatment outcome, improving the quality of life of patients, and developing new treatments in the fight against cancer. Encompasses updated, revised and state-of-the-art information to advance cancer research Bridges the gaps between nutrition, oxidative stress, and cancer, presenting a holistic approach for health care and research Contains wide applicability to cancer research, from prevention to novel therapeutics

Role of Capsaicin in Oxidative Stress and Cancer

Sanjay K. Srivastava
Role of Capsaicin in Oxidative Stress and Cancer Book PDF

Author : Sanjay K. Srivastava
Publisher : Springer Science & Business Media
Page : 178 pages
File Size : 40,7 Mb
Release : 2013-04-23
Category : Medical
ISBN : 9789400763173

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Role of Capsaicin in Oxidative Stress and Cancer by Sanjay K. Srivastava Pdf

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.