Pharmaceutical Formulation Development Of Peptides And Proteins Second Edition

Author : Lars Hovgaard,Sven Frokjaer,Marco van de Weert
Publisher : CRC Press
Page : 395 pages
File Size : 53,7 Mb
Release : 2012-11-14
Category : Medical
ISBN : 9781439853887

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Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition by Lars Hovgaard,Sven Frokjaer,Marco van de Weert Pdf

The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therapeutic peptides and proteins, from the production of active compounds via basic pre-formulation and formulation to the registration of the final product. Providing integrated solutions, this book discusses: The synthesis of peptides and the biotechnological production of proteins through recombinant DNA technology The physicochemical characteristics and stability of peptides and proteins The formulation of proteins as suspensions, solutions, and (mostly freeze-dried) solids The opportunities and challenges of non-parenteral delivery of peptides and proteins Risk factors, specifically the development of an unwanted immune response A simulation approach to describe the fate of peptides and proteins upon administration to a biological system The documentation required to register a protein-based drug Scientists in the pharmaceutical industry and academia as well as postgraduate students in pharmaceutical science will find this a valuable resource.

Author : Eugene J. McNally,Eugene McNally,Jayne E. Hastedt
Publisher : CRC Press
Page : 372 pages
File Size : 44,8 Mb
Release : 2007-10-26
Category : Medical
ISBN : 9780849379529

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Protein Formulation and Delivery by Eugene J. McNally,Eugene McNally,Jayne E. Hastedt Pdf

This title is intended to assist pharmaceutical scientists in the development of stable protein formulations during the early stages of the product development process, providing a comprehensive review of mechanisms and causes of protein instability in formulation development, coverage of accelerated stability testing methods and relevant analytica

Author : Anonim
Publisher : Unknown
Page : 238 pages
File Size : 44,8 Mb
Release : 2000
Category : Peptide drugs
ISBN : 0203792424

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Pharmaceutical Formulation Development of Peptides and Proteins by Anonim Pdf

Author : Ajay K. Banga
Publisher : CRC Press
Page : 375 pages
File Size : 55,8 Mb
Release : 2005-09-14
Category : Medical
ISBN : 9781420039832

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Therapeutic Peptides and Proteins by Ajay K. Banga Pdf

Upon publication of the first edition of Therapeutic Peptides and Proteins ten years ago there were only 19 biotechology medicines on the market. Currently there are more than 100, with at least 400 more in various stages of development. That alone would be grounds for a new edition. Add to that the fact that it is still difficult to find up

Author : Lars Hovgaard,Sven Frokjaer,Marco van de Weert
Publisher : CRC Press
Page : 238 pages
File Size : 53,8 Mb
Release : 1999-12-16
Category : Medical
ISBN : 1135737703

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Pharmaceutical Formulation Development of Peptides and Proteins by Lars Hovgaard,Sven Frokjaer,Marco van de Weert Pdf

Pharmaceutical formulation of peptides and proteins has become an important part of modern drug development. Many new drugs are based on peptide or protein recombinant technology going hand in hand with more traditional pharmaceutical formulation. In order to develop products with optimal characters, it is important to give scientists interdisciplinary knowledge and a thorough understanding of the complex nature of pharmaceutical formulation of peptides and proteins. This comprehensive volume brings the different aspects of peptide and protein formulation into focus, beginning with the fundamentals of the production of peptides and proteins, ranging from peptide synthesis and recombinant DNA technology to protein purification. It discusses the characterization and chemical stability of peptides and proteins, before moving on to formulation, detailing peptides and proteins in solution and as suspensions, as well as lyophilized peptide and protein products. There follows a case study on drug delivery systems for alternative routes of administration. Finally, regulatory aspects are discussed in terms of chemical and pharmaceutical documentation. Each chapter is written by experts in their respective areas. Scientists in the industry and academia, and postgraduate students in pharmaceutical science will find this a valuable resource, which can be dipped in to as a reference, or studied as a whole.

Author : Zahra Shahrokh
Publisher : Unknown
Page : 248 pages
File Size : 47,9 Mb
Release : 1997
Category : Dosage forms
ISBN : UOM:39015041771521

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Therapeutic Protein and Peptide Formulation and Delivery by Zahra Shahrokh Pdf

This volume reviews protein stability and the analytical and biophysical characterization of proteins. It emphasizes drug delivery approaches, especially local delivery through the skin. Including both academic and industrial perspectives from such companies as Genentech, Amgen, and Merck, the book also discusses novel drug delivery polymers and the development of pharmaceutical protein formulations.

Author : Ajay K. Banga
Publisher : CRC Press
Page : 396 pages
File Size : 45,6 Mb
Release : 2015-04-23
Category : Medical
ISBN : 9781466566071

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Therapeutic Peptides and Proteins by Ajay K. Banga Pdf

There are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis. The c

Author : Rodney Pearlman,Y. John Wang
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 52,5 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489912367

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Stability and Characterization of Protein and Peptide Drugs by Rodney Pearlman,Y. John Wang Pdf

This is the first volume to make available specific case histories of therapeutic proteins and peptides that have been marketed or are currently under clinical testing. The editors have selected a wide range of molecules derived from monoclonal antibodies, recombinant DNA, and natural and chemical sources to provide formulation scientists with practical examples of the development of pharmaceutical products.

Author : Steve L. Nail,Michael J. Akers
Publisher : Springer Science & Business Media
Page : 479 pages
File Size : 42,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461505495

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Development and Manufacture of Protein Pharmaceuticals by Steve L. Nail,Michael J. Akers Pdf

In this era of biotechnology there have been many books covering the fundamentals of recombinant DNA technology and protein chemistry. However, not many sources are available for the pharmaceutical develop ment scientist and other personnel responsible for the commercialization of the finished dosage forms of these new biopharmaceuticals and other products from biotechnology. This text will help to fill this gap. Once active biopharmaceutical molecules are candidates for clinical trial investigation and subsequent commercialization, a number of other activities must take place while research and development on these molecules continues. The active ingredient itself must be formulated into a finished dosage form that can be conveniently used by health care professionals and patients. Properties of the biopharmaceutical molecule must be clearly understood so that the appropriate finished product formulation can be developed. Finished product formulation development includes not only the chemical formulation, but also the packaging system, the manufacturing process, and appropriate control strategies to assure such good manufacturing practice attributes as safety, identity, strength, purity, and quality.

Author : Chris Van Der Walle
Publisher : Academic Press
Page : 380 pages
File Size : 44,8 Mb
Release : 2011-05-12
Category : Science
ISBN : 0123849365

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Peptide and Protein Delivery by Chris Van Der Walle Pdf

The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market

Author : Puneet Tyagi,Anand Subramony
Publisher : Academic Press
Page : 318 pages
File Size : 50,5 Mb
Release : 2022-08-18
Category : Business & Economics
ISBN : 9780128210604

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Oral Delivery of Therapeutic Peptides and Proteins by Puneet Tyagi,Anand Subramony Pdf

Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport. Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource. Demonstrates how proteins and peptides transport throughout the gastrointestinal tract and how to evaluate their biological fate when encapsulated into certain delivery systems Examines developing technologies to improve future oral bioavailability Includes the in vitro and preclinical techniques needed for development

Author : Aakanchha Jain,Sonia Malik
Publisher : Elsevier
Page : 331 pages
File Size : 45,8 Mb
Release : 2023-10-10
Category : Science
ISBN : 9780443189265

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Peptide and Protein Drug Delivery Using Polysaccharides by Aakanchha Jain,Sonia Malik Pdf

Peptide and Protein Drug Delivery Using Polysaccharides offers an interdisciplinary discussion of polysaccharides applied in peptide and protein drug delivery. Chapters consider basic biology of different polysaccharides of current interest and their production at pilot and large-scale stages by various techniques including, but not limited to, cell and hairy root cultures. Other sections examine factors affecting polysaccharide absorption, metabolism, and excretion in nascent, encapsulated, or conjugated forms, with unique coverage of vaccine absorption, metabolism, and drug delivery. A final section considers analytical methods for detection in tissue fluids and homogenates. Accessible figures, tables, and graphical abstracts are included throughout to support understanding. Specific polysaccharides discussed for therapeutic purposes include cellulose, hyaluronic acid, heparin, carageenan, alginic acid, agar and myrrh, acacia, tragacanth, ghatti gum, chitin, chitosan, starch, glycogen and dextran. Adopts an interdisciplinary approach across biochemistry, molecular biology, pharmaceutical sciences and drug delivery, and biotechnological perspectives Features accessible figures, tables and graphical abstracts across all chapters to support understanding Examines various polysaccharides of current interest and aspects affecting their absorption, metabolism, excretion and detection

Author : Seetharama D. Jois
Publisher : Springer Nature
Page : 321 pages
File Size : 43,6 Mb
Release : 2022-09-26
Category : Medical
ISBN : 9783031045448

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Peptide Therapeutics by Seetharama D. Jois Pdf

This book explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as well as regulatory issues. It covers the design concept of peptide therapeutics from fundamental principles using structural biology and computational approaches. The chapters are arranged in a linear fashion. A fresh graduate or a scientist who works on small molecules can use this to follow the design and development of peptide therapeutics to use as understanding the basic concepts. Each chapter is written by experts from academia as well as industry. Rather than covering extensive literature, the book provides concepts of design, synthesis, delivery, as well as regulatory affairs and manufacturing of peptides in a systematic way with examples in each case. The book can be used as a reference for a pharmaceutical or biomedical scientist or graduate student who wants to pursue their career in peptide therapeutics. Some chapters will be written as a combination of basic principles and protocol so that scientists can adopt these methods to their research work. The examples provided can be used to perform peptide formulation considerations for the designed peptides. The book has nine chapters, and each chapter can be read as an independent unit on a particular concept.

Author : John F. Carpenter,Mark C. Manning
Publisher : Springer Science & Business Media
Page : 218 pages
File Size : 52,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461505570

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Rational Design of Stable Protein Formulations by John F. Carpenter,Mark C. Manning Pdf

Recombinant proteins and polypeptides continue to be the most important class of biotechnology-derived agents in today's pharmaceutical industry. Over the past few years, our fundamental understanding of how proteins degrade and how stabilizing agents work has made it possible to approach formulation of protein pharmaceuticals from a much more rational point of view. This book describes the current level of understanding of protein instability and the strategies for stabilizing proteins under a variety of stressful conditions.

Author : Ronald Reid
Publisher : CRC Press
Page : 918 pages
File Size : 50,8 Mb
Release : 1999-11-12
Category : Medical
ISBN : 1420001337

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Peptide and Protein Drug Analysis by Ronald Reid Pdf

Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design. Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication. Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry demonstrates uses of unnatural mutagenesis and combinatorial chemistry explores mass spectrometry, protein sequence, and carbohydrate analysis illustrates bioassays and other new functional analysis methods surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR) addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering and more! Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.