Peptide And Peptidomimetic Therapeutics

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Peptide and Peptidomimetic Therapeutics

Nir Qvit,Samuel J.S. Rubin
Peptide and Peptidomimetic Therapeutics Book PDF

Author : Nir Qvit,Samuel J.S. Rubin
Publisher : Academic Press
Page : 792 pages
File Size : 48,6 Mb
Release : 2022-09-22
Category : Science
ISBN : 9780128204474

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Peptide and Peptidomimetic Therapeutics by Nir Qvit,Samuel J.S. Rubin Pdf

Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics. Helps researchers and clinicians harness the full of power of peptides and peptidomimetics in their daily work and drug discovery Features chapters running from “bench to bedside , providing a thorough grounding in fundamental peptide science, drug delivery methods, and targeting of specific disease types Features chapter contributions from international leaders in peptide science and drug development

Peptidomimetics in Organic and Medicinal Chemistry

Antonio Guarna,Andrea Trabocchi
Peptidomimetics in Organic and Medicinal Chemistry Book PDF

Author : Antonio Guarna,Andrea Trabocchi
Publisher : John Wiley & Sons
Page : 334 pages
File Size : 49,5 Mb
Release : 2014-03-14
Category : Science
ISBN : 9781118683149

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Peptidomimetics in Organic and Medicinal Chemistry by Antonio Guarna,Andrea Trabocchi Pdf

A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery

Henry I. Mosberg,Carrie Haskell-Luevano,Tomi K. Sawyer
Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery Book PDF

Author : Henry I. Mosberg,Carrie Haskell-Luevano,Tomi K. Sawyer
Publisher : MDPI
Page : 406 pages
File Size : 46,7 Mb
Release : 2020-03-13
Category : Medical
ISBN : 9783039282883

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Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery by Henry I. Mosberg,Carrie Haskell-Luevano,Tomi K. Sawyer Pdf

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.

Peptide-based Drug Discovery

Ved Srivastava
Peptide based Drug Discovery Book PDF

Author : Ved Srivastava
Publisher : Royal Society of Chemistry
Page : 589 pages
File Size : 46,7 Mb
Release : 2017-06-22
Category : Science
ISBN : 9781788011716

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Peptide-based Drug Discovery by Ved Srivastava Pdf

With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.

Peptide Therapeutics

Seetharama D. Jois
Peptide Therapeutics Book PDF

Author : Seetharama D. Jois
Publisher : Springer Nature
Page : 321 pages
File Size : 42,6 Mb
Release : 2022-09-26
Category : Medical
ISBN : 9783031045448

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Peptide Therapeutics by Seetharama D. Jois Pdf

This book explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as well as regulatory issues. It covers the design concept of peptide therapeutics from fundamental principles using structural biology and computational approaches. The chapters are arranged in a linear fashion. A fresh graduate or a scientist who works on small molecules can use this to follow the design and development of peptide therapeutics to use as understanding the basic concepts. Each chapter is written by experts from academia as well as industry. Rather than covering extensive literature, the book provides concepts of design, synthesis, delivery, as well as regulatory affairs and manufacturing of peptides in a systematic way with examples in each case. The book can be used as a reference for a pharmaceutical or biomedical scientist or graduate student who wants to pursue their career in peptide therapeutics. Some chapters will be written as a combination of basic principles and protocol so that scientists can adopt these methods to their research work. The examples provided can be used to perform peptide formulation considerations for the designed peptides. The book has nine chapters, and each chapter can be read as an independent unit on a particular concept.

Peptide Therapeutics

Ved Srivastava
Peptide Therapeutics Book PDF

Author : Ved Srivastava
Publisher : Royal Society of Chemistry
Page : 572 pages
File Size : 42,9 Mb
Release : 2019-08-28
Category : Science
ISBN : 9781788014335

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Peptide Therapeutics by Ved Srivastava Pdf

Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, reviewing applications on a case-by-case basis. Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls covers efficient manufacturing of peptide drug substances, a review of the process for submitting applications to the regulatory authority for drug approval, a holistic approach for quality attributes and quality control from a regulatory perspective, emerging analytical tools for the characterisation of impurities, and the assessment of stability. This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.

Peptide Therapeutics and Peptidomimetic Design

Juan J. Perez
Peptide Therapeutics and Peptidomimetic Design Book PDF

Author : Juan J. Perez
Publisher : Wiley
Page : 328 pages
File Size : 50,5 Mb
Release : 2015-08-31
Category : Medical
ISBN : 0470937777

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Peptide Therapeutics and Peptidomimetic Design by Juan J. Perez Pdf

By combining interdisciplinary approaches of organic and medicinal chemistry, biophysical methods, and computational chemistry, Peptide Therapeutics and Peptidomimetic Design provides a guide to rational strategies for designing peptidomimetic drugs. Author Juan Perez addresses an active field of biologics research that the pharmaceutical industry and researchers are aggressively moving into, highlighting examples of peptidomimetic drugs as enzyme inhibitors, GPCR ligands, and protein-protein interaction inhibitors.

Mid-size Drugs Based on Peptides and Peptidomimetics

Hirokazu Tamamura,Takuya Kobayakawa,Nami Ohashi
Mid size Drugs Based on Peptides and Peptidomimetics Book PDF

Author : Hirokazu Tamamura,Takuya Kobayakawa,Nami Ohashi
Publisher : Springer
Page : 100 pages
File Size : 49,6 Mb
Release : 2018-01-16
Category : Science
ISBN : 9789811076916

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Mid-size Drugs Based on Peptides and Peptidomimetics by Hirokazu Tamamura,Takuya Kobayakawa,Nami Ohashi Pdf

This brief describes studies conducted by the authors on mid-size drugs utilizing peptides and peptidomimetics, and on the development of anti-HIV agents. Peptides are important biological molecules and have various physiological actions. Peptide-based drug discovery may help bring about the development of useful medicines that are highly safe and show potent pharmacological effects in small doses. Recently, it has been shown that there is an important drug-like space in the mid-sized region between low- and high-molecular-weight compounds. Thus, mid-size drugs such as peptide compounds are being focused on. To date, several peptidomimetics that mimic primary, secondary, and tertiary structures of peptides have been developed to maintain and improve biological activities and actions of peptides. In this book, the features and advantages of mid-size drugs are described in detail. In addition, the merits of utilizing peptidomimetics in the development of mid-size drugs are referred to. Understanding such peptide-derived mid-size drugs will lead to a comprehensive expansion of medicinal chemistry.

Therapeutic Peptides and Proteins

Ajay K. Banga
Therapeutic Peptides and Proteins Book PDF

Author : Ajay K. Banga
Publisher : CRC Press
Page : 400 pages
File Size : 47,9 Mb
Release : 2015-04-23
Category : Medical
ISBN : 9781466566071

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Therapeutic Peptides and Proteins by Ajay K. Banga Pdf

There are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis. The clinical application of these therapeutic peptides and proteins is limited by several problems, such as lack of physical and chemical stability or the lack of desirable attributes for adequate absorption or distribution. Thus, as these therapeutic peptides and proteins are made available, it will be essential to formulate these drugs into safe, stable, and efficacious delivery systems. The pharmaceutical scientist involved in this effort needs to call upon the knowledge of several disciplines, such as pharmaceutics, medicinal chemistry, biochemistry, microbiology, and chemical engineering and needs to keep abreast with the latest research in the published literature. Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Third Edition provides a comprehensive overview of the field for scientists in industry and academia and for students, while also providing practical information on the challenges facing the formulation and delivery aspects of these unique macromolecules. In particular, the book: Explains how recombinant DNA techniques now allow us to produce therapeutic proteins in a commercially viable form Discusses the physical and chemical pathways of peptide and protein degradation Includes a detailed discussion of protein formulation and lyophilization Overviews the pharmacokinetic aspects of therapeutic peptides and proteins and discusses controlled delivery systems for parenteral administration, including microsphere formulations Discusses research progress on oral, transdermal, mucosal, and topical delivery systems discusses transdermal and topical delivery

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery: A Themed Issue Honoring Professor Victor J. Hruby on the Occasion of His 80th Birthday

Carrie Haskell-Luevano,Tomi Sawyer,Henry Mosberg
Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery A Themed Issue Honoring Professor Victor J Hruby on the Occasion of His 80th Birthday Book PDF

Author : Carrie Haskell-Luevano,Tomi Sawyer,Henry Mosberg
Publisher : Unknown
Page : 406 pages
File Size : 55,7 Mb
Release : 2020
Category : Medicine (General)
ISBN : 3039282891

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Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery: A Themed Issue Honoring Professor Victor J. Hruby on the Occasion of His 80th Birthday by Carrie Haskell-Luevano,Tomi Sawyer,Henry Mosberg Pdf

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.

Biologically Active Peptides

David B. Weiner,William V. Williams
Biologically Active Peptides Book PDF

Author : David B. Weiner,William V. Williams
Publisher : CRC Press
Page : 382 pages
File Size : 54,7 Mb
Release : 1993-11-04
Category : Medical
ISBN : 0877629358

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Biologically Active Peptides by David B. Weiner,William V. Williams Pdf

Investigation into basic and advanced peptide design, synthesis, evaluation and utilization. New therapeutic approaches from experimental systems.

Peptide and Protein Delivery

Chris Van Der Walle
Peptide and Protein Delivery Book PDF

Author : Chris Van Der Walle
Publisher : Academic Press
Page : 380 pages
File Size : 40,5 Mb
Release : 2011-05-12
Category : Science
ISBN : 0123849365

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Peptide and Protein Delivery by Chris Van Der Walle Pdf

The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market

Advances in Amino Acid Mimetics and Peptidomimetics

A. Abell
Advances in Amino Acid Mimetics and Peptidomimetics Book PDF

Author : A. Abell
Publisher : Elsevier
Page : 300 pages
File Size : 50,6 Mb
Release : 1999-12-20
Category : Science
ISBN : 0080552633

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Advances in Amino Acid Mimetics and Peptidomimetics by A. Abell Pdf

Peptidomimetics have found wide application as bioavailable, and often potent mimetics of natural peptides. They form the basis of important classes of enzyme inhibitors, they act as receptor agonists and antagonists, and they have even been used to mimic DNA structure. Recent advances in the use of solid-phase organic synthesis have paved the way for the preparation of libraries of these structures to allow the rapid optimization of theri biological properties and hence therapeutic potential. We are also beginning to gain a greater understanding of the structural features of this class of compounds that influence their ability to permeate membranes, and their rate of clearance and metabolism. This volume brings together many of these critical issues by highlighting recent advances in a number of core peptidomimetic-based research.

Biologically Active Peptides

David B. Weiner,William V. Williams
Biologically Active Peptides Book PDF

Author : David B. Weiner,William V. Williams
Publisher : CRC Press
Page : 377 pages
File Size : 40,9 Mb
Release : 2023-07-28
Category : Medical
ISBN : 9781000942927

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Biologically Active Peptides by David B. Weiner,William V. Williams Pdf

Investigation into basic and advanced peptide design, synthesis, evaluation and utilization. New therapeutic approaches from experimental systems.

Therapeutic Peptides and Proteins

Ajay K. Banga
Therapeutic Peptides and Proteins Book PDF

Author : Ajay K. Banga
Publisher : CRC Press
Page : 336 pages
File Size : 52,5 Mb
Release : 1997-07-01
Category : Medical
ISBN : 1566763290

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Therapeutic Peptides and Proteins by Ajay K. Banga Pdf

From the Preface At the time of this writing, the American biotechnology and pharmaceutical industry has more than two dozen biotechnology-derived therapeutic proteins on the market, while several hundred are in various stages of human clinical trials or at the FDA for review. Today, more than a thousand companies are involved in biotechnology research, with a total revenue of $7.7 billion for 1993. Therapeutic peptides and proteins are expected to mitigate suffering in coming years as anticancer agents, hormones, growth factors, analgesics, anti-hypertensives, and thrombolytics, among others. However, the clinical application of these therapeutic peptides and proteins is limited by several problems, such as lack of physical and chemical stability or the lack of desirable attributes for adequate absorption or distribution. Thus, as these therapeutic peptides and proteins are made available, it will be essential to formulate these drugs into safe, stable and efficacious delivery systems. The pharmaceutical scientist involved in this effort needs to call upon the knowledge of several disciplines, such as pharmaceutics, medicinal chemistry, biochemistry, and microbiology, and needs to keep abreast with the latest research in the published literature. This book presents these principles in a simple, interesting and practically useful manner for the benefit of scientists working in this area and to further research in this area. This book will also provide useful information for students and academic researchers and add to their interest in this area. The book should also be useful in a hospital setting to understand potential physicochemical stability problems that may result during reconstitution or administration of the new recombinant proteins. Since this field is relatively new and rapidly evolving, efforts were made to include very recent literature in the book. As a result, over 40% of the literature citations in the book are for the work published in the last two years.