Prions And Neurodegenerative Diseases

Author : Anonim
Publisher : Academic Press
Page : 400 pages
File Size : 54,7 Mb
Release : 2020-09-19
Category : Science
ISBN : 9780128200032

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Prions and Neurodegenerative Diseases by Anonim Pdf

Prions and Neurodegenerative Diseases, Volume 172, in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Cell-free amplification of prions: where do we stand? Transgenic mouse models for the study of prion diseases and much more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Author : Gregg Books
Publisher : Unknown
Page : 122 pages
File Size : 48,5 Mb
Release : 2020-10-17
Category : Electronic
ISBN : 9798699129188

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Prions & Neurodegenerative Disease by Gregg Books Pdf

Prions provides a unique perspective of the recenetly identified infectious agent. Prions are proven to be the cause of many different diseases both in humans and animals. The topic is a hot topic in modern-day science. Scientists seemingly cannot agree whether or not prions cause other very common neurodegenerative diseases such as Alzheimer's, ALS, Parkinson's, and countless others. Excluding the controversy, other topics found inside the book include: ★ History of Prion Diseases ★ Cause of Prion Diseases ★ Genetics (Risk-Factors) Associated w/ Prion Diseases ★ Symptoms of Prion Diseases ★ Potential ways to prevent Prion Diseases ★ Treatment options available for Prion Diseases The idiosyncrasy of the material is the inclusion of prestigious researcher opinions on prions and their potential role in the cause of individual neurodegenerative disease. Prions are self-infectious proteins proven to be the agent responsible for causing prion diseases. The recent discovery of prions in 1982 has sparked controversy inside the research field of neurodegenerative disease.

Author : Anonim
Publisher : Elsevier
Page : 512 pages
File Size : 42,7 Mb
Release : 2018-06-07
Category : Medical
ISBN : 9780444639530

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Human Prion Diseases by Anonim Pdf

Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Author : Jorg Tatzelt
Publisher : Unknown
Page : 80 pages
File Size : 51,6 Mb
Release : 2010
Category : Prions
ISBN : 0954333527

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The Prion Protein by Jorg Tatzelt Pdf

A conformational transition of the cellular prion protein (PrPC) into an aberrantly folded isoform designated scrapie prion protein (PrPSc) is the hallmark of a variety of neurodegenerative disorders collectively called prion diseases. They include Creutzfeldt-Jakob disease and Gerstmann-Stäussler-Scheinker syndrome in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and chronic wasting disease (CWD) in free-ranging deer. In contrast to the deadly properties of misfolded PrP, PrPC seems to possess a neuroprotective activity. More-over, animal models indicated that the stress-protective activity of PrPC and the neurotoxic effects of PrPSc are somehow interconnected. In this timely book, leading scientists in the field have come together to highlight the apparently incongruous activities of different PrP conformers. The articles outline current research on celluar pathways implicated in the formation and signaling of neurotoxic and physiological PrP isoforms and delineate future research direction. Topics covered include the physiologcial activity of PrPC and its possible role as a neurotrophic factor, the finding that aberrant PrP conformers can cause neurodegeneration in the absence of infectious prion propagation, the requirement of the GPI anchor of PrPC for the neurotoxic effects of scrapie prions, the pathways implicated in the formation and neurotoxic properties of cytosolically localized PrP, the impact of metal ions on the processing of PrP, and the role of autophagy in the propagation and clearance of PrPSc. The book is fully illustrated and chapters include comprehensive reference sections. Essential reading for scientists involved in prion research.

Author : Gregg Books
Publisher : Unknown
Page : 128 pages
File Size : 52,9 Mb
Release : 2020
Category : Nervous system
ISBN : 8699129181

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Prions & Neurodegenerative Diseases by Gregg Books Pdf

Author : Michael S. Wolfe
Publisher : Academic Press
Page : 560 pages
File Size : 45,6 Mb
Release : 2018-03-29
Category : Medical
ISBN : 9780128113059

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The Molecular and Cellular Basis of Neurodegenerative Diseases by Michael S. Wolfe Pdf

The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Author : Stanley B. Prusiner
Publisher : Unknown
Page : 690 pages
File Size : 55,8 Mb
Release : 2017
Category : MEDICAL
ISBN : IND:30000152876029

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Prion Diseases by Stanley B. Prusiner Pdf

Diseases such as Creutzfeldt-Jakob disease and kuru develop when PrP proteins form prions by misfolding, clumping together, and spreading from cell to cell. Over the past decade, a number of proteins have been reported to possess the characteristics of PrP prions. A growing collection of disorders has been found to be caused by prions; some of these prion diseases include such devastating illnesses as Alzheimer's and Parkinson's and possibly type 2 diabetes. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the progress that has recently been made in our understanding of the pathophysiology of prion diseases, as well as ongoing efforts to develop effective therapeutics. The contributors discuss how proteins such as tau, islet amyloid polypeptide, and alpha-synuclein adopt alternative shapes that lead them to aggregate, resulting in cellular degeneration. Therapies for human and animal diseases caused by prions are also covered. This volume is therefore useful for all biomedical scientists and physicians wishing to understand and treat this expanding group of devastating disorders.

Author : Claudio Soto
Publisher : CRC Press
Page : 184 pages
File Size : 53,8 Mb
Release : 2005-12-20
Category : Medical
ISBN : 9781420040128

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Prions by Claudio Soto Pdf

Prion-related diseases, known as transmissible spongiform encephalopathies (TSEs), are infectious, fatal neurodegenerative disorders for which there is no cure, treatment, nor even a means for early diagnosis. The horrific advent of Mad Cow Disease -- transmitted to humans through eating meat from steers sickened by bovine spongiform encephalopathy

Author : Ivo Nikolaev Sirakov
Publisher : BoD – Books on Demand
Page : 84 pages
File Size : 45,6 Mb
Release : 2019-01-30
Category : Medical
ISBN : 9781789850178

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Prions by Ivo Nikolaev Sirakov Pdf

The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE.

Author : Gabor G. Kovacs
Publisher : Cambridge University Press
Page : 319 pages
File Size : 46,5 Mb
Release : 2014-12-04
Category : Medical
ISBN : 9781107442429

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Neuropathology of Neurodegenerative Diseases Book and Online by Gabor G. Kovacs Pdf

This heavily illustrated, must-have practical guide aids medical specialists and trainees in the diagnosis of neurodegenerative diseases. Includes diagnostic algorithms.

Author : David R. Brown
Publisher : Springer Science & Business Media
Page : 478 pages
File Size : 50,6 Mb
Release : 2005-07-26
Category : Medical
ISBN : 9780387239231

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Neurodegeneration and Prion Disease by David R. Brown Pdf

This is the first and only book on the subject of prions to cover the cause of cell death in the disease. It covers the full range of competing theories on the subject, from broad description and basic points up to the final details of the basic science.

Author : Giuseppe Legname,Gabriele Giachin
Publisher : Unknown
Page : 0 pages
File Size : 53,9 Mb
Release : 2015
Category : Nervous system
ISBN : 1634833996

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Prion Phenomena in Neurodegenerative Diseases by Giuseppe Legname,Gabriele Giachin Pdf

The most fascinating and unique feature of prion diseases is that they are caused almost exclusively by a proteinaceous and infectious particle termed prions by the Nobel Prize laureate S B Prusiner, who discovered this class of pathogens. In the latter part of the 1990s, mad-cow disease, a disease caused by prions acquired through foodborne transmission, raised unprecedented public concern due to the concrete possibility that prions in animals could be transmitted to humans through the food chain. For roughly two decades, prions were under intense scrutiny and many studies were undertaken worldwide. These investigations have led our community to a better risk assessment and management of prion diseases in humans and in animals, substantially limiting the possibility of new prion epidemics. Nowadays, prions have been brought once again to the foreground after the discovery that a variety of neurodegenerative diseases, in particular Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis, share fundamental features with prions, including protein misfolding and aggregation in the brain, cell-to-cell transmission and in vivo infectivity. Therefore, studying prions might help to understand the pathological mechanism of these disorders. The Prion Phenomena In Neurodegenerative Diseases: New Frontiers in Neuroscience is a book that benefits from the contribution of leading scientists in different fields of neuroscience, including Gianluigi Zanusso, Holger Wille, Fabrizio Tagliavini, Andrew F Hill, Jerson L Silva, Vladimir N Uversky, Henrike Heise, David W Colby, Neil R Cashman and the Nobel Prize laureate Eric R Kandel. This chapter collection discusses the development of prions and their various diseases, and provides a detailed overview about the state of the art of the novel prion phenomena observed in other fatally damaging protein misfolding disorders. This book represents an up-to-date review of different protein-misfolding diseases, serving as an invaluable tool for both specialized researchers working in the field of neurodegeneration and for a broad spectrum of academic readers that wish to learn more about the prion phenomena.

Author : Forum on Neuroscience and Nervous System Disorders,Board on Health Sciences Policy,Institute of Medicine
Publisher : National Academies Press
Page : 0 pages
File Size : 41,7 Mb
Release : 2013-12-26
Category : Medical
ISBN : 0309285674

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Neurodegeneration by Forum on Neuroscience and Nervous System Disorders,Board on Health Sciences Policy,Institute of Medicine Pdf

Neurodegeneration: Exploring Commonalities Across Diseases is the summary of a workshop hosted by the Institute of Medicine\'s (IOM\'s) Forum on Neuroscience and Nervous System Disorders in Spring 2012 to explore commonalities across neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Participants from academia; pharmaceutical and biotechnology industries; government agencies such as the National Institutes of Health and the U.S. Department of Veterans Affairs (VA); patient advocacy groups; and private foundations presented and identified potential opportunities for collaboration across the respective research and development communities. This report identifies and discusses commonalities related to genetic and cellular mechanisms, identifies areas of fundamental science needed to facilitate therapeutics development, and explores areas of potential collaboration among the respective research communities. Neurodegenerative diseases, such as Alzheimer\'s disease, Parkinson\'s disease, ALS, and FTD, are becoming increasingly prevalent in the United States due to an aging population. Implications are grave for quality of life and health care costs. Research on neurodegenerative diseases has expanded greatly over the past four decades. Nevertheless, fundamental questions remain about the biology of these diseases, and further insights into the mechanisms of these diseases would help to inform the development of effective means to prevent and to efficiently treat them. Recent findings have revealed certain commonalities in genetic and cellular mechanisms across neurodegenerative diseases. These findings suggest that it might be valuable - at least in some cases - to change the traditional way of studying these diseases by no longer seeing each as an independent entity, but rather as clinical variants of common cellular and molecular biological defects. This approach could help enhance basic scientific understanding of neurodegenerative disease, and could help with the development of biomarkers and new therapeutics.

Author : Wen-Quan Zou,Pierluigi Gambetti
Publisher : Springer Nature
Page : 773 pages
File Size : 51,6 Mb
Release : 2023-01-01
Category : Medical
ISBN : 9783031205651

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Prions and Diseases by Wen-Quan Zou,Pierluigi Gambetti Pdf

Transmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including the protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases. The new second edition covers such important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.

Author : Mathias Jucker,Yves Christen
Publisher : Springer Science & Business Media
Page : 163 pages
File Size : 48,6 Mb
Release : 2013-03-27
Category : Medical
ISBN : 9783642354915

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Proteopathic Seeds and Neurodegenerative Diseases by Mathias Jucker,Yves Christen Pdf

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer ́s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society. ​