New Horizons In Predictive Drug Metabolism And Pharmacokinetics

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New Horizons in Predictive Drug Metabolism and Pharmacokinetics

Alan G E Wilson
New Horizons in Predictive Drug Metabolism and Pharmacokinetics Book PDF

Author : Alan G E Wilson
Publisher : Royal Society of Chemistry
Page : 422 pages
File Size : 51,7 Mb
Release : 2015-11-20
Category : Medical
ISBN : 9781782622376

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New Horizons in Predictive Drug Metabolism and Pharmacokinetics by Alan G E Wilson Pdf

Drug metabolism, pharmacokinetics and toxicokinetics as determinants of drug attrition and the safety of xenobiotics are critically important. This book presents a comprehensive treatise on the current issues and challenges facing drug metabolism and pharmacokinetics. Readers will find a thorough exploration of their predictive role in impacting drug discovery and development and in improving the success rate and safety assessment of pharmaceuticals and industrial or occupational chemicals. Chapters not only focus on the current state of art, with distinct examples, but on future needs and approaches likely to improve our prediction of potential human risk. Discussions of critical properties that are determinants of a compound’s metabolic and pharmacokinetic fate follow introductory chapters. The Drug Discovery process increasingly incorporates pharmacokinetics and drug metabolism screening and focus has shifted towards in silico, computational and systems biology approaches. Core chapters reflect this and the recent interest and need to assess the role of transporters, along with drug metabolizing enzymes, as potential determinants of pharmacokinetic behaviour, toxicity and drug-drug interactions. Lastly, chapters cover the issues and factors involved in translating pharmacokinetics from in silico to in vivo and from animal models to man, and postulate future directions and opportunities. Leading experts from academia, industry and regulatory bodies across the globe contribute their knowledge to this book, which scientists involved in many aspects of the drug discovery process, as well as regulators and postgraduate students, will find a useful resource.

New Horizons in Predictive Toxicology

Alan G. E. Wilson
New Horizons in Predictive Toxicology Book PDF

Author : Alan G. E. Wilson
Publisher : Royal Society of Chemistry
Page : 711 pages
File Size : 47,7 Mb
Release : 2012
Category : Medical
ISBN : 9781849730518

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New Horizons in Predictive Toxicology by Alan G. E. Wilson Pdf

The sophistication of modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of critical importance. The integration of predictive toxicology approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including in silico, in vitro and in vivo approaches that are being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen and improve our ability to predict the safety and risks posed by industrial and pharmaceutical chemicals in humans. The reader will find extensive information on the use of current animal models used for various toxicities and target mediated toxicities. Also discussed are the recent regulatory initiatives to improve the safety assessment of chemicals. The book provides an expert and comprehensive discussion on the current status and future directions of predictive toxicology and its application. The various chapters in the book also reflect the growing need for improvements in our technologies and abilities to predict toxicities of pharmaceutical and industrial chemicals to ensure product safety and protect public health.

Drug Metabolism and Pharmacokinetics Quick Guide

Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
Drug Metabolism and Pharmacokinetics Quick Guide Book PDF

Author : Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 50,9 Mb
Release : 2011-04-07
Category : Medical
ISBN : 9781441956293

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Drug Metabolism and Pharmacokinetics Quick Guide by Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop Pdf

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Pharmacokinetics and Metabolism in Drug Design

Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker
Pharmacokinetics and Metabolism in Drug Design Book PDF

Author : Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker
Publisher : John Wiley & Sons
Page : 269 pages
File Size : 43,9 Mb
Release : 2012-05-14
Category : Medical
ISBN : 9783527329540

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Pharmacokinetics and Metabolism in Drug Design by Dennis A. Smith,Charlotte Allerton,Amit S. Kalgutkar,Han van de Waterbeemd,Don K. Walker Pdf

In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.

Pharmacokinetics and Metabolism in Drug Design

Dennis A. Smith,Han van de Waterbeemd,Don K. Walker
Pharmacokinetics and Metabolism in Drug Design Book PDF

Author : Dennis A. Smith,Han van de Waterbeemd,Don K. Walker
Publisher : John Wiley & Sons
Page : 207 pages
File Size : 51,8 Mb
Release : 2006-08-21
Category : Medical
ISBN : 9783527608287

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Pharmacokinetics and Metabolism in Drug Design by Dennis A. Smith,Han van de Waterbeemd,Don K. Walker Pdf

In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.

Predictive ADMET

Jianling Wang,Laszlo Urban
Predictive ADMET Book PDF

Author : Jianling Wang,Laszlo Urban
Publisher : John Wiley & Sons
Page : 604 pages
File Size : 55,7 Mb
Release : 2014-02-28
Category : Medical
ISBN : 9781118783405

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Predictive ADMET by Jianling Wang,Laszlo Urban Pdf

This book helps readers integrate in silico, in vitro, and in vivo ADMET (absorption, distribution, metabolism, elimination and toxicity) and PK (pharmacokinetics) data with routine testing applications so that pharmaceutical scientists can diagnose ADMET problems and present appropriate recommendations to move drug discovery programs forward. The book introduces the current clinical practice for drug discovery and development along with the impact on early risk assessment; consolidates the tools and models to intelligently integrate existing in silico, in vitro and in vivo ADMET data; and demonstrates successful cases and lessons learned from real drug discovery and development. In short, it is a book aimed to provide a practical road map for drug discovery and development scientists to generate efficacious and safe drugs for unmet medical needs.

New Horizons in Predictive Drug Metabolism and Pharmacokinetics

Alan G. E. Wilson
New Horizons in Predictive Drug Metabolism and Pharmacokinetics Book PDF

Author : Alan G. E. Wilson
Publisher : Royal Society of Chemistry
Page : 444 pages
File Size : 47,9 Mb
Release : 2015-11-20
Category : Medical
ISBN : 9781849738286

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New Horizons in Predictive Drug Metabolism and Pharmacokinetics by Alan G. E. Wilson Pdf

This book thoroughly explores the predictive role of drug metabolism and pharmacokinetics in drug discovery and in improving success rates and safety assessments of chemicals.

Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape

Neal Davies,Kishor Wasan
Pharmacokinetics and Drug Metabolism in Canada The Current Landscape Book PDF

Author : Neal Davies,Kishor Wasan
Publisher : Unknown
Page : 128 pages
File Size : 44,5 Mb
Release : 2018
Category : Electronic
ISBN : 3038427985

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Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape by Neal Davies,Kishor Wasan Pdf

Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape.

Computational Chemistry Methods

Ponnadurai Ramasami
Computational Chemistry Methods Book PDF

Author : Ponnadurai Ramasami
Publisher : Walter de Gruyter GmbH & Co KG
Page : 194 pages
File Size : 52,6 Mb
Release : 2020-08-10
Category : Science
ISBN : 9783110631623

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Computational Chemistry Methods by Ponnadurai Ramasami Pdf

This book reviews a variety of methods in computational chemistry and their applications in different fields of current research. Ab initio methods and regression analyses are discussed with special focus on their application to investigate chemical structures as for example dyes or drug compounds. Further topics are the use of computational methods in the modeling of spectroscopic data or to study reaction mechanisms.

P5 Medicine and Justice

Santo Davide Ferrara
P5 Medicine and Justice Book PDF

Author : Santo Davide Ferrara
Publisher : Springer
Page : 635 pages
File Size : 49,8 Mb
Release : 2018-03-27
Category : Medical
ISBN : 9783319670928

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P5 Medicine and Justice by Santo Davide Ferrara Pdf

This book describes the state of the art and future prospects of the most important bio-medicolegal subdisciplines in the post-genomic framework of personalized medicine. Focusing on the three main themes Innovation, Unitariness and Evidence, the book addresses a wide range of topics, including: Bio-Medicolegal and Criminological Sciences, Forensic Pathology and Anthropology, Clinical and Forensic Medicine in Living Persons (from Interpersonal Violence to Personal Injury and Damage, Malpractice, Personal Identification and Age Estimation), Forensic Genetics and Genomics, and Toxicology and Imaging. The unitariness of the “Bio-Medicolegal Sciences”, historically founded on the accuracy and rigor of the methods of ascertainment and criteria of evaluation, should be re-established on the basis of molecular evidence, and used to promote Personalized Justice. Taken together, the book’s conclusions and future perspectives outline a vision of transdisciplinary innovation and future evidence in the framework of personalized justice.

Protein Degradation with New Chemical Modalities

Hilmar Weinmann,Craig Crews
Protein Degradation with New Chemical Modalities Book PDF

Author : Hilmar Weinmann,Craig Crews
Publisher : Royal Society of Chemistry
Page : 382 pages
File Size : 46,7 Mb
Release : 2020-10-07
Category : Medical
ISBN : 9781839160776

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Protein Degradation with New Chemical Modalities by Hilmar Weinmann,Craig Crews Pdf

Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.

New Tools to Interrogate Endocannabinoid Signalling

Mauro Maccarrone
New Tools to Interrogate Endocannabinoid Signalling Book PDF

Author : Mauro Maccarrone
Publisher : Royal Society of Chemistry
Page : 473 pages
File Size : 46,5 Mb
Release : 2020-11-16
Category : Science
ISBN : 9781788018012

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New Tools to Interrogate Endocannabinoid Signalling by Mauro Maccarrone Pdf

New Tools to Interrogate Endocannabinoid Signalling comprehensively covers the innovative research into both natural and synthetic compounds. This timely volume will be a valuable resource to pharmaceutical researchers and medicinal chemists working in natural products and endocannabinoid drug discovery in academia and industry.

Oral Drug Delivery for Modified Release Formulations

Edmund S. Kostewicz,Maria Vertzoni,Heather A. E. Benson,Michael S. Roberts
Oral Drug Delivery for Modified Release Formulations Book PDF

Author : Edmund S. Kostewicz,Maria Vertzoni,Heather A. E. Benson,Michael S. Roberts
Publisher : John Wiley & Sons
Page : 516 pages
File Size : 53,5 Mb
Release : 2022-04-26
Category : Medical
ISBN : 9781119772699

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Oral Drug Delivery for Modified Release Formulations by Edmund S. Kostewicz,Maria Vertzoni,Heather A. E. Benson,Michael S. Roberts Pdf

ORAL DRUG DELIVERY FOR MODIFIED RELEASE FORMULATIONS Provides pharmaceutical development scientists with a detailed reference guide for the development of MR formulations Oral Drug Delivery for Modified Release Formulations is an up-to-date review of the key aspects of oral absorption from modified-release (MR) dosage forms. This edited volume provides in-depth coverage of the physiological factors that influence drug release and of the design and evaluation of MR formulations. Divided into three sections, the book begins by describing the gastrointestinal tract (GIT) and detailing the conditions and absorption processes occurring in the GIT that determine a formulation’s oral bioavailability. The second section explores the design of modified release formulations, covering early drug substance testing, the biopharmaceutics classification system, an array of formulation technologies that can be used for MR dosage forms, and more. The final section focuses on in vitro, in silico, and in vivo evaluation and regulatory considerations for MR formulations. Topics include biorelevant dissolution testing, preclinical evaluation, and physiologically-based pharmacokinetic modelling (PBPK) of in vivo behaviour. Featuring contributions from leading researchers with expertise in the different aspects of MR formulations, this volume: Provides authoritative coverage of physiology, physicochemical determinants, and in-vitro in-vivo correlation (IVIVC) Explains the different types of MR formulations and defines the key terms used in the field Discusses the present status of MR technologies and identifies current gaps in research Includes a summary of regulatory guidelines from both the US and the EU Shares industrial experiences and perspectives on the evaluation of MR dosage formulations Oral Drug Delivery for Modified Release Formulations is an invaluable reference and guide for researchers, industrial scientists, and graduate students in general areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Drug Delivery Approaches

Bret Berner,Toufigh Gordi,Heather A. E. Benson,Michael S. Roberts
Drug Delivery Approaches Book PDF

Author : Bret Berner,Toufigh Gordi,Heather A. E. Benson,Michael S. Roberts
Publisher : John Wiley & Sons
Page : 466 pages
File Size : 54,6 Mb
Release : 2021-08-04
Category : Medical
ISBN : 9781119772750

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Drug Delivery Approaches by Bret Berner,Toufigh Gordi,Heather A. E. Benson,Michael S. Roberts Pdf

Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.

Peptide-based Drug Discovery

Ved Srivastava
Peptide based Drug Discovery Book PDF

Author : Ved Srivastava
Publisher : Royal Society of Chemistry
Page : 589 pages
File Size : 50,6 Mb
Release : 2017-06-26
Category : Science
ISBN : 9781782627326

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Peptide-based Drug Discovery by Ved Srivastava Pdf

With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.