Polymeric Micelles Principles Perspectives And Practices

Author : Sachin Kumar Singh,Monica Gulati,Srinivas Mutalik,Muralikrishnan Dhanasekaran,Kamal Dua
Publisher : Springer Nature
Page : 302 pages
File Size : 40,5 Mb
Release : 2023-04-08
Category : Medical
ISBN : 9789819903610

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Polymeric Micelles: Principles, Perspectives and Practices by Sachin Kumar Singh,Monica Gulati,Srinivas Mutalik,Muralikrishnan Dhanasekaran,Kamal Dua Pdf

This book thoroughly reviews the advancements in design and applications of Polymeric Micelles (PMs) in drug delivery. It provides information on the synthesis of amphiphilic block copolymers and their types, functional chemistry for targeting and sensing, and biomedical applications. The book further provides the possibilities for designing PMs in a range of drug delivery approaches. The book addresses the molecular parameters of amphiphilic block copolymers that are required for functionalizing PMs for drug delivery applications. Additionally, the book presents recent advances in applications of PMs such as co-delivery, sensing, theranostics, delivery of nucleic acids, and proteins. Towards the end, it discusses different physico-chemical strategies to enhance the stability and drug retention of polymeric micelles and reviews the preclinical and clinical toxicity and immunogenicity-related aspects of polymeric micelles. This book is an invaluable source for academics, research, and industry professionals working in the field of polymeric micelles and drug delivery.

Author : Neeraj Mishra,Vikas Pandey
Publisher : Springer Nature
Page : 440 pages
File Size : 41,7 Mb
Release : 2023-11-29
Category : Medical
ISBN : 9789819969173

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Block Co-polymeric Nanocarriers: Design, Concept, and Therapeutic Applications by Neeraj Mishra,Vikas Pandey Pdf

This book focuses on current advancements in the field of block copolymers and covers design, concept, and various therapeutic applications in the drug delivery. It also reviews the use of block copolymers in drug delivery applications from the development of sustained release products to smart polymeric delivery systems such as stimuli-responsive polymeric systems, for example, thermosensitive, redox-sensitive, photo-sensitive, and enzyme-sensitive. The book further discusses the nano assemblies from amphiphilic block copolymers as nanomedicine platforms for diagnosis and therapy due to their relatively small size, high drug loading capacity, controlled drug release, in vivo stability, and prolonged blood circulation. The chapters also review the various patents and ongoing clinical trials on the applications, covering several important new concepts and findings in the field of block copolymers. The book is aimed at researchers, academicians, and industrial scientists involved in the development of drug-delivery systems based on polymers.

Author : Shin-ichi Yusa,Pratap Bahadur,Hideki Matsuoka,Takahiro Sato
Publisher : MDPI
Page : 229 pages
File Size : 40,6 Mb
Release : 2018-04-20
Category : Electronic book
ISBN : 9783038428077

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Polymer Micelles by Shin-ichi Yusa,Pratap Bahadur,Hideki Matsuoka,Takahiro Sato Pdf

This book is a printed edition of the Special Issue "Polymer Micelles" that was published in Polymers

Author : Morteza Rasoulianboroujeni
Publisher : Unknown
Page : 0 pages
File Size : 42,8 Mb
Release : 2023
Category : Electronic
ISBN : OCLC:1427256104

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New Insights Into the Fabrication of Drug-loaded Polymeric Micelles by Morteza Rasoulianboroujeni Pdf

This study aimed to develop a safe and scalable method for fabricating drug-loaded polymeric micelles while addressing the challenges of long-term storage. Current fabrication methods present serious challenges in the development procedure, including the utilization of toxic solvents, the requirement for specialized equipment, and difficulties in solid form production. We hypothesized that by utilizing low molecular weight PEGs, known for their ability to dissolve hydrophobic drugs at elevated temperatures, as an alternative solvent, these challenges could be overcome in the production of drug-loaded micelles.We first focused on investigating micelle formation in a copolymer/PEG/water mixture using a model based on mean-field lattice theory. The model considered the free energy and translational entropy of the micelles, revealing the existence of entropy-driven liquid-liquid phase separation (LLPS) preceding micelle formation. This event can be controlled by varying the degree of polymerization. Experimental validation confirmed the accuracy of the model using PEG4kDa-b-PLA2.2kDa as the copolymer and PEG as the solvent. Building on this system, we introduced the "PEG-assist" method for fabricating drug-loaded polymeric micelles by hydrating a mixture of PEG, copolymer, and drug. The properties of the resulting micelles were influenced by the molecular weight of PEG and temperature, both areknown to impact LLPS and solvation power of PEG. The method's adaptability to other drugs and copolymers, scalability, freeze-drying feasibility, and stability were also proved. Furthermore, we proposed a formulation strategy for producing drug-loaded polymeric micelles directly from solid drug-loaded copolymer crystals. The crystals formed through crystallization from a supersaturated solution of the copolymer and drug in low molecular weight PEG. Parameters like PEG molecular weight and crystallization conditions were found to impact the formation of drug-loaded micelles through hydration and the properties of the resulting micelles. In summary, this study presents a comprehensive approach for fabricating drug-loaded polymeric micelles from a physical chemistry perspective, providing alternatives to current fabrication methods.

Author : Maulin P. Shah,Navneeta Bharadvaja,Lakhan Kumar
Publisher : Springer Nature
Page : 501 pages
File Size : 52,7 Mb
Release : 2024-01-03
Category : Science
ISBN : 9783031459566

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Biogenic Nanomaterials for Environmental Sustainability: Principles, Practices, and Opportunities by Maulin P. Shah,Navneeta Bharadvaja,Lakhan Kumar Pdf

Environmental pollution is a worldwide concern now. A major section of the world population is struggling for drinking water. Polluted soil is resulting into low agricultural productivity and thus creating challenges in the way of sustainable livelihood of a large section of human population. Biological treatment can offer both green solutions for wastewater treatment and resource recovery as well. Like algal-based systems can be utilized for wastewater treatment and production of biofuels from the biomass grown on the wastewater. Bio-based nanomaterials have been extensively studied for their employability in the health care, process optimization, water resource management, dealing with environmental pollutants, biosensors, and many others. Bioprospecting of novel biological agents, bio-based products, and bioresource recovery are paving the way for sustainable development as they are providing local solutions for a number of problems. In this proposed book, we start with the introduction to bio-nanotechnological principles and later on discuss bio-based nanomaterials employability for a diverse range of applications from environment to energy to health care. This book provides with current trends in bio-nanotechnology for anthropogonic purposes, prospects, challenges, and way forward.

Author : Monica L. Adams
Publisher : Unknown
Page : 174 pages
File Size : 42,6 Mb
Release : 2003
Category : Drug carriers (Pharmacy)
ISBN : WISC:89079546867

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Chemically Tailored Polymeric Micelles for Drug Delivery by Monica L. Adams Pdf

Author : Richard G Jones,Edward S Wilks,W. Val Metanomski,Jaroslav Kahovec,Michael Hess,Robert Stepto,Tatsuki Kitayama
Publisher : Royal Society of Chemistry
Page : 464 pages
File Size : 41,6 Mb
Release : 2009-01-19
Category : Science
ISBN : 9781847559425

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Compendium of Polymer Terminology and Nomenclature by Richard G Jones,Edward S Wilks,W. Val Metanomski,Jaroslav Kahovec,Michael Hess,Robert Stepto,Tatsuki Kitayama Pdf

The IUPAC system of polymer nomenclature has aided the generation of unambiguous names that re ect the historical development of chemistry. However, the explosion in the circulation of information and the globalization of human activities mean that it is now necessary to have a common language for use in legal situations, patents, export-import regulations, and environmental health and safety information. Rather than recommending a ‘unique name’ for each structure, rules have been developed for assigning ‘preferred IUPAC names’, while continuing to allow alternatives in order to preserve the diversity and adaptability of nomenclature. Compendium of Polymer Terminology and Nomenclature is the only publication to collect the most important work on this subject into a single volume. It serves as a handy compendium for scientists and removes the need for time consuming literature searches. One of a series issued by the International Union of Pure and Applied Chemistry (IUPAC), it covers the terminology used in many and varied aspects of polymer science as well as the nomenclature of several di erent types of polymer including regular and irregular single-strand organic polymers, copolymers and regular double-strand (ladder and spiro) organic polymers.

Author : Stephen L. Rosen
Publisher : Wiley-Interscience
Page : 456 pages
File Size : 45,7 Mb
Release : 1993
Category : Science
ISBN : UOM:39015029226076

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Fundamental Principles of Polymeric Materials by Stephen L. Rosen Pdf

Expanded discussion of extended-chain crystals and their commercial developments; phase behavior in polymer-solvent systems; and three-dimensional stress and strain introduction to the Flory-Huggins theory; the "modified Cross" model; and Tobolsky's "Procedure X" for extracting discrete relaxation times and moduli from data. New sections on scaleup calculations for the laminar flow of non-Newtonian fluids; liquid-crystal polymers; and group-transfer polymerization, including a quantitative treatment of Ziegler-Natta polymerization with worked-out examples. All kinetic expressions are written in terms of conversions (rather than monomer concentration) for greater generality and ease of application. Kinetic expressions incorporate the possibility of a variable-volume reaction mass, and feature new examples to illustrate the effects of variable volume.

Author : Steven John Abbott
Publisher : Unknown
Page : 0 pages
File Size : 51,5 Mb
Release : 2017
Category : Emulsions
ISBN : 1605954845

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Surfactant Science by Steven John Abbott Pdf

A concise and practical reference for understanding surfactant systems Offers original formulas and phase diagrams for improved surfactant design and performance¿ Equations related to online computer apps allow readers to test their own data Written in a conversational form, with a focus on real-world problems and troubleshooting Applications to detergents, coatings, cosmetics, soil and water remediation, and biosurfactants Full chapter included on foam and anti-foam science

Author : Raj K. Keservani,Anil K. Sharma
Publisher : CRC Press
Page : 422 pages
File Size : 46,8 Mb
Release : 2019-01-23
Category : Medical
ISBN : 9781351137256

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Nanoparticulate Drug Delivery Systems by Raj K. Keservani,Anil K. Sharma Pdf

Focusing on nanoparticulate nanocarriers and recent advances in the field of drug delivery, the volume begins with chapters that provide an informative introduction to polymeric nanoparticles—their general physicochemical features and characteristics, their applications in drug delivery systems, and the challenges involved. Specific applications are discussed, with attention paid to treatment of particular diseases and disorders and the targeting of specific organs. Part 2 looks at more specific applications and techniques of nanoparticulate nanocarriers for drug delivery, such as the use of magnetic nanoparticles, gold nanoparticles in therapeutics, and superparamagnetic iron oxide nanoparticles (SPIONs) for the treatment of cancer. Part 3 discusses lipid-based nanoparticulates for various applications, including skin care. The last section of the book explores some of the newer nanoarchitectures, including dendrimers in gene delivery and carbon nanotubes for drug delivery. Together, the insightful research presented here provides valuable information for those involved in this area, including scientists and researchers and faculty and upper-level students, as well as for industry professionals.

Author : George Odian
Publisher : John Wiley & Sons
Page : 850 pages
File Size : 49,7 Mb
Release : 2004-02-09
Category : Technology & Engineering
ISBN : 9780471274001

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Principles of Polymerization by George Odian Pdf

The new edition of a classic text and reference The large chains of molecules known as polymers are currently used in everything from "wash and wear" clothing to rubber tires to protective enamels and paints. Yet the practical applications of polymers are only increasing; innovations in polymer chemistry constantly bring both improved and entirely new uses for polymers onto the technological playing field. Principles of Polymerization, Fourth Edition presents the classic text on polymer synthesis, fully updated to reflect today's state of the art. New and expanded coverage in the Fourth Edition includes: * Metallocene and post-metallocene polymerization catalysts * Living polymerizations (radical, cationic, anionic) * Dendrimer, hyperbranched, brush, and other polymer architectures and assemblies * Graft and block copolymers * High-temperature polymers * Inorganic and organometallic polymers * Conducting polymers * Ring-opening polymer ization * In vivo and in vitro polymerization Appropriate for both novice and advanced students as well as professionals, this comprehensive yet accessible resource enables the reader to achieve an advanced, up-to-date understanding of polymer synthesis. Different methods of polymerization, reaction parameters for synthesis, molecular weight, branching and crosslinking, and the chemical and physical structure of polymers all receive ample coverage. A thorough discussion at the elementary level prefaces each topic, with a more advanced treatment following. Yet the language throughout remains straightforward and geared towards the student. Extensively updated, Principles of Polymerization, Fourth Edition provides an excellent textbook for today's students of polymer chemistry, chemical engineering, and materials science, as well as a current reference for the researcher or other practitioner working in these areas.

Author : David Julian McClements
Publisher : CRC Press
Page : 633 pages
File Size : 48,6 Mb
Release : 2004-12-16
Category : Technology & Engineering
ISBN : 9781420039436

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Food Emulsions by David Julian McClements Pdf

Food Emulsions: Principles, Practice, and Techniques, Second Edition introduces the fundamentals of emulsion science and demonstrates how this knowledge can be applied to better understand and control the appearance, stability, and texture of many common and important emulsion-based foods. Revised and expanded to reflect recent developments, this s

Author : Munmaya Mishra
Publisher : CRC Press
Page : 1516 pages
File Size : 41,7 Mb
Release : 2015-12-01
Category : Medical
ISBN : 9781482232349

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Handbook of Encapsulation and Controlled Release by Munmaya Mishra Pdf

The field of encapsulation, especially microencapsulation, is a rapidly growing area of research and product development. The Handbook of Encapsulation and Controlled Release covers the entire field, presenting the fundamental processes involved and exploring how to use those processes for different applications in industry. Written at a level comp

Author : Ali Demir Sezer
Publisher : BoD – Books on Demand
Page : 400 pages
File Size : 40,9 Mb
Release : 2016-02-10
Category : Medical
ISBN : 9789535122470

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Smart Drug Delivery System by Ali Demir Sezer Pdf

This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Author : Firdos Alam Khan
Publisher : CRC Press
Page : 293 pages
File Size : 54,7 Mb
Release : 2023-09-22
Category : Technology & Engineering
ISBN : 9781000924701

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Materials for Medical Applications by Firdos Alam Khan Pdf

This book discusses advanced knowledge about the synthesis and application of materials in the medical field for diagnostic and therapeutic conditions. These materials have been extensively used in various biological and medical applications, especially in drug delivery, tumor screening, bioimaging, diagnosis, and therapies. Materials for Medical Applications provides comprehensive but concise information about materials and their medical applications. The readers will get information about the trends in materials and their medical applications, as well as current material-based products that are used in the medical field. The book has 11 chapters, where shapes, sizes, and structural differences of materials and methods of synthesis have been described, and a few chapters are also dedicated to the characterization of materials and their medical applications. The book also discusses how materials are tested in research laboratories, preclinical (animal) trials, and clinical (human) trials, and how material-based products go through various regulatory and safety phases before reaching patients. It also discusses topics such as materials delivery, imaging, and treatments for various diseases. It includes a chapter dedicated to regulatory guidelines and policies in the application of nanomaterials and will include current clinical trial information on the materials. Finally, the book has topics such as health safety, toxicity, dosages, and long-term implications of materials. This book is intended for researchers, material scientists, and students in bioengineering, biomedical engineering, and biopharmaceuticals working on the development of biomaterials.