Phosphoinositide 3 Kinase Signalling Pathway The Key To Cell Proliferation And Death

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Phosphoinositide 3-kinase Signalling Pathway: The Key To Cell Proliferation And Death

Lam Eric Wing-fai
Phosphoinositide 3 kinase Signalling Pathway The Key To Cell Proliferation And Death Book PDF

Author : Lam Eric Wing-fai
Publisher : World Scientific Publishing Company
Page : 252 pages
File Size : 41,5 Mb
Release : 2006-06-08
Category : Science
ISBN : 9781911299202

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Phosphoinositide 3-kinase Signalling Pathway: The Key To Cell Proliferation And Death by Lam Eric Wing-fai Pdf

Aimed at advanced undergraduates, postgraduates and researchers, this important textbook provides a detailed description of the structure and mechanisms of phosphoinositide 3-kinase (PI3Ks) signalling of all classes, with focus on the cellular context of PI3K activity, including its relevance to normal tissue and diseased states.This book contains a general review chapter detailing the mechanisms of cell proliferation and apoptosis, which are two of the main cellular targets of PI3K signalling. In addition, it provides a detailed description of the role of PI3K on the regulation of FOXO proteins, which are now becoming one of the most closely studied and important proteins in the regulation of cell death, cell proliferation and senescence./a

Phosphoinositide 3-kinase Signalling Pathway

Eric W.-F. Lam
Phosphoinositide 3 kinase Signalling Pathway Book PDF

Author : Eric W.-F. Lam
Publisher : Unknown
Page : 238 pages
File Size : 54,5 Mb
Release : 2006
Category : Science
ISBN : 1860946267

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Phosphoinositide 3-kinase Signalling Pathway by Eric W.-F. Lam Pdf

Aimed at advanced undergraduates, postgraduates and researchers, this important textbook provides a detailed description of the structure and mechanisms of phosphoinositide 3-kinase (PI3Ks) signalling of all classes, with focus on the cellular context of PI3K activity, including its relevance to normal tissue and diseased states. This book contains a general review chapter detailing the mechanisms of cell proliferation and apoptosis, which are two of the main cellular targets of PI3K signalling. In addition, it provides a detailed description of the role of PI3K on the regulation of FOXO proteins, which are now becoming one of the most closely studied and important proteins in the regulation of cell death, cell proliferation and senescence. Contents: Introduction (E W-F Lam); Cell Proliferation and Cell Death; In Vivo Roles of Cell Cycle and Apoptosis Regulators; The Role of Phosphoinositide 3-Kinase in Proliferation and Apoptosis (A Sunters & E W-F Lam); Phosphoinositide 3-Kinase Signalling Pathway; Class IA PI3K Enzymes; Class IB PI3K Enzymes; Class II PI3K Enzymes; Class III PI3K Enzymes; Expression of PI3K Enzymes; 3-Phosphoinositide Binding Domains; Downstream Targets of 3-Phosphoinositide; Manipulation of PI3K Enzyme Expression; Biological Role of PI3K Signalling Pathway; Phosphoinositide Phosphatases; The Role of the PI3K Pathway in Disease (J Domin); PI3K Signalling to Cell Survival and Proliferation; Molecules Directly Regulated by D3 Lipids; Genetic Studies of PI3K Function in Model Organisms; Molecules Downstream of PI3K and D3 Lipids; PI3K Regulation of Cell Survival; Signalling from PI3K to Cell Proliferation; Alterations of PI3K and Its Pathways in Cancer; Cancer Therapeutics (P Brennan); FOXO Transcription Factors; Forkhead Transcription Factors; FOXO Transcription Factors; Signalling to FOXO Proteins; Cellular Relocation Mechanism; FOXO Protein Processing; Transcriptional Activity of FoxO Proteins; Functions of FOXO in Vivo; FOXO Targets and Function; FOXO Proteins in Transformation and Diseases (S Fernandez de Mattos et al.). Key Features Provides a clear and well-organized review of PI3K signalling garnered from an exhaustive review of the available literature Readership: Undergraduates, postgraduates, academic researchers, clinicians and scientists working in industry.

Phosphoinositide 3-kinase in Health and Disease

Christian Rommel,Bart Vanhaesebroeck,Peter K. Vogt
Phosphoinositide 3 kinase in Health and Disease Book PDF

Author : Christian Rommel,Bart Vanhaesebroeck,Peter K. Vogt
Publisher : Springer Science & Business Media
Page : 308 pages
File Size : 50,7 Mb
Release : 2010-10-17
Category : Medical
ISBN : 9783642148163

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Phosphoinositide 3-kinase in Health and Disease by Christian Rommel,Bart Vanhaesebroeck,Peter K. Vogt Pdf

PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target

Phosphoinositide 3-kinase in Health and Disease

Christian Rommel,Bart Vanhaesebroeck,Peter K. Vogt
Phosphoinositide 3 kinase in Health and Disease Book PDF

Author : Christian Rommel,Bart Vanhaesebroeck,Peter K. Vogt
Publisher : Springer Science & Business Media
Page : 311 pages
File Size : 55,8 Mb
Release : 2010-10-17
Category : Medical
ISBN : 9783642136634

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Phosphoinositide 3-kinase in Health and Disease by Christian Rommel,Bart Vanhaesebroeck,Peter K. Vogt Pdf

From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

M. A. Hayat
Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging Book PDF

Author : M. A. Hayat
Publisher : Academic Press
Page : 430 pages
File Size : 46,7 Mb
Release : 2016-12-28
Category : Medical
ISBN : 9780128094273

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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by M. A. Hayat Pdf

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

PI3K signalling

Klaus Okkenhaug,Martin Turner, Michael R Gold
PI3K signalling Book PDF

Author : Klaus Okkenhaug,Martin Turner, Michael R Gold
Publisher : Frontiers Media SA
Page : 140 pages
File Size : 50,9 Mb
Release : 2015-03-05
Category : Immunologic diseases. Allergy
ISBN : 9782889194193

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PI3K signalling by Klaus Okkenhaug,Martin Turner, Michael R Gold Pdf

The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.

Protein Kinase-mediated Decisions Between Life and Death

Ayse Basak Engin,Atilla Engin
Protein Kinase mediated Decisions Between Life and Death Book PDF

Author : Ayse Basak Engin,Atilla Engin
Publisher : Springer Nature
Page : 415 pages
File Size : 43,5 Mb
Release : 2021-02-04
Category : Medical
ISBN : 9783030498443

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Protein Kinase-mediated Decisions Between Life and Death by Ayse Basak Engin,Atilla Engin Pdf

Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Molecules to Medicine with mTOR

Kenneth Maiese
Molecules to Medicine with mTOR Book PDF

Author : Kenneth Maiese
Publisher : Academic Press
Page : 472 pages
File Size : 48,6 Mb
Release : 2016-02-21
Category : Medical
ISBN : 9780128027554

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Molecules to Medicine with mTOR by Kenneth Maiese Pdf

Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin. Covers the role of mTOR by internationally recognized expert contributors in the field. Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels. Includes analysis of the role of mTOR and in both health and disease. Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.

Cell-wide Metabolic Alterations Associated with Malignancy

Anonim
Cell wide Metabolic Alterations Associated with Malignancy Book PDF

Author : Anonim
Publisher : Academic Press
Page : 0 pages
File Size : 40,7 Mb
Release : 2014-06-16
Category : Medical
ISBN : 012801329X

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Cell-wide Metabolic Alterations Associated with Malignancy by Anonim Pdf

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods providing a a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation.

Encyclopedia of Cancer

Manfred Schwab
Encyclopedia of Cancer Book PDF

Author : Manfred Schwab
Publisher : Springer Science & Business Media
Page : 3307 pages
File Size : 51,6 Mb
Release : 2008-09-23
Category : Medical
ISBN : 9783540368472

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Encyclopedia of Cancer by Manfred Schwab Pdf

This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

Sajal Chakraborti
Handbook of Oxidative Stress in Cancer Therapeutic Aspects Book PDF

Author : Sajal Chakraborti
Publisher : Springer Nature
Page : 4078 pages
File Size : 55,9 Mb
Release : 2022-09-28
Category : Medical
ISBN : 9789811654220

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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects by Sajal Chakraborti Pdf

This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​

Holland-Frei Cancer Medicine

Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Holland Frei Cancer Medicine Book PDF

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 48,8 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

How Tobacco Smoke Causes Disease

Anonim
How Tobacco Smoke Causes Disease Book PDF

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 51,8 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Signal Transduction in Cancer

David A. Frank
Signal Transduction in Cancer Book PDF

Author : David A. Frank
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 41,9 Mb
Release : 2002-12-31
Category : Medical
ISBN : 9781402073403

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Signal Transduction in Cancer by David A. Frank Pdf

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Advances in Prostate Cancer

Gerhard Hamilton
Advances in Prostate Cancer Book PDF

Author : Gerhard Hamilton
Publisher : BoD – Books on Demand
Page : 706 pages
File Size : 49,5 Mb
Release : 2013-01-16
Category : Medical
ISBN : 9789535109327

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Advances in Prostate Cancer by Gerhard Hamilton Pdf

Prostate cancer is one of the most common types of cancer in men and its treatment was constricted to surgery for confined state and androgen ablation for advanced disease until new options have become available. The present book covers a broad range of novel aspects of prostate cancer diagnosis, treatment and patient care, as well as new research on relevant cell biology. In detail, this special volume focusses on supportive modalities for prostate cancer patients, appropriate selection of novel therapeutic regimens, including inhibitors of steroidal synthesis, cytotoxic agents, as well as intermittent androgen suppression and the roles of prostate cancer stem cells and inflammatory processes.