Principles Of Genetic Toxicology

Author : D. Brusick
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 52,8 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489919809

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Principles of Genetic Toxicology by D. Brusick Pdf

The field of genetic toxicology has gone through remarkable development in the seven years since the appearance of the first edition of Principles of Genetic Toxicology. One branch of toxicology research, chemical mutagenesis, has been elucidated and expanded as a result of increased effort, testing, and the sharing of data. This expansion has occurred not only in the industrialized countries, but also in countries that are comparatively less advanced in scientific implementation. These developing countries have taken advan tage of the basic practical methods that were so well described in the first edition of this work. It is significant to note how many centers have been established throughout the world and are now studying the basic concepts and applying them to practical problems such as the detection of genetic effects caused by exposure to chemicals. In fact, there are now toxicology training centers in twelve countries. Genetic toxicology, in addition to being investigated as a science unto itself, has been taught to people in the applied fields so that these techniques may be put to use in solving other biological problems. For these reasons, it is most useful to have an update of the basic methods and their development. Dr. Brusick should be congratulated for doing such an excellent job of assembling a text that will be worthwhile to any researcher who is interested in the principles of genetic toxicology. Alexander Hollaender Council for Research Planning in Biological Sciences, Inc. Washington, D. C.

Author : James M. Parry,Elizabeth M. Parry
Publisher : Humana Press
Page : 433 pages
File Size : 55,8 Mb
Release : 2011-12-07
Category : Medical
ISBN : 1617794201

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Genetic Toxicology by James M. Parry,Elizabeth M. Parry Pdf

The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in this tremendously important area of study. The volume covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods, all aimed primarily at scientists in the safety departments of the industries working with both natural and synthetic chemicals. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Intuitive and cutting-edge, Genetic Toxicology: Principles and Methods provides crucial support to both laboratory workers in providing quality information on the appropriate application of techniques and to study directors in their assay selection and protocol design in this vital field.

Author : David Brusick
Publisher : Unknown
Page : 300 pages
File Size : 51,7 Mb
Release : 1980-07-01
Category : Electronic
ISBN : 1461576628

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Principles of Genetic Toxicology by David Brusick Pdf

Author : Albert P. Li
Publisher : CRC Press
Page : 508 pages
File Size : 47,5 Mb
Release : 1991-03-27
Category : Medical
ISBN : 0849388155

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Genetic Toxicology by Albert P. Li Pdf

Genetic Toxicology is a comprehensive book covering the historical perspective of genetic toxicology; basic mechanisms of mutations and chromosomal effects; health consequences of genetic damage, including cancer and inheritable mutations; properties of physical, chemical, and biological mutagens; risk assessment of human exposure to genotoxicants; and the current position of some government regulatory agencies in the United States on the issues of genetic toxicology. The book will be a useful reference for students and researchers in toxicology, genetics, cancer biology, and medicine who are interested in the basic and applied principles of genetic toxicology. It will also benefit industrial toxicologists, products registration specialists, and government regulatory specialists with responsibility for the safety evaluation of industrial and environmental agents.

Author : Ray Proudlock
Publisher : Academic Press
Page : 460 pages
File Size : 43,6 Mb
Release : 2016-05-28
Category : Medical
ISBN : 9780128010068

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Genetic Toxicology Testing by Ray Proudlock Pdf

Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own. Offers practical and consistent guidance on the most commonly-performed tests and procedures in a genetic toxicology lab Describes standard genetic toxicology assays, their methodology, reagents, suppliers, and analysis of their results Includes guidance on general approaches: formulation for in vitro assays, study monitoring, and Good Laboratory Practice (GLP) Serves as an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own lab

Author : Clases Ramel,Bo Lambert,Jan Magnusson
Publisher : John Wiley & Sons
Page : 674 pages
File Size : 41,6 Mb
Release : 1986-09
Category : Electronic
ISBN : 0471860204

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Genetic Toxicology of Environmental Chemicals by Clases Ramel,Bo Lambert,Jan Magnusson Pdf

Author : Claes Ramel,Bo Lambert,Jan Magnusson
Publisher : Unknown
Page : 686 pages
File Size : 51,9 Mb
Release : 1986
Category : Medical
ISBN : UOM:39015010128760

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Genetic Toxicology of Environmental Chemicals: Basic principles and mechanisms of action by Claes Ramel,Bo Lambert,Jan Magnusson Pdf

Author : Hisham K. Hamadeh,Cynthia A. Afshari
Publisher : John Wiley & Sons
Page : 386 pages
File Size : 54,9 Mb
Release : 2004-09-06
Category : Science
ISBN : 0471434175

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Toxicogenomics by Hisham K. Hamadeh,Cynthia A. Afshari Pdf

Toxicogenomics: Principles and Applications fills the need for a single, thorough text on the key breakthrough technologies in genomics, proteomics, metabolomics, and bioinformatics, and their applications to toxicology research. The first section following a general introduction is on genomics and toxicogenomics, and qPCR. The next sections are toxicoproteomics and metabolomics. The final section covers bioinformatics aspects, from databases to data integration strategies. A practical resource for specialists and non-specialists alike, this book includes numerous illustrations that support the textual explanations. It offers practical guidance to investigators wishing to pursue this line of research, and lists key relevant software and Internet resources.

Author : Anonim
Publisher : Unknown
Page : 309 pages
File Size : 54,5 Mb
Release : 2015
Category : Electronic
ISBN : 938416108X

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Genetic Toxicology by Anonim Pdf

Author : Wai Nang Choy
Publisher : CRC Press
Page : 405 pages
File Size : 45,5 Mb
Release : 2001-08-31
Category : Medical
ISBN : 9780824745226

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Genetic Toxicology and Cancer Risk Assessment by Wai Nang Choy Pdf

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

Author : Frank A. Barile
Publisher : CRC Press
Page : 338 pages
File Size : 54,8 Mb
Release : 2007-07-23
Category : Medical
ISBN : 9781420008326

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Principles of Toxicology Testing by Frank A. Barile Pdf

The evolution of toxicology testing finds its impetus in the continuing growth of the chemical and pharmaceutical industries, as well as the awareness of public health initiatives, needs, and responses that demand faster, more accurate, more economical methods for screening potential toxicity. Concurrent advances in biotechnology enable viable in v

Author : Joseph LaDou
Publisher : McGraw Hill Professional
Page : 865 pages
File Size : 51,9 Mb
Release : 2006-10-23
Category : Medical
ISBN : 9780071443135

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CURRENT Occupational & Environmental Medicine: Fourth Edition by Joseph LaDou Pdf

Up-to-the-minute, thorough, clinical coverage of common and important occupational and environmental diseases, injuries, and exposures Complete, yet concise, this clinically focused guide offers the definitive overview of common occupational and environmental illnesses, covering their diagnosis and treatment-plus preventive and remedial measures in the workplace and community. With its practical format and emphasis on fundamental topics, CURRENT Occupational and Environmental Medicine is just as essential for students and residents as it is for practicing physicians. You can count on the new fourth edition to deliver the bottom-line answers you need to stay on track in this complex, fast-breaking field. Features: The latest OSHA/NIOSH guidelines for occupational exposure standards Detailed diagnostic checklist for major diseases, injuries, and exposure that help expedite diagnosis and treatment The most clinically relevant perspectives on disability prevention-required reading for the occupational physician Skill-building insights on the importance of ergonomics in the workplace A step-by-step review of how to effectively manage an occupational health and safety program Details on substance abuse and employee assistance programs, health risk analysis, and the legal aspects of occupational and environmental medicine Preventive approaches to terrorist attacks on industry Information-packed primer on epidemiology and biostatistics for the occupational and environmental health specialist Up-to-date references with PMID numbers and peer-reviewed websites

Author : Phillip L. Williams,Robert C. James,Stephen M. Roberts
Publisher : John Wiley & Sons
Page : 625 pages
File Size : 49,5 Mb
Release : 2003-10-10
Category : Science
ISBN : 9780471459231

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Principles of Toxicology by Phillip L. Williams,Robert C. James,Stephen M. Roberts Pdf

A fully updated and expanded edition of the bestselling guide on toxicology and its practical application The field of toxicology has grown enormously since Industrial Toxicology: Safety and Health Applications in the Workplace was first published in 1985. And while the original edition was hugely popular among occupational health professionals, the time is ripe to address toxic agents not only in the industrial setting but also in the environment at large. Renamed Principles of Toxicology: Environmental and Industrial Applications, this new edition provides health protection professionals as well as environmental scientists with precise, up-to-date, practical information on how to apply the science of toxicology in both the occupational and environmental setting. Through contributions from leading experts in diverse fields, Principles of Toxicology, Second Edition features: Clear explanations of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems Coverage of occupational medicine and epidemiological issues The manifestation of toxic agents such as metals, pesticides, organic solvents, and natural toxins Special emphasis on the evaluation and control of toxic hazards Specific case histories on applying risk assessment methods in the modern workplace Ample figures, references, and a comprehensive glossary of toxicological terms

Author : John Timbrell
Publisher : CRC Press
Page : 405 pages
File Size : 55,7 Mb
Release : 1999-10-21
Category : Medical
ISBN : 9780748407361

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Principles of Biochemical Toxicology, Third Edition by John Timbrell Pdf

Research into the biochemical basis of toxicology has expanded rapidly over recent years, amidst concerns over the adverse effects of drugs, environmental pollution and occupational hazards. Following on from the acclaimed first two editions of Principles of Biochemical Toxicology, John Timbrell has expanded the text to include: summary sections questions and model answers thoroughly revised artwork These features, plus the new easy-to-read format will make biochemical toxicology more accessible to undergraduates and postgraduates coming across the subject for the first time, particularly when undertaking self-directed study. This comprehensive textbook provides a thorough explanation of dose-response relationships; disposition and metabolism; toxic responses to foreign compounds, and detailed examples to illustrate mechanisms of toxicity. There is also an expanded and updated bibliography, directing the reader to further reading if required. Students and lecturers will find the clear and concise approach, which established this book as the leading textbook in its field, an essential aid to learning and teaching.

Author : Stine Karen,Thomas M. Brown
Publisher : CRC Press
Page : 392 pages
File Size : 45,8 Mb
Release : 2006-01-24
Category : Medical
ISBN : 9780849328565

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Principles of Toxicology, Second Edition by Stine Karen,Thomas M. Brown Pdf

Written by two experienced toxicology lecturers, Principles of Toxicology provides a broad-based yet in-depth introduction to this diverse subject. Comprehensive and easy-to-read, the book covers this broad and interdisciplinary field from the viewpoint of three different functional levels: molecular and cellular; physiological; and ecological and environmental. This revised second edition expands the coverage of the book while keeping the organizational format that made the first edition a bestseller. It also includes a series of brief case studies illustrating the application of toxicological principles to current issues of interest. Each and every chapter has been revised, several have been significantly rewritten, and three are entirely new. This new edition retains the extensive cross-referencing system that links all sections and enhances the integration of material. It also includes an appendix of selected toxicants that describes chemical structure and category of use. These features combine to make finding specific information quick and easy. The highly readable format and uniform, consistent presentation of information will make this the most used reference on your shelf. See what's new in the second edition: