Pharmacology Of Itch

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Pharmacology of Itch

Alan Cowan,Gil Yosipovitch
Pharmacology of Itch Book PDF

Author : Alan Cowan,Gil Yosipovitch
Publisher : Springer
Page : 382 pages
File Size : 54,6 Mb
Release : 2015-04-15
Category : Medical
ISBN : 3662446065

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Pharmacology of Itch by Alan Cowan,Gil Yosipovitch Pdf

Basic research on the pharmacology of itch has exploded in the wake of two very influential papers that were published in Nature (2007) and Science (2009). Long overlooked as a milder form of pain, itching has rapidly gained a new appreciation in both research and clinical communities because of its complexity and its negative effects on the quality of life of the distressed patients. Like pain, not all itches are the same. Unlike pain, there are no standard drugs equivalent to aspirin and morphine. Epidemiological studies emphasize the high incidence and economic costs of itch (pruritus). It is the most prevalent symptom of a wide variety of allergic and inflammatory skin conditions (e.g., psoriasis, atopic dermatitis), is associated with several systemic diseases (e.g., chronic kidney and liver disease), and occurs in patients undergoing hemodialysis, spinal administration of opioids, and in those suffering from AIDS. The reader will learn about the multiple pathways for itch and their interactions with pain. The relationship between these closely related, yet distinct sensory phenomena, will be emphasized. Both itch and pain use several common molecules to send signals to the brain. Thus, drugs that have been, and are being, developed as analgesics may also attenuate intractable itch. This has been an exciting and very necessary turn of events since traditional H-1 receptor antagonists are ineffective in blocking the pruritus associated with kidney failure and cholestasis. The clinical chapters will provide insights into contemporary treatment regimens for pruritus in different human scenarios.

Itch

E. Carstens,Tasuku Akiyama
Itch Book PDF

Author : E. Carstens,Tasuku Akiyama
Publisher : CRC Press
Page : 482 pages
File Size : 49,9 Mb
Release : 2014-02-25
Category : Science
ISBN : 9781466505438

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Itch by E. Carstens,Tasuku Akiyama Pdf

Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Itch

Gil Yosipovitch,Malcolm W. Greaves,Jr., Alan B. Fleischer,Francis McGlone
Itch Book PDF

Author : Gil Yosipovitch,Malcolm W. Greaves,Jr., Alan B. Fleischer,Francis McGlone
Publisher : CRC Press
Page : 342 pages
File Size : 52,9 Mb
Release : 2004-01-06
Category : Medical
ISBN : 9780824759742

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Itch by Gil Yosipovitch,Malcolm W. Greaves,Jr., Alan B. Fleischer,Francis McGlone Pdf

Offering details on the pharmacology of itch, techniques of itch evaluation, and neurogenic itch, this reference presents new concepts in the neurophysiology and central mechanisms of itch, animal models of itch, and processing of histamine itch in the human cerebral cortex. The text clarifies itch in systemic and skin disease, exploring renal itch

Pharmacology of Itch

Alan Cowan,Gil Yosipovitch
Pharmacology of Itch Book PDF

Author : Alan Cowan,Gil Yosipovitch
Publisher : Springer
Page : 382 pages
File Size : 48,7 Mb
Release : 2015-04-10
Category : Medical
ISBN : 9783662446058

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Pharmacology of Itch by Alan Cowan,Gil Yosipovitch Pdf

Basic research on the pharmacology of itch has exploded in the wake of two very influential papers that were published in Nature (2007) and Science (2009). Long overlooked as a milder form of pain, itching has rapidly gained a new appreciation in both research and clinical communities because of its complexity and its negative effects on the quality of life of the distressed patients. Like pain, not all itches are the same. Unlike pain, there are no standard drugs equivalent to aspirin and morphine. Epidemiological studies emphasize the high incidence and economic costs of itch (pruritus). It is the most prevalent symptom of a wide variety of allergic and inflammatory skin conditions (e.g., psoriasis, atopic dermatitis), is associated with several systemic diseases (e.g., chronic kidney and liver disease), and occurs in patients undergoing hemodialysis, spinal administration of opioids, and in those suffering from AIDS. The reader will learn about the multiple pathways for itch and their interactions with pain. The relationship between these closely related, yet distinct sensory phenomena, will be emphasized. Both itch and pain use several common molecules to send signals to the brain. Thus, drugs that have been, and are being, developed as analgesics may also attenuate intractable itch. This has been an exciting and very necessary turn of events since traditional H-1 receptor antagonists are ineffective in blocking the pruritus associated with kidney failure and cholestasis. The clinical chapters will provide insights into contemporary treatment regimens for pruritus in different human scenarios.

Histamine in Inflammation

Robin Thurmond
Histamine in Inflammation Book PDF

Author : Robin Thurmond
Publisher : Springer Science & Business Media
Page : 153 pages
File Size : 45,7 Mb
Release : 2011-06-29
Category : Medical
ISBN : 9781441980564

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Histamine in Inflammation by Robin Thurmond Pdf

The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.

Pharmacology of Itch

Alan Cowan,Gil Yosipovitch
Pharmacology of Itch Book PDF

Author : Alan Cowan,Gil Yosipovitch
Publisher : Springer
Page : 0 pages
File Size : 40,9 Mb
Release : 2015-04-22
Category : Medical
ISBN : 3662446049

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Pharmacology of Itch by Alan Cowan,Gil Yosipovitch Pdf

Basic research on the pharmacology of itch has exploded in the wake of two very influential papers that were published in Nature (2007) and Science (2009). Long overlooked as a milder form of pain, itching has rapidly gained a new appreciation in both research and clinical communities because of its complexity and its negative effects on the quality of life of the distressed patients. Like pain, not all itches are the same. Unlike pain, there are no standard drugs equivalent to aspirin and morphine. Epidemiological studies emphasize the high incidence and economic costs of itch (pruritus). It is the most prevalent symptom of a wide variety of allergic and inflammatory skin conditions (e.g., psoriasis, atopic dermatitis), is associated with several systemic diseases (e.g., chronic kidney and liver disease), and occurs in patients undergoing hemodialysis, spinal administration of opioids, and in those suffering from AIDS. The reader will learn about the multiple pathways for itch and their interactions with pain. The relationship between these closely related, yet distinct sensory phenomena, will be emphasized. Both itch and pain use several common molecules to send signals to the brain. Thus, drugs that have been, and are being, developed as analgesics may also attenuate intractable itch. This has been an exciting and very necessary turn of events since traditional H-1 receptor antagonists are ineffective in blocking the pruritus associated with kidney failure and cholestasis. The clinical chapters will provide insights into contemporary treatment regimens for pruritus in different human scenarios.

Itch - Management in Clinical Practice

J. Szepietowski,E. Weisshaar
Itch Management in Clinical Practice Book PDF

Author : J. Szepietowski,E. Weisshaar
Publisher : Karger Medical and Scientific Publishers
Page : 210 pages
File Size : 41,7 Mb
Release : 2016-08-30
Category : Medical
ISBN : 9783318058895

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Itch - Management in Clinical Practice by J. Szepietowski,E. Weisshaar Pdf

Albeit a very common symptom in dermatology, internal medicine, psychosomatics, neurology, and even oncology, itching was under-researched up until 15 years ago. Since then, the clinical aspects of acute and chronic itch have been examined extensively. As a result, some books on the topic have become available. Whereas most publications focus on experimental aspects and diagnostics, this volume of the series 'Current Problems in Dermatology' provides a comprehensive overview regarding the management of chronic itch. Select authors consider interdisciplinary aspects as well as age, body region, and specific diseases as they present a great variety of available treatments. All physicians with patients suffering from itch – especially dermatologists, general practitioners, gerontologists, nephrologists, hepatologists, neurologists, and palliative care doctors – will find this publication to be an essential source of information.

Translational Studies on Inflammation

Ane C.F. Nunes
Translational Studies on Inflammation Book PDF

Author : Ane C.F. Nunes
Publisher : BoD – Books on Demand
Page : 249 pages
File Size : 40,6 Mb
Release : 2020-01-08
Category : Medical
ISBN : 9781789843576

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Translational Studies on Inflammation by Ane C.F. Nunes Pdf

Inflammation is known worldwide, from the bench to the bedside, but it is a hard theme to approach with one single point of view.In this sense, a selection of translational studies would support the medical-scientific community to better understand the complex network of the inflammatory process, its maintenance, and potential treatment targets. The eleven chapters that compose this book present interesting insights into inflammation and its mechanisms, merging classic background with innovative approaches. From the molecular basis to experimental models, the chapters selected for this book bring to readers at different academic levels updated and practical data on inflammation. Find out what drives interdisciplinary medical research on inflammation and enjoy this informative collection.

Advances in Integrative Dermatology

Katlein França,Torello Lotti
Advances in Integrative Dermatology Book PDF

Author : Katlein França,Torello Lotti
Publisher : John Wiley & Sons
Page : 552 pages
File Size : 48,9 Mb
Release : 2019-01-18
Category : Medical
ISBN : 9781119476092

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Advances in Integrative Dermatology by Katlein França,Torello Lotti Pdf

An authoritative overview of contemporary approaches to integrative skin health The popularity of integrative medical treatment of skin disorders has increased significantly in recent years—requiring practicing clinicians to keep pace with continuingdevelopments in dermatological research and methods. Advances in Integrative Dermatology offers a comprehensive survey of this dynamic field, providing up-to-date information on both preventative and therapeutic approaches to skin health. Combining clinical medicine with complimentary treatment plans, integrative dermatology provides an innovative perspective to individual patient care. This essential text explores new research in areas including the effects of stress and pollution on the skin, the importance of high-quality sleep, complementary methods of averting skin conditions, and more. Recognizing the impact skin disorders have on physiological, psychological, and emotional health, editors Katlein França and Torello Lotti illustrate key components of inclusive skin health strategies, such as therapeutic diets and nutritional supplements, topical botanicals, and other complementary therapies. Filling a significant gap in current literature on integrative dermatology, this valuable resource: Answers the common questions asked by patients in real-world dermatology practices Addresses pervasive misconceptions of integrative dermatological methods and principles with evidence-based review of current practices Examines contemporary research in the diagnosis and treatment of dermatological disorders Presents comprehensive treatment options for a wide range of conditions such as rosacea, melanoma, and psoriasis Advances in Integrative Dermatology is an indispensable volume for physicians seeking to incorporate holistic techniques into their practices, expand their knowledge of integrative medicine, and provide the best possible care for their patients.

Glutamate and GABA Receptors and Transporters

Jan Egebjerg,Arne Schousboe,Povl Krogsgaard-Larsen
Glutamate and GABA Receptors and Transporters Book PDF

Author : Jan Egebjerg,Arne Schousboe,Povl Krogsgaard-Larsen
Publisher : CRC Press
Page : 456 pages
File Size : 43,7 Mb
Release : 2001-10-04
Category : Science
ISBN : 0748408819

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Glutamate and GABA Receptors and Transporters by Jan Egebjerg,Arne Schousboe,Povl Krogsgaard-Larsen Pdf

The ubiquitous presence of glutamate and GABA receptors in the nervous system makes these receptor systems pivotal to our understanding of neurotransmission. Cloning of the molecular components of these receptor systems has provided insights to the selectivity of many drugs and detailed characterisation at the molecular level is emerging. Moreover, continuous development of novel and selective drugs has revealed detailed information on the mechanism of receptor activation and regulation. However, the rapid development of different aspects of glutamate and GABA receptor research makes it increasingly difficult to establish a general view of the field. Studies of the receptors are a multi-disciplinary task employing many specialised techniques. This book conveys recent discoveries in a framework of the basic concepts in the field of glutamate and GABA receptor research. Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology is suitable for postgraduate students studying ligand gated channels but also beneficial for industrial and academic research scientists in both the glutamate and GABA field. Universities offering programs in neuroscience, molecular pharmacology or medicinal chemistry will find this a valuable reference.

Itch and Pain

Gil Yosipovitch,Lars Arendt-Nielsen,Hjalte Andersen
Itch and Pain Book PDF

Author : Gil Yosipovitch,Lars Arendt-Nielsen,Hjalte Andersen
Publisher : Lippincott Williams & Wilkins
Page : 473 pages
File Size : 53,6 Mb
Release : 2020-03-20
Category : Medical
ISBN : 9781975153052

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Itch and Pain by Gil Yosipovitch,Lars Arendt-Nielsen,Hjalte Andersen Pdf

Providing for the first time a comprehensive overview of the common and different pathways and mechanisms of itch and pain, this unique title explores these two distinct and still somehow similar sensory experiences and utilize the cross-fertilization between the two fields to develop better treatments for patients. Itch and Pain: Similarities, Interactions and Differences is the only available, up-to-date guide to current information in this important area, ideal for basic scientists as well as clinicians in dermatology, pain, neurology, medicine, psychology, or other specialties.

Pruritus, An Issue of Dermatologic Clinics, E-Book

Gil Yosipovitch
Pruritus An Issue of Dermatologic Clinics E Book Book PDF

Author : Gil Yosipovitch
Publisher : Elsevier Health Sciences
Page : 193 pages
File Size : 41,5 Mb
Release : 2018-06-23
Category : Medical
ISBN : 9780323610810

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Pruritus, An Issue of Dermatologic Clinics, E-Book by Gil Yosipovitch Pdf

This issue of Dermatologic Clinics, guest edited by Dr. Gil Yosipovitch, is devoted to Pruritus (Itch). Articles in this issue include: Pathophysiology of Chronic Itch; Work-up of Chronic Itchy Patient; Management of Prurigo Nodularis; Chronic Pruritus in the Geriatric Population; Diagnosis and Management of Neuropathic Itch; Female Genital Itch; End Stage Renal Disease Chronic Itch and its Management; Management of Chronic Hepatic Itch; Pruritus in Scabies; Pruritus Associated with Targeted Cancer Therapies and Their Management; Pruritus in Lymphoma and its Management; Pruritus in Pregnancy and its Management; Pruritus in Connective Tissue Disorders; Immunomodulating Agents as Anti Pruritics; Psychogenic Pruritus and its Management; and Drugs on the Horizon for Chronic Itch.

The Kappa Opioid Receptor

Lee-Yuan Liu-Chen,Saadet Inan
The Kappa Opioid Receptor Book PDF

Author : Lee-Yuan Liu-Chen,Saadet Inan
Publisher : Springer
Page : 0 pages
File Size : 43,9 Mb
Release : 2022-11-26
Category : Medical
ISBN : 3030890767

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The Kappa Opioid Receptor by Lee-Yuan Liu-Chen,Saadet Inan Pdf

This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds. It is divided up into the three parts: Molecular aspects of KOR, Preclinical research on pharmacology of KOR agonists and antagonists in animals and KOR agonists and antagonists in clinical use and in past and present clinical trials. The chapters "Biosensors monitor ligand-selective effects at kappa opioid receptors" and "The role of dynorphin and the kappa opioid receptor in schizophrenia and major depressive disorder: a translational approach" of this book are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Advanced Practice Palliative Nursing

Constance Dahlin,Patrick J. Coyne,Betty R. Ferrell
Advanced Practice Palliative Nursing Book PDF

Author : Constance Dahlin,Patrick J. Coyne,Betty R. Ferrell
Publisher : Oxford University Press
Page : 752 pages
File Size : 49,9 Mb
Release : 2016-02-25
Category : Medical
ISBN : 9780190643881

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Advanced Practice Palliative Nursing by Constance Dahlin,Patrick J. Coyne,Betty R. Ferrell Pdf

Advanced Practice Palliative Nursing is the first text devoted to advanced practice nursing care of the seriously ill and dying. This comprehensive work addresses all aspects of palliative care including physical, psychological, social, and spiritual needs. Chapters include: symptoms common in serious illness, pediatric palliative care, spiritual and existential issues, issues around the role and function of the advanced practice nurse (APN), reimbursement, and nursing leadership on palliative care teams. Each chapter contains case examples and a strong evidence base to support the highest quality of care. The text is written by leaders in the field and includes authors who have pioneered the role of the advanced practice nurse in palliative care. This volume offers advanced practice content and practical resources for clinical practice across all settings of care and encompassing all ages, from pediatrics to geriatrics.

TRP Channels as Therapeutic Targets

Arpad Szallasi
TRP Channels as Therapeutic Targets Book PDF

Author : Arpad Szallasi
Publisher : Academic Press
Page : 536 pages
File Size : 40,8 Mb
Release : 2015-04-09
Category : Medical
ISBN : 9780124200791

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TRP Channels as Therapeutic Targets by Arpad Szallasi Pdf

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings. Contains comprehensive coverage of TRP channels as therapeutic targets, from emerging clinical indications to completed clinical trials Discusses TRP channels as validated targets, ranging from obesity and diabetes through cancer and respiratory disorders, kidney diseases, hypertension, neurodegenerative disorders, and more Provides critical analysis of the complications and side effects that have surfaced during clinical trials, offering evidence-based suggestions for overcoming them