Atlas Of Tumor Pathology Of The Fischer Rat

Author : Sherman F. Stinson,Hildegard M. Schuller,Gerd Reznik
Publisher : CRC Press
Page : 564 pages
File Size : 47,5 Mb
Release : 1990-01-17
Category : Medical
ISBN : 0849354625

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Atlas of Tumor Pathology of the Fischer Rat by Sherman F. Stinson,Hildegard M. Schuller,Gerd Reznik Pdf

This book provides a comprehensive resource of the most recent findings on the pathogenesis and pathology in the Fischer rat. Each chapter, adequately illustrated with light and electron photomicrographs, deals with a specific organ system. It includes a summary of the spontaneous neoplasms found in over 5,000 untreated control animals as well as a detailed, step by step necropsy procedure completely illustrated by photographs. It refers to a listing of common and rare tumors associated with the administration of various environmental agents obtained from over 200 carcinogenesis bioassays of the National Cancer Institute and National Toxicology Program. This work also reveals detailed information on spontaneous occurrence and the induction of neoplasms. Scientists involved in the evaluation of toxicological and carcinogenesis bioassays and investigators conducting basic and applied carcinogenesis research will find this atlas indispensable.

Author : Stinson SF Ed
Publisher : Unknown
Page : 128 pages
File Size : 44,9 Mb
Release : 1990
Category : Electronic
ISBN : OCLC:985930414

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Atlas of Tumor Pathology of the Fischer Rat by Stinson SF Ed Pdf

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 55,8 Mb
Release : 1969
Category : Tumors
ISBN : LCCN:70017079

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Atlas of Tumor Pathology by Anonim Pdf

Author : Mary J Tucker
Publisher : CRC Press
Page : 269 pages
File Size : 44,5 Mb
Release : 1997-05-21
Category : Medical
ISBN : 9780748405213

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Dieseases of the Wistar Rat by Mary J Tucker Pdf

This text provides a complete account of this particular rat strain. The book includes extensive data on reproductive indices, congenital abnormalities, growth, clinical signs, mortality, organ weights and chemical pathology. The data are derived from around 9000 control animals used in toxicology studies of two weeks to two years duration, completed between 1960 and 1992, and include 24 two-year studies and one life-span study of a 51 month duration. These extended periods of study have shown that many diseases are seen more frequently in later years.; Diseases are dealt with by body system and include clinical signs, macroscopic features and histopathology illustrations of the important or unusual diseases. Incidence levels are provided for all diseases and these are compared with published data for other rat strains.

Author : National Institutes of Health (U.S.).
Publisher : Unknown
Page : 564 pages
File Size : 50,6 Mb
Release : 1990
Category : Biochemistry
ISBN : MINN:31951D008755076

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Published Scientific Papers of the National Institutes of Health by National Institutes of Health (U.S.). Pdf

Presents the broad outline of NIH organizational structure, theprofessional staff, and their scientific and technical publications covering work done at NIH.

Author : Gary A. Boorman
Publisher : San Diego : Academic Press
Page : 580 pages
File Size : 48,6 Mb
Release : 1990
Category : Medical
ISBN : 0121156400

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Pathology of the Fischer Rat by Gary A. Boorman Pdf

Studies in rodents of the toxicity and carcinogenicity of drugs, agricultural agents (e.g., pesticides and herbicides), environmental pollutants, industrial agents (e.g., solvents and intermediates), and other chemicals are the cornerstone of human safety evaluations in the development, use, and/or regulation of these agents. Those who perform the pathological evaluations from these studies need standard diagnostic criteria and pathology terminology. Pathology of the Fischer Rat is a comprehensive pathology reference text on the Fischer 344 rat, the strain widely used for safety evaluations and almost exclusively by the National Toxicology Program.****Every chapter follows the same format of introduction; embryology; normal anatomy, histology, and physiology; and congenital, degenerative, inflammatory and vascular, hyperplastic and neoplastic, miscellaneous, and toxicological lesions. The spectrum of spontaneous and treatment-related, neoplastic and nonneoplastic lesions found in each tissue is described and photographed.****The text is useful not only to pathologists but also to investigators from a variety of disciplines who use the rat as an animal model. It will also prove valuable to toxicologists, biologists, and other scientists engaged in regulatory toxicology who must make the transition from pathology results to promulgation of meaningful regulations.

Author : Stephen W. Barthold,Stephen M. Griffey,Dean H. Percy
Publisher : John Wiley & Sons
Page : 384 pages
File Size : 50,5 Mb
Release : 2016-01-04
Category : Medical
ISBN : 9781118924037

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Pathology of Laboratory Rodents and Rabbits by Stephen W. Barthold,Stephen M. Griffey,Dean H. Percy Pdf

Now in its fourth edition, Pathology of Laboratory Rodents and Rabbits has become a standard text for veterinary pathologists, laboratory animal veterinarians, students, and others interested in these species. • The standard reference on the pathogenesis and cardinal diagnostic features of diseases of mice, rats, hamsters, gerbils, guinea pigs, and rabbits • Expanded coverage of rabbit disease, normal anatomic features, and biology • Over 450 color photographs illustrating gross and microscopic pathology • Companion website offering images from the text in PowerPoint

Author : George J. Krinke
Publisher : Elsevier
Page : 756 pages
File Size : 49,7 Mb
Release : 2000-06-20
Category : Medical
ISBN : 0080533469

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The Laboratory Rat by George J. Krinke Pdf

This reference series will provide all researchers using laboratory animals with comprehensive practical information on the various species. Each title in the series is devoted to a particular species, and draws together all available data in a "one-stop", easily accessible source. Each has similar format, with sections on the strains available, their husbandry, and special diets. Also included are sections on gross anatomy, endocrinology, and reproduction, followed by more detailed sections on neuroanatomy, vasculature, cell biology, and histology of particular organs and structures, and a section on molecular biology. High quality illustrations are included throughout and a color plate section is provided. A glossary, list of equipment suppliers, and "Quick Reference Section" are added features. The "Quick Reference Section" brings together all tables from the text, allowing readers to find data swiftly. The first volume in The Handbook of Experimental Animals Series, The Laboratory Rat, provides researchers in academia and industry using laboratory animals with comprehensive, practical information on the species. The Laboratory Rat has been divided into eight sections dealing with: * Strains and their selection for research * Housing and maintenance * Pathogens and diseases * Breeding and reproduction * Anatomy * Physiology * Procedures, including experimental surgery * Emerging techniques, including genetic engineering and molecular technology Key Features * Provides a valuable, comprehensive reference source for anybody working with the laboratory rat * Formatted in a two-color, user-friendly layout * Includes high-quality illustrations throughout as well as a color plate section * Glossary * Tables in the text are also arranged into one Quick Reference Section for ease of access to the data * Appendix of equipment suppliers

Author : Peter Greaves
Publisher : Elsevier
Page : 960 pages
File Size : 45,5 Mb
Release : 2007-03-23
Category : Medical
ISBN : 0080471307

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Histopathology of Preclinical Toxicity Studies by Peter Greaves Pdf

This work covers effectively all aspects of drug-induced pathology that may be encountered within preclinical toxicity studies. It fills a gap in the pathology literature relating to the preclinical safety assessment of new medicines. It systematically describes, in one volume, both spontaneous and drug induced pathology on an organ by organ basis. Information relevant to understanding the nature of pathological changes in pre-clinical studies and assessment of their relevance to the clinical investigation of new drugs is also covered. Numerous colour photographs are included that highlight and embellish the histopathological features that are described. It also contains many pertinent references to both human and animal pathology forming an essential basis for the assessment of drug-induced pathology. NEW TO THE THIRD EDITION: * Covers drug induced pathology in preclinical (animal) studies and their relevance for patients or volunteers in clinical studies * General comments to each chapter about the relevance of pathological findings to humans * Provides essential information that can help decide the relevance of particular lesions for patients

Author : Thomas C. Jones,Ulrich Mohr,Ronald D. Hunt
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 47,8 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9783642835162

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Nervous System by Thomas C. Jones,Ulrich Mohr,Ronald D. Hunt Pdf

The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmon ize toxicological testing, to advance a more uniform inter pretation of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scien tists. The Monographs on the Pathology of Laboratory Ani mals are designed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others concerned with evaluating toxicity and carcinogen icity studies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our ex pectations that understanding and cooperation will be im proved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on the nervous system, is the sixth volume of a set pre pared under the sponsorship of the International Life Sciences Insti tute (ILSI).

Author : Wanda M. Haschek,Colin G. Rousseaux,Matthew A. Wallig,Brad Bolon,Ricardo Ochoa
Publisher : Elsevier
Page : 2160 pages
File Size : 47,9 Mb
Release : 2001-10-16
Category : Medical
ISBN : 9780080491448

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Haschek and Rousseaux's Handbook of Toxicologic Pathology by Wanda M. Haschek,Colin G. Rousseaux,Matthew A. Wallig,Brad Bolon,Ricardo Ochoa Pdf

A comprehensive understanding of toxicologic pathology is essential for those in industry, academia, and government who make decisions concerning the safety and efficacy of drugs and chemicals. Toxicologic pathology relies heavily on the fields of both toxicology and pathology, which are well covered individually in various texts and references; however, there are few texts that address the field of toxicologic pathology. The Handbook of Toxicologic Pathology fills this void and is thus essential for all health professionals within or interacting with the field of toxicologic pathology. This two-volume set provides the reader with a single reference for toxicologic pathology. In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the "practice" toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury. Key Features * Easy to find, up-to-date reference information * Graphic and photographic plates * Current hot topics and anticipated changes in toxicologic pathology * Standardized chapter format * Topics that are addressed in both a broad and deep manner, resulting in a stand alone text * Added coverage of important environmental toxicants * Chapters authored by internationally recognized experts and peer-reviewed

Author : Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath
Publisher : CRC Press
Page : 1019 pages
File Size : 55,8 Mb
Release : 2013-04-09
Category : Medical
ISBN : 9781439872109

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Toxicologic Pathology by Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath Pdf

As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical drug research, Toxicologic Pathology: Nonclinical Safety Assessment presents a histopathologic description of lesions observed during drug development and discusses their implication in the drug development process. Divided into two sections, the book systematically assists pathologists in making a determination as to the origin and potential importance of a lesion and its relevance for assessing human risk. The first section includes eight "concept" chapters to orient pathologists in areas that are important for effective interaction with other pathologists as well as the many non-pathologists involved in drug development. The second section is made up of organ-based chapters, each including light microscopic and electron microscopic descriptions of pathological lesions, differential diagnoses, biological consequences, pathogenesis, mechanism of lesion formation, and the expected clinical pathology correlates. This volume presents critical information—both published and unpublished and gained through personal experience—to improve the quality of drug safety evaluation and to expedite and improve the efficiency of the process. This book is crafted to assist students, residents, and toxicologic pathologists in their early career phase by serving as a resource that can effectively be used as a ready reference next to the microscope. In addition, more experienced pathologists will find this volume to be invaluable during their assessments. The book is also a valuable reference for toxicologists to assist in understanding compound-related pathological findings and to provide background for working on a range of toxicological problems.

Author : National Toxicology Program (U.S.)
Publisher : Unknown
Page : 340 pages
File Size : 53,7 Mb
Release : 1988
Category : Toxicity testing
ISBN : UCSD:31822008197295

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Annual Plan for Fiscal Year ... by National Toxicology Program (U.S.) Pdf

Author : John E. Harkness,Patricia V. Turner,Susan VandeWoude,Colette L. Wheler
Publisher : John Wiley & Sons
Page : 487 pages
File Size : 54,7 Mb
Release : 2013-03-22
Category : Medical
ISBN : 9781118708903

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Harkness and Wagner's Biology and Medicine of Rabbits and Rodents by John E. Harkness,Patricia V. Turner,Susan VandeWoude,Colette L. Wheler Pdf

Harkness and Wagner's Biology and Medicine of Rabbits and Rodents, Fifth Edition is a practical reference in small mammal husbandry and health, encompassing the fields of laboratory animal medicine and pet practice. Part of ACLAM's series of laboratory animal books, this text offers concise but complete coverage on rabbits and the most common rodent species, with an emphasis on biology, clinical procedures, clinical signs, and diseases and conditions. By providing useful, accessible assessment and diagnostic information, Harkness and Wagner's Biology and Medicine of Rabbits and Rodents aids the practitioner in diagnosing and treating conditions in small mammals.

Author : Hiraku Takebe
Publisher : IOS Press
Page : 568 pages
File Size : 52,7 Mb
Release : 2001
Category : Medical
ISBN : 1586031058

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Biological and Health Effects from Exposure to Power-line Frequency Electromagnetic Fields by Hiraku Takebe Pdf

The possible health effects of electro-magnetic (EMF) from high-voltage electric power lines have been discussed sine the 1970s. The concern was triggered by epidemilogical studies in the United States and Europe that suggested a slightly increased incidence of leukaemia's and brain tumours occured among those living and working near high-voltage power lines. Although studies can indicate an associate between factor and effect, the studies themselves cannot confirm a cause-effect relationship. Whether EMF is producing these ill effects must be confirmed by experimental studies.