Precision Cancer Therapies Volume 1

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Precision Cancer Therapies, Volume 2: Immunologic Approaches for the Treatment of Lymphoid Malignancies

Owen A. O'Connor,Stephen M. Ansell,John Gribben

Author : Owen A. O'Connor,Stephen M. Ansell,John Gribben
Publisher : John Wiley & Sons
Page : 501 pages
File Size : 44,8 Mb
Release : 2024-04-29
Category : Medical
ISBN : 9781119824541

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Precision Cancer Therapies, Volume 2: Immunologic Approaches for the Treatment of Lymphoid Malignancies by Owen A. O'Connor,Stephen M. Ansell,John Gribben Pdf

Presents timely and authoritative information on the development of precision cancer therapies as applied to hematologic malignancies The Precision Cancer Therapies series focuses on how to understand and translate fundamental basic science into information that can be directly applied to patients to advance care. Each volume of the series integrates the relevant biological concepts and principles necessary for translating this science to practitioners of this science. Precision Cancer Therapies, Volume Two, focuses on sophisticated immunotherapies targeting cancers affecting the blood, bone marrow, and lymph nodes. Edited and authored by the foremost authorities in the field, this comprehensive reference text covers targeting of cell surface receptors, antibody-drug conjugates (ADC), targeting immune checkpoint, targeting macrophages, EBV-directed immunotherapies, tumor-associated antigens (TAA), and chimeric antigen receptor T-cells (CAR-T). Divided into nine sections, Volume Two includes an overview of the history of immunotherapy development in cancer, as well as a concluding section addressing the mechanistic basis and role of immunomodulatory drugs, analytical tools to quantitate immune-mediated effects, and other topics in immunotherapy. Chapters on specific therapeutics or therapeutic classes include a basic explanation of the underlying pathway and target, the pharmacology of the drug/class, relevant preclinical and clinical data, and discussion of clinical management and potential predictive biomarkers of response. This book also: Delivers a definitive, state-of-the-art review of the relevant biology and its importance in the broader context of cancer biology Focuses on agents that mediate cell killing in lymphoma through a variety of immunologic mechanisms Covers FDA-approved drugs and their indications, as well as drugs currently in development Provides information on monotherapy and combination therapy, summary tables of trials, and discussion of toxicity and efficacy Includes boxed sections highlighting major unique points about the information in the chapter Precision Cancer Therapies, Volume Two: Immunologic Approaches for the Treatment of Lymphoid Malignancies, From Concept to Practice is an indispensable resource for medical, scientific, and allied medical professionals, advanced students, and interested general readers with background knowledge in the subject.

Precision Cancer Medicine

Sameek Roychowdhury,Eliezer M. Van Allen

Author : Sameek Roychowdhury,Eliezer M. Van Allen
Publisher : Springer Nature
Page : 196 pages
File Size : 52,7 Mb
Release : 2020-01-02
Category : Medical
ISBN : 9783030236373

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Precision Cancer Medicine by Sameek Roychowdhury,Eliezer M. Van Allen Pdf

Genomic sequencing technologies have augmented the classification of cancer beyond tissue of origin and towards a molecular taxonomy of cancer. This has created opportunities to guide treatment decisions for individual patients with cancer based on their cancer’s unique molecular characteristics, also known as precision cancer medicine. The purpose of this text will be to describe the contribution and need for multiple disciplines working together to deliver precision cancer medicine. This entails a multi-disciplinary approach across fields including molecular pathology, computational biology, clinical oncology, cancer biology, drug development, genetics, immunology, and bioethics. Thus, we have outlined a current text on each of these fields as they work together to overcome various challenges and create opportunities to deliver precision cancer medicine. As trainees and junior faculty enter their respective fields, this text will provide a framework for understanding the role and responsibility for each specialist to contribute to this team science approach.

Precision Medicine in Cancer Therapy

Daniel D. Von Hoff,Haiyong Han

Author : Daniel D. Von Hoff,Haiyong Han
Publisher : Springer
Page : 283 pages
File Size : 42,8 Mb
Release : 2019-06-17
Category : Medical
ISBN : 9783030163914

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Precision Medicine in Cancer Therapy by Daniel D. Von Hoff,Haiyong Han Pdf

This book presents the latest advances in precision medicine in some of the most common cancer types, including hematological, lung and breast malignancies. It also discusses emerging technologies that are making a significant impact on precision medicine in cancer therapy. In addition to describing specific approaches that have already entered clinical practice, the book explores new concepts and tools that are being developed. Precision medicine aims to deliver personalized healthcare tailored to a patient’s genetics, lifestyle and environment, and cancer therapy is one of the areas in which it has flourished in recent years. Documenting the latest advances, this book is of interest to physicians and clinical fellows in the front line of the war on cancer, as well as to basic scientists working in the fields of cancer biology, drug development, biomarker discovery, and biomedical engineering. The contributing authors include translational physicians with first-hand experience in precision patient care.

Advances in Precision Medicine Oncology

Hilal Arnouk,Bassam Hassan

Author : Hilal Arnouk,Bassam Hassan
Publisher : BoD – Books on Demand
Page : 262 pages
File Size : 45,9 Mb
Release : 2021-07-21
Category : Medical
ISBN : 9781839688676

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Advances in Precision Medicine Oncology by Hilal Arnouk,Bassam Hassan Pdf

Recent advances in precision medicine and immuno-oncology have led to highly specific and efficacious cancer therapies such as monoclonal antibodies and immune checkpoint inhibitors (ICIs). This book provides an up-to-date overview of advances in the field of immuno-oncology. Chapters cover such topics as ICIs and how they mount a robust immune response against cancer cells as well as the response of ICIs to treatment predictive biomarkers and their potential immune-related adverse events (irAEs). Additionally, the book includes a comprehensive review of the powerful FDA-approved therapeutic agent doxorubicin, highlighting the molecular mechanisms behind doxorubicin’s drug resistance and critical side effects.

Precision Cancer Therapies, Volume 1

Stephen M. Ansell,John F. Seymour

Author : Stephen M. Ansell,John F. Seymour
Publisher : John Wiley & Sons
Page : 516 pages
File Size : 49,5 Mb
Release : 2023-06-06
Category : Medical
ISBN : 9781119819929

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Precision Cancer Therapies, Volume 1 by Stephen M. Ansell,John F. Seymour Pdf

A Thorough Compilation of the Many Scientific Breakthroughs in the Ongoing Development of Precision Cancer Therapies Related to Lymphoma Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice focuses on lymphoma, an area which has seen a remarkable number of breakthroughs in the ongoing development of precision cancer therapies. Each section on a specific biology or class of drugs has an introductory chapter written by an authority in the field, exclusively focused on the science and its relevance to cancer biology. This approach addresses the need for scientists, physicians, and the private sector to understand the broader context of the extraordinary advances that have produced such astonishing advances in the disease. The work primarily focuses on how to understand and translate fundamental principles of basic science into information that can be directly applied to patients – hence the subtitle, From Concept to Practice. To aid in readers’ comprehension, the first page of each chapter contains a box entitled ‘Take Home Points’. This short text will highlight the major unique points about the information contained within the chapter. Some of the key topics addressed in the work are as follows: Biological basis of the lymphoid malignancies: fundamental principles of lymphomagenesis and molecular classification of lymphoid malignancies Targeting programmed cell death: principles for understanding the many types of cell death and promising combinations of drugs targeting apoptosis Targeting the PI3K pathway: understanding the intricacies of this complex biology and precisely how targeted drugs can be leveraged therapeutically Targeting the cancer epigenome: pharmacologic features of drugs targeting the epigenome and future prospects for targeting various aspects of epigenetic control Targeting the tumour proteome: understanding the mechanisms of protein degradation in cancer including both older drugs like proteasome inhibitors, and newer PROTAC based approaches Written primarily for scientists and physicians in both the public and private sectors, Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies: From Concept to Practice is a comprehensive reference work for those interested in the growing area of Precision Cancer Therapies. Seamlessly integrating the basic and applied science, this volume will be an indispensable reference for those interested in translating the most important advances in science to innovative novel treatments for patients.

Precision Cancer Medicine

Bharat Jasani,Ralf Huss,Clive R. Taylor

Author : Bharat Jasani,Ralf Huss,Clive R. Taylor
Publisher : Springer Nature
Page : 239 pages
File Size : 49,5 Mb
Release : 2022-01-04
Category : Medical
ISBN : 9783030840877

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Precision Cancer Medicine by Bharat Jasani,Ralf Huss,Clive R. Taylor Pdf

This book describes the changing role of pathology in aiding reproducible and accurate patient selection for predictive cancer therapy. Particular attention is given to the clinical application of cutting-edge cancer biomarkers to accurately select patients for targeted cancer therapy and how artificial intelligence can improve the precision of treatments. The advent and basis of predictive cancer care, the role of pathologists in translational cancer research, the analysis of cancer samples, the management of biopsy results, and the accuracy of biopsy results are also discussed. Precision Cancer Medicine: Role of the Pathologist details how pathologists can use the latest biomarkers and apply artificial intelligence technology in cancer diagnosis and management. It is also relevant to oncologists and medical practitioners involved in cancer management seeking an up-to-date resource on the topic.

Problem Solving through Precision Oncology

Peter Selby

Author : Peter Selby
Publisher : EBN Health, an imprint of Evidence-based Networks Ltd
Page : 256 pages
File Size : 49,5 Mb
Release : 2016-11-07
Category : Medical
ISBN : 9781846926532

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Problem Solving through Precision Oncology by Peter Selby Pdf

Winner of the BMA Oncology Book of the Year Award. This practical learning and reference handbook provides an overview of the latest progress in the developing field of precision oncology, plus a ground breaking collection of case studies ("Problems") showing precision oncology in practice. The book includes a clear, readable summary of developments, alongside real-life case studies, providing a valuable update for all involved in the oncology community. The editors lead research and clinical teams at four UK centres of excellence in the field.

Targeted Therapies for Solid Tumors

Antonio Russo,Rafael Rosell,Christian Rolfo

Author : Antonio Russo,Rafael Rosell,Christian Rolfo
Publisher : Humana Press
Page : 269 pages
File Size : 43,8 Mb
Release : 2015-03-11
Category : Medical
ISBN : 9781493920471

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Targeted Therapies for Solid Tumors by Antonio Russo,Rafael Rosell,Christian Rolfo Pdf

This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

Targeted Therapy in Translational Cancer Research

Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson

Author : Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson
Publisher : John Wiley & Sons
Page : 320 pages
File Size : 41,7 Mb
Release : 2015-10-08
Category : Medical
ISBN : 9781118468685

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Targeted Therapy in Translational Cancer Research by Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson Pdf

Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy. Introduces cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities

Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume 1

Ganji Purnachandra Nagaraju,Sujatha Peela

Author : Ganji Purnachandra Nagaraju,Sujatha Peela
Publisher : Academic Press
Page : 388 pages
File Size : 42,8 Mb
Release : 2022-02-16
Category : Psychology
ISBN : 9780323993647

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Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume 1 by Ganji Purnachandra Nagaraju,Sujatha Peela Pdf

Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume One: Biology and Pathophysiology provides comprehensive information about ongoing research and clinical data surrounding liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. This volume discusses topics such as tumor microenvironment in hepatocellular carcinoma, endoplasmic reticulum stress and unfolded protein response, effects of cirrhosis and hepatitis on the prognosis of HCC, mitochondrial metabolism, next generation sequencing, and telomerase. In addition, it discusses exosomes role in HCC progression, metastasis and chemokines. This is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer for their research work or clinical setting. Provides an updated literature review and detailed understanding of liver cancer tumor biology Discusses abnormal changes in the liver caused, resulting from, or associated with hepatocellular carcinoma from a holistic view Presents the content with fully colored images and summarizing tables for easy understanding of complex topics

Handbook of Research on Advancements in Cancer Therapeutics

Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh

Author : Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh
Publisher : IGI Global
Page : 913 pages
File Size : 43,7 Mb
Release : 2020-11-27
Category : Medical
ISBN : 9781799865315

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Handbook of Research on Advancements in Cancer Therapeutics by Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh Pdf

The complexity of cancer demands an integrated approach from both a cancer biology standpoint and a pharmaceutical basis to understand the different anticancer modalities. Current research has been focused on conventional and newer anticancer modalities, recent discoveries in cancer research, and also the advancements in cancer treatment. There is a current need for more research on the advances in cancer therapeutics that bridge the gap between basic research (pharmaceutical drug development processes, regulatory issues, and translational experimentation) and clinical application. Recent promising discoveries such as immunotherapies, promising therapies undergoing clinical trials, synthetic lethality, carbon beam radiation, and other exciting targeted therapies are being studied to improve and advance the studies of modern cancer treatment. The Handbook of Research on Advancements in Cancer Therapeutics serves as a comprehensive guide in modern cancer treatment by combining and merging the knowledge from both cancer biology and the pharmacology of anticancer modalities. The chapters come from multi-disciplinary backgrounds, including scientists and clinicians from both academia and various industries, to discuss nascent personalized therapies and big data-driven cancer treatment. While highlighting topic areas that include cancer prevention, cancer therapeutics, and cancer treatments through the lenses of technology, medicine/drugs, and alternate therapies, this book is ideally intended for oncologists, radiation oncologists, surgical oncologists, and cancer biologists, along with practitioners, stakeholders, researchers, academicians, and students who are interested in understanding the most fundamental aspects of cancer and the available therapeutic opportunities.

Translational Research in Breast Cancer

Dong-Young Noh,Wonshik Han,Masakazu Toi

Author : Dong-Young Noh,Wonshik Han,Masakazu Toi
Publisher : Springer Nature
Page : 630 pages
File Size : 41,9 Mb
Release : 2021-05-13
Category : Medical
ISBN : 9789813296206

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Translational Research in Breast Cancer by Dong-Young Noh,Wonshik Han,Masakazu Toi Pdf

This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.

Targeted Therapies in Breast Cancer

Gw Sledge,George W. Sledge (Jr.)

Author : Gw Sledge,George W. Sledge (Jr.)
Publisher : Clinical Pub
Page : 0 pages
File Size : 40,6 Mb
Release : 2012-06
Category : Breast
ISBN : 1846920663

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Targeted Therapies in Breast Cancer by Gw Sledge,George W. Sledge (Jr.) Pdf

This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

Nosheen Masood,Saima Shakil Malik

Author : Nosheen Masood,Saima Shakil Malik
Publisher : Springer Nature
Page : 499 pages
File Size : 53,5 Mb
Release : 2020-03-20
Category : Medical
ISBN : 9789811510670

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'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine by Nosheen Masood,Saima Shakil Malik Pdf

This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Biomarkers in Cancer Detection and Monitoring of Therapeutics

Ranbir Chander Sobti,Awtar Krishan,Aastha Sobti

Author : Ranbir Chander Sobti,Awtar Krishan,Aastha Sobti
Publisher : Academic Press
Page : 400 pages
File Size : 47,9 Mb
Release : 2023-11-24
Category : Computers
ISBN : 9780323951173

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Biomarkers in Cancer Detection and Monitoring of Therapeutics by Ranbir Chander Sobti,Awtar Krishan,Aastha Sobti Pdf

Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics, Volume One, Discovery and Technologies discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancer types. This first volume in the series focuses on techniques and approaches recently developed to assist in the decision of which biomarker to use for specific conditions. Topics covered include circulating tumor cells and circulating tumor DNA, exomes, tumor microenvironment, gene editing, artificial intelligence and robotics. In addition, the book discusses the development and applications of organoids and precision medicine.This book will be a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of biomarkers in cancer research. Provides up-to-date information on current molecular biomarkers research for cancer Presents basic research aspects and novel technologies applied in the discovery of new biomarkers Discusses several technologies, including artificial intelligence, robotics, data mining, gene editing, omics and their applicability for specific cancer types

Precision Cancer Therapies Volume 1

Precision Cancer Therapies, Volume 2: Immunologic Approaches for the Treatment of Lymphoid Malignancies by Owen A. O'Connor,Stephen M. Ansell,John Gribben Pdf

Precision Cancer Medicine by Sameek Roychowdhury,Eliezer M. Van Allen Pdf

Precision Medicine in Cancer Therapy by Daniel D. Von Hoff,Haiyong Han Pdf

Advances in Precision Medicine Oncology by Hilal Arnouk,Bassam Hassan Pdf

Precision Cancer Therapies, Volume 1 by Stephen M. Ansell,John F. Seymour Pdf

Precision Cancer Medicine by Bharat Jasani,Ralf Huss,Clive R. Taylor Pdf

Problem Solving through Precision Oncology by Peter Selby Pdf

Targeted Therapies for Solid Tumors by Antonio Russo,Rafael Rosell,Christian Rolfo Pdf

Targeted Therapy in Translational Cancer Research by Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson Pdf

Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume 1 by Ganji Purnachandra Nagaraju,Sujatha Peela Pdf

Handbook of Research on Advancements in Cancer Therapeutics by Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh Pdf

Translational Research in Breast Cancer by Dong-Young Noh,Wonshik Han,Masakazu Toi Pdf

Targeted Therapies in Breast Cancer by Gw Sledge,George W. Sledge (Jr.) Pdf

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine by Nosheen Masood,Saima Shakil Malik Pdf

Biomarkers in Cancer Detection and Monitoring of Therapeutics by Ranbir Chander Sobti,Awtar Krishan,Aastha Sobti Pdf

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