Genetic Toxicology And Cancer Risk Assessment

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Genetic Toxicology and Cancer Risk Assessment

Wai Nang Choy
Genetic Toxicology and Cancer Risk Assessment Book PDF

Author : Wai Nang Choy
Publisher : CRC Press
Page : 405 pages
File Size : 48,6 Mb
Release : 2001-08-31
Category : Medical
ISBN : 9780824745226

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Genetic Toxicology and Cancer Risk Assessment by Wai Nang Choy Pdf

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

Cancer Risk Assessment

Ching-Hung Hsu,Todd Stedeford
Cancer Risk Assessment Book PDF

Author : Ching-Hung Hsu,Todd Stedeford
Publisher : John Wiley & Sons
Page : 727 pages
File Size : 47,6 Mb
Release : 2010-12-08
Category : Science
ISBN : 9781118035122

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Cancer Risk Assessment by Ching-Hung Hsu,Todd Stedeford Pdf

With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.

Toxicogenomics in Predictive Carcinogenicity

Russell S Thomas,Michael D Waters
Toxicogenomics in Predictive Carcinogenicity Book PDF

Author : Russell S Thomas,Michael D Waters
Publisher : Royal Society of Chemistry
Page : 524 pages
File Size : 42,8 Mb
Release : 2016-06-16
Category : Medical
ISBN : 9781782624059

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Toxicogenomics in Predictive Carcinogenicity by Russell S Thomas,Michael D Waters Pdf

Research over the past decade has demonstrated that TGx methods of various types can be used to discriminate modes of mutagenesis as a function of dose. TGx can quickly inform safety evaluation regarding potential mechanisms of conventional outcomes and can provide essential dose-response information. This can then be used to ascertain the sequence of key events in a putative mode of action as may apply in quantitative cancer risk assessment. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data integration and health risk assessment. Furthermore, it is essential to consider how novel test systems and newer methods and approaches may be used in future to gain a better understanding of mechanisms. Toxicogenomics in Predictive Carcinogenicity describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. It illustrates these methods using case studies that have yielded significant new information on compounds and classes of compounds that have proven difficult to evaluate using conventional methods alone. This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology. This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology.

Toxicological Risk Assessment

David B. Clayson,Daniel R. Krewski,Ian C. Munro
Toxicological Risk Assessment Book PDF

Author : David B. Clayson,Daniel R. Krewski,Ian C. Munro
Publisher : CRC Press
Page : 243 pages
File Size : 45,9 Mb
Release : 2019-07-30
Category : Medical
ISBN : 9781000694284

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Toxicological Risk Assessment by David B. Clayson,Daniel R. Krewski,Ian C. Munro Pdf

First Published in 1986, this two-volume set explores the methods of toxicological risk assessment. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for toxicologists and other practitioners in their respective fields.

Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Emerging Issues and Data on Environmental Contaminants,Committee on How Toxicogenomics Could Inform Critical Issues in Carcinogenic Risk Assessment of Environmental Chemicals
Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Emerging Issues and Data on Environmental Contaminants,Committee on How Toxicogenomics Could Inform Critical Issues in Carcinogenic Risk Assessment of Environmental Chemicals
Publisher : National Academies Press
Page : 68 pages
File Size : 51,5 Mb
Release : 2005-11-17
Category : Science
ISBN : 9780309097000

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Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Emerging Issues and Data on Environmental Contaminants,Committee on How Toxicogenomics Could Inform Critical Issues in Carcinogenic Risk Assessment of Environmental Chemicals Pdf

Toxicogenomics is a discipline that combines expertise in toxicology, genetics, molecular biology, and environmental health to help understand the response of living organisms to stressful environments. The National Research Council convened a workshop to discuss how toxicogenomic data could be applied to improve risk assessments, particularly cancer risk from environmental exposure to chemicals. Risk assessments serve as the basis of many public-health decisions in environmental, occupational, and consumer protection from chemicals. The workshop provided a forum for communities of experts, including those working in "-omics" and those in the policy arena, to discuss where their fields intersect, and how toxicogenomics could address critical knowledge gaps in risk assessments.

Genetic Toxicology

Albert P. Li
Genetic Toxicology Book PDF

Author : Albert P. Li
Publisher : CRC Press
Page : 508 pages
File Size : 41,8 Mb
Release : 1991-03-27
Category : Medical
ISBN : 0849388155

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Genetic Toxicology by Albert P. Li Pdf

Genetic Toxicology is a comprehensive book covering the historical perspective of genetic toxicology; basic mechanisms of mutations and chromosomal effects; health consequences of genetic damage, including cancer and inheritable mutations; properties of physical, chemical, and biological mutagens; risk assessment of human exposure to genotoxicants; and the current position of some government regulatory agencies in the United States on the issues of genetic toxicology. The book will be a useful reference for students and researchers in toxicology, genetics, cancer biology, and medicine who are interested in the basic and applied principles of genetic toxicology. It will also benefit industrial toxicologists, products registration specialists, and government regulatory specialists with responsibility for the safety evaluation of industrial and environmental agents.

Toxicology and Risk Assessment

Helmut Greim,Robert Snyder
Toxicology and Risk Assessment Book PDF

Author : Helmut Greim,Robert Snyder
Publisher : John Wiley & Sons
Page : 838 pages
File Size : 51,5 Mb
Release : 2018-11-05
Category : Science
ISBN : 9781119135913

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Toxicology and Risk Assessment by Helmut Greim,Robert Snyder Pdf

Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.

Translational Toxicology and Therapeutics

Michael D. Waters,Claude L. Hughes
Translational Toxicology and Therapeutics Book PDF

Author : Michael D. Waters,Claude L. Hughes
Publisher : John Wiley & Sons
Page : 790 pages
File Size : 51,7 Mb
Release : 2018-01-04
Category : Medical
ISBN : 9781119023609

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Translational Toxicology and Therapeutics by Michael D. Waters,Claude L. Hughes Pdf

Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms

Cancer Risk Assessment

Peter G. Shields
Cancer Risk Assessment Book PDF

Author : Peter G. Shields
Publisher : CRC Press
Page : 800 pages
File Size : 45,8 Mb
Release : 2005-05-24
Category : Medical
ISBN : 9781000611342

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Cancer Risk Assessment by Peter G. Shields Pdf

The assessment of cancer risk is a complex process that requires the examination of etiological agents, real-world environments, and individual rates of exposure. This reference offers practical approaches to determine cancer risk in individuals, groups of exposed persons, and the general public in relation to individual genetic and acquired suscep

Principles of Genetic Toxicology

D. Brusick
Principles of Genetic Toxicology Book PDF

Author : D. Brusick
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 46,5 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489919809

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Principles of Genetic Toxicology by D. Brusick Pdf

The field of genetic toxicology has gone through remarkable development in the seven years since the appearance of the first edition of Principles of Genetic Toxicology. One branch of toxicology research, chemical mutagenesis, has been elucidated and expanded as a result of increased effort, testing, and the sharing of data. This expansion has occurred not only in the industrialized countries, but also in countries that are comparatively less advanced in scientific implementation. These developing countries have taken advan tage of the basic practical methods that were so well described in the first edition of this work. It is significant to note how many centers have been established throughout the world and are now studying the basic concepts and applying them to practical problems such as the detection of genetic effects caused by exposure to chemicals. In fact, there are now toxicology training centers in twelve countries. Genetic toxicology, in addition to being investigated as a science unto itself, has been taught to people in the applied fields so that these techniques may be put to use in solving other biological problems. For these reasons, it is most useful to have an update of the basic methods and their development. Dr. Brusick should be congratulated for doing such an excellent job of assembling a text that will be worthwhile to any researcher who is interested in the principles of genetic toxicology. Alexander Hollaender Council for Research Planning in Biological Sciences, Inc. Washington, D. C.

Perspectives on Biologically Based Cancer Risk Assessment

Vincent James Cogliano,E. Georg Luebeck,Giovanni A. Zapponi
Perspectives on Biologically Based Cancer Risk Assessment Book PDF

Author : Vincent James Cogliano,E. Georg Luebeck,Giovanni A. Zapponi
Publisher : Springer Science & Business Media
Page : 329 pages
File Size : 41,5 Mb
Release : 2012-12-06
Category : Technology & Engineering
ISBN : 9781461547419

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Perspectives on Biologically Based Cancer Risk Assessment by Vincent James Cogliano,E. Georg Luebeck,Giovanni A. Zapponi Pdf

The first meeting of the NATO/CCMS Pilot Study "Dose-Response Analysis and Biologically-Based Risk assessment for Initiator and Promoter Carcinogens" was held in Rome, Italy, in the spring of 1991, and was followed by annual or bi-annual meetings held in Germany, Greece, Netherlands, Portugal, USA, up to the end of 1995; in large part supported by NATO/CCMS grants or fellowships, and organized by Pilot Study participants. The Pilot Study activity has been characterized by a higly collaborative atmosphere, which was essential for a deep and detailed analysis of a problem on which different points of view, methodological approaches and regulations exist in the various member countries. The Pilot Study was aimed at proposing a carcinogenic risk assessment procedure which is based on a detailed analysis of the relevant biological processes, and may also consent the verification of hypotheses. The specific form of theoretical and mathe matical models is identified by considering and using the whole set of objective data available. The multidisciplinary approach of the pilot study is reflected by the struc ture of this book. Each chapter is the result of the cooperation of several authors from to produce a comprehensive manual that includes different countries; its objective was both theoretical and practical information.

Methods for Genetic Risk Assessment

David Brusick
Methods for Genetic Risk Assessment Book PDF

Author : David Brusick
Publisher : CRC Press
Page : 274 pages
File Size : 49,9 Mb
Release : 1994-01-11
Category : Science
ISBN : 1566700396

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Methods for Genetic Risk Assessment by David Brusick Pdf

Genetic disease contributes to a major portion of our health care costs. While most of the human genetic burden is transmitted from generation to generation, environmental chemicals capable of reacting with germ cell DNA could produce new mutations, resulting in an even greater genetic liability for the next generation. The potential impact of environmental mutagens on the health and viability of other living things is important to consider as well. Methods for Genetic Risk Assessment features contributions from international experts to provide a comprehensive review of the current status of genetic risk assessment. You'll learn about various methods and strategies for when and how to conduct genetic risk assessments on human populations. You will also learn about the potential effects of environmental genotoxins on nonhuman organisms. Topics considered include:

Science and Decisions

National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Improving Risk Analysis Approaches Used by the U.S. EPA
Science and Decisions Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Improving Risk Analysis Approaches Used by the U.S. EPA
Publisher : National Academies Press
Page : 422 pages
File Size : 43,9 Mb
Release : 2009-03-24
Category : Political Science
ISBN : 9780309120463

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Science and Decisions by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Improving Risk Analysis Approaches Used by the U.S. EPA Pdf

Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.

Genetic Toxicology of Complex Mixtures

Michael D. Waters,F.Bernhard Daniel,Joellen Lewtas,Martha M. Moore,Stephen Nesnow
Genetic Toxicology of Complex Mixtures Book PDF

Author : Michael D. Waters,F.Bernhard Daniel,Joellen Lewtas,Martha M. Moore,Stephen Nesnow
Publisher : Springer Science & Business Media
Page : 368 pages
File Size : 48,9 Mb
Release : 2013-03-13
Category : Medical
ISBN : 9781468458503

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Genetic Toxicology of Complex Mixtures by Michael D. Waters,F.Bernhard Daniel,Joellen Lewtas,Martha M. Moore,Stephen Nesnow Pdf

Contained in this volume are the proceedings of the international conference on the "Genetic Toxicology of Complex Mixtures," held from July 4-7, 1989, in Washington, DC. This meeting was a satellite of the "Fifth International Conference on Environmental Mutagens" and the seventh in a biennial series of conferences on "Short-term Bioassays in the Analysis of Complex Environmental Mixtures. " Our central objective in calling together key researchers from around the world was to extend our knowledge of the application of the methods of genetic toxicology and analytical chemistry in the evaluation of chemical mixtures as they exist in the environment. This conference emphasized the study of genotoxicants in air and water, and the assessment of human exposure and cancer risk. The latest strategies and methodologies for biomonitoring of genotoxicants (including transformation products) were described in the context of the ambient environment. Source character ization and source apportionment were discussed as an aid to understand ing the origin and relative contribution of various kinds of complex mix tures to the ambient environment. Similarly, investigations of genotoxi cants found in the indoor environment (sidestream cigarette smoke) and in drinking water (chlorohydroxyfuranones) were given special attention in terms of their potential health impacts. New molecular techniques were described to enable more precise quantitation of internal dose and dose to-target tissues. The emphasis of presentations on exposures/effects assessment was on integrated quantitative evaluation of human exposure and potential health effects.

Genotoxicity and Carcinogenicity Testing of Pharmaceuticals

Michael J. Graziano,David Jacobson-Kram
Genotoxicity and Carcinogenicity Testing of Pharmaceuticals Book PDF

Author : Michael J. Graziano,David Jacobson-Kram
Publisher : Springer
Page : 206 pages
File Size : 43,6 Mb
Release : 2015-11-02
Category : Medical
ISBN : 9783319220840

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Genotoxicity and Carcinogenicity Testing of Pharmaceuticals by Michael J. Graziano,David Jacobson-Kram Pdf

This book provides an overview of the nonclinical testing strategies that are used to asses and de-risk the genotoxicity and carcinogenicity properties of human pharmaceuticals. It includes a review of relevant ICH guidelines, numerous case studies where follow-up studies were conducted to further investigate positive findings, and practical considerations for the use of alternative and emerging tests. With contributions from recognized experts in the pharmaceutical industry and health authorities, this volume presents a balanced view on the interpretation and application of genotoxicity and carcinogenicity regulatory guidances. Genotoxicity and Carcinogenicity Testing of Pharmaceuticals is a valuable resource for scientists, regulators, and consultants that are engaged in the conduct, reporting, and review of nonclinical studies. This book will also help academicians better understand and appreciate the complexity of the regulations and breadth of toxicology research that are necessary to support the development and marketing of new drugs.