Peptide Based Drug Design

Peptide Based Drug Design Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Peptide Based Drug Design book. This book definitely worth reading, it is an incredibly well-written.

Peptide-Based Drug Design

Laszlo Otvos
Peptide Based Drug Design Book PDF

Author : Laszlo Otvos
Publisher : Humana Press
Page : 0 pages
File Size : 47,6 Mb
Release : 2010-11-19
Category : Medical
ISBN : 1617378690

Get Book

Peptide-Based Drug Design by Laszlo Otvos Pdf

Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.

Peptide-Based Drug Design

Laszlo Otvos
Peptide Based Drug Design Book PDF

Author : Laszlo Otvos
Publisher : Humana Press
Page : 0 pages
File Size : 53,8 Mb
Release : 2008-10-09
Category : Medical
ISBN : 1588299902

Get Book

Peptide-Based Drug Design by Laszlo Otvos Pdf

Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.

Peptide Chemistry and Drug Design

Ben M. Dunn
Peptide Chemistry and Drug Design Book PDF

Author : Ben M. Dunn
Publisher : John Wiley & Sons
Page : 8 pages
File Size : 47,9 Mb
Release : 2015-03-09
Category : Medical
ISBN : 9780470317617

Get Book

Peptide Chemistry and Drug Design by Ben M. Dunn Pdf

This book focuses on peptides as drugs, a growing area of pharmaceutical research and development. It helps readers solve problems of discovering, developing, producing, and delivering peptide-based drugs. • Identifies promising new areas in peptide drug discovery • Includes chapters on discovery from natural sources, metabolic modification, and drug delivery • Overviews separation methods and techniques for analysis, bond formation, and purification • Offers readers both a professional reference and a text or resource for graduate-level students

Peptide-based Drug Discovery

Ved Srivastava
Peptide based Drug Discovery Book PDF

Author : Ved Srivastava
Publisher : Royal Society of Chemistry
Page : 589 pages
File Size : 40,6 Mb
Release : 2017-06-26
Category : Science
ISBN : 9781782627326

Get Book

Peptide-based Drug Discovery by Ved Srivastava Pdf

With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.

Mid-size Drugs Based on Peptides and Peptidomimetics

Hirokazu Tamamura,Takuya Kobayakawa,Nami Ohashi
Mid size Drugs Based on Peptides and Peptidomimetics Book PDF

Author : Hirokazu Tamamura,Takuya Kobayakawa,Nami Ohashi
Publisher : Springer
Page : 100 pages
File Size : 54,6 Mb
Release : 2018-01-16
Category : Science
ISBN : 9789811076916

Get Book

Mid-size Drugs Based on Peptides and Peptidomimetics by Hirokazu Tamamura,Takuya Kobayakawa,Nami Ohashi Pdf

This brief describes studies conducted by the authors on mid-size drugs utilizing peptides and peptidomimetics, and on the development of anti-HIV agents. Peptides are important biological molecules and have various physiological actions. Peptide-based drug discovery may help bring about the development of useful medicines that are highly safe and show potent pharmacological effects in small doses. Recently, it has been shown that there is an important drug-like space in the mid-sized region between low- and high-molecular-weight compounds. Thus, mid-size drugs such as peptide compounds are being focused on. To date, several peptidomimetics that mimic primary, secondary, and tertiary structures of peptides have been developed to maintain and improve biological activities and actions of peptides. In this book, the features and advantages of mid-size drugs are described in detail. In addition, the merits of utilizing peptidomimetics in the development of mid-size drugs are referred to. Understanding such peptide-derived mid-size drugs will lead to a comprehensive expansion of medicinal chemistry.

Peptide Therapeutics

Seetharama D. Jois
Peptide Therapeutics Book PDF

Author : Seetharama D. Jois
Publisher : Springer Nature
Page : 321 pages
File Size : 49,6 Mb
Release : 2022-09-26
Category : Medical
ISBN : 9783031045448

Get Book

Peptide Therapeutics by Seetharama D. Jois Pdf

This book explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as well as regulatory issues. It covers the design concept of peptide therapeutics from fundamental principles using structural biology and computational approaches. The chapters are arranged in a linear fashion. A fresh graduate or a scientist who works on small molecules can use this to follow the design and development of peptide therapeutics to use as understanding the basic concepts. Each chapter is written by experts from academia as well as industry. Rather than covering extensive literature, the book provides concepts of design, synthesis, delivery, as well as regulatory affairs and manufacturing of peptides in a systematic way with examples in each case. The book can be used as a reference for a pharmaceutical or biomedical scientist or graduate student who wants to pursue their career in peptide therapeutics. Some chapters will be written as a combination of basic principles and protocol so that scientists can adopt these methods to their research work. The examples provided can be used to perform peptide formulation considerations for the designed peptides. The book has nine chapters, and each chapter can be read as an independent unit on a particular concept.

Peptide Drug Discovery and Development

Miguel Castanho,Nuno Santos
Peptide Drug Discovery and Development Book PDF

Author : Miguel Castanho,Nuno Santos
Publisher : John Wiley & Sons
Page : 547 pages
File Size : 50,7 Mb
Release : 2011-10-24
Category : Medical
ISBN : 9783527636747

Get Book

Peptide Drug Discovery and Development by Miguel Castanho,Nuno Santos Pdf

Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.

Peptide Therapeutics

Ved Srivastava
Peptide Therapeutics Book PDF

Author : Ved Srivastava
Publisher : Royal Society of Chemistry
Page : 572 pages
File Size : 45,6 Mb
Release : 2019-08-28
Category : Science
ISBN : 9781788014335

Get Book

Peptide Therapeutics by Ved Srivastava Pdf

Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, reviewing applications on a case-by-case basis. Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls covers efficient manufacturing of peptide drug substances, a review of the process for submitting applications to the regulatory authority for drug approval, a holistic approach for quality attributes and quality control from a regulatory perspective, emerging analytical tools for the characterisation of impurities, and the assessment of stability. This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery

Henry I. Mosberg,Carrie Haskell-Luevano,Tomi K. Sawyer
Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery Book PDF

Author : Henry I. Mosberg,Carrie Haskell-Luevano,Tomi K. Sawyer
Publisher : MDPI
Page : 406 pages
File Size : 42,5 Mb
Release : 2020-03-13
Category : Medical
ISBN : 9783039282883

Get Book

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery by Henry I. Mosberg,Carrie Haskell-Luevano,Tomi K. Sawyer Pdf

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.

Peptide and Peptidomimetic Therapeutics

Nir Qvit,Samuel J.S. Rubin
Peptide and Peptidomimetic Therapeutics Book PDF

Author : Nir Qvit,Samuel J.S. Rubin
Publisher : Academic Press
Page : 792 pages
File Size : 51,8 Mb
Release : 2022-09-22
Category : Science
ISBN : 9780128204474

Get Book

Peptide and Peptidomimetic Therapeutics by Nir Qvit,Samuel J.S. Rubin Pdf

Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics. Helps researchers and clinicians harness the full of power of peptides and peptidomimetics in their daily work and drug discovery Features chapters running from “bench to bedside , providing a thorough grounding in fundamental peptide science, drug delivery methods, and targeting of specific disease types Features chapter contributions from international leaders in peptide science and drug development

Peptide-based Drug Design

Michael D. Taylor
Peptide based Drug Design Book PDF

Author : Michael D. Taylor
Publisher : Wiley-VCH
Page : 600 pages
File Size : 50,8 Mb
Release : 1995-04-13
Category : Science
ISBN : UOM:39015035752792

Get Book

Peptide-based Drug Design by Michael D. Taylor Pdf

Peptide-based drugs resemble natural peptides in their activity and, thus, increased understanding of peptide transport and metabolism permit optimization of the delivery properties of these new therapeutic agents. After an introduction to basic advances in molecular biology, drug metabolism, and drug transport of amino acids and peptides, this volume deals with intestinal peptide transport, liver peptide transport, peptide delivery through the blood-brain barrier, peptide transport in microorganisms, approaches to limiting peptide metabolism, and experimental systems to evaluate peptide transport and metabolism. Annotation copyright by Book News, Inc., Portland, OR

Peptidomimetics in Organic and Medicinal Chemistry

Antonio Guarna,Andrea Trabocchi
Peptidomimetics in Organic and Medicinal Chemistry Book PDF

Author : Antonio Guarna,Andrea Trabocchi
Publisher : John Wiley & Sons
Page : 334 pages
File Size : 51,9 Mb
Release : 2014-03-14
Category : Science
ISBN : 9781118683149

Get Book

Peptidomimetics in Organic and Medicinal Chemistry by Antonio Guarna,Andrea Trabocchi Pdf

A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.

Peptide Applications in Biomedicine, Biotechnology and Bioengineering

Sotirios Koutsopoulos
Peptide Applications in Biomedicine Biotechnology and Bioengineering Book PDF

Author : Sotirios Koutsopoulos
Publisher : Woodhead Publishing
Page : 656 pages
File Size : 48,5 Mb
Release : 2017-11-16
Category : Technology & Engineering
ISBN : 9780081007426

Get Book

Peptide Applications in Biomedicine, Biotechnology and Bioengineering by Sotirios Koutsopoulos Pdf

Peptide Applications in Biomedicine, Biotechnology and Bioengineering summarizes the current knowledge on peptide applications in biomedicine, biotechnology and bioengineering. After a general introduction to peptides, the book addresses the many applications of peptides in biomedicine and medical technology. Next, the text focuses on peptide applications in biotechnology and bioengineering and reviews of peptide applications in nanotechnology. This book is a valuable resource for biomaterial scientists, polymer scientists, bioengineers, mechanical engineers, synthetic chemists, medical doctors and biologists. Presents a self-contained work for the field of biomedical peptides Summarizes the current knowledge on peptides in biomedicine, biotechnology and bioengineering Covers current and potential applications of biomedical peptides

Protein and Peptide Mass Spectrometry in Drug Discovery

Michael L. Gross,Guodong Chen,Birendra Pramanik
Protein and Peptide Mass Spectrometry in Drug Discovery Book PDF

Author : Michael L. Gross,Guodong Chen,Birendra Pramanik
Publisher : John Wiley & Sons
Page : 484 pages
File Size : 55,7 Mb
Release : 2011-09-26
Category : Medical
ISBN : 9781118116548

Get Book

Protein and Peptide Mass Spectrometry in Drug Discovery by Michael L. Gross,Guodong Chen,Birendra Pramanik Pdf

The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery highlights current analytical approaches, industry practices, and modern strategies for the characterization of both peptides and proteins in drug discovery. Illustrating the critical role MS technology plays in characterizing target proteins and protein products, the methods used, ion mobility, and the use of microwave radiation to speed proteolysis, the book also covers important emerging applications for neuroproteomics and antigenic peptides. Placing an emphasis on the pharmaceutical industry, the book stresses practice and applications, presenting real-world examples covering the most recent advances in mass spectrometry, and providing an invaluable resource for pharmaceutical scientists in industry and academia, analytical and bioanalytical chemists, and researchers in protein science and proteomics.

Practical Medicinal Chemistry with Macrocycles

Eric Marsault,Mark L. Peterson
Practical Medicinal Chemistry with Macrocycles Book PDF

Author : Eric Marsault,Mark L. Peterson
Publisher : John Wiley & Sons
Page : 617 pages
File Size : 44,5 Mb
Release : 2017-09-12
Category : Science
ISBN : 9781119092568

Get Book

Practical Medicinal Chemistry with Macrocycles by Eric Marsault,Mark L. Peterson Pdf

Including case studies of macrocyclic marketed drugs and macrocycles in drug development, this book helps medicinal chemists deal with the synthetic and conceptual challenges of macrocycles in drug discovery efforts. Provides needed background to build a program in macrocycle drug discovery –design criteria, macrocycle profiles, applications, and limitations Features chapters contributed from leading international figures involved in macrocyclic drug discovery efforts Covers design criteria, typical profile of current macrocycles, applications, and limitations