Disordered Pharmaceutical Materials

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Disordered Pharmaceutical Materials

Marc Descamps
Disordered Pharmaceutical Materials Book PDF

Author : Marc Descamps
Publisher : John Wiley & Sons
Page : 542 pages
File Size : 44,5 Mb
Release : 2016-08-08
Category : Science
ISBN : 9783527331253

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Disordered Pharmaceutical Materials by Marc Descamps Pdf

A one-stop resource for researchers, developers, and post graduate students in pharmaceutical science. This handbook and ready reference provides detailed, but not overloaded information -- presenting the topic without unnecessarily complex formalism. As such, it gives a systematic and coherent overview of disordered materials for pharmaceutical applications, covering fundamental aspects, as well as preparation and characterization techniques for the target-oriented development of drug delivery systems based on disordered crystals and amorphous solids. Special attention is paid to examine the different facets and levels of disorder in their structural and dynamic aspects as well as the effect of disorder on dissolution and stability. Chapters on processing induced disorder and on patenting issues round off the book. As a result the book helps overcoming the challenges of using these materials in the pharmaceutical industry. For pharmaceutical and medicinal chemists, materials scientists, clinical physicists, and pharmaceutical laboratories looking to make better and more potent pharmaceuticals.

Amorphous Drugs

Marzena Rams-Baron,Renata Jachowicz,Elena Boldyreva,Deliang Zhou,Witold Jamroz,Marian Paluch
Amorphous Drugs Book PDF

Author : Marzena Rams-Baron,Renata Jachowicz,Elena Boldyreva,Deliang Zhou,Witold Jamroz,Marian Paluch
Publisher : Springer
Page : 230 pages
File Size : 55,9 Mb
Release : 2018-02-09
Category : Science
ISBN : 9783319720029

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Amorphous Drugs by Marzena Rams-Baron,Renata Jachowicz,Elena Boldyreva,Deliang Zhou,Witold Jamroz,Marian Paluch Pdf

This book explains theoretical and technological aspects of amorphous drug formulations. It is intended for all those wishing to increase their knowledge in the field of amorphous pharmaceuticals. Conversion of crystalline material into the amorphous state, as described in this book, is a way to overcome limited water solubility of drug formulations, in this way enhancing the chemical activity and bioavailability inside the body. Written by experts from various fields and backgrounds, the book introduces to fundamental physical aspects (explaining differences between the ordered and the disordered solid states, the enhancement of solubility resulting from drugs amorphization, physical instability and how it can be overcome) as well as preparation and formulation procedures to produce and stabilize amorphous pharmaceuticals. Readers will thus gain a well-funded understanding and find a multi-faceted discussion of the properties and advantages of amorphous drugs and of the challenges in producing and stabilizing them. The book is an ideal source of information for researchers and students as well as professionals engaged in research and development of amorphous pharmaceutical products.

Solid-State Properties of Pharmaceutical Materials

Stephen R. Byrn,George Zografi,Xiaoming (Sean) Chen
Solid State Properties of Pharmaceutical Materials Book PDF

Author : Stephen R. Byrn,George Zografi,Xiaoming (Sean) Chen
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 43,5 Mb
Release : 2017-07-12
Category : Science
ISBN : 9781119264446

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Solid-State Properties of Pharmaceutical Materials by Stephen R. Byrn,George Zografi,Xiaoming (Sean) Chen Pdf

Presents a detailed discussion of important solid-state properties, methods, and applications of solid-state analysis Illustrates the various phases or forms that solids can assume and discussesvarious issues related to the relative stability of solid forms and tendencies to undergo transformation Covers key methods of solid state analysis including X-ray powder diffraction, thermal analysis, microscopy, spectroscopy, and solid state NMR Reviews critical physical attributes of pharmaceutical materials, mainly related to drug substances, including particle size/surface area, hygroscopicity, mechanical properties, solubility, and physical and chemical stability Showcases the application of solid state material science in rational selection of drug solid forms, analysis of various solid forms within drug substance and the drug product, and pharmaceutical product development Introduces appropriate manufacturing and control procedures using Quality by Design, and other strategies that lead to safe and effective products with a minimum of resources and time

Amorphous Food and Pharmaceutical Systems

Harry Levine
Amorphous Food and Pharmaceutical Systems Book PDF

Author : Harry Levine
Publisher : Royal Society of Chemistry
Page : 360 pages
File Size : 52,9 Mb
Release : 2007-10-31
Category : Technology & Engineering
ISBN : 9781847550118

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Amorphous Food and Pharmaceutical Systems by Harry Levine Pdf

During the past decade, the importance of amorphous water-soluble substances has been increasingly recognised within the food and pharmaceutical industries. In response, Amorphous Food and Pharmaceutical Systems brings together current leading experts to contribute to this unique cross-disciplinary account of the subject. Coverage includes: water-compatible amorphous solids (physical, chemical behaviour), low water content systems (water as plasticizer); applications in food and pharmaceutical sciences and industries (processing and stability) along with state-of-the-art technology in food and pharmaceutical systems. This timely publication will be welcomed by academic and industrial researchers and professionals in the pharmaceuticals, food, materials and polymer sciences.

Polymorphism in the Pharmaceutical Industry

Rolf Hilfiker,Markus von Raumer
Polymorphism in the Pharmaceutical Industry Book PDF

Author : Rolf Hilfiker,Markus von Raumer
Publisher : John Wiley & Sons
Page : 512 pages
File Size : 52,9 Mb
Release : 2019-04-29
Category : Science
ISBN : 9783527340408

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Polymorphism in the Pharmaceutical Industry by Rolf Hilfiker,Markus von Raumer Pdf

"Polymorphism in the Pharmaceutical Industry - Solid Form and Drug Development" highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus on quality by design (QbD) concepts. It covers all important issues by way of case studies, ranging from properties and crystallization, via thermodynamics, analytics and theoretical modelling right up to patent issues. As such, the book underscores the importance of solid-state chemistry within chemical and pharmaceutical development. It emphasizes why solid-state issues are important, the approaches needed to avoid problems and the opportunities offered by solid-state properties. The authors include true polymorphs as well as solvates and hydrates, while providing information on physicochemical properties, crystallization thermodynamics, quantum-mechanical modelling, and up-scaling. Important analytical tools to characterize solid-state forms and to quantify mixtures are summarized, and case studies on solid-state development processes in industry are also provided. Written by acknowledged experts in the field, this is a high-quality reference for researchers, project managers and quality assurance managers in pharmaceutical, agrochemical and fine chemical companies as well as for academics and newcomers to organic solid-state chemistry.

NMR in Pharmaceutical Science

Jeremy R. Everett,Robin K. Harris,John C. Lindon,Ian D. Wilson
NMR in Pharmaceutical Science Book PDF

Author : Jeremy R. Everett,Robin K. Harris,John C. Lindon,Ian D. Wilson
Publisher : John Wiley & Sons
Page : 504 pages
File Size : 48,8 Mb
Release : 2015-08-24
Category : Science
ISBN : 9781118660232

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NMR in Pharmaceutical Science by Jeremy R. Everett,Robin K. Harris,John C. Lindon,Ian D. Wilson Pdf

NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists. This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies. Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes. About eMagRes Handbooks eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this handbook and the complete content of eMagRes at your fingertips! Visit: www.wileyonlinelibrary.com/ref/eMagRes

Solid State Characterization of Pharmaceuticals

Richard A. Storey,Ingvar Ymén
Solid State Characterization of Pharmaceuticals Book PDF

Author : Richard A. Storey,Ingvar Ymén
Publisher : John Wiley & Sons
Page : 557 pages
File Size : 40,7 Mb
Release : 2011-03-31
Category : Science
ISBN : 9781119970170

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Solid State Characterization of Pharmaceuticals by Richard A. Storey,Ingvar Ymén Pdf

The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties. This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field. The following topics are included: Physical properties and processes Thermodynamics Intellectual guidance X-ray diffraction Spectroscopy Microscopy Particle sizing Mechanical properties Vapour sorption Thermal analysis & Calorimetry Polymorph prediction Form selection

Pharmaceutical Crystals

Tong Li,Alessandra Mattei
Pharmaceutical Crystals Book PDF

Author : Tong Li,Alessandra Mattei
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 51,8 Mb
Release : 2018-10-16
Category : Science
ISBN : 9781119046295

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Pharmaceutical Crystals by Tong Li,Alessandra Mattei Pdf

An important resource that puts the focus on understanding and handling of organic crystals in drug development Since a majority of pharmaceutical solid-state materials are organic crystals, their handling and processing are critical aspects of drug development. Pharmaceutical Crystals: Science and Engineering offers an introduction to and thorough coverage of organic crystals, and explores the essential role they play in drug development and manufacturing. Written contributions from leading researchers and practitioners in the field, this vital resource provides the fundamental knowledge and explains the connection between pharmaceutically relevant properties and the structure of a crystal. Comprehensive in scope, the text covers a range of topics including: crystallization, molecular interactions, polymorphism, analytical methods, processing, and chemical stability. The authors clearly show how to find solutions for pharmaceutical form selection and crystallization processes. Designed to be an accessible guide, this book represents a valuable resource for improving the drug development process of small drug molecules. This important text: Includes the most important aspects of solid-state organic chemistry and its role in drug development Offers solutions for pharmaceutical form selection and crystallization processes Contains a balance between the scientific fundamental and pharmaceutical applications Presents coverage of crystallography, molecular interactions, polymorphism, analytical methods, processing, and chemical stability Written for both practicing pharmaceutical scientists, engineers, and senior undergraduate and graduate students studying pharmaceutical solid-state materials, Pharmaceutical Crystals: Science and Engineering is a reference and textbook for understanding, producing, analyzing, and designing organic crystals which is an imperative skill to master for anyone working in the field.

Impedance Spectroscopy

Evgenij Barsoukov,J. Ross Macdonald
Impedance Spectroscopy Book PDF

Author : Evgenij Barsoukov,J. Ross Macdonald
Publisher : John Wiley & Sons
Page : 560 pages
File Size : 46,8 Mb
Release : 2018-03-19
Category : Science
ISBN : 9781119333173

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Impedance Spectroscopy by Evgenij Barsoukov,J. Ross Macdonald Pdf

The Essential Reference for the Field, Featuring Protocols, Analysis, Fundamentals, and the Latest Advances Impedance Spectroscopy: Theory, Experiment, and Applications provides a comprehensive reference for graduate students, researchers, and engineers working in electrochemistry, physical chemistry, and physics. Covering both fundamentals concepts and practical applications, this unique reference provides a level of understanding that allows immediate use of impedance spectroscopy methods. Step-by-step experiment protocols with analysis guidance lend immediate relevance to general principles, while extensive figures and equations aid in the understanding of complex concepts. Detailed discussion includes the best measurement methods and identifying sources of error, and theoretical considerations for modeling, equivalent circuits, and equations in the complex domain are provided for most subjects under investigation. Written by a team of expert contributors, this book provides a clear understanding of impedance spectroscopy in general as well as the essential skills needed to use it in specific applications. Extensively updated to reflect the field’s latest advances, this new Third Edition: Incorporates the latest research, and provides coverage of new areas in which impedance spectroscopy is gaining importance Discusses the application of impedance spectroscopy to viscoelastic rubbery materials and biological systems Explores impedance spectroscopy applications in electrochemistry, semiconductors, solid electrolytes, corrosion, solid state devices, and electrochemical power sources Examines both the theoretical and practical aspects, and discusses when impedance spectroscopy is and is not the appropriate solution to an analysis problem Researchers and engineers will find value in the immediate practicality, while students will appreciate the hands-on approach to impedance spectroscopy methods. Retaining the reputation it has gained over years as a primary reference, Impedance Spectroscopy: Theory, Experiment, and Applications once again present a comprehensive reference reflecting the current state of the field.

Polymorphism in the Pharmaceutical Industry

Rolf Hilfiker,Markus von Raumer
Polymorphism in the Pharmaceutical Industry Book PDF

Author : Rolf Hilfiker,Markus von Raumer
Publisher : John Wiley & Sons
Page : 618 pages
File Size : 46,6 Mb
Release : 2019-01-04
Category : Science
ISBN : 9783527697854

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Polymorphism in the Pharmaceutical Industry by Rolf Hilfiker,Markus von Raumer Pdf

"Polymorphism in the Pharmaceutical Industry - Solid Form and Drug Development" highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus on quality by design (QbD) concepts. It covers all important issues by way of case studies, ranging from properties and crystallization, via thermodynamics, analytics and theoretical modelling right up to patent issues. As such, the book underscores the importance of solid-state chemistry within chemical and pharmaceutical development. It emphasizes why solid-state issues are important, the approaches needed to avoid problems and the opportunities offered by solid-state properties. The authors include true polymorphs as well as solvates and hydrates, while providing information on physicochemical properties, crystallization thermodynamics, quantum-mechanical modelling, and up-scaling. Important analytical tools to characterize solid-state forms and to quantify mixtures are summarized, and case studies on solid-state development processes in industry are also provided. Written by acknowledged experts in the field, this is a high-quality reference for researchers, project managers and quality assurance managers in pharmaceutical, agrochemical and fine chemical companies as well as for academics and newcomers to organic solid-state chemistry.

Pain Management and the Opioid Epidemic

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse
Pain Management and the Opioid Epidemic Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse
Publisher : National Academies Press
Page : 483 pages
File Size : 48,9 Mb
Release : 2017-09-28
Category : Medical
ISBN : 9780309459570

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Pain Management and the Opioid Epidemic by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Pain Management and Regulatory Strategies to Address Prescription Opioid Abuse Pdf

Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Federal Regulation of Methadone Treatment

Committee on Federal Regulation of Methadone Treatment,Institute of Medicine
Federal Regulation of Methadone Treatment Book PDF

Author : Committee on Federal Regulation of Methadone Treatment,Institute of Medicine
Publisher : National Academies Press
Page : 251 pages
File Size : 47,5 Mb
Release : 1995-02-01
Category : Medical
ISBN : 9780309598620

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Federal Regulation of Methadone Treatment by Committee on Federal Regulation of Methadone Treatment,Institute of Medicine Pdf

For nearly three decades, methadone hydrochloride has been the primary means of treating opiate addiction. Today, about 115,000 people receive such treatment, and thousands more have benefited from it in the past. Even though methadone's effectiveness has been well established, its use remains controversial, a fact reflected by the extensive regulation of its manufacturing, labeling, distribution, and use. The Food and Drug Administration regulates the safety and effectiveness of methadone, as it does for all drugs, and the Drug Enforcement Administration regulates it as a controlled substance. However, methadone is also subjected to a unique additional tier of regulation that prescribes how and under what circumstances it may be used to treat opiate addiction. Federal Regulation of Methadone Treatment examines current Department of Health and Human Services standards for narcotic addiction treatment and the regulation of methadone treatment programs pursuant to those standards. The book includes an evaluation of the effect of federal regulations on the provision of methadone treatment services and an exploration of options for modifying the regulations to allow optimal clinical practice. The volume also includes an assessment of alternatives to the existing regulations.

The State of Knowledge on Medical Assistance in Dying Where a Mental Disorder Is the Sole Underlying Medical Condition

The Expert Panel Working Group on MAID Where a Mental Disorder Is the Sole Underlying Medical Condition
The State of Knowledge on Medical Assistance in Dying Where a Mental Disorder Is the Sole Underlying Medical Condition Book PDF

Author : The Expert Panel Working Group on MAID Where a Mental Disorder Is the Sole Underlying Medical Condition
Publisher : Council of Canadian Academies
Page : 272 pages
File Size : 55,6 Mb
Release : 2018-12-12
Category : Social Science
ISBN : 9781926522494

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The State of Knowledge on Medical Assistance in Dying Where a Mental Disorder Is the Sole Underlying Medical Condition by The Expert Panel Working Group on MAID Where a Mental Disorder Is the Sole Underlying Medical Condition Pdf

In December 2016, the CCA was asked by then Minister of Health Jane Philpott and Minister of Justice and Attorney General of Canada Jody Wilson-Raybould to undertake independent reviews related to medical assistance in dying (MAID). Specifically, the CCA was tasked with examining three particularly complex types of requests for MAID that were identified for further review and study in the legislation passed by Parliament in 2016: requests by mature minors, advance requests, and requests where a mental disorder is the sole underlying medical condition. On December 12, 2018 the CCA released the three final reports of the Expert Panel, one on each type of request: The State of Knowledge on Medical Assistance in Dying for Mature Minors; The State of Knowledge on Advance Requests for Medical Assistance in Dying; and The State of Knowledge on Medical Assistance in Dying Where a Mental Disorder is the Sole Underlying Medical Condition.

Engineering of Biomaterials for Drug Delivery Systems

Anilkumar Parambath
Engineering of Biomaterials for Drug Delivery Systems Book PDF

Author : Anilkumar Parambath
Publisher : Woodhead Publishing
Page : 404 pages
File Size : 51,7 Mb
Release : 2018-02-01
Category : Technology & Engineering
ISBN : 9780081017517

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Engineering of Biomaterials for Drug Delivery Systems by Anilkumar Parambath Pdf

Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its use in vivo. Chapters then focus on alternative polymer systems for drug delivery systems. Finally, nanoparticles and future perspectives are examined. This book is a valuable resource for scientists and researchers in biomaterials, pharmaceuticals and nanotechnology, and all those who wish to broaden their knowledge in this field. Provides a self-contained work for the field of biomaterials for drug delivery Summarizes the current knowledge on PEGylation and strategies for bypassing it Presents research on an important, though under-represented issue in biomaterials Written by a world-class team of research scientists, engineers and clinicians

Advances in Organic Crystal Chemistry

Masami Sakamoto,Hidehiro Uekusa
Advances in Organic Crystal Chemistry Book PDF

Author : Masami Sakamoto,Hidehiro Uekusa
Publisher : Springer Nature
Page : 532 pages
File Size : 51,7 Mb
Release : 2020-07-10
Category : Science
ISBN : 9789811550850

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Advances in Organic Crystal Chemistry by Masami Sakamoto,Hidehiro Uekusa Pdf

This book summarizes and records the recent notable advances in diverse topics in organic crystal chemistry, which has made substantial progress along with the rapid development of a variety of analysis and measurement techniques for solid organic materials. This review book is one of the volumes that are published periodically on this theme. The previous volume, published in 2015, systematically summarized the remarkable progress in assorted topics of organic crystal chemistry using organic solids and organic–inorganic hybrid materials during the previous 5 years, and it has been widely read. The present volume also shows the progress of organic solid chemistry in the last 5 years, with contributions mainly by invited members of the Division of Organic Crystal Chemistry of the Chemical Society of Japan (CSJ), together with prominent invited authors from countries other than Japan.