Phosphoinositides In Subcellular Targeting And Enzyme Activation
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Phosphoinositides in Subcellular Targeting and Enzyme Activation by Harald Stenmark Pdf
Cells of the immune system are activated by a variety of stimuli that are derived from other cells, ingested material or from invading microorganisms. This issue of CTMI focuses on the mechanisms of phosphoinositide-mediated protein recruitment to intracellular membranes.
Coronavirus Replication and Reverse Genetics by Luis Enjuanes Pdf
Human coronaviruses caused the SARS epidemic that infected more than 8000 people, killing about ten percent of them in 32 countries. This book provides essential information on these viruses and the development of vaccines to control coronavirus infections.
Hot Topics in Neural Membrane Lipidology by Akhlaq A. Farooqui Pdf
Glycerophospholipid and sphingolipid-derived lipid mediators facilitate the transfer of messages not only from one cell to another but also from one subcellular organelle to another. These molecules are not only components of neural membranes but also storage depots for lipid mediators. Information on the generation and involvement of lipid mediators in neurological disorders is scattered throughout the literature in the form of original papers and reviews. This book will provide readers with a comprehensive description of glycerophospholipid, sphingolipid and cholesterol-derived lipid mediators and their involvement in neurological disorders.
Glycerophospholipids in the Brain by Akhlaq A. Farooqui,Lloyd A. Horrocks Pdf
This volume provides a comprehensive description of phospholipid metabolism in brain, activities of phospholipases A2, and their involvement in neurological disorders. The purpose of this book is to present readers with cutting edge information in a lively manner that is useful not only to student and teachers but also to researchers and physicians.
Molecular Analysis of B Lymphocyte Development and Activation by Harinder Singh,Rudolf Grosschedl Pdf
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
Author : A. S. N. Reddy,Maxim V. Golovkin Publisher : Springer Science & Business Media Page : 323 pages File Size : 40,7 Mb Release : 2008-04-16 Category : Science ISBN : 9783540767763
Nuclear pre-mRNA Processing in Plants by A. S. N. Reddy,Maxim V. Golovkin Pdf
During the last few years, tremendous progress has been made in understanding various aspects of pre-mRNA processing. This book, with contributions from leading scientists in this area, summarizes recent advances in nuclear pre-mRNA processing in plants. It provides researchers in the field, as well as those in related areas, with an up-to-date and comprehensive, yet concise, overview of the current status and future potential of this research in understanding plant biology.
Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology by Bruce Beutler Pdf
This monograph deals with the impact of classical genetics in immunology, prov- ing examples of how large immunological questions were solved, and new fields opened to analysis through the study of phenotypes, either spontaneous or induced. As broad as biology has become, there are those who do not fully understand what the genetic approach is, and how it differs fundamentally from most of the methods available to natural scientists. They may hold the opinion that genetics has run its course since Mendel read his paper on peas in 1865. “Why bother with classical genetics,” they may ask. “Won’t all genes be knocked out soon anyway?” Or they are intimidated by genetics, with its heavy reliance on model organisms that seem so alien. “What has C. elegans to do with me?” the questioning might go. “It doesn’t even have lymphocytes. ” Such skeptics may be unaware that the mouse is fast becoming as tractable a model organism as the fly, and that humans may not be too far behind. So I would like to introduce the topic with a few words about the power of genetics, and why it has contributed so much to immunology, and to bi- ogy in general. Genetics, as the word is used here, is not merely the science of heredity, but much more than that. It is the science of exceptions: the science that takes note of heritable variation and seeks to explain it at the most fundamental level.
Author : Diane E. Griffin,Michael B. A. Oldstone Publisher : Springer Science & Business Media Page : 296 pages File Size : 48,5 Mb Release : 2008-10-30 Category : Medical ISBN : 9783540706175
Measles by Diane E. Griffin,Michael B. A. Oldstone Pdf
Measles virus, one of the most contagious of all human viruses, has been largely contained by the development and use of a vaccine that was introduced 50 years ago. These two volumes were timed to honor the introduction of the vaccine and to record the enormous advancements made in understanding the molecular and cell biology, pathogenesis, and control of this infectious disease. Where vaccine has been effectively delivered, endemic measles virus transmission has been eliminated. However, difficulties in vaccine delivery, lack of health care support and objection to vaccination in some communities continue to result in nearly 40 million cases and over 300,000 deaths per year from measles.
Specialization and Complementation of Humoral Immune Responses to Infection by Tim Manser Pdf
The importance of specific antibodies for the clearance of and long-term resistance to many infectious pathogens has long been appreciated. In the last five years, data from these areas of research has coalesced, resulting in the emergence of a new and more complete understanding of how antibody-mediated resistance to pathogens is elaborated. This volume will highlight this new perspective on antibody responses to infection and convey its practical implications.
Author : Patrick J. Paddison,Peter K. Vogt Publisher : Springer Science & Business Media Page : 277 pages File Size : 42,9 Mb Release : 2008-01-01 Category : Medical ISBN : 9783540751571
RNA Interference by Patrick J. Paddison,Peter K. Vogt Pdf
In the last few years the major effect that RNAi has had in invertebrate systems is beginning to take hold in mammalian systems through both single gene knockdown experiments and genome-scale screens. In the next decade, there will no doubt be both notable successes and failures as we attempt to apply this genetic tool to various biological problems. Through the introduction of RNAi, mammalian systems have finally gained admittance to the pantheon of model genetic systems.
Membrane Trafficking in Viral Replication by Mark Marsh Pdf
Viruses are major pathogens in humans, and in the organisms with which we share this planet. The massive health and economic burden these agents impose has spurred a huge research effort to understand their most intimate details. One outcome of this effort has been the production, in many but certainly not all cases, of effective vaccines and therapies. - other consequence has been the realization that we can exploit viruses and put them to work on our behalf. Viruses are still seen to have the most - tential as vehicles for gene delivery and other therapeutic applications. However, their ability to exploit cellular functions to their own ends makes viruses not only highly effective pathogens but also exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. For membrane traffic in parti- lar, viruses have been crucial in providing insights into key cellular fu- tions and the molecular mechanisms underlying these events.
Signalling from Internalised Growth Factor Receptors by Inger Helene Madshus Pdf
The book will concentrate on how growth factor receptors are down-regulated by endocytosis and intracellular trafficking. The authors will further discuss what is currently understood about the effect of cellular microenvironments on signal transduction.
Foot-and-mouth disease (FMD) has been recognized in printed records dating from the sixteenth century, and since the eradication of rinderpest (cattle plague) in the early part of the twentieth century it has been rec- nized as the most important and feared disease of cattle and other dom- tic livestock. The beginning of the twenty-first century brought the worst outbreak of FMD ever experienced in England, which had been completely free of the disease for 33 years. This tragic epidemic, which spread to Northern Ireland, Scotland, France and the Netherlands with severe e- nomic consequences, emphasized the need for further research into better methods for the detection and control of the disease. FMD is caused by a small RNA virus which is highly contagious and can survive in meat and other animal products for long periods at normal pH levels. The virus typically infects cloven-hoofed animals, including c- tle, goats, pigs and sheep, as well as a wide range of non-domesticated a- mals in regions of the world where FMD virus is endemic, such as the Af- can continent. There are seven recognized serotypes of FMD virus, with numerous subtypes, and as a consequence vaccine production and administration is complex and a major debate surrounds every disease outbreak regarding the relative merits of vaccination as opposed to the slaughter of all infected animals.
Confronting Metaphor in Use by Mara Sophia Zanotto,Lynne Cameron,Marilda C. Cavalcanti Pdf
It is timely for researchers to approach metaphor as social and situated, as a matter of language and discourse, and not just as a matter of thought. Over the last twenty five years, scholars have come to appreciate in depth the cognitive, motivated and embodied nature of metaphor, but have tended to background the linguistic form of metaphor and have largely ignored how this connects to its role in the discourses in which our lives are constructed and lived. This book brings language and social dimensions into the picture, offering snapshots of metaphor use in real language and in real lives across the very different cultures of Europe and Brazil and contributing to the theorizing of metaphor in discourse.
