Pathology Of The Fischer Rat

Author : Gary A. Boorman
Publisher : San Diego : Academic Press
Page : 580 pages
File Size : 45,9 Mb
Release : 1990
Category : Medical
ISBN : 0121156400

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Pathology of the Fischer Rat by Gary A. Boorman Pdf

Studies in rodents of the toxicity and carcinogenicity of drugs, agricultural agents (e.g., pesticides and herbicides), environmental pollutants, industrial agents (e.g., solvents and intermediates), and other chemicals are the cornerstone of human safety evaluations in the development, use, and/or regulation of these agents. Those who perform the pathological evaluations from these studies need standard diagnostic criteria and pathology terminology. Pathology of the Fischer Rat is a comprehensive pathology reference text on the Fischer 344 rat, the strain widely used for safety evaluations and almost exclusively by the National Toxicology Program.****Every chapter follows the same format of introduction; embryology; normal anatomy, histology, and physiology; and congenital, degenerative, inflammatory and vascular, hyperplastic and neoplastic, miscellaneous, and toxicological lesions. The spectrum of spontaneous and treatment-related, neoplastic and nonneoplastic lesions found in each tissue is described and photographed.****The text is useful not only to pathologists but also to investigators from a variety of disciplines who use the rat as an animal model. It will also prove valuable to toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to promulgation of meaningful regulations.

Author : Sherman F. Stinson,Hildegard M. Schuller,Gerd Reznik
Publisher : CRC Press
Page : 564 pages
File Size : 54,8 Mb
Release : 1990-01-17
Category : Medical
ISBN : 0849354625

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Atlas of Tumor Pathology of the Fischer Rat by Sherman F. Stinson,Hildegard M. Schuller,Gerd Reznik Pdf

This book provides a comprehensive resource of the most recent findings on the pathogenesis and pathology in the Fischer rat. Each chapter, adequately illustrated with light and electron photomicrographs, deals with a specific organ system. It includes a summary of the spontaneous neoplasms found in over 5,000 untreated control animals as well as a detailed, step by step necropsy procedure completely illustrated by photographs. It refers to a listing of common and rare tumors associated with the administration of various environmental agents obtained from over 200 carcinogenesis bioassays of the National Cancer Institute and National Toxicology Program. This work also reveals detailed information on spontaneous occurrence and the induction of neoplasms. Scientists involved in the evaluation of toxicological and carcinogenesis bioassays and investigators conducting basic and applied carcinogenesis research will find this atlas indispensable.

Author : Stinson SF Ed
Publisher : Unknown
Page : 128 pages
File Size : 45,9 Mb
Release : 1990
Category : Electronic
ISBN : OCLC:985930414

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Atlas of Tumor Pathology of the Fischer Rat by Stinson SF Ed Pdf

Author : Mark A. Suckow,Steven H. Weisbroth,Craig L. Franklin
Publisher : Elsevier
Page : 928 pages
File Size : 51,8 Mb
Release : 2005-12-20
Category : Science
ISBN : 9780080454320

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The Laboratory Rat by Mark A. Suckow,Steven H. Weisbroth,Craig L. Franklin Pdf

The Laboratory Rat, Second Edition features updated information on a variety of topics including: rat genetics and genomics, both spontaneous and induced disease; state-of-the-art technology for housing and husbandry; occupational health, and experimental models. A premier source of information on the laboratory rat that will be of interest to veterinary and medical students, senior graduate, graduate students, post-docs and researchers who utilize animals in biomedical research. At least 50% new information than first edition Includes topics on rat genetics and genomics, occupational health, and experimental models The premier source of information on the laboratory rat

Author : Andrew W. Suttie,Joel R. Leininger,Alys E. Bradley
Publisher : Academic Press
Page : 748 pages
File Size : 40,7 Mb
Release : 2017-12-18
Category : Medical
ISBN : 9780123914897

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Boorman's Pathology of the Rat by Andrew W. Suttie,Joel R. Leininger,Alys E. Bradley Pdf

Boorman’s Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers an added emphasis on the Sprague-Dawley and Wistar rat strains that is consistent with current research across academia, government, and industry. In addition, the book provides standard diagnostic criteria, basic content on histology, histological changes that result from drug toxicity and neoplasm, pathology terminology, and four-color photographs from the NTP archive and database. With updated references and photographs, as well as coverage of all rat strains, this book is not only the standard in the field, but also an invaluable resource for toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to the promulgation of meaningful regulations. Contains full, four color photographs from the NTP archive and database and coverage of all rat strains Provides an organ-by-organ and system-by-system approach that presents standard diagnostic criteria and basic content on histology and histological changes Includes comprehensive and detailed background incidence data Presents detailed descriptive content regarding changes in rat models during research

Author : Peter Greaves
Publisher : Elsevier
Page : 960 pages
File Size : 41,9 Mb
Release : 2007-03-23
Category : Medical
ISBN : 0080471307

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Histopathology of Preclinical Toxicity Studies by Peter Greaves Pdf

This work covers effectively all aspects of drug-induced pathology that may be encountered within preclinical toxicity studies. It fills a gap in the pathology literature relating to the preclinical safety assessment of new medicines. It systematically describes, in one volume, both spontaneous and drug induced pathology on an organ by organ basis. Information relevant to understanding the nature of pathological changes in pre-clinical studies and assessment of their relevance to the clinical investigation of new drugs is also covered. Numerous colour photographs are included that highlight and embellish the histopathological features that are described. It also contains many pertinent references to both human and animal pathology forming an essential basis for the assessment of drug-induced pathology. NEW TO THE THIRD EDITION: * Covers drug induced pathology in preclinical (animal) studies and their relevance for patients or volunteers in clinical studies * General comments to each chapter about the relevance of pathological findings to humans * Provides essential information that can help decide the relevance of particular lesions for patients

Author : George J. Krinke
Publisher : Elsevier
Page : 756 pages
File Size : 53,7 Mb
Release : 2000-06-20
Category : Medical
ISBN : 0080533469

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The Laboratory Rat by George J. Krinke Pdf

This reference series will provide all researchers using laboratory animals with comprehensive practical information on the various species. Each title in the series is devoted to a particular species, and draws together all available data in a "one-stop", easily accessible source. Each has similar format, with sections on the strains available, their husbandry, and special diets. Also included are sections on gross anatomy, endocrinology, and reproduction, followed by more detailed sections on neuroanatomy, vasculature, cell biology, and histology of particular organs and structures, and a section on molecular biology. High quality illustrations are included throughout and a color plate section is provided. A glossary, list of equipment suppliers, and "Quick Reference Section" are added features. The "Quick Reference Section" brings together all tables from the text, allowing readers to find data swiftly. The first volume in The Handbook of Experimental Animals Series, The Laboratory Rat, provides researchers in academia and industry using laboratory animals with comprehensive, practical information on the species. The Laboratory Rat has been divided into eight sections dealing with: * Strains and their selection for research * Housing and maintenance * Pathogens and diseases * Breeding and reproduction * Anatomy * Physiology * Procedures, including experimental surgery * Emerging techniques, including genetic engineering and molecular technology Key Features * Provides a valuable, comprehensive reference source for anybody working with the laboratory rat * Formatted in a two-color, user-friendly layout * Includes high-quality illustrations throughout as well as a color plate section * Glossary * Tables in the text are also arranged into one Quick Reference Section for ease of access to the data * Appendix of equipment suppliers

Author : National Institutes of Health (U.S.).
Publisher : Unknown
Page : 564 pages
File Size : 48,6 Mb
Release : 1990
Category : Biochemistry
ISBN : MINN:31951D008755076

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Published Scientific Papers of the National Institutes of Health by National Institutes of Health (U.S.). Pdf

Presents the broad outline of NIH organizational structure, theprofessional staff, and their scientific and technical publications covering work done at NIH.

Author : Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath,Page Bouchard
Publisher : CRC Press
Page : 1897 pages
File Size : 54,6 Mb
Release : 2018-08-14
Category : Medical
ISBN : 9780429997457

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Toxicologic Pathology by Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath,Page Bouchard Pdf

Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk. Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions. The 13 organ system chapters provide the specifics related to pathologic characteristics, differential diagnosis, and interpretation of toxic responses in each organ system. These chapters are specifically important for the bench pathologist but also for the toxicologist who interacts with pathologists and function as study toxicologists and project team representatives in the drug development arena.

Author : Lynn C. Anderson,Glen Otto,Kathleen R. Pritchett-Corning,Mark T. Whary
Publisher : Elsevier
Page : 1727 pages
File Size : 44,8 Mb
Release : 2015-07-04
Category : Technology & Engineering
ISBN : 9780124166134

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Laboratory Animal Medicine by Lynn C. Anderson,Glen Otto,Kathleen R. Pritchett-Corning,Mark T. Whary Pdf

Laboratory Animal Medicine, Third Edition, is a fully revised publication from the American College of Laboratory Medicine’s acclaimed blue book series. It presents an up-to-date volume that offers the most thorough coverage of the biology, health, and care of laboratory animals. The book is organized by species, with new inclusions of chinchillas, birds, and program and employee management, and is written and edited by known experts in the fields. Users will find gold-standard guidance on the study of laboratory animal science, as well as valuable information that applies across all of the biological and biomedical sciences that work with animals. Organized by species for in-depth understanding of biology, health, and best care of animals Features the inclusion of chinchillas, quail, and zebra finches as animal models Offers guidance on program and employee management Covers regulations, policies, and laws for laboratory animal management worldwide

Author : J. Turton,J. Hooson
Publisher : CRC Press
Page : 456 pages
File Size : 48,5 Mb
Release : 1997-10-06
Category : Medical
ISBN : 9780203481929

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Target Organ Pathology by J. Turton,J. Hooson Pdf

The major organs of the body are targets for chemically-induced effects in animals and humans. This book reviews the mechanisms of these toxic effects and the structure/functional changes which occur in the target organ tissues as a result.

Author : P.J. Bert Hakkinen,Gerald Kennedy,Frederick W. Stoss
Publisher : Elsevier
Page : 953 pages
File Size : 47,6 Mb
Release : 2000-01-10
Category : Medical
ISBN : 9780080534664

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Information Resources in Toxicology by P.J. Bert Hakkinen,Gerald Kennedy,Frederick W. Stoss Pdf

Information Resources in Toxicology, Third Edition is a sourcebook for anyone who needs to know where to find toxicology information. It provides an up-to-date selective guide to a large variety of sources--books, journals, organizations, audiovisuals, internet and electronic sources, and more. For the Third Edition, the editors have selected, organized, and updated the most relevant information available. New information on grants and other funding opportunities, physical hazards, patent literature, and technical reports have also been added.This comprehensive, time-saving tool is ideal for toxicologists, pharmacologists, drug companies, testing labs, libraries, poison control centers, physicians, legal and regulatory professionals, and chemists. Serves as an all-in-one resource for toxicology information New edition includes information on publishers, grants and other funding opportunities, physical hazards, patent literature, and technical reports Updated to include the latest internet and electronic sources, e-mail addresses, etc. Provides valuable data about the new fields that have emerged within toxicological research; namely, the biochemical, cellular, molecular, and genetic aspects

Author : Patricia V. Turner,Marina L. Brash,Dale A. Smith
Publisher : John Wiley & Sons
Page : 448 pages
File Size : 48,5 Mb
Release : 2017-09-20
Category : Medical
ISBN : 9781118969595

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Pathology of Small Mammal Pets by Patricia V. Turner,Marina L. Brash,Dale A. Smith Pdf

Pathology of Small Mammal Pets presents a ready reference for veterinarians, veterinary pathologists, and technicians who work with small mammal companion animals. Provides up-to-date, practical information on common disease conditions in small mammal companion animals Offers chapters logically organized by species, with comprehensive information on diagnosing diseases in each species Takes a practical, system-based approach to individual disease conditions Covers clinical signs, laboratory diagnostics, gross pathology, histopathology, and differential diagnoses in detail Includes relevant information for conventional breeding operations and breeding facilities, with strategies for disease management in herds and colonies Features information on normal anatomy in included species to assist in recognizing pathology

Author : Elizabeth Fiona McInnes
Publisher : Elsevier Health Sciences
Page : 256 pages
File Size : 40,9 Mb
Release : 2011-10-24
Category : Medical
ISBN : 9780702049248

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Background Lesions in Laboratory Animals E-Book by Elizabeth Fiona McInnes Pdf

Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas. over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals a chapter on common artifacts that may be observed in histological glass slides extensive references to each lesion described aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies

Author : Thomas C. Jones,Charles C. Capen,Ulrich Mohr
Publisher : Springer Science & Business Media
Page : 796 pages
File Size : 43,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642609961

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Endocrine System by Thomas C. Jones,Charles C. Capen,Ulrich Mohr Pdf

Approximately 10 years have elapsed since the first volume of the International Life Sciences Institute (ILSI) Monographs on Pathology of Laboratory Animals, Endocrine System was completed. New information of interest to pathologists has developed at a rather remarkable pace during the intervening years. Exceptional progress has been made in the routine identification of cell products in endo crine cells. A better understanding has developed of the mechanisms involved in cell metabolism, particularly involving toxins and car cinogens. Clear concepts have developed concerning the significance of some pathologic lesions in the endocrine system and their relation to human health and risk assessment. Standardized nomenclature has developed significantly during the 1O-year period since the first volume and is being utilized on an international basis. This has resulted in significant improvement in communication of pathologic data to regulatory agencies and in scientific publications worldwide. This monograph series and others sponsored by ILSI have produced a significant effect on improved communications and the international acceptance of standardized nomenclature. In this second edition, new formats have been used where more appropriate for the subjects to be covered. In many cases, the format used in the first edition still is useful. It is still necessary to recognize the morphologic features of pathologic lesions in order to identify them precisely, an essential step toward development of new insights into pathogenetic mechanisms and their use in decisions eventually applicable to public health.