Peptide Therapeutics

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Peptide Therapeutics

Ved Srivastava
Peptide Therapeutics Book PDF

Author : Ved Srivastava
Publisher : Royal Society of Chemistry
Page : 572 pages
File Size : 40,7 Mb
Release : 2019-08-28
Category : Science
ISBN : 9781788014335

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Peptide Therapeutics by Ved Srivastava Pdf

Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, reviewing applications on a case-by-case basis. Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls covers efficient manufacturing of peptide drug substances, a review of the process for submitting applications to the regulatory authority for drug approval, a holistic approach for quality attributes and quality control from a regulatory perspective, emerging analytical tools for the characterisation of impurities, and the assessment of stability. This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.

Peptide Therapeutics

Ved Srivastava
Peptide Therapeutics Book PDF

Author : Ved Srivastava
Publisher : Royal Society of Chemistry
Page : 572 pages
File Size : 46,8 Mb
Release : 2019-08-16
Category : Science
ISBN : 9781788018692

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Peptide Therapeutics by Ved Srivastava Pdf

Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, reviewing applications on a case-by-case basis. Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls covers efficient manufacturing of peptide drug substances, a review of the process for submitting applications to the regulatory authority for drug approval, a holistic approach for quality attributes and quality control from a regulatory perspective, emerging analytical tools for the characterisation of impurities, and the assessment of stability. This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.

Peptide and Peptidomimetic Therapeutics

Nir Qvit,Samuel J.S. Rubin
Peptide and Peptidomimetic Therapeutics Book PDF

Author : Nir Qvit,Samuel J.S. Rubin
Publisher : Academic Press
Page : 792 pages
File Size : 49,8 Mb
Release : 2022-09-22
Category : Science
ISBN : 9780128204474

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Peptide and Peptidomimetic Therapeutics by Nir Qvit,Samuel J.S. Rubin Pdf

Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis. Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics. Helps researchers and clinicians harness the full of power of peptides and peptidomimetics in their daily work and drug discovery Features chapters running from “bench to bedside , providing a thorough grounding in fundamental peptide science, drug delivery methods, and targeting of specific disease types Features chapter contributions from international leaders in peptide science and drug development

Peptide-based Drug Discovery

Ved Srivastava
Peptide based Drug Discovery Book PDF

Author : Ved Srivastava
Publisher : Royal Society of Chemistry
Page : 589 pages
File Size : 54,9 Mb
Release : 2017-06-22
Category : Science
ISBN : 9781788011716

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Peptide-based Drug Discovery by Ved Srivastava Pdf

With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.

Therapeutic Peptides and Proteins

Ajay K. Banga
Therapeutic Peptides and Proteins Book PDF

Author : Ajay K. Banga
Publisher : CRC Press
Page : 400 pages
File Size : 44,6 Mb
Release : 2015-04-23
Category : Medical
ISBN : 9781466566071

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Therapeutic Peptides and Proteins by Ajay K. Banga Pdf

There are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis. The clinical application of these therapeutic peptides and proteins is limited by several problems, such as lack of physical and chemical stability or the lack of desirable attributes for adequate absorption or distribution. Thus, as these therapeutic peptides and proteins are made available, it will be essential to formulate these drugs into safe, stable, and efficacious delivery systems. The pharmaceutical scientist involved in this effort needs to call upon the knowledge of several disciplines, such as pharmaceutics, medicinal chemistry, biochemistry, microbiology, and chemical engineering and needs to keep abreast with the latest research in the published literature. Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Third Edition provides a comprehensive overview of the field for scientists in industry and academia and for students, while also providing practical information on the challenges facing the formulation and delivery aspects of these unique macromolecules. In particular, the book: Explains how recombinant DNA techniques now allow us to produce therapeutic proteins in a commercially viable form Discusses the physical and chemical pathways of peptide and protein degradation Includes a detailed discussion of protein formulation and lyophilization Overviews the pharmacokinetic aspects of therapeutic peptides and proteins and discusses controlled delivery systems for parenteral administration, including microsphere formulations Discusses research progress on oral, transdermal, mucosal, and topical delivery systems discusses transdermal and topical delivery

Peptide Chemistry and Drug Design

Ben M. Dunn
Peptide Chemistry and Drug Design Book PDF

Author : Ben M. Dunn
Publisher : John Wiley & Sons
Page : 8 pages
File Size : 49,5 Mb
Release : 2015-03-09
Category : Medical
ISBN : 9780470317617

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Peptide Chemistry and Drug Design by Ben M. Dunn Pdf

This book focuses on peptides as drugs, a growing area of pharmaceutical research and development. It helps readers solve problems of discovering, developing, producing, and delivering peptide-based drugs. • Identifies promising new areas in peptide drug discovery • Includes chapters on discovery from natural sources, metabolic modification, and drug delivery • Overviews separation methods and techniques for analysis, bond formation, and purification • Offers readers both a professional reference and a text or resource for graduate-level students

Peptide Therapeutics

Seetharama D. Jois
Peptide Therapeutics Book PDF

Author : Seetharama D. Jois
Publisher : Springer Nature
Page : 321 pages
File Size : 50,5 Mb
Release : 2022-09-26
Category : Medical
ISBN : 9783031045448

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Peptide Therapeutics by Seetharama D. Jois Pdf

This book explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as well as regulatory issues. It covers the design concept of peptide therapeutics from fundamental principles using structural biology and computational approaches. The chapters are arranged in a linear fashion. A fresh graduate or a scientist who works on small molecules can use this to follow the design and development of peptide therapeutics to use as understanding the basic concepts. Each chapter is written by experts from academia as well as industry. Rather than covering extensive literature, the book provides concepts of design, synthesis, delivery, as well as regulatory affairs and manufacturing of peptides in a systematic way with examples in each case. The book can be used as a reference for a pharmaceutical or biomedical scientist or graduate student who wants to pursue their career in peptide therapeutics. Some chapters will be written as a combination of basic principles and protocol so that scientists can adopt these methods to their research work. The examples provided can be used to perform peptide formulation considerations for the designed peptides. The book has nine chapters, and each chapter can be read as an independent unit on a particular concept.

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery

Henry I. Mosberg,Carrie Haskell-Luevano,Tomi K. Sawyer
Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery Book PDF

Author : Henry I. Mosberg,Carrie Haskell-Luevano,Tomi K. Sawyer
Publisher : MDPI
Page : 406 pages
File Size : 44,7 Mb
Release : 2020-03-13
Category : Medical
ISBN : 9783039282883

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Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery by Henry I. Mosberg,Carrie Haskell-Luevano,Tomi K. Sawyer Pdf

Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.

Proteins and Peptides

Randall J. Mrsny,Ann Daugherty
Proteins and Peptides Book PDF

Author : Randall J. Mrsny,Ann Daugherty
Publisher : CRC Press
Page : 288 pages
File Size : 50,7 Mb
Release : 2009-10-19
Category : Medical
ISBN : 9781420078077

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Proteins and Peptides by Randall J. Mrsny,Ann Daugherty Pdf

Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is

Peptide Drug Discovery and Development

Miguel Castanho,Nuno Santos
Peptide Drug Discovery and Development Book PDF

Author : Miguel Castanho,Nuno Santos
Publisher : John Wiley & Sons
Page : 547 pages
File Size : 43,9 Mb
Release : 2011-10-24
Category : Medical
ISBN : 9783527636747

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Peptide Drug Discovery and Development by Miguel Castanho,Nuno Santos Pdf

Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "bench to bedside" translational approach to drug development. Clearly structured into three major parts, the book stakes out the boundaries of peptide drug development in the preclinical as well as clinical stages. The first part provides a general background and focuses on the characteristic strengths and weaknesses of peptide drugs. The second section contains five cases studies of peptides from diverse therapeutic fields, and the lessons to be learned from them, while the final part looks at new targets and opportunities, discussing several drug targets and diseases for which peptide drugs are currently being developed.

Peptide-Based Drug Design

Laszlo Otvos
Peptide Based Drug Design Book PDF

Author : Laszlo Otvos
Publisher : Humana Press
Page : 0 pages
File Size : 50,9 Mb
Release : 2010-11-19
Category : Medical
ISBN : 1617378690

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Peptide-Based Drug Design by Laszlo Otvos Pdf

Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs. In Peptide-Based Drug Design: Methods and Protocols, expert researchers provide a handbook which offers a selection of research and production tools suitable for transforming a promising protein fragment or stand-alone native peptide into a pharmaceutically acceptable composition. The volume delves into contemporary, cutting-edge subjects such as hit isolation and target validation, computer-aided design, sequence modifications to satisfy pharmacologists, in vivo stability and imaging, and the actual production of difficult sequences. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include readily reproducible, step-by-step laboratory protocols, lists of materials, and the Notes section, which highlights tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Peptide-Based Drug Design: Methods and Protocols shows its subject to be an independent science on the rise, and provides scientists with a clear, concise guide for continuing this vital research.

Peptide and Protein Delivery

Chris Van Der Walle
Peptide and Protein Delivery Book PDF

Author : Chris Van Der Walle
Publisher : Academic Press
Page : 380 pages
File Size : 53,9 Mb
Release : 2011-05-12
Category : Science
ISBN : 0123849365

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Peptide and Protein Delivery by Chris Van Der Walle Pdf

The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market

Peptide Applications in Biomedicine, Biotechnology and Bioengineering

Sotirios Koutsopoulos
Peptide Applications in Biomedicine Biotechnology and Bioengineering Book PDF

Author : Sotirios Koutsopoulos
Publisher : Woodhead Publishing
Page : 656 pages
File Size : 43,5 Mb
Release : 2017-11-16
Category : Technology & Engineering
ISBN : 9780081007426

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Peptide Applications in Biomedicine, Biotechnology and Bioengineering by Sotirios Koutsopoulos Pdf

Peptide Applications in Biomedicine, Biotechnology and Bioengineering summarizes the current knowledge on peptide applications in biomedicine, biotechnology and bioengineering. After a general introduction to peptides, the book addresses the many applications of peptides in biomedicine and medical technology. Next, the text focuses on peptide applications in biotechnology and bioengineering and reviews of peptide applications in nanotechnology. This book is a valuable resource for biomaterial scientists, polymer scientists, bioengineers, mechanical engineers, synthetic chemists, medical doctors and biologists. Presents a self-contained work for the field of biomedical peptides Summarizes the current knowledge on peptides in biomedicine, biotechnology and bioengineering Covers current and potential applications of biomedical peptides

Stability and Characterization of Protein and Peptide Drugs

Rodney Pearlman,Y. John Wang
Stability and Characterization of Protein and Peptide Drugs Book PDF

Author : Rodney Pearlman,Y. John Wang
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 43,7 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489912367

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Stability and Characterization of Protein and Peptide Drugs by Rodney Pearlman,Y. John Wang Pdf

This is the first volume to make available specific case histories of therapeutic proteins and peptides that have been marketed or are currently under clinical testing. The editors have selected a wide range of molecules derived from monoclonal antibodies, recombinant DNA, and natural and chemical sources to provide formulation scientists with practical examples of the development of pharmaceutical products.

Peptides as Drugs

Bernd Groner
Peptides as Drugs Book PDF

Author : Bernd Groner
Publisher : John Wiley & Sons
Page : 242 pages
File Size : 53,8 Mb
Release : 2009-11-18
Category : Medical
ISBN : 9783527626847

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Peptides as Drugs by Bernd Groner Pdf

By covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges associated with this molecular class. The first part discusses current approaches to developing pharmaceutically active peptides, including case studies of the use of peptidic drugs in cancer and AIDS therapy. The second part surveys strategies for the development and targeting of peptidic drugs. With its integration of biochemical, pharmaceutical and clinical research, this work reveals the full picture of modern peptide drug research in a single volume, making it an invaluable reference for medicinal chemists, biochemists, biotechnologists, and those in the pharmaceutical and biotechnological industries.