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Author : Steven G. Younkin,Rudolph E. Tanzi
Publisher : Springer Science & Business Media
Page : 111 pages
File Size : 41,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642721038
The role of the familial Alzheimer's Disease genes called "presenilins" in causing neuronal cell death and Alzheimer-related pathology.
Author : Cary Esselens
Publisher : Leuven University Press
Page : 140 pages
File Size : 45,9 Mb
Release : 2005
Category : Alzheimer's disease
ISBN : 9058674681
Author : Jos Tournoy
Publisher : Leuven University Press
Page : 124 pages
File Size : 44,6 Mb
Release : 2006
Category : Alzheimer's disease
ISBN : 9058675262
Author : Omar Nyabi
Publisher : Leuven University Press
Page : 122 pages
File Size : 49,8 Mb
Release : 2005
Category : Alzheimer's disease
ISBN : 9058674592
Alzheimer's disease is a major health problem. The disease is clinically characterized by the progressive mental decline of the patients and pathologically by the accumulation of amyloid plaques and tangles and neurodegenerative changes in the brain. The cause of the disease remains unclear but in some cases, genetic (missense) mutations in the Amyloid Precursor Protein (APP) and in the Presenilin genes (PS1 & PS2) are sufficient to initiate the whole disease cascade. All these mutations cause in essence an increase in the generation or a change of the characteristics of the AB peptide making it more prone to produce amyloid plaques. The AB peptide is generated from the APP protein and the question how Presenilin influences APP processing and AB production is the main topic of our work.
Author : Sangram S. Sisodia,Rudolph E. Tanzi
Publisher : Springer Science & Business Media
Page : 291 pages
File Size : 41,9 Mb
Release : 2007-02-16
Category : Medical
ISBN : 9780387351353
This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.
Author : J.D. Turner,K. Beyreuther,F. Theuring
Publisher : Springer Science & Business Media
Page : 252 pages
File Size : 43,7 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9783662032480
Alzheimer's Disease is a progressive neurodegenerative disorder of late life with devastating consequences for the afflicted and their carers and poses one of the major challenges to medical research. Until recently, little hope of effective therapies capable of slowing the disease process or preventing its occurrence was apparent. With recent advances in the genetics and molecular biology of the disease processes and the demonstration of the involvement of multiple aetiological factors, however, real chances are now appearing for the identification of preventive drugs. In this discussion, experts from disciplines ranging from molecular genetics to the clinic provide review and novel data concerning the aetiology of AD and the establishment of drugfinding screening methods.
Author : Christian Haass
Publisher : CRC Press
Page : 350 pages
File Size : 49,6 Mb
Release : 2003-09-02
Category : Science
ISBN : 9780203303610
Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.
Author : Jürgen Langner,Siegfried Ansorge
Publisher : Springer Science & Business Media
Page : 522 pages
File Size : 47,7 Mb
Release : 2006-04-11
Category : Medical
ISBN : 9780306468261
Of the many special roles played by proteolytic enzymes in immune reactions, this book addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and regulation of membrane peptidases in vivo and in vitro. A number of newly discovered peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are described, with special emphasis given to the role of peptidases in immune and defense reactions and in the pathogenesis of inflammatory and other diseases, including rheumatoid arthritis, pancreatitis, multiple sclerosis, Alzheimer's disease and tumours of various origins. The focus on the involvement of a selection of proteolytic enzymes in immune reactions and diseases is a unique feature of this multifaceted work , which combines biochemical, immunological and clinical research reports with literary reviews of the field.
Author : Lauren Stutzbach
Publisher : Unknown
Page : 0 pages
File Size : 44,8 Mb
Release : 2007
Category : Alzheimer's disease
ISBN : OCLC:1430597033
Author : Nigel M. Hooper,Uwe Lendeckel
Publisher : Springer Science & Business Media
Page : 147 pages
File Size : 51,7 Mb
Release : 2007-06-21
Category : Medical
ISBN : 9781402063114
Authors Nigel M. Hooper and Otto von Guericke, world leaders in protease research, have written the first book that focuses on recent data stemming from the structural determination of intramembrane-cleaving proteases (I-CLiPs). You get the latest findings concerning the various roles that these proteases play in biology and in the course of diseases such as Alzheimer’s and viral infection.
Author : Nigel M. Hooper
Publisher : Springer Science & Business Media
Page : 411 pages
File Size : 48,9 Mb
Release : 2008-02-02
Category : Medical
ISBN : 9781592591954
Alzheimer's disease is the most common cause of senile dementia. Since the discovery in 1984 of the amyloid ?-peptide (A?) as the core protein of the senile plaques present in the brains of Alzheimer's disease sufferers, an immense amount of research has gone into mapping out the molecular basis of this debilitating disease. The aim of Alzheimer's Disease: Methods and Protocols is to bring together the main biochemical, cell biological, and molecular biological techniques and approaches that are being used to investigate the molecular basis of Alzheimer's disease. This volume begins with chapters of an introductory/ review nature. Chapter 1 provides a historical introduction to Alzheimer's d- ease with particular emphasis on the central role played by A? and its re- tion to tau. Chapter 2 examines the genetics underlying this neurodegenerative disease, covering the amyloid precursor protein, apolipoprotein E, and the presenilins. Chapter 3 presents an overview of currently available therapeutic agents and prospects for drugs of the future.
Author : Khalid Iqbal,Sangram S. Sisodia,Bengt Winblad
Publisher : John Wiley & Sons
Page : 888 pages
File Size : 52,9 Mb
Release : 2003-01-24
Category : Medical
ISBN : 9780470851746
Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume provides a unique source of reference to the important work being done in this field, it gives academics and clinicians an opportunity to learn about cutting edge developments and covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.
Author : Abel Lajtha,Regino Perez-Polo,Steffen Roßner
Publisher : Springer Science & Business Media
Page : 332 pages
File Size : 42,8 Mb
Release : 2008-06-06
Category : Medical
ISBN : 9780387326702
The nervous system is highly fragile, especially during aging, illness and trauma. This book addresses a small sampling of major constituents of neural function at the cellular and molecular level that play crucial roles in development and aging.
Author : Colin J. Barrow,David H. Small
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 51,8 Mb
Release : 2006-12-22
Category : Medical
ISBN : 9781846284403
Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer’s Disease (AD). This book summarizes current knowledge of the Abeta peptide and its role in AD. Written by specialists in this fast moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta.
Author : Uday Kishore
Publisher : BoD – Books on Demand
Page : 642 pages
File Size : 48,7 Mb
Release : 2013-05-15
Category : Medical
ISBN : 9789535110880
This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.
