Peptide And Protein Delivery

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Peptide and Protein Delivery

Chris Van Der Walle
Peptide and Protein Delivery Book PDF

Author : Chris Van Der Walle
Publisher : Academic Press
Page : 380 pages
File Size : 48,7 Mb
Release : 2011-05-12
Category : Science
ISBN : 0123849365

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Peptide and Protein Delivery by Chris Van Der Walle Pdf

The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market

Peptide and Protein Drug Delivery

Vincent Lee
Peptide and Protein Drug Delivery Book PDF

Author : Vincent Lee
Publisher : CRC Press
Page : 916 pages
File Size : 45,7 Mb
Release : 1990-11-19
Category : Science
ISBN : 0824778960

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Peptide and Protein Drug Delivery by Vincent Lee Pdf

This reference/text covers fundamentals of peptide and protein drug delivery, including such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics; bioavailability from routes of administration, detai

Oral Delivery of Therapeutic Peptides and Proteins

Puneet Tyagi,Anand Subramony
Oral Delivery of Therapeutic Peptides and Proteins Book PDF

Author : Puneet Tyagi,Anand Subramony
Publisher : Academic Press
Page : 318 pages
File Size : 48,9 Mb
Release : 2022-08-18
Category : Business & Economics
ISBN : 9780128210604

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Oral Delivery of Therapeutic Peptides and Proteins by Puneet Tyagi,Anand Subramony Pdf

Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport. Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource. Demonstrates how proteins and peptides transport throughout the gastrointestinal tract and how to evaluate their biological fate when encapsulated into certain delivery systems Examines developing technologies to improve future oral bioavailability Includes the in vitro and preclinical techniques needed for development

Biological Barriers to Protein Delivery

Kenneth L. Andus,Thomas L. Raub
Biological Barriers to Protein Delivery Book PDF

Author : Kenneth L. Andus,Thomas L. Raub
Publisher : Springer Science & Business Media
Page : 507 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461528982

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Biological Barriers to Protein Delivery by Kenneth L. Andus,Thomas L. Raub Pdf

In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.

Trends and Future Perspectives in Peptide and Protein Drug Delivery

Vincent Lee
Trends and Future Perspectives in Peptide and Protein Drug Delivery Book PDF

Author : Vincent Lee
Publisher : CRC Press
Page : 400 pages
File Size : 45,9 Mb
Release : 1995-02-01
Category : Medical
ISBN : 3718656418

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Trends and Future Perspectives in Peptide and Protein Drug Delivery by Vincent Lee Pdf

First published in 1995. Routledge is an imprint of Taylor & Francis, an informa company.

Therapeutic Peptides and Proteins

Ajay K. Banga
Therapeutic Peptides and Proteins Book PDF

Author : Ajay K. Banga
Publisher : CRC Press
Page : 400 pages
File Size : 40,9 Mb
Release : 2015-04-23
Category : Medical
ISBN : 9781466566071

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Therapeutic Peptides and Proteins by Ajay K. Banga Pdf

There are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis. The clinical application of these therapeutic peptides and proteins is limited by several problems, such as lack of physical and chemical stability or the lack of desirable attributes for adequate absorption or distribution. Thus, as these therapeutic peptides and proteins are made available, it will be essential to formulate these drugs into safe, stable, and efficacious delivery systems. The pharmaceutical scientist involved in this effort needs to call upon the knowledge of several disciplines, such as pharmaceutics, medicinal chemistry, biochemistry, microbiology, and chemical engineering and needs to keep abreast with the latest research in the published literature. Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Third Edition provides a comprehensive overview of the field for scientists in industry and academia and for students, while also providing practical information on the challenges facing the formulation and delivery aspects of these unique macromolecules. In particular, the book: Explains how recombinant DNA techniques now allow us to produce therapeutic proteins in a commercially viable form Discusses the physical and chemical pathways of peptide and protein degradation Includes a detailed discussion of protein formulation and lyophilization Overviews the pharmacokinetic aspects of therapeutic peptides and proteins and discusses controlled delivery systems for parenteral administration, including microsphere formulations Discusses research progress on oral, transdermal, mucosal, and topical delivery systems discusses transdermal and topical delivery

Therapeutic Peptides and Proteins

Ajay K. Banga
Therapeutic Peptides and Proteins Book PDF

Author : Ajay K. Banga
Publisher : CRC Press
Page : 375 pages
File Size : 51,5 Mb
Release : 2005-09-14
Category : Medical
ISBN : 9781420039832

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Therapeutic Peptides and Proteins by Ajay K. Banga Pdf

Upon publication of the first edition of Therapeutic Peptides and Proteins ten years ago there were only 19 biotechology medicines on the market. Currently there are more than 100, with at least 400 more in various stages of development. That alone would be grounds for a new edition. Add to that the fact that it is still difficult to find up

Protein Delivery

Lynda M. Sanders,R. Wayne Hendren
Protein Delivery Book PDF

Author : Lynda M. Sanders,R. Wayne Hendren
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 43,7 Mb
Release : 2006-04-11
Category : Science
ISBN : 9780306468032

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Protein Delivery by Lynda M. Sanders,R. Wayne Hendren Pdf

Thirteen chapters by industrial and academic authorities in this rapidly evolving field present detailed case histories and reviews of current sophisticated protein-drug delivery technologies. Highlights include a comprehensive overview of insulin delivery and a discussion of the use of biodegradable microspheres.

Delivery Technologies for Biopharmaceuticals

Lene Jorgensen,Hanne Morck Nielson
Delivery Technologies for Biopharmaceuticals Book PDF

Author : Lene Jorgensen,Hanne Morck Nielson
Publisher : John Wiley & Sons
Page : 442 pages
File Size : 54,5 Mb
Release : 2009-10-23
Category : Science
ISBN : 9780470688403

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Delivery Technologies for Biopharmaceuticals by Lene Jorgensen,Hanne Morck Nielson Pdf

Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites. Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include: challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and protein injectables non-viral chemical vectors and viral technology for delivery of nucleic acid based drugs immune response, adjuvants and delivery systems for vaccines several examples of delivery systems for different biopharmaceuticals a critical assessment of delivery technologies for biopharmaceuticals Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.

Drug Delivery Systems

Kewal K. Jain
Drug Delivery Systems Book PDF

Author : Kewal K. Jain
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 42,6 Mb
Release : 2008-03-07
Category : Science
ISBN : 9781588298911

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Drug Delivery Systems by Kewal K. Jain Pdf

In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.

Delivery Systems for Peptide Drugs

S.S. Davis,Lisbeth Illum,E. Tomlinson
Delivery Systems for Peptide Drugs Book PDF

Author : S.S. Davis,Lisbeth Illum,E. Tomlinson
Publisher : Springer Science & Business Media
Page : 363 pages
File Size : 41,8 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781475799606

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Delivery Systems for Peptide Drugs by S.S. Davis,Lisbeth Illum,E. Tomlinson Pdf

Recent years have seen enormous advances in the field of protein and peptide engineering and a greater understanding in the way in which biological response modifiers function in the body. It is now possible through the use of recombinant DNA techniques, or by solid phase protein synthesis, to produce significant quantities of a wide variety of regulatory agents that are therapeutically applicable. The list of these response modifiers expands almost daily to include interferons, macrophage activation factors, neuropeptides and agents that may have potential in cardiovascular disease, inflammation, contraception etc. Prospects to use some of these materials in medicine have reached the stage where products have either been approved by regulatory authorities or are the subject of applications as investigatory drugs or as new therapeutic agents. In some uses the pertinent agent will be administered on an acute basis in the form of a simple injection, as, for example, the use of a tissue plasminogen activator for the treatment of coronary infarct. In other cases regulatory proteins and peptides are indicated for chronic therapy and here they will need to be administered by an appropriate delivery system. Unfortunately, the research on delivery systems for peptides and proteins has not kept pace with the rapid progress in biotechnology and, consequently, there are presently few systems that are entirely appropriate for the administration of macromolecular drugs according to complex dosage regimens, (eg intermittent and pulsed therapy). Furthermore essential pharmacokinetic and pharmacodynamic data may be missing.

Protein Formulation and Delivery

Eugene J. McNally,Eugene McNally,Jayne E. Hastedt
Protein Formulation and Delivery Book PDF

Author : Eugene J. McNally,Eugene McNally,Jayne E. Hastedt
Publisher : CRC Press
Page : 372 pages
File Size : 50,8 Mb
Release : 2007-10-26
Category : Medical
ISBN : 9780849379529

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Protein Formulation and Delivery by Eugene J. McNally,Eugene McNally,Jayne E. Hastedt Pdf

This title is intended to assist pharmaceutical scientists in the development of stable protein formulations during the early stages of the product development process, providing a comprehensive review of mechanisms and causes of protein instability in formulation development, coverage of accelerated stability testing methods and relevant analytica

Peptide and Protein Drug Delivery Using Polysaccharides

Aakanchha Jain,Sonia Malik
Peptide and Protein Drug Delivery Using Polysaccharides Book PDF

Author : Aakanchha Jain,Sonia Malik
Publisher : Elsevier
Page : 331 pages
File Size : 51,5 Mb
Release : 2023-10-10
Category : Science
ISBN : 9780443189265

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Peptide and Protein Drug Delivery Using Polysaccharides by Aakanchha Jain,Sonia Malik Pdf

Peptide and Protein Drug Delivery Using Polysaccharides offers an interdisciplinary discussion of polysaccharides applied in peptide and protein drug delivery. Chapters consider basic biology of different polysaccharides of current interest and their production at pilot and large-scale stages by various techniques including, but not limited to, cell and hairy root cultures. Other sections examine factors affecting polysaccharide absorption, metabolism, and excretion in nascent, encapsulated, or conjugated forms, with unique coverage of vaccine absorption, metabolism, and drug delivery. A final section considers analytical methods for detection in tissue fluids and homogenates. Accessible figures, tables, and graphical abstracts are included throughout to support understanding. Specific polysaccharides discussed for therapeutic purposes include cellulose, hyaluronic acid, heparin, carageenan, alginic acid, agar and myrrh, acacia, tragacanth, ghatti gum, chitin, chitosan, starch, glycogen and dextran. Adopts an interdisciplinary approach across biochemistry, molecular biology, pharmaceutical sciences and drug delivery, and biotechnological perspectives Features accessible figures, tables and graphical abstracts across all chapters to support understanding Examines various polysaccharides of current interest and aspects affecting their absorption, metabolism, excretion and detection

Proteins and Peptides

Randall J. Mrsny,Ann Daugherty
Proteins and Peptides Book PDF

Author : Randall J. Mrsny,Ann Daugherty
Publisher : CRC Press
Page : 288 pages
File Size : 48,5 Mb
Release : 2009-10-19
Category : Medical
ISBN : 9781420078077

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Proteins and Peptides by Randall J. Mrsny,Ann Daugherty Pdf

Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is

Challenges in Delivery of Therapeutic Genomics and Proteomics

Ambikanandan Misra
Challenges in Delivery of Therapeutic Genomics and Proteomics Book PDF

Author : Ambikanandan Misra
Publisher : Elsevier
Page : 686 pages
File Size : 55,6 Mb
Release : 2010-09-09
Category : Science
ISBN : 9780123849656

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Challenges in Delivery of Therapeutic Genomics and Proteomics by Ambikanandan Misra Pdf

Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of interest to researchers in both academia and industry Highlights what’s currently known and where further research is needed