Targeted Therapy In Translational Cancer Research

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Targeted Therapy in Translational Cancer Research

Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson

Author : Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson
Publisher : John Wiley & Sons
Page : 320 pages
File Size : 41,5 Mb
Release : 2015-10-14
Category : Medical
ISBN : 9781118468661

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Targeted Therapy in Translational Cancer Research by Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson Pdf

Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy. Introduces cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities

Immunotherapy in Translational Cancer Research

Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran

Author : Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran
Publisher : John Wiley & Sons
Page : 306 pages
File Size : 52,9 Mb
Release : 2018-05-01
Category : Medical
ISBN : 9781118123225

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Immunotherapy in Translational Cancer Research by Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran Pdf

A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapy Explores the breath of treatments that reflect the complexity of the immune system itself Includes contributions from a panel international experts in the field of immunotherapy Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

Targeted Therapies in Breast Cancer

Gw Sledge,George W. Sledge (Jr.)

Author : Gw Sledge,George W. Sledge (Jr.)
Publisher : Clinical Pub
Page : 0 pages
File Size : 42,5 Mb
Release : 2012-06
Category : Breast
ISBN : 1846920663

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Targeted Therapies in Breast Cancer by Gw Sledge,George W. Sledge (Jr.) Pdf

This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

Targeted Therapies in Oncology

Giuseppe Giaccone,Jean-Charles Soria

Author : Giuseppe Giaccone,Jean-Charles Soria
Publisher : CRC Press
Page : 498 pages
File Size : 44,6 Mb
Release : 2013-10-21
Category : Medical
ISBN : 9781842145463

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Targeted Therapies in Oncology by Giuseppe Giaccone,Jean-Charles Soria Pdf

Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edi

Translational Research in Breast Cancer

Erwei Song,Hai Hu

Author : Erwei Song,Hai Hu
Publisher : Springer
Page : 418 pages
File Size : 51,7 Mb
Release : 2017-12-28
Category : Medical
ISBN : 9789811060205

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Translational Research in Breast Cancer by Erwei Song,Hai Hu Pdf

This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer. With the latest developments in breast cancer research, our understanding of the genomic changes and the oncogenic signaling cascade of breast cancer has made considerable strides. Further, the immuno-environment has been demonstrated as the barrier to clinical cancer. In addition, major advances in cancer biology, immunology, genomics and metabolism have broken new ground for designing therapeutic approaches and selecting appropriate treatments on the basis of more precise information on the individual patient. As a result of these two trends, a clearer picture of the molecular landscape of breast cancers has facilitated the development of diagnostic, prognostic and predictive biomarkers for clinical oncology. All these aspects are addressed in this volume, which offers a comprehensive resource for researchers, graduate students and oncologists in cancer research.

Targeted Therapies for Solid Tumors

Antonio Russo,Rafael Rosell,Christian Rolfo

Author : Antonio Russo,Rafael Rosell,Christian Rolfo
Publisher : Humana Press
Page : 269 pages
File Size : 47,6 Mb
Release : 2015-03-11
Category : Medical
ISBN : 9781493920471

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Targeted Therapies for Solid Tumors by Antonio Russo,Rafael Rosell,Christian Rolfo Pdf

This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

Molecular Targeted Therapy of Lung Cancer

Yuichi Takiguchi

Author : Yuichi Takiguchi
Publisher : Springer
Page : 327 pages
File Size : 47,8 Mb
Release : 2017-01-24
Category : Medical
ISBN : 9789811020025

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Molecular Targeted Therapy of Lung Cancer by Yuichi Takiguchi Pdf

This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.

Targeted Therapies

Daniel Gioeli

Author : Daniel Gioeli
Publisher : Springer Science & Business Media
Page : 211 pages
File Size : 53,7 Mb
Release : 2011-06-02
Category : Medical
ISBN : 9781607614784

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Targeted Therapies by Daniel Gioeli Pdf

This volume explores the mechanisms of resistance to targeted therapeutics. The focus is on the cancer cell signaling network, although other mechanisms of resistance including target mutation, and new areas of study such as cancer stem cells are included. Targeted Therapies: Mechanisms of Resistance highlights examples of changes in the signaling network in response to inhibition of a signaling event and underscores the importance in having a mechanistic understanding of the signaling network in cancer for developing effective targeted cancer therapies. Moreover, cutting edge tools to analyze the cell signaling network will be discussed. This includes the leading edge of techniques as well as computational biology and systems theory. This volume provides the reader with both an overview as well as a detailed perspective on the mechanisms of resistance to targeted therapeutics and will be of great value to the oncologist, the physician-scientist treating patients and the translational scientist working on any aspect of targeted therapeutics.

Targeted Therapies for Lung Cancer

Ravi Salgia

Author : Ravi Salgia
Publisher : Springer
Page : 238 pages
File Size : 43,7 Mb
Release : 2019-06-26
Category : Medical
ISBN : 9783030178321

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Targeted Therapies for Lung Cancer by Ravi Salgia Pdf

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

Handbook of Targeted Cancer Therapy and Immunotherapy

Daniel D. Karp,Gerald S. Falchook,JoAnn D. Lim

Author : Daniel D. Karp,Gerald S. Falchook,JoAnn D. Lim
Publisher : Lippincott Williams & Wilkins
Page : 1277 pages
File Size : 42,5 Mb
Release : 2022-03-28
Category : Medical
ISBN : 9781975179267

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Handbook of Targeted Cancer Therapy and Immunotherapy by Daniel D. Karp,Gerald S. Falchook,JoAnn D. Lim Pdf

Designed for quick, everyday reference, Handbook of Targeted Cancer Therapy and Immunotherapy, 3rd Edition, includes clinical trial results of more than 250 state-of-the-art targeted therapy and immunotherapy agents, providing a practical, intuitive, colorful overview of this rapidly advancing field. Comprehensive yet concise, this easy-access resource by Drs. Daniel D. Karp, Gerald S. Falchook, and JoAnn D. Lim, helps you navigate through the newest research reports and apply the most recent discoveries as they pertain to specific tumor types, actionable molecular targets, and clinical performance of investigational targeted agents and combinations of agents. This handbook presents information distilled by dozens of translational research clinicians and other healthcare experts with hundreds of years of cumulative experience in the revolutionary area of genomically based precision oncology.

Cancer Gene Therapy by Viral and Non-viral Vectors

Malcolm Brenner,Mien-Chie Hung

Author : Malcolm Brenner,Mien-Chie Hung
Publisher : John Wiley & Sons
Page : 176 pages
File Size : 50,5 Mb
Release : 2014-02-25
Category : Medical
ISBN : 9781118501658

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Cancer Gene Therapy by Viral and Non-viral Vectors by Malcolm Brenner,Mien-Chie Hung Pdf

Provides expert, state-of-the-art insight into the currentprogress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era ofpersonalized or precision medicine. No longer a one-size-fits-allapproach, the treatment of cancer is now based on an understandingof underlying biologic mechanisms and is increasingly beingtailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinentmolecular discoveries in the cancer field and explains how theseare being used for gene-based cancer therapies. Designed as avolume in the Translational Oncology book series, Cancer GeneTherapy by Viral and Non-viral Vectors deals with the practiceof gene-therapy, with reference to vectors for gene expression andgene transfer, as well as viral therapy. It covers the history andcurrent and future applications of gene transfer in cancer, andprovides expert insight on the progress of viral and non-viral genetherapy with regard to delivery system, vector design, potentialtherapeutic genes, and principles and regulations for cancer genetherapy. Presented in three parts, Cancer Gene Therapy by Viral andNon-viral Vectors covers: Delivery Systems • Translational Cancer Research: Gene Therapy by Viraland Non-viral Vectors • Retroviruses for Cancer Therapy • DNA Plasmids for Non-viral Gene Therapy ofCancer • Cancer Therapy with RNAi delivered by Non-viralMembrane/Core Nanoparticles Targeted Expression • Cancer Gene Therapy by Tissue-specific andCancer-targeting Promptors • MicroRNAs as Drugs and Drug Targets in Cancer Principles of Clinical Trials in Gene Therapy • Regulatory issues for Manufacturers of Viral Vectorsand Vector-transduced Cells for Phase I/II Trials • US Regulations Governing Clinical Trials in GeneTherapy • Remaining Obstacles to the Success of Cancer GeneTherapy Focusing on speeding the process in clinical cancer care bybringing therapies as quickly as possible from bench to bedside,Cancer Gene Therapy by Viral and Non-viral Vectors is anabsolutely vital book for physicians, clinicians, researchers, andstudents involved in this area of medicine.

Molecularly Targeted Therapy for Childhood Cancer

Peter J. Houghton,Robert J. Arceci

Author : Peter J. Houghton,Robert J. Arceci
Publisher : Springer Science & Business Media
Page : 536 pages
File Size : 40,9 Mb
Release : 2010-09-10
Category : Medical
ISBN : 9780387690629

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Molecularly Targeted Therapy for Childhood Cancer by Peter J. Houghton,Robert J. Arceci Pdf

Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ‘drivers’ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.

Targeted Therapies in Cancer

Marc Lacroix

Author : Marc Lacroix
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 44,7 Mb
Release : 2016
Category : Cancer
ISBN : 1634846680

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Targeted Therapies in Cancer by Marc Lacroix Pdf

Besides surgery, radiation therapy, endocrine therapy or chemotherapy, which were widely used in cancer patients for decades, the 21st century has seen the emergence of "targeted" therapy, resulting from the identification of molecular pathways in cells and their alterations in tumors. An increasing number of compounds targeting specific molecules or cancer cells have been developed and, for some of them, approved by the United States Food and Drug Administration (FDA) as well as other regulators in EU and Japan Additional new and more efficient types of compounds, are still in clinical trials, but are expected to gain future approval. More than eighty FDA-approved targeted therapies are described here, along with about eighty other promising compounds. These drugs are members of various therapy classes, including tyrosine kinase inhibitors; serine/threonine kinase inhibitors; dual specificity kinase inhibitors; lipid kinase inhibitors; poly ADP ribose polymerase inhibitors; monoclonal antibodies; microtubule targeting agents; histone deacetylase inhibitors; proteasome inhibitors; antimetabolites; immunomodulatory agents; DNA methyltransferase inhibitors; hedgehog pathway inhibitors; enzymes; protein translation inhibitors; vaccines, oncolytic viruses; chimeric antigen receptor T-cells (CAR-T); and so on. A series of "companion" diagnostics intended to be used as an indication for specific therapies, and approved to this aim are also mentioned. The book aims to present the broad landscape of compounds and companion diagnostics that are expected to pave the way towards a future of hope for cancer patients.

Gene Therapy of Cancer

Edmund C. Lattime,Stanton L. Gerson

Author : Edmund C. Lattime,Stanton L. Gerson
Publisher : Academic Press
Page : 554 pages
File Size : 53,7 Mb
Release : 2013-08-28
Category : Medical
ISBN : 9780123946324

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Gene Therapy of Cancer by Edmund C. Lattime,Stanton L. Gerson Pdf

Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response. Explains the underlying cancer biology necessary for understanding proposed therapeutic approaches Presents in-depth description of targeting systems and treatment strategies Covers the breadth of gene therapy approaches including immunotherapeutic, drug resistance,oncolytic viruses, as well as regulatory perspectives from both the NCI and FDA

Translational Research in Cancer

Sivapatham Sundaresan,Yeun-Hwa Gu

Author : Sivapatham Sundaresan,Yeun-Hwa Gu
Publisher : BoD – Books on Demand
Page : 212 pages
File Size : 49,8 Mb
Release : 2021-02-03
Category : Medical
ISBN : 9781838805340

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Translational Research in Cancer by Sivapatham Sundaresan,Yeun-Hwa Gu Pdf

Translational research in oncology benefits from an abundance of knowledge resulting from genome-scale studies concerning the molecular pathways involved in tumorigenesis. Translational oncology represents a bridge between basic research and clinical practice in cancer medicine. The vast majority of cancer cases are due to environmental risk factors. Many of these environmental factors are controllable lifestyle choices. Experimental cancer treatments are studied in clinical trials to compare the proposed treatment to the best existing treatment through translational research. The key features of the book include: 1) New screening for the development of radioprotectors: radioprotection and anti-cancer effect of β-Glucan (Enterococcus faecalis) 2) Translational perspective on hepatocellular carcinoma 3) Brachytherapy for endometrial cancer 4) Discovery of small molecule inhibitors for histone methyltransferases in cancer

Targeted Therapy In Translational Cancer Research

Targeted Therapy in Translational Cancer Research by Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson Pdf

Immunotherapy in Translational Cancer Research by Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran Pdf

Targeted Therapies in Breast Cancer by Gw Sledge,George W. Sledge (Jr.) Pdf

Targeted Therapies in Oncology by Giuseppe Giaccone,Jean-Charles Soria Pdf

Translational Research in Breast Cancer by Erwei Song,Hai Hu Pdf

Targeted Therapies for Solid Tumors by Antonio Russo,Rafael Rosell,Christian Rolfo Pdf

Molecular Targeted Therapy of Lung Cancer by Yuichi Takiguchi Pdf

Targeted Therapies by Daniel Gioeli Pdf

Targeted Therapies for Lung Cancer by Ravi Salgia Pdf

Handbook of Targeted Cancer Therapy and Immunotherapy by Daniel D. Karp,Gerald S. Falchook,JoAnn D. Lim Pdf

Cancer Gene Therapy by Viral and Non-viral Vectors by Malcolm Brenner,Mien-Chie Hung Pdf

Molecularly Targeted Therapy for Childhood Cancer by Peter J. Houghton,Robert J. Arceci Pdf

Targeted Therapies in Cancer by Marc Lacroix Pdf

Gene Therapy of Cancer by Edmund C. Lattime,Stanton L. Gerson Pdf

Translational Research in Cancer by Sivapatham Sundaresan,Yeun-Hwa Gu Pdf

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