Pharmacokinetics And Metabolism In Drug Design Volume 13

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Pharmacokinetics and Metabolism in Drug Design

Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker
Pharmacokinetics and Metabolism in Drug Design Book PDF

Author : Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker
Publisher : John Wiley & Sons
Page : 269 pages
File Size : 41,6 Mb
Release : 2012-05-14
Category : Medical
ISBN : 9783527329540

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Pharmacokinetics and Metabolism in Drug Design by Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker Pdf

In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.

Pharmacokinetics and Metabolism in Drug Design, Volume 13

Dennis A. Smith,Han van de Waterbeemd,Don K. Walker
Pharmacokinetics and Metabolism in Drug Design Volume 13 Book PDF

Author : Dennis A. Smith,Han van de Waterbeemd,Don K. Walker
Publisher : Wiley-VCH
Page : 172 pages
File Size : 54,9 Mb
Release : 2001
Category : Medical
ISBN : UOM:39015056694030

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Pharmacokinetics and Metabolism in Drug Design, Volume 13 by Dennis A. Smith,Han van de Waterbeemd,Don K. Walker Pdf

The medical benefits of a drug are not only dependent on its biological effect, but also on its "life cycle" within the organism - from its absorption into the blood, distribution to tissue until its eventual breakdown or excretion by the liver and kidneys. This book explains in readily comprehensible terms the problems that may arise, and how these may be taken into account at an early stage in drug development.

Pharmacokinetics and Metabolism in Drug Design

Dennis A. Smith,Han van de Waterbeemd,Don K. Walker
Pharmacokinetics and Metabolism in Drug Design Book PDF

Author : Dennis A. Smith,Han van de Waterbeemd,Don K. Walker
Publisher : John Wiley & Sons
Page : 207 pages
File Size : 52,7 Mb
Release : 2006-08-21
Category : Medical
ISBN : 9783527608287

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Pharmacokinetics and Metabolism in Drug Design by Dennis A. Smith,Han van de Waterbeemd,Don K. Walker Pdf

In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.

Pharmacokinetics in Drug Development

Peter L. Bonate
Pharmacokinetics in Drug Development Book PDF

Author : Peter L. Bonate
Publisher : Springer Science & Business Media
Page : 648 pages
File Size : 47,5 Mb
Release : 2005-12-05
Category : Medical
ISBN : 0971176744

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Pharmacokinetics in Drug Development by Peter L. Bonate Pdf

These volumes are designed to be the most complete guide to pharmacokinetics (PK) and its role in drug development. They fill a gap between the academic science and the practical application of that knowledge in drug development. Volume 1 discusses the role that PK plays in selected clinical study designs. Volume 2 details the key regulatory and development paradigms in which PK supplements decision-making during drug development.

Drug Metabolism and Pharmacokinetics Quick Guide

Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
Drug Metabolism and Pharmacokinetics Quick Guide Book PDF

Author : Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 48,8 Mb
Release : 2011-04-07
Category : Medical
ISBN : 9781441956293

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Drug Metabolism and Pharmacokinetics Quick Guide by Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop Pdf

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Metabolism, Pharmacokinetics, and Toxicity of Functional Groups

Dennis A. Smith
Metabolism Pharmacokinetics and Toxicity of Functional Groups Book PDF

Author : Dennis A. Smith
Publisher : Royal Society of Chemistry
Page : 545 pages
File Size : 45,9 Mb
Release : 2010
Category : Medical
ISBN : 9781849730167

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Metabolism, Pharmacokinetics, and Toxicity of Functional Groups by Dennis A. Smith Pdf

Written by medicinal chemists and ADMET scientists with a combined experience of over 300 years this aid to discovering drugs provides detailed coverage on absorption, distribution, metabolism, excretion and toxicology issues associated with new drugs.

New Horizons in Predictive Drug Metabolism and Pharmacokinetics

Alan G. E. Wilson
New Horizons in Predictive Drug Metabolism and Pharmacokinetics Book PDF

Author : Alan G. E. Wilson
Publisher : Royal Society of Chemistry
Page : 444 pages
File Size : 41,5 Mb
Release : 2015-11-20
Category : Medical
ISBN : 9781849738286

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New Horizons in Predictive Drug Metabolism and Pharmacokinetics by Alan G. E. Wilson Pdf

This book thoroughly explores the predictive role of drug metabolism and pharmacokinetics in drug discovery and in improving success rates and safety assessments of chemicals.

Handbook of Drug Metabolism

Thomas Woolf
Handbook of Drug Metabolism Book PDF

Author : Thomas Woolf
Publisher : CRC Press
Page : 612 pages
File Size : 43,7 Mb
Release : 2019-08-30
Category : Electronic
ISBN : 0367399857

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Handbook of Drug Metabolism by Thomas Woolf Pdf

Bringing together nearly forty collaborators from academic and industrial laboratories, this reference furnishes an overview of the subject from a historical, kinetic, and chemical context. A source of expertise for a rapidly changing and expanding field, the book provides a framework for drug metabolism in drug discovery and development. Containing tables, drawings, photographs, and equations, it highlights the importance of pharmacokinetics and cytochrome P450, explains clearance, volume of distribution, sequential metabolism, and nonlinear kinetics, summarizes concepts of Phase 1 and 2 metabolites, evaluates tertiary amine metabolism and reactive metabolite chemistry, and more.

Handbook of Drug Metabolism

Thomas F. Woolf
Handbook of Drug Metabolism Book PDF

Author : Thomas F. Woolf
Publisher : Unknown
Page : 612 pages
File Size : 41,5 Mb
Release : 1999
Category : MEDICAL
ISBN : 0367800748

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Handbook of Drug Metabolism by Thomas F. Woolf Pdf

Bringing together nearly forty collaborators from academic and industrial laboratories, this reference furnishes an overview of the subject from a historical, kinetic, and chemical context. A source of expertise for a rapidly changing and expanding field, the book provides a framework for drug metabolism in drug discovery and development. Containing tables, drawings, photographs, and equations, it highlights the importance of pharmacokinetics and cytochrome P450, explains clearance, volume of distribution, sequential metabolism, and nonlinear kinetics, summarizes concepts of Phase 1 and 2 metabolites, evaluates tertiary amine metabolism and reactive metabolite chemistry, and more.

Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists

Younggil Kwon
Handbook of Essential Pharmacokinetics Pharmacodynamics and Drug Metabolism for Industrial Scientists Book PDF

Author : Younggil Kwon
Publisher : Springer Science & Business Media
Page : 291 pages
File Size : 43,9 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9780306468209

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Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists by Younggil Kwon Pdf

In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

Encyclopedia of Drug Metabolism and Interactions, 6 Volume Set

Anonim
Encyclopedia of Drug Metabolism and Interactions 6 Volume Set Book PDF

Author : Anonim
Publisher : Wiley
Page : 0 pages
File Size : 47,5 Mb
Release : 2012-11-05
Category : Medical
ISBN : 0470450150

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Encyclopedia of Drug Metabolism and Interactions, 6 Volume Set by Anonim Pdf

“This one-stop reference brings together information scattered throughout the literature, and it involved the efforts of 270 expert authors from 16 countries — a global endeavor accomplished under the leadership of editor Alexander Lyubimov.” –Book News Inc., February 2013 The Encyclopedia of Drug Metabolism and Interactions provides essential support during all phases of drug development, from drug design to drug action and interaction in patients. This multivolume work covers both preclinical and clinical aspects of drug metabolism and interactions. It also provides a wealth of toxicological, regulatory, and marketing information, all written by leading international experts in the field. Using this reference you’ll discover: • Enzymes that can be inhibited or induced and their impact on drug toxicity and altered response in both animal and human models • Effect of genetic differences and non-genetic factors on drug metabolism • Balance among drug metabolism, its inactivation/activation, and its potential toxicity • Examples demonstrating all aspects of drug metabolism and interactions in silico, in laboratory animals, and in humans • Methods and detailed protocols enabling you to perform seamless studies of metabolism and drug interactions This reference is essential for researchers interested in all aspects of drug development, and chemists, pharmacologists, pharmaceutical specialists, toxicologists, molecular toxicologists, and clinicians, including practitioners and physicians. Enjoy the Online Advantage... The Encyclopedia of Drug Metabolism and Interactions is available online now. For further information visit wileyonlinelibrary.com/ref/lyubimov

Drug Metabolism in Drug Design and Development

Donglu Zhang,Mingshe Zhu,William G. Humphreys
Drug Metabolism in Drug Design and Development Book PDF

Author : Donglu Zhang,Mingshe Zhu,William G. Humphreys
Publisher : John Wiley & Sons
Page : 448 pages
File Size : 55,6 Mb
Release : 2007-11-16
Category : Science
ISBN : 0470191686

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Drug Metabolism in Drug Design and Development by Donglu Zhang,Mingshe Zhu,William G. Humphreys Pdf

The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.

Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists

Younggil Kwon
Handbook of Essential Pharmacokinetics Pharmacodynamics and Drug Metabolism for Industrial Scientists Book PDF

Author : Younggil Kwon
Publisher : Springer
Page : 291 pages
File Size : 41,9 Mb
Release : 2013-04-26
Category : Medical
ISBN : 147578693X

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Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists by Younggil Kwon Pdf

In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

Pharmacokinetics in Drug Discovery and Development

Ronald D. Schoenwald
Pharmacokinetics in Drug Discovery and Development Book PDF

Author : Ronald D. Schoenwald
Publisher : CRC Press
Page : 444 pages
File Size : 48,7 Mb
Release : 2002-03-06
Category : Medical
ISBN : 1420010085

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Pharmacokinetics in Drug Discovery and Development by Ronald D. Schoenwald Pdf

Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the many existi

A Handbook of Bioanalysis and Drug Metabolism

Gary Evans
A Handbook of Bioanalysis and Drug Metabolism Book PDF

Author : Gary Evans
Publisher : CRC Press
Page : 408 pages
File Size : 44,7 Mb
Release : 2019-08-30
Category : Electronic
ISBN : 0367394421

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A Handbook of Bioanalysis and Drug Metabolism by Gary Evans Pdf

Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting - until now. A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug-drug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills. This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.