Translational Studies On Inflammation

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Translational Studies on Inflammation

Ane C.F. Nunes
Translational Studies on Inflammation Book PDF

Author : Ane C.F. Nunes
Publisher : BoD – Books on Demand
Page : 249 pages
File Size : 47,6 Mb
Release : 2020-01-08
Category : Medical
ISBN : 9781789843576

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Translational Studies on Inflammation by Ane C.F. Nunes Pdf

Inflammation is known worldwide, from the bench to the bedside, but it is a hard theme to approach with one single point of view.In this sense, a selection of translational studies would support the medical-scientific community to better understand the complex network of the inflammatory process, its maintenance, and potential treatment targets. The eleven chapters that compose this book present interesting insights into inflammation and its mechanisms, merging classic background with innovative approaches. From the molecular basis to experimental models, the chapters selected for this book bring to readers at different academic levels updated and practical data on inflammation. Find out what drives interdisciplinary medical research on inflammation and enjoy this informative collection.

Translational Inflammation

Anonim
Translational Inflammation Book PDF

Author : Anonim
Publisher : Academic Press
Page : 294 pages
File Size : 42,9 Mb
Release : 2018-11-24
Category : Medical
ISBN : 9780128138335

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Translational Inflammation by Anonim Pdf

Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. Emphasizes the role of inflammation in disease and therapeutic approaches Integrates broad concepts relating inflammation to other fields Offers a bridge to review literature and primary research on the inflammatory response towards medical application

Fundamentals of Inflammation

Charles N. Serhan,Peter A. Ward,Derek W. Gilroy
Fundamentals of Inflammation Book PDF

Author : Charles N. Serhan,Peter A. Ward,Derek W. Gilroy
Publisher : Cambridge University Press
Page : 489 pages
File Size : 41,6 Mb
Release : 2010-04-26
Category : Medical
ISBN : 9780521887298

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Fundamentals of Inflammation by Charles N. Serhan,Peter A. Ward,Derek W. Gilroy Pdf

The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion.

Smoking and Lung Inflammation

Thomas J. Rogers,Gerard J. Criner,William D. Cornwell
Smoking and Lung Inflammation Book PDF

Author : Thomas J. Rogers,Gerard J. Criner,William D. Cornwell
Publisher : Springer Science & Business Media
Page : 213 pages
File Size : 43,5 Mb
Release : 2013-10-12
Category : Medical
ISBN : 9781461473510

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Smoking and Lung Inflammation by Thomas J. Rogers,Gerard J. Criner,William D. Cornwell Pdf

Smoking and Lung Inflammation is the first book directly related to chronic lung inflammation of its kind in several respects. First, the it focuses on both basic and clinical research on COPD, and the inflammatory mechanisms that function in these diseases. Second, it is unique with respect to scope of the discussion of the unusual characteristics of the immune response which occurs in these patients. Third, it includes knowledge being gained from translational research conducted through clinical trials at several Medical Schools in the United States. Not only is this research providing information about novel drugs and therapies, but it is also advancing our understanding of the genetics of these diseases. This work will illuminate the molecular basis for these diseases, and hopefully will permit us to individualize the therapies for these diseases.

Translational Methods for Multiple Sclerosis Research

Sergiu Groppa,Sven G. Meuth
Translational Methods for Multiple Sclerosis Research Book PDF

Author : Sergiu Groppa,Sven G. Meuth
Publisher : Humana
Page : 335 pages
File Size : 55,7 Mb
Release : 2021-08-03
Category : Medical
ISBN : 1071612123

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Translational Methods for Multiple Sclerosis Research by Sergiu Groppa,Sven G. Meuth Pdf

This volume explores the recent advances in the study of translational paths in central inflammation and focuses on ongoing pathophysiological processes and the transition between inflammatory stages and progressive states with neurodegeneration. Chapters cover topics such as pathophysiological hallmarks of neuroinflammation from tissue damage to reorganization; connecting studies of mouse models; and investigations of humans with multiple sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Methods for Multiple Sclerosis Research is a valuable resource for researchers who want to learn more about this chronic ad progressive disease, and pave the way for new advancements.

Translational Immunology

Seng-Lai Tan
Translational Immunology Book PDF

Author : Seng-Lai Tan
Publisher : Academic Press
Page : 384 pages
File Size : 52,8 Mb
Release : 2015-11-18
Category : Medical
ISBN : 9780128017579

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Translational Immunology by Seng-Lai Tan Pdf

Translational Immunology: Mechanisms and Pharmacologic Approaches highlights and summarizes the most important advances in human immunology, clinical translations, new tools to analyze therapeutic targets, and new pharmacological approaches for autoimmunity, inflammatory disorders, and cancer. The book is an essential resource for those seeking to understand the potential translational applications of burgeoning studies in human immunology, helping readers make sense of the existing and emerging scientific advances. The book grounds fundamental science in the translational realm, providing insights from world renowned researchers at the top of their game in their respective fields, in both industry and academic settings. Readers will gain an understanding of the rationale and mechanisms underlying current and emerging pharmacologic approaches for interventional immunology, the gaps therein, and new ideas for better and safer therapeutic approaches, and physicians will glean information about pharmacological limitations in altering disease progression and complications. This reference on the translational realization of the burgeoning findings in immunology provides a go-to reference for experienced professional clinicians, researchers, industry scientists, and those seeking more information on the field. Delivers comprehensive coverage of seminal human immunology discoveries and the resulting impact on therapeutic strategies Presents potential novel targets and approaches for clinical applications in organ specific and systemic autoimmunity, transplant rejection, cancer, and vaccine development Discusses lessons learned from successful and failed clinical trials with specific interventions, including pharmacological issues and limitations, and complications due to immunosuppression Provides information on new strategies and outstanding issues that should be addressed in future research

Inflammation in Heart Failure

Matthijs Blankesteijn,Raffaele Altara
Inflammation in Heart Failure Book PDF

Author : Matthijs Blankesteijn,Raffaele Altara
Publisher : Academic Press
Page : 220 pages
File Size : 49,6 Mb
Release : 2014-12-05
Category : Medical
ISBN : 9780128004852

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Inflammation in Heart Failure by Matthijs Blankesteijn,Raffaele Altara Pdf

Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure’s breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students. Presents updated information and research on the relevant inflammatory mediators of heart failure to aid in targeting future translational research as well as the improvement of early diagnosis and treatment Provides research into better understanding the different inflammatory mediators that signal the underlying diseases that potentially lead to heart failure Contains 20 years of research, offering a brief overview of the topic leading to current opinions on, and treatment of, heart failure Provides a structured, systematic and balanced overview of the role of inflammation in heart failure making it a useful resource for researchers and clinicians, as well as those studying cardiovascular diseases

Translational Methods for Multiple Sclerosis Research

Sergiu Groppa,Sven G. Meuth
Translational Methods for Multiple Sclerosis Research Book PDF

Author : Sergiu Groppa,Sven G. Meuth
Publisher : Humana
Page : 333 pages
File Size : 47,7 Mb
Release : 2022-06-07
Category : Medical
ISBN : 1071612158

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Translational Methods for Multiple Sclerosis Research by Sergiu Groppa,Sven G. Meuth Pdf

This volume explores the recent advances in the study of translational paths in central inflammation and focuses on ongoing pathophysiological processes and the transition between inflammatory stages and progressive states with neurodegeneration. Chapters cover topics such as pathophysiological hallmarks of neuroinflammation from tissue damage to reorganization; connecting studies of mouse models; and investigations of humans with multiple sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Methods for Multiple Sclerosis Research is a valuable resource for researchers who want to learn more about this chronic ad progressive disease, and pave the way for new advancements.

Translational Systems Biology: Concepts and Practice for the Future of Biomedical Research

Yoram Vodovotz,Gary An
Translational Systems Biology Concepts and Practice for the Future of Biomedical Research Book PDF

Author : Yoram Vodovotz,Gary An
Publisher : Academic Press
Page : 178 pages
File Size : 51,6 Mb
Release : 2017-11-13
Category : Computers
ISBN : 0128101474

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Translational Systems Biology: Concepts and Practice for the Future of Biomedical Research by Yoram Vodovotz,Gary An Pdf

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation. Provides an explicit, reasoned, and systematic approach to dealing with the challenges of translational science across disciplines Establishes the case for including computational modeling at all stages of biomedical research and healthcare delivery, from early pre-clinical studies to long-term care, by clearly delineating efficiency and costs saving important to business investment Guides readers on how to communicate across domains and disciplines, particularly between biologists and computational researchers, to effectively develop multi- and trans-disciplinary research teams "

Translational Research in Coronary Artery Disease

Wilbert S. Aronow,John Arthur McClung
Translational Research in Coronary Artery Disease Book PDF

Author : Wilbert S. Aronow,John Arthur McClung
Publisher : Academic Press
Page : 244 pages
File Size : 52,8 Mb
Release : 2015-10-29
Category : Medical
ISBN : 9780128026052

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Translational Research in Coronary Artery Disease by Wilbert S. Aronow,John Arthur McClung Pdf

Translational Research in Coronary Artery Disease: Pathophysiology to Treatment covers the entire spectrum of basic science, genetics, drug treatment, and interventions for coronary artery disease. With an emphasis on vascular biology, this reference fully explains the fundamental aspects of coronary artery disease pathophysiology. Included are important topics, including endothelial function, endothelial injury, and endothelial repair in various disease states, vascular smooth muscle function and its interaction with the endothelium, and the interrelationship between inflammatory biology and vascular function. By providing this synthesis of current research literature, this reference allows the cardiovascular scientist and practitioner to access everything they need from one source. Provides a concise summary of recent developments in coronary and vascular research, including previously unpublished data Summarizes in-depth discussions of the pathobiology and novel treatment strategies for coronary artery disease Provides access to an accompanying website that contains photos and videos of noninvasive diagnostic modalities for evaluation of coronary artery disease

Translational Systems Medicine and Oral Disease

Stephen Sonis,Alessandro Villa
Translational Systems Medicine and Oral Disease Book PDF

Author : Stephen Sonis,Alessandro Villa
Publisher : Academic Press
Page : 458 pages
File Size : 53,7 Mb
Release : 2019-09-14
Category : Medical
ISBN : 9780128137635

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Translational Systems Medicine and Oral Disease by Stephen Sonis,Alessandro Villa Pdf

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care

Introduction to Translational Cardiovascular Research

Dennis V. Cokkinos
Introduction to Translational Cardiovascular Research Book PDF

Author : Dennis V. Cokkinos
Publisher : Springer
Page : 610 pages
File Size : 44,9 Mb
Release : 2014-11-06
Category : Medical
ISBN : 9783319087986

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Introduction to Translational Cardiovascular Research by Dennis V. Cokkinos Pdf

The term “Translational Research” reflects today’s integration of basic research (“bench”) findings with the clinical practice of medicine, and in a wider scope the application of results from the individual patient (“bedside”) to entire populations for the improvement of public health. This book offers future researchers a stimulus in many aspects of cardiovascular research, so as to promote their interest in future fields of cardiovascular disease, diagnosis and treatment. Introduction to Translational Cardiovascular Research discusses the fundamental and important aspects of the topic. It describes the renin-angiotensin-aldosterone system, the beta adrenergic receptors and the hypothalamic-pituitary-adrenal axis, while covering genetic polymorphisms both generally and specifically as regards the vascular endothelium and the use of microRNAs. As such, this book will be relevant to young physicians, nurses and other scientists engaged in the clinical cardiovascular field who want to added research-oriented dimension to their efforts towards better understanding and practicing of medicine. It also aims to attract young basic researchers who want to develop a better comprehension of the organism as a whole, man or animal, that they are investigating.

Recent Developments in Anti-Inflammatory Therapy

Parteek Prasher,Flavia Zacconi,Kamal Dua,Michael Rathbone,Jeffrey Withey
Recent Developments in Anti Inflammatory Therapy Book PDF

Author : Parteek Prasher,Flavia Zacconi,Kamal Dua,Michael Rathbone,Jeffrey Withey
Publisher : Academic Press
Page : 414 pages
File Size : 43,7 Mb
Release : 2023-02-17
Category : Medical
ISBN : 9780323914161

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Recent Developments in Anti-Inflammatory Therapy by Parteek Prasher,Flavia Zacconi,Kamal Dua,Michael Rathbone,Jeffrey Withey Pdf

Advances in Anti-inflammatory Therapy explores the cutting-edge in anti-inflammation therapy in clear and concise language, with insights from academia and industry. Sections cover key regulatory pathways that mediate acute and chronic inflammation and disease onset. Further chapters are devoted to advanced anti-inflammatory pharmaceuticals, including chemical moieties, pharmacophores, APIs, natural products, herbal therapies, molecular nanomedicine and advanced drug delivery vectors. Systematically planned chapters and illustrations enable potential readers to gain essential insights on the most recent advancements in the field. Arranged with systematic chapters covering a broad range of inflammatory diseases, discussions on past, current and future therapeutics and advanced anti-inflammatory pharmaceuticals, this book will be useful to a wide range of researchers, especially medicinal chemists, drug design experts, and biological and translational researchers working in the field of inflammation. Identifies recent developments and current trends in anti-inflammation therapy Discusses advanced chemotherapeutics, SAR analysis of novel pharmacophores and natural products Outlines the pathophysiology of inflammatory pathways in the pathogenesis of disease onset, including strategies to counter these intricacies Contains a blend of editors from both academia and industry

Perspectives in Translational Research in Life Sciences and Biomedicine

Ena Ray Banerjee
Perspectives in Translational Research in Life Sciences and Biomedicine Book PDF

Author : Ena Ray Banerjee
Publisher : Springer
Page : 132 pages
File Size : 40,6 Mb
Release : 2017-10-17
Category : Science
ISBN : 9789811058707

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Perspectives in Translational Research in Life Sciences and Biomedicine by Ena Ray Banerjee Pdf

This book is a collation of translational research outcomes in the area of life research, which was formerly used mainly for academic pursuits. The studies described focus on innovative interdisciplinary approaches to unraveling problems in life sciences and biomedicine using biodiversity exploration and green technology. The techniques and models presented offer a ready reckoner for researchers in academic institutions and industry, and also provide valuable insights into fundamental research. The book discusses topics such as tissue engineering to create lineage-specific cells for tissue-specific regeneration; how combination cultures of commensalistic bacteria can help boost immunity; development of functional food from natural products from plant, animal, and microbial sources in the nutraceuticals domain; as well as synthesis and mechanisms in nanomedicine and nanoscaffolds in biomedicine. The studies and discourses described touch upon topics that explore biodiversity for the development of disease models, toxicity studies, developmental studies, and harvesting of bioactive compounds for alternative income generation and poverty alleviation, and as a result, bring about economic and ecologic sustainability. This multidimensional and multidisciplinary book focuses on tissue-specific targeting by nanodrugs, development of bioengineering formats for cell- based, nutraceutical-based, functional-food-based and antibody-based green therapy designed tackle multifaceted diseases and syndromes.

Cytokines and Pain

L.R. Watkins,S.F. Maier
Cytokines and Pain Book PDF

Author : L.R. Watkins,S.F. Maier
Publisher : Springer
Page : 232 pages
File Size : 51,6 Mb
Release : 2013-03-08
Category : Medical
ISBN : 9783034887496

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Cytokines and Pain by L.R. Watkins,S.F. Maier Pdf

Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.