Platelet Function

Author : Martin Quinn,Desmond Fitzgerald,Dermott Cox
Publisher : Springer Science & Business Media
Page : 398 pages
File Size : 46,7 Mb
Release : 2007-11-13
Category : Medical
ISBN : 9781592599172

Get Book

Platelet Function by Martin Quinn,Desmond Fitzgerald,Dermott Cox Pdf

A cutting-edge review of the latest findings on the complexities of platelet function and the various means of inhibiting platelet clot formation. The authors delineate an up-to-date picture of platelet biology and describe methods for assessing platelet function, including the commonly used platelet aggregation, thromboxane production, procoagulant function, platelet function under flow, and the expression of platelet activation markers. The focus is both on the technology and the outcome of research on platelets, including the fast developing fields of proteomics and genomics and their application to platelet research. The clinical applications of the various methods for the assessment of platelet function in vivo, as well as antiplatelet therapy, are fully discussed.

Author : Alan D. Michelson
Publisher : Elsevier
Page : 1386 pages
File Size : 51,5 Mb
Release : 2011-08-29
Category : Medical
ISBN : 9780080465869

Get Book

Platelets by Alan D. Michelson Pdf

Platelets, Second Edition is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. First edition won Best Book in Medical Science Award from the Association of American Publishers Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references

Author : Pier Mannuccio Mannucci,Sergio Gorini
Publisher : Springer
Page : 384 pages
File Size : 53,9 Mb
Release : 1972
Category : Medical
ISBN : UCAL:B4530689

Get Book

Platelet Function and Thrombosis by Pier Mannuccio Mannucci,Sergio Gorini Pdf

The special contribution of the present volume is that of gathering a large amount of up-to-date information on the formidable problem of the methods used for testing platelet function in thrombosis. The methods used for studying platelet behavior in hemorrhagic disorders due to abnormal platelet function are undoubtedly characterized by difficulties in interpretation and by poor reproducibility. However, all will agree that the problem of the significance and importance of platelet function tests in thrombosis and atherosclerosis is an absolute "morass," and recent and past papers on the measurement of platelet adhesiveness in myocardial infarction could well appear in a special issue of the new "Journal of Irreproducible Results". This volume includes both general papers on the role of platelets in thrombosis by G. V. R. Born, Duncan P. Thomas, and J. R.

Author : Asim K. Duttaroy
Publisher : John Wiley & Sons
Page : 262 pages
File Size : 41,5 Mb
Release : 2018-06-05
Category : Technology & Engineering
ISBN : 9781119376019

Get Book

Nutraceuticals and Human Blood Platelet Function by Asim K. Duttaroy Pdf

A comprehensive review of the impact of dietary nutraceuticals on platelet function and its relationship to cardiovascular disease Nutraceuticals and Human Blood Platelet Function offers a summary of the most current evidence on the effects of anti-platelet factors isolated mainly from food and natural sources, their structure function relationship, bioavailability, mechanisms of actions, and also information on human trials data. The author—a noted expert in the field— explores platelet function and their roles in development of CVD, functional foods and bioactive compounds in CVD risk factors. The author highlights platelets, their mechanisms of actions, data from epidemiological studies, structure-function relationship clinical trial data, ex vivo and in vitro data. This important resource will focus primarily on human studies and emphasize functional and physiological implications of the nutritional impact on platelet function and CVD that could be an important approach to highlight the concept of preventive CVD nutrition. An authoritative text, Nutraceuticals and Human Blood Platelet Function: Offers a unique resource that connects nutrition with platelet function and its impact on cardiovascular disease Contains an evidenced-based approach, including data from human and animal clinical studies Reveals the impact of bioactive compounds and their effect on platelets Presents a text that is authored by an expert with vast experience in the field of nutrition and platelet function Written for professionals, academics, researchers, and students associated in the area of nutrition, Nutraceuticals and Human Blood Platelet Function offers a review of the most current research on the effects of platelet function and their roles in development of CVD, functional foods and bioactive compounds in CVD risk factors.

Author : Alan D. Michelson
Publisher : Academic Press
Page : 1399 pages
File Size : 43,6 Mb
Release : 2013-01-09
Category : Medical
ISBN : 9780123878373

Get Book

Platelets by Alan D. Michelson Pdf

Platelets - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. Highly Commended BMA Medical Book Award 2013: Internal Medicine Comprehensive and definitive source of knowledge about platelets for clinicians, pathologists and scientists Integrates the entire field of platelet biology, pathophysiology, and clinical medicine Full color reference comprising 64 chapters, 1400 pages, and 16,000 references Contributions from 126 world leaders in their fields New chapters on topics such as the regulation of platelet life span, platelet microRNAs, GPVI and CLEC-2, monitoring of antiplatelet therapy, novel antiplatelet therapy, and making platelets ex vivo

Author : Paolo Gresele,Neal S. Kleiman,José A. Lopez,Clive P. Page
Publisher : Springer
Page : 1445 pages
File Size : 52,5 Mb
Release : 2017-03-08
Category : Medical
ISBN : 9783319474625

Get Book

Platelets in Thrombotic and Non-Thrombotic Disorders by Paolo Gresele,Neal S. Kleiman,José A. Lopez,Clive P. Page Pdf

This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.

Author : Steve W. Kerrigan,Niamh Moran
Publisher : BoD – Books on Demand
Page : 250 pages
File Size : 46,8 Mb
Release : 2015-11-18
Category : Medical
ISBN : 9789535122081

Get Book

The Non-Thrombotic Role of Platelets in Health and Disease by Steve W. Kerrigan,Niamh Moran Pdf

Platelets play a key role in thrombosis and haemostasis. However recent evidence clearly demonstrates that the functional role of platelets extends to many other processes in the body. With an internationally recognised list of contributing authors, The Non-Thrombotic Role of Platelets in Health and Disease, is a unique and definitive source of state-of-the-art knowledge about the additional role of platelets outside thrombosis and haemostasis. The intended audience for The Non-Thrombotic Role of Platelets in Health and Disease includes platelet biologists, microbiologists, immunologists, haematologists, oncologists, respiratory physicians, cardiologists, neurobiologists, tissue engineers, as well as students and fellows in these areas.

Author : Robert Fitridge,M. M. Thompson
Publisher : University of Adelaide Press
Page : 589 pages
File Size : 43,7 Mb
Release : 2011
Category : Medical
ISBN : 9781922064004

Get Book

Mechanisms of Vascular Disease by Robert Fitridge,M. M. Thompson Pdf

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Author : Jun Teruya
Publisher : Springer Nature
Page : 461 pages
File Size : 53,6 Mb
Release : 2021-01-05
Category : Medical
ISBN : 9783030563387

Get Book

Management of Bleeding Patients by Jun Teruya Pdf

This latest edition provides a comprehensive, state-of-the-art overview of the major issues specific to managing bleeding patients. Like the previous edition, the sections of this new edition have been structured to review the overall scope of issues, among them bleeding associated with disease condition, bleeding from specific organs, bleeding associated with medication, and bleeding associated with procedures. In addition to thoroughly revised and updated chapters from the previous edition, the latest edition features new chapters on such topics as the basics of hemostasis, bleeding due to rare coagulation factor deficiencies, bleeding associated with connective tissue disorders, massive transfusion protocol, bleeding associated with ventricular assist device, and evaluation of bleeding risk prior to invasive procedures. The volume also includes brief etiology and a practical reference guide regarding type of blood components, medication, dose, and duration. Written by authors from a variety of integrated disciplines, Management of Bleeding Patients, Second Edition is a valuable resource for clinicians working in the area of bleeding management.

Author : Beth H. Shaz,Christopher D. Hillyer,Mikhail Roshal,Charles S. Abrams
Publisher : Newnes
Page : 1014 pages
File Size : 51,9 Mb
Release : 2013-05-13
Category : Science
ISBN : 9780123977885

Get Book

Transfusion Medicine and Hemostasis by Beth H. Shaz,Christopher D. Hillyer,Mikhail Roshal,Charles S. Abrams Pdf

The second edition of Transfusion Medicine and Hemostasis continues to be the only "pocket-size" quick reference for pathology residents and transfusion medicine fellows. It covers all topics in blood banking, transfusion medicine, and clinical and laboratory based coagulation. Short, focused chapters, organized by multiple hierarchical headings, are supplemented with up to 10 suggested reading citations. This single reference covers essentially all the topics required to meet the goals and objectives of a major program in transfusion medicine and clinical coagulation. New chapters in the coagulation testing section reflect the development of new tests available and their incorporation into clinical practice. Coverage includes essential updates on the importance of new cellular therapies, peripheral blood and bone marrow hematopoietic progenitor cells, as well as cord blood banking and regenerative medicine. The authors also examine advances in the understanding of molecular testing and pathogen reduction in two separate quality control chapters (one for blood centers and one for hospitals). Updated content covers new coagulation tests, cellular therapies, and quality control issues Easy to use, with focused, well-defined chapters in a standardized format throughout Offers quick "cross-reference" lists at the end of each chapter Includes lists of common abbreviations and indexes that cross reference diagnostic, clinical and therapeutic commonalities

Author : Melanie McCabe White,Lisa K. Jennings
Publisher : Elsevier
Page : 131 pages
File Size : 51,6 Mb
Release : 1999-04-21
Category : Science
ISBN : 9780080539126

Get Book

Platelet Protocols by Melanie McCabe White,Lisa K. Jennings Pdf

Platelets are fragments of blood cells that occur in the blood of vertebrates and are associated with blood clotting. Scientists have made great strides in recent years in understanding what stimulates platelets to form blood clots at the molecular level and in developing drugs to inhibit platelet action. Their work has a direct effect on millions of people who deal with cardiovascular disease, strokes, surgery, physical trauma, and other conditions. While references to platelet function have been included in some large texts, there has not been a basic reference manual that researchers and clinicians can use in their daily work until now. Platelet Protocols fills the need for a straightforward and comprehensive laboratory manual on current procedures for evaluating and analyzing platelet function and abnormalities. It is an easy-to-read, understandable resource which can be kept at the bench and referred to frequently by scientists, clinicians, and laboratory staff involved in platelet related areas. Topics range from the basics of anticoagulants to the latest developments in platelet testing. Includes: A basic introduction to platelet anatomy and physiology Testing procedures for new anti-platelet therapies Descriptions of platelet function abnormalities Therapeutic approaches to inhibition of platelet function Step-by-step methodologies with clear explanations Helpful appendixes of recipes, instructions, sources of reagents, and more

Author : Gesina Longenecker
Publisher : Elsevier
Page : 508 pages
File Size : 53,9 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323147705

Get Book

The Platelets by Gesina Longenecker Pdf

The Platelets: Physiology and Pharmacology is a critical review of the basic platelet systems, methodologic critiques, and platelet involvement in major disease states. This book is composed of 20 chapters that specifically deal with the physiology and biochemistry of the platelet system, along with possibilities for, and consequences of, pharmacologic manipulation. The opening chapters examine the basic processes of platelet aggregation and adhesion. These topics are followed by discussions on the types and functions of platelet a-granule proteins; the aspects of adenine nucleotide levels, regulation, and storage; and receptors for catecholamines and consequences of their agonism. Other chapters are devoted to the metabolism of arachidonic acid, its manipulation, consequences, and metabolite receptors. The discussion then shifts to the second-messenger entities, specifically calmodulin, calcium, and cyclic adenosine monophosphate. A chapter presents the comparisons of man and commonly used laboratory animals concerning platelet behavior variability. Another chapter looks into the use and appropriateness of the use of platelets as models of neurons, with a special emphasis on serotonergic neurons. The remaining chapters contain critical reviews of platelet involvement in diabetes, hypertension and peripheral vascular disease, atherogenesis/atherosclerosis, and ischemic heart disease. These chapters also include specific techniques for platelet analysis, including lumiaggregometry, eicosanoid measurements, and serotonin uptake and release. This book is an invaluable source for pharmacologists, biochemists, researchers, and clinicians who are interested in platelet involvement in disease.

Author : Jonathan M. Gibbins,Martyn P. Mahaut-Smith
Publisher : Springer Science & Business Media
Page : 389 pages
File Size : 40,6 Mb
Release : 2008-02-04
Category : Medical
ISBN : 9781592597826

Get Book

Platelets and Megakaryocytes by Jonathan M. Gibbins,Martyn P. Mahaut-Smith Pdf

12 The average human body has in the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1.

Author : H. James Day,Holm Holmsen,Marjorie Bass Zucker
Publisher : Unknown
Page : 768 pages
File Size : 44,7 Mb
Release : 1978
Category : Blood platelet aggregation
ISBN : PURD:32754081210498

Get Book

Platelet Function Testing by H. James Day,Holm Holmsen,Marjorie Bass Zucker Pdf

Author : Laurence A. Harker,Theodore S. Zimmerman
Publisher : Unknown
Page : 264 pages
File Size : 51,9 Mb
Release : 1983
Category : Medical
ISBN : UOM:39015006704723

Get Book

Measurements of Platelet Function by Laurence A. Harker,Theodore S. Zimmerman Pdf