Pharmaceutical Crystals

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Pharmaceutical Salts and Co-crystals

Johan Wouters,Luc Quéré
Pharmaceutical Salts and Co crystals Book PDF

Author : Johan Wouters,Luc Quéré
Publisher : Royal Society of Chemistry
Page : 406 pages
File Size : 50,5 Mb
Release : 2011-11-04
Category : Medical
ISBN : 9781849733502

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Pharmaceutical Salts and Co-crystals by Johan Wouters,Luc Quéré Pdf

From crystal structure prediction to totally empirical screening, the quest for new crystal forms has become one of the most challenging issues in the solid state science and particularly in the pharmaceutical world. In this context, multi-component crystalline materials like co-crystals have received renewed interest as they offer the prospect of optimized physical properties. As illustrated in this first book_ entirely dedicated to this emerging class of pharmaceutical compounds_ the outcome of such endeavours into crystal engineering have demonstrated clear impacts on production, marketing and intellectual property protection of active pharmaceutical ingredients (APIs). Indeed, co-crystallization influences relevant physico-chemical parameters (such as solubility, dissolution rate, chemical stability, melting point, hygroscopicity, à) and often offers solids with properties superior to those of the free drug. Combining both reports of the latest research and comprehensive overviews of basic principles, with contributions from selected experts in both academia and industry, this unique book is an essential reference, ideal for pharmaceutical development scientists and graduate students in pharmaceutical science.

Pharmaceutical Crystals

Tonglei Li,Alessandra Mattei
Pharmaceutical Crystals Book PDF

Author : Tonglei Li,Alessandra Mattei
Publisher : John Wiley & Sons
Page : 528 pages
File Size : 55,6 Mb
Release : 2018-09-03
Category : Science
ISBN : 9781119046349

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Pharmaceutical Crystals by Tonglei Li,Alessandra Mattei Pdf

An important resource that puts the focus on understanding and handling of organic crystals in drug development Since a majority of pharmaceutical solid-state materials are organic crystals, their handling and processing are critical aspects of drug development. Pharmaceutical Crystals: Science and Engineering offers an introduction to and thorough coverage of organic crystals, and explores the essential role they play in drug development and manufacturing. Written contributions from leading researchers and practitioners in the field, this vital resource provides the fundamental knowledge and explains the connection between pharmaceutically relevant properties and the structure of a crystal. Comprehensive in scope, the text covers a range of topics including: crystallization, molecular interactions, polymorphism, analytical methods, processing, and chemical stability. The authors clearly show how to find solutions for pharmaceutical form selection and crystallization processes. Designed to be an accessible guide, this book represents a valuable resource for improving the drug development process of small drug molecules. This important text: Includes the most important aspects of solid-state organic chemistry and its role in drug development Offers solutions for pharmaceutical form selection and crystallization processes Contains a balance between the scientific fundamental and pharmaceutical applications Presents coverage of crystallography, molecular interactions, polymorphism, analytical methods, processing, and chemical stability Written for both practicing pharmaceutical scientists, engineers, and senior undergraduate and graduate students studying pharmaceutical solid-state materials, Pharmaceutical Crystals: Science and Engineering is a reference and textbook for understanding, producing, analyzing, and designing organic crystals which is an imperative skill to master for anyone working in the field.

Pharmaceutical Salts and Co-crystals

Johan Wouters,Luc Quéré
Pharmaceutical Salts and Co crystals Book PDF

Author : Johan Wouters,Luc Quéré
Publisher : Royal Society of Chemistry
Page : 407 pages
File Size : 53,6 Mb
Release : 2011
Category : Health & Fitness
ISBN : 9781849731584

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Pharmaceutical Salts and Co-crystals by Johan Wouters,Luc Quéré Pdf

This book covers the hot topic of pharmaceutical salts and co-crystals focusing on the following essential aspects: an overview of fundamental aspects on salts and co-crystals, racemic resolution via diastereomer separation, optimization of relevant physico-chemical parameters, and strengthening of intellectual property.

Pharmaceutical Crystals

Etsuo Yonemochi,Hidehiro Uekusa
Pharmaceutical Crystals Book PDF

Author : Etsuo Yonemochi,Hidehiro Uekusa
Publisher : MDPI
Page : 148 pages
File Size : 44,7 Mb
Release : 2020-04-03
Category : Science
ISBN : 9783039287123

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Pharmaceutical Crystals by Etsuo Yonemochi,Hidehiro Uekusa Pdf

The crystalline state is the most commonly used essential solid active pharmaceutical ingredient (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines, but the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. This book entitled “Pharmaceutical Crystals" focuses on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts, and hydrates, and polymorph crystals are reported. Such crystal structures were investigated in the latest studies that combined morphology, spectroscopic, theoretical calculation, and thermal analysis with crystallographic study. This book highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure–property study of pharmaceutical crystals. The Guest Editors of this book hope the readers enjoy a wide variety of recent studies on Pharmaceutical Crystals.

Pharmaceutical Crystals

Etsuo Yonemochi,Hidehiro Uekusa
Pharmaceutical Crystals Book PDF

Author : Etsuo Yonemochi,Hidehiro Uekusa
Publisher : Unknown
Page : 148 pages
File Size : 44,7 Mb
Release : 2020
Category : Chemistry
ISBN : 3039287133

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Pharmaceutical Crystals by Etsuo Yonemochi,Hidehiro Uekusa Pdf

The crystalline state is the most commonly used essential solid active pharmaceutical ingredient (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines, but the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. This book entitled “Pharmaceutical Crystals"" focuses on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts, and hydrates, and polymorph crystals are reported. Such crystal structures were investigated in the latest studies that combined morphology, spectroscopic, theoretical calculation, and thermal analysis with crystallographic study. This book highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure-property study of pharmaceutical crystals. The Guest Editors of this book hope the readers enjoy a wide variety of recent studies on Pharmaceutical Crystals.

Pharmaceutical Crystals (Volume II).

Etsuo Yonemochi,Hidehiro Uekusa
Pharmaceutical Crystals Volume II Book PDF

Author : Etsuo Yonemochi,Hidehiro Uekusa
Publisher : Unknown
Page : 0 pages
File Size : 55,8 Mb
Release : 2023
Category : Electronic
ISBN : 3036554742

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Pharmaceutical Crystals (Volume II). by Etsuo Yonemochi,Hidehiro Uekusa Pdf

The crystalline state is the most commonly used as an essential solid in active pharmaceutical ingredients (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines. Still, the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. These properties should be understood in terms of molecular structures and interactions between molecules in crystals. Information on three-dimensional molecular structures also affords insights into the biological activity of molecules. The second reprint in the series, "Crystalline Pharmaceuticals (Volume II)" focused on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts and hydrates, and polymorph crystals, were reported with interest. Such crystal structures contributed to the latest studies that combine morphology, spectroscopic, theoretical calculation, and thermal analysis with the crystallographic study. Thus, this reprint highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure-property study of pharmaceutical crystals. The Guest Editors of this reprint hope the readers enjoy a wide variety of recent studies on "Crystalline Pharmaceuticals."

Pharmaceutical Crystallography

Andrew Bond
Pharmaceutical Crystallography Book PDF

Author : Andrew Bond
Publisher : Royal Society of Chemistry
Page : 304 pages
File Size : 47,9 Mb
Release : 2019-07-24
Category : Medical
ISBN : 9781788018517

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Pharmaceutical Crystallography by Andrew Bond Pdf

The pharmaceutical industry has become acutely aware of the importance of the solid state, but pharmaceutical scientists often lack specific training in topics related to solid-state structure and crystallography. This book provides needed support in this topical area. Taking an intuitive and informal approach to solid-state structure and crystallographic concepts, this book is written for anyone who needs a clear understanding of modern crystallography, with specific reference to small-molecule pharmaceutical solids. The author describes molecular crystals and crystal structures, symmetry, space groups, single-crystal and powder X-ray diffraction techniques and the analysis and interpretation of crystallographic data. Useful technical details are presented where necessary and case studies from the pharmaceutical literature put theory into a practical context. Written by an internationally leading figure and with its focus on molecular crystals, this book is equally applicable to chemists with a need to understand and apply X-ray crystal-structure determination.

Polymorphism in the Pharmaceutical Industry

Rolf Hilfiker,Markus von Raumer
Polymorphism in the Pharmaceutical Industry Book PDF

Author : Rolf Hilfiker,Markus von Raumer
Publisher : John Wiley & Sons
Page : 618 pages
File Size : 47,5 Mb
Release : 2019-01-04
Category : Science
ISBN : 9783527697854

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Polymorphism in the Pharmaceutical Industry by Rolf Hilfiker,Markus von Raumer Pdf

"Polymorphism in the Pharmaceutical Industry - Solid Form and Drug Development" highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus on quality by design (QbD) concepts. It covers all important issues by way of case studies, ranging from properties and crystallization, via thermodynamics, analytics and theoretical modelling right up to patent issues. As such, the book underscores the importance of solid-state chemistry within chemical and pharmaceutical development. It emphasizes why solid-state issues are important, the approaches needed to avoid problems and the opportunities offered by solid-state properties. The authors include true polymorphs as well as solvates and hydrates, while providing information on physicochemical properties, crystallization thermodynamics, quantum-mechanical modelling, and up-scaling. Important analytical tools to characterize solid-state forms and to quantify mixtures are summarized, and case studies on solid-state development processes in industry are also provided. Written by acknowledged experts in the field, this is a high-quality reference for researchers, project managers and quality assurance managers in pharmaceutical, agrochemical and fine chemical companies as well as for academics and newcomers to organic solid-state chemistry.

Multi-Component Crystals

Edward Tiekink,Julio Zukerman-Schpector
Multi Component Crystals Book PDF

Author : Edward Tiekink,Julio Zukerman-Schpector
Publisher : Walter de Gruyter GmbH & Co KG
Page : 362 pages
File Size : 50,5 Mb
Release : 2017-11-20
Category : Science
ISBN : 9783110464955

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Multi-Component Crystals by Edward Tiekink,Julio Zukerman-Schpector Pdf

In this volume, contributions covering the theoretical and practical aspects of multicomponent crystals provide a timely and contemporary overview of the state-of-the art of this vital aspect of crystal engineering/materials science. With a solid foundation in fundamentals, multi-component crystals can be formed, for example, to enhance pharmaceutical properties of drugs, for the specific control of optical responses to external stimuli and to assemble molecules to allow chemical reactions that are generally intractable following conventional methods. Contents Pharmaceutical co-crystals: crystal engineering and applications Pharmaceutical multi-component crystals: improving the efficacy of anti-tuberculous agents Qualitative and quantitative crystal engineering of multi-functional co-crystals Control of photochromism in N-salicylideneaniline by crystal engineering Quinoline derivatives for multi-component crystals: principles and applications N-oxides in multi-component crystals and in bottom-up synthesis and applications Multi-component crystals and non-ambient conditions Co-crystals for solid-state reactivity and thermal expansion Solution co-crystallisation and its applications The salt-co-crystal continuum in halogen-bonded systems Large horizontal displacements of benzene-benzene stacking interactions in co-crystals Simultaneous halogen and hydrogen bonding to carbonyl and thiocarbonylfunctionality Crystal chemistry of the isomeric N,N’-bis(pyridin-n-ylmethyl)-ethanediamides, n = 2, 3 or 4 Solute・solvent interactions mediated by main group element (lone-pair)・・・π(aryl) interactions

Co-crystals

Christer B Aakeröy,Abhijeet S Sinha
Co crystals Book PDF

Author : Christer B Aakeröy,Abhijeet S Sinha
Publisher : Royal Society of Chemistry
Page : 354 pages
File Size : 49,6 Mb
Release : 2018-07-13
Category : Science
ISBN : 9781788014892

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Co-crystals by Christer B Aakeröy,Abhijeet S Sinha Pdf

Multi-component crystalline systems or co-crystals have received tremendous attention from academia and industry alike in the past decade. Applications of co-crystals are varied and are likely to positively impact a wide range of industries dealing with molecular solids. Co-crystallization has been used to improve the properties and performance of materials from pharmaceuticals to energetic materials, as well as for separation of compounds. This book combines co-crystal applications of commercial and practical interest from diverse fields in to a single volume. It also examines effective structural design of co-crystals, and provides insights into practical synthesis and characterization techniques. Providing a useful resource for postgraduate students new to applied co-crystal research and crystal engineering, it will also be of interest to established researchers in academia or industry.

Cocrystal Applications in Drug Delivery

Andrea Erxleben
Cocrystal Applications in Drug Delivery Book PDF

Author : Andrea Erxleben
Publisher : MDPI
Page : 172 pages
File Size : 41,9 Mb
Release : 2021-02-17
Category : Science
ISBN : 9783039439836

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Cocrystal Applications in Drug Delivery by Andrea Erxleben Pdf

In 2015, the first pharmaceutical cocrystal was approved by the FDA. Since then, the number of cocrystals on the market and in the development pipeline has been slowly but steadily growing. It is now well established that cocrystals are a versatile new approach to oral drug formulation. This Reprint Book is a collection of articles that show the utility of pharmaceutical cocrystals and various aspects of cocrystal research: • Cocrystals as a strategy to modify the physicochemical properties of a drug such as dissolution behaviour, tabletability, and melting point; • Development of new coformers; • Screening studies for multiple cocrystal forms; • Cocrystals in nano-sized drug delivery.

Physicochemical Basis of Pharmaceuticals

Humphrey Moynihan,Abina Crean
Physicochemical Basis of Pharmaceuticals Book PDF

Author : Humphrey Moynihan,Abina Crean
Publisher : Oxford University Press, USA
Page : 316 pages
File Size : 46,8 Mb
Release : 2009-07-23
Category : Business & Economics
ISBN : 9780199232840

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Physicochemical Basis of Pharmaceuticals by Humphrey Moynihan,Abina Crean Pdf

What are the physical and chemical properties that determine how a drug interacts with the body? What determines which dosage form is best, if it will reach its intended target, and how it will be metabolised once it has entered the body? The Physicochemical Basis of Pharmaceuticals explores the phenomena which affect the formulation and bio-availability of drug substances to give a straightforward, accessible treatment of the essential concepts affecting the absorption and distribution of drugs. It provides the reader with the conceptual 'tool-kit' necessary to understand the physicochemical aspects of drug design and action, and shows how these concepts apply in practice. The book introduces key underlying physical chemistry principles before exploring pharmaceutical solutions, the pharmaceutical solid phase, solid - liquid dispersal systems, biological interfaces, absorption, distribution, metabolism and excretion, to give a complete view of the field. Focusing at all times on the essential principles and concepts, The Physicochemical Basis of Pharmaceuticals avoids excessive detail, presenting the key facts, backed up with pertinent examples and easy-to-digest illustrations, making it the ideal primer for those who need to understand physicochemical issues in the context of their broader field of study. Online Resource Centre For registered adopters of the text: · Figures from the book in electronic format, ready to download For students: · A hyperlinked bibliography of references given in the text.

Drug Formulation Design

Rahul Shukla,Aleksey Kuznetsov,Akbar Ali
Drug Formulation Design Book PDF

Author : Rahul Shukla,Aleksey Kuznetsov,Akbar Ali
Publisher : BoD – Books on Demand
Page : 330 pages
File Size : 50,8 Mb
Release : 2023-06-07
Category : Medical
ISBN : 9781837684717

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Drug Formulation Design by Rahul Shukla,Aleksey Kuznetsov,Akbar Ali Pdf

This book discusses the theoretical and practical aspects required to formulate conventional drug dosage forms and advanced technology-based therapeutics. It is organized into four sections: “Preformulation”, “Formulation Design and Approaches”, “Characterization and Analysis”, and “Cocrystal Engineering”. The approaches discussed enhance the overall quality of treatment and overcome the side effects of available therapies. The book is a collection of scholarly literature relevant to pharmaceutical technology and existing pharmaceutical technologies. It is a useful reference for industrial personnel working on developing novel pharmaceutical dosage forms.

Disordered Pharmaceutical Materials

Marc Descamps
Disordered Pharmaceutical Materials Book PDF

Author : Marc Descamps
Publisher : John Wiley & Sons
Page : 542 pages
File Size : 52,5 Mb
Release : 2016-08-08
Category : Science
ISBN : 9783527331253

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Disordered Pharmaceutical Materials by Marc Descamps Pdf

A one-stop resource for researchers, developers, and post graduate students in pharmaceutical science. This handbook and ready reference provides detailed, but not overloaded information -- presenting the topic without unnecessarily complex formalism. As such, it gives a systematic and coherent overview of disordered materials for pharmaceutical applications, covering fundamental aspects, as well as preparation and characterization techniques for the target-oriented development of drug delivery systems based on disordered crystals and amorphous solids. Special attention is paid to examine the different facets and levels of disorder in their structural and dynamic aspects as well as the effect of disorder on dissolution and stability. Chapters on processing induced disorder and on patenting issues round off the book. As a result the book helps overcoming the challenges of using these materials in the pharmaceutical industry. For pharmaceutical and medicinal chemists, materials scientists, clinical physicists, and pharmaceutical laboratories looking to make better and more potent pharmaceuticals.

Handbook of Industrial Crystallization

Allan Myerson
Handbook of Industrial Crystallization Book PDF

Author : Allan Myerson
Publisher : Butterworth-Heinemann
Page : 304 pages
File Size : 48,8 Mb
Release : 2002-01-08
Category : Science
ISBN : 0080533515

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Handbook of Industrial Crystallization by Allan Myerson Pdf

Crystallization is an important separation and purification process used in industries ranging from bulk commodity chemicals to specialty chemicals and pharmaceuticals. In recent years, a number of environmental applications have also come to rely on crystallization in waste treatment and recycling processes. The authors provide an introduction to the field of newcomers and a reference to those involved in the various aspects of industrial crystallization. It is a complete volume covering all aspects of industrial crystallization, including material related to both fundamentals and applications. This new edition presents detailed material on crystallization of biomolecules, precipitation, impurity-crystal interactions, solubility, and design. Provides an ideal introduction for industrial crystallization newcomers Serves as a worthwhile reference to anyone involved in the field Covers all aspects of industrial crystallization in a single, complete volume