Physics Of Molecular And Cellular Processes

Author : Krastan B. Blagoev,Herbert Levine
Publisher : Springer Nature
Page : 265 pages
File Size : 43,9 Mb
Release : 2022-09-08
Category : Science
ISBN : 9783030986063

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Physics of Molecular and Cellular Processes by Krastan B. Blagoev,Herbert Levine Pdf

This is a graduate-level introduction to quantitative concepts and methods in the science of living systems. It relies on a systems approach for understanding the physical principles operating in biology. Physical phenomena are treated at the appropriate spatio-temporal scale and phenomenological equations are used in order to reflect the system of interest. Biological details enter to the degree necessary for understanding specific processes, but in many cases the approach is not reductionist. This is in line with the approach taken by physics to many other complex systems. The book bridges the gap between graduate students’ general physics courses and research papers published in professional journals. It gives students the foundations needed for independent research in biological physics and for working in collaborations aimed at quantitative biology and biomedical research. Also included are modern mathematical and theoretical physics methods, giving the student a broad knowledge of tools that can shed light on the sophisticated mechanisms brought forth by evolution in biological systems. The content covers many aspects that have been the focus of active research over the past twenty years, reflecting the authors' experience as leading researchers and teachers in this field.

Author : Jack A. Tuszynski
Publisher : CRC Press
Page : 540 pages
File Size : 41,9 Mb
Release : 2018-10-24
Category : Science
ISBN : 9781420011722

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Molecular and Cellular Biophysics by Jack A. Tuszynski Pdf

From quantum theory to statistical mechanics, the methodologies of physics are often used to explain some of life's most complex biological problems. Exploring this challenging yet fascinating area of study, Molecular and Cellular Biophysics covers both molecular and cellular structures as well as the biophysical processes that occur in these structures. Designed for advanced undergraduate and beginning graduate students in biophysics courses, this textbook features a quantitative approach that avoids being too abstract in its presentation. Logically organized from small-scale (molecular) to large-scale (cellular) systems, the text first defines life, discussing the scientific controversies between mechanists and vitalists, the characteristics of living things, and the evolution of life. It then delves into molecular structures, including nucleic acids, DNA, RNA, interatomic interactions, and hydrogen bonds. After looking at these smaller systems, the author probes the larger cellular structures. He examines the cytoplasm, the cytoskeleton, chromosomes, mitochondria, motor proteins, and more. The book concludes with discussions on biophysical processes, including oxidative phosphorylation, diffusion, bioenergetics, conformational transitions in proteins, vesicle transport, subcellular structure formation, and cell division.

Author : Kim Sneppen,Giovanni Zocchi
Publisher : Cambridge University Press
Page : 328 pages
File Size : 49,9 Mb
Release : 2005-08-25
Category : Science
ISBN : 0521844193

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Physics in Molecular Biology by Kim Sneppen,Giovanni Zocchi Pdf

This book, first published in 2005, is a discussion for advanced physics students of how to use physics to model biological systems.

Author : Valerica Raicu,Aurel Popescu
Publisher : Springer Science & Business Media
Page : 254 pages
File Size : 49,5 Mb
Release : 2008-06-17
Category : Science
ISBN : 9781402082689

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Integrated Molecular and Cellular Biophysics by Valerica Raicu,Aurel Popescu Pdf

Biophysics represents perhaps one of the best examples of interdisciplinary research areas, where concepts and methods from disciplines such as physics, biology, b- chemistry, colloid chemistry, and physiology are integrated. It is by no means a new ?eld of study and has actually been around, initially as quantitative physiology and partly as colloid science, for over a hundred years. For a long time, biophysics has been taught and practiced as a research discipline mostly in medical schools and life sciences departments, and excellent biophysics textbooks have been published that are targeted at a biologically literate audience. With a few exceptions, it is only relatively recently that biophysics has started to be recognized as a physical science and integrated into physics departments’ curr- ula, sometimes under the new name of biological physics. In this period of cryst- lization and possible rede?nition of biophysics, there still exists some uncertainty as to what biophysics might actually represent. A particular tendency among phy- cists is to associate biophysics research with the development of powerful new te- niques that should eventually be used not by physicists to study physical processes in living matter, but by biologists in their biological investigations. There is value in that judgment, and excellent books have been published that introduce the int- ested reader to the use of physical principles for the development of new methods of investigation in life sciences.

Author : Paul C. Bressloff
Publisher : Springer Nature
Page : 773 pages
File Size : 46,8 Mb
Release : 2022-01-04
Category : Mathematics
ISBN : 9783030725150

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Stochastic Processes in Cell Biology by Paul C. Bressloff Pdf

This book develops the theory of continuous and discrete stochastic processes within the context of cell biology. In the second edition the material has been significantly expanded, particularly within the context of nonequilibrium and self-organizing systems. Given the amount of additional material, the book has been divided into two volumes, with volume I mainly covering molecular processes and volume II focusing on cellular processes. A wide range of biological topics are covered in the new edition, including stochastic ion channels and excitable systems, molecular motors, stochastic gene networks, genetic switches and oscillators, epigenetics, normal and anomalous diffusion in complex cellular environments, stochastically-gated diffusion, active intracellular transport, signal transduction, cell sensing, bacterial chemotaxis, intracellular pattern formation, cell polarization, cell mechanics, biological polymers and membranes, nuclear structure and dynamics, biological condensates, molecular aggregation and nucleation, cellular length control, cell mitosis, cell motility, cell adhesion, cytoneme-based morphogenesis, bacterial growth, and quorum sensing. The book also provides a pedagogical introduction to the theory of stochastic and nonequilibrium processes – Fokker Planck equations, stochastic differential equations, stochastic calculus, master equations and jump Markov processes, birth-death processes, Poisson processes, first passage time problems, stochastic hybrid systems, queuing and renewal theory, narrow capture and escape, extreme statistics, search processes and stochastic resetting, exclusion processes, WKB methods, large deviation theory, path integrals, martingales and branching processes, numerical methods, linear response theory, phase separation, fluctuation-dissipation theorems, age-structured models, and statistical field theory. This text is primarily aimed at graduate students and researchers working in mathematical biology, statistical and biological physicists, and applied mathematicians interested in stochastic modeling. Applied probabilists should also find it of interest. It provides significant background material in applied mathematics and statistical physics, and introduces concepts in stochastic and nonequilibrium processes via motivating biological applications. The book is highly illustrated and contains a large number of examples and exercises that further develop the models and ideas in the body of the text. It is based on a course that the author has taught at the University of Utah for many years.

Author : Liam Graham
Publisher : Springer Nature
Page : 277 pages
File Size : 50,7 Mb
Release : 2023-11-02
Category : Mathematics
ISBN : 9783031386817

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Molecular Storms by Liam Graham Pdf

“Following in the footsteps of Stephen Hawking's ‘A brief history of time’ and Simon Singh's ‘Fermat’s Last Theorem’ this exceptionally accessible book will you leave marveling at the wonders of the world and, if you didn't listen to your science teachers, wishing you had. Graham writes with the mind of a physicist and the soul of a poet.” Nicki Hayes, CCO, The Communications Practice, author of First Aid for Feelings. “Only a few writers have managed to turn the highly technical jargon of science into language accessible for interested lay readers. Isaac Asimov showed us how it could be done, and Carl Zimmer and Brian Greene are continuing today. In Molecular Storms, his first book, Liam Graham has shown that he has the essential quality required to join this group, a love of first learning then explaining how the universe works." David Deamer, Professor of Biomolecular Engineering, University of California, Santa Cruz, author of Assembling Life. Why is the universe the way it is? Wherever we look, we find ordered structures: from stars to planets to living cells. This book shows that the same driving force is behind structure everywhere: the incessant random motion of the components of matter. Physicists call it thermal noise. Let’s call it the molecular storm. This storm drives the fusion reactions that make stars shine. It drives whirlpools and currents in atmospheres and oceans. It spins and distorts molecules until they are in the right orientation to react and form new substances. In living cells, it drives proteins to fold and molecules to self-assemble. It is behind every detail of the astonishing molecular machines that control cellular processes. Using cutting-edge research, “Molecular Storms” takes us on a dazzling journey from the early universe to the interior of the smallest living things. There, in a nanoscale world of biological devices, it explains the physics behind the chemical system which we call Life. Whether you're someone with a general interest in science or a student looking to add context to your studies, this book is for you. "Molecular Storms" is an accessible and captivating read that will deepen your appreciation of the power of science to explain the world.

Author : Franklin M. Harold
Publisher : Oxford University Press
Page : 320 pages
File Size : 51,9 Mb
Release : 2001-06-21
Category : Science
ISBN : 9780198030881

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The Way of the Cell by Franklin M. Harold Pdf

What is life? Fifty years after physicist Erwin Schrodinger posed this question in his celebrated and inspiring book, the answer remains elusive. In The Way of the Cell, one of the world's most respected microbiologists draws on his wide knowledge of contemporary science to provide fresh insight into this intriguing and all-important question. What is the relationship of living things to the inanimate realm of chemistry and physics? How do lifeless but special chemicals come together to form those intricate dynamic ensembles that we recognize as life? To shed light on these questions, Franklin Harold focuses here on microorganisms--in particular, the supremely well-researched bacterium E. coli--because the cell is the simplest level of organization that manifests all the features of the phenomenon of life. Harold shows that as simple as they appear when compared to ourselves, every cell displays a dynamic pattern in space and time, orders of magnitude richer than its elements. It integrates the writhings and couplings of billions of molecules into a coherent whole, draws matter and energy into itself, constructs and reproduces its own order, and persists in this manner for numberless generations while continuously adapting to a changing world. A cell constitutes a unitary whole, a unit of life, and in this volume one of the leading authorities on the cell gives us a vivid picture of what goes on within this minute precinct. The result is a richly detailed, meticulously crafted account of what modern science can tell us about life as well as one scientist's personal attempt to wring understanding from the tide of knowledge.

Author : Mikhail Vladimirovich Volʹkenshteĭn
Publisher : Springer
Page : 540 pages
File Size : 47,8 Mb
Release : 1970
Category : Gardening
ISBN : UOM:39015004323625

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Molecules and Life by Mikhail Vladimirovich Volʹkenshteĭn Pdf

acids. The achievements of molecular biology testify to the success of material science in a realm which, until recently, appeared totally enig matic and mysterious. Further scientific developments should bring to mankind vast developments both in theoretical knowledge and in practical applications, namely, in agriculture, medicine, and technology. The purpose of this book is to explain molecular biophysics to all who might wish to learn about it, to biologists, to physicists, to chemists. This book contains descriptive sections, as well as sections devoted to rigorous mathematical treatment ofa number of problems, some of which have been studied by the author and his collaborators. These sections may be omitted during a first reading. Each chapter has a selected bibliography. This book is far from an exhaustive treatise on molecular biophysics. It deals principally with questions related to the structures and functions of proteins and nucleic acids. M. V. Vol'kenshtein Leningrad, September, 1964 CONTENTS Chapter 1 Physics and Biology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Physics and Life. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Molecular Physics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Molecular Biophysics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Thermodynamics and Biology. . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Information Theory. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Chapter 2 Cells, Viruses, and Heredity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 The Living Cell. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Cell Division. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 Viruses and Bacteriophages . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44 Basic Laws of Genetics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 Mutations and Mutability. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60 Genetics of Bacteria and Phages . . . . . . . . . . . . . . . . . . . . . . . . . . 66 Chapter 3 Biological Molecules. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 Amino Acids and Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 Asymmetry of Biological Molecules . . . . . . . . . . . . . . . . . . . . . . . 87 Primary Structure of Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . 94 Nucleic Acids. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101 Some Biochemical Processes in the Cell. . . . . . . . . . . . . . . . . . . . 109 Chapter 4 Physics of Macromolecules. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123 Physical Properties of Macromolecules . . . . . . . . . . . . . . . . . . . .

Author : Mikhail V Vol Kenshtein
Publisher : Unknown
Page : 528 pages
File Size : 43,8 Mb
Release : 1974-04-01
Category : Electronic
ISBN : 1461585953

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Molecules and Life by Mikhail V Vol Kenshtein Pdf

Author : Daniel M. Zuckerman
Publisher : CRC Press
Page : 356 pages
File Size : 55,5 Mb
Release : 2010-06-02
Category : Mathematics
ISBN : 9781420073799

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Statistical Physics of Biomolecules by Daniel M. Zuckerman Pdf

From the hydrophobic effect to protein-ligand binding, statistical physics is relevant in almost all areas of molecular biophysics and biochemistry, making it essential for modern students of molecular behavior. But traditional presentations of this material are often difficult to penetrate. Statistical Physics of Biomolecules: An Introduction brin

Author : Ron Milo,Rob Phillips
Publisher : Garland Science
Page : 400 pages
File Size : 42,8 Mb
Release : 2015-12-07
Category : Science
ISBN : 9781317230694

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Cell Biology by the Numbers by Ron Milo,Rob Phillips Pdf

A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Division on Engineering and Physical Sciences,Board on Physics and Astronomy,Solid State Sciences Committee,Committee on Biomolecular Materials and Processes
Publisher : National Academies Press
Page : 170 pages
File Size : 54,9 Mb
Release : 2008-06-17
Category : Science
ISBN : 9780309134293

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Inspired by Biology by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Division on Engineering and Physical Sciences,Board on Physics and Astronomy,Solid State Sciences Committee,Committee on Biomolecular Materials and Processes Pdf

Scientists have long desired to create synthetic systems that function with the precision and efficiency of biological systems. Using new techniques, researchers are now uncovering principles that could allow the creation of synthetic materials that can perform tasks as precise as biological systems. To assess the current work and future promise of the biology-materials science intersection, the Department of Energy and the National Science Foundation asked the NRC to identify the most compelling questions and opportunities at this interface, suggest strategies to address them, and consider connections with national priorities such as healthcare and economic growth. This book presents a discussion of principles governing biomaterial design, a description of advanced materials for selected functions such as energy and national security, an assessment of biomolecular materials research tools, and an examination of infrastructure and resources for bridging biological and materials science.

Author : Helmut Schiessel
Publisher : CRC Press
Page : 420 pages
File Size : 41,8 Mb
Release : 2013-12-20
Category : Science
ISBN : 9789814241656

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Biophysics for Beginners by Helmut Schiessel Pdf

Biophysics is a new way of looking at living matter. It uses quantitative experimental and theoretical methods to open a new window for studying and understanding life processes. This textbook gives compact introductions to the basics of the field, including molecular cell biology and statistical physics. It then presents in-depth discussions of more advanced biophysics subjects, progressing to state-of-the-art experiments and their theoretical interpretations. The book is unique by offering a general introduction to biophysics, yet at the same time restricting itself to processes that occur inside the cell nucleus and that involve biopolymers (DNA, RNA, and proteins). This allows for an accessible read for beginners and a springboard for specialists who wish to continue their study in more detail.

Author : Meyer B. Jackson
Publisher : Cambridge University Press
Page : 536 pages
File Size : 54,8 Mb
Release : 2006-01-12
Category : Science
ISBN : 052162441X

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Molecular and Cellular Biophysics by Meyer B. Jackson Pdf

Molecular and Cellular Biophysics provides advanced undergraduate and graduate students with a foundation in the basic concepts of biophysics. Students who have taken physical chemistry and calculus courses will find this book an accessible and valuable aid in learning how these concepts can be used in biological research. The text provides a rigorous treatment of the fundamental theories in biophysics and illustrates their application with examples. Conformational transitions of proteins are studied first using thermodynamics, and subsequently with kinetics. Allosteric theory is developed as the synthesis of conformational transitions and association reactions. Basic ideas of thermodynamics and kinetics are applied to topics such as protein folding, enzyme catalysis and ion channel permeation. These concepts are then used as the building blocks in a treatment of membrane excitability. Through these examples, students will gain an understanding of the general importance and broad applicability of biophysical principles to biological problems.

Author : Subrata Pal
Publisher : Academic Press
Page : 518 pages
File Size : 44,9 Mb
Release : 2019-08-13
Category : Science
ISBN : 9780128148563

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Fundamentals of Molecular Structural Biology by Subrata Pal Pdf

Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche. Provides a current and easily digestible resource on molecular structural biology, discussing both foundations and the latest advances Addresses critical issues surrounding macromolecular structures, such as structure-based drug discovery, single-particle analysis, computational molecular biology/molecular dynamic simulation, cell signaling and immune response, macromolecular assemblies, and systems biology Presents discussions that ultimately lead the reader toward a more detailed understanding of the basis and origin of disease