Progress In The Chemistry Of Organic Natural Products 110

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu
Publisher : Springer Nature
Page : 271 pages
File Size : 42,7 Mb
Release : 2019-10-16
Category : Science
ISBN : 9783030146320

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Progress in the Chemistry of Organic Natural Products 110 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu Pdf

The book summarizes important aspects of cheminformatics that are relevant for natural product research. It highlights cheminformatics tools that help to match natural products with their respective biological targets or off-targets, and discusses the potential and limitations of this approach.

Author : A. Douglas Kinghorn,Heinz Falk,Junichi Kobayashi
Publisher : Unknown
Page : 260 pages
File Size : 50,5 Mb
Release : 2014-08-31
Category : Electronic
ISBN : 3319049011

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Progress in the Chemistry of Organic Natural Products 99 by A. Douglas Kinghorn,Heinz Falk,Junichi Kobayashi Pdf

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi
Publisher : Springer
Page : 246 pages
File Size : 49,5 Mb
Release : 2017-01-25
Category : Science
ISBN : 9783319456188

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Progress in the Chemistry of Organic Natural Products 104 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi Pdf

The first contribution describes apolar and polar molecular fossils and, in particular biomarkers, along the lines usually followed in organic chemistry textbooks, and points to their bioprecursors when available. Thus, the apolar compounds are divided in linear and branched alkanes followed by alicyclic compounds and aromatic and heterocyclic molecules, and, in particular, the geoporphyrins. The polar molecular fossils contain as functional groups or constituent units ethers, alcohols, phenols, carbonyl groups, flavonoids, quinones, and acids, or are polymers like kerogen, amber, melanin, proteins, or nucleic acids. The final sections discuss the methodology used and the fundamental processes encountered by the biomolecules described, including diagenesis, catagenesis, and metagenesis. The second contribution covers the distribution of phthalides in nature and the findings in the structural diversity, chemical reactivity, biotransformations, syntheses, and bioactivity of natural and semisynthetic phthalides.

Author : H. Grisebach,G. W. Kirby
Publisher : Unknown
Page : 128 pages
File Size : 45,9 Mb
Release : 1978
Category : Electronic
ISBN : OCLC:797256870

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Fortschritte Der Chemie Organischer Naturstoffe by H. Grisebach,G. W. Kirby Pdf

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi
Publisher : Springer
Page : 252 pages
File Size : 42,7 Mb
Release : 2016-07-05
Category : Science
ISBN : 9783319331720

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Progress in the Chemistry of Organic Natural Products 102 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi Pdf

The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its “reverse-pharmacology” focus. The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Yoshinori Asakawa,Ji-Kai Liu,Verena M. Dirsch
Publisher : Springer Nature
Page : 298 pages
File Size : 42,9 Mb
Release : 2023-07-01
Category : Science
ISBN : 9783031267680

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Progress in the Chemistry of Organic Natural Products 122 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Yoshinori Asakawa,Ji-Kai Liu,Verena M. Dirsch Pdf

This volume highlights some recent developments on plants used widely as botanical dietary supplements and herbal medicines, especially in terms of knowledge of the chemical types and diverse biological activities of their constituents, as well as laboratory approaches for their quality control and taxonomic identification. In the first chapter, the biologically active secondary metabolites are described of selected botanicals that have a wide current use in the United States, with recent information provided also on their in vitro and in vivo biological activities. The second chapter constitutes an updated survey of the different chromatographic, spectroscopic, and metabolomics techniques that can be utilized for the quality control of botanical products. The penultimate chapter covers different nomenclatural systems that are of use for the taxonomic identification of source plants used in botanical products. Finally, deoxyribonucleic acid molecular barcoding techniques for the identification for plants used as dietary supplements are covered.

Author : Anonim
Publisher : Springer Science & Business Media
Page : 262 pages
File Size : 46,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783709187593

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Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 295 pages
File Size : 51,5 Mb
Release : 1981
Category : Electronic
ISBN : OCLC:39554219

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Progress in the Chemistry of Organic Natural Products by Anonim Pdf

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu
Publisher : Springer Nature
Page : 341 pages
File Size : 44,9 Mb
Release : 2021-04-01
Category : Science
ISBN : 9783030594442

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Progress in the Chemistry of Organic Natural Products 114 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu Pdf

This book describes current understandings and recent progress in four areas: in the first one, the cytochalasans, a group of fungal derived natural products characterized by a perhydro-isoindolone core fused with a macrocyclic ring are shown to exhibit high structural diversity and a broad spectrum of bioactivities. The second one is dedicated to a description of bioactive compounds from the medicinal plants of Myanmar, the third one is dedicated to new structure elucidation techniques in the field of sesquiterpenes. The last one discusses the endogenous natural products that are produced by human cells including endogenous amines, steroids, and fatty acid derived natural products. The co-metabolism and natural product production of the human microbiome is also described including tryptophan, bile acids, choline, and cysteine.

Author : Springer London, Limited
Publisher : Unknown
Page : 373 pages
File Size : 55,6 Mb
Release : 1983
Category : Electronic
ISBN : 3540817069

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Progress in the Chemistry of Organic Natural Products by Springer London, Limited Pdf

Author : A Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu
Publisher : Springer Nature
Page : 247 pages
File Size : 47,5 Mb
Release : 2021-04-16
Category : Science
ISBN : 9783030530280

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Progress in the Chemistry of Organic Natural Products 113 by A Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu Pdf

In this book, chemical studies are described mainly from literature reports appearing since 2000, inclusive of investigations performed by the present authors, on the diversity in secondary metabolites of Ligularia growing in the Hengduan Mountains area of China, focusing on eremophilane sesquiterpenoids and other metabolites. More than 100 Ligularia species and their related genera in the plant family Senecioneae plants (Cremanthodium, Cacalia, Senecio, and others) grow in East Asia. For many years, researchers have studied the chemical constituents of these plants, and terpenoids, flavonoids, steroids, alkaloids, and aromatic compounds have been isolated. Among these, in particular, numerous sesquiterpenoids were reported. Within this book terpenoids and aromatic compounds (total 1049), both previously unknown and known, are presented. Finally, genetic studies and synthesis investigations are briefly reviewed.

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Yoshinori Asakawa,Ji-Kai Liu,Verena M. Dirsch
Publisher : Springer Nature
Page : 214 pages
File Size : 49,7 Mb
Release : 2021-04-02
Category : Science
ISBN : 9783030648534

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Progress in the Chemistry of Organic Natural Products 115 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Yoshinori Asakawa,Ji-Kai Liu,Verena M. Dirsch Pdf

This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.

Author : A. Akhila,G. Adam,K. Rani,J. Schmidt,B. Schneider
Publisher : Springer Science & Business Media
Page : 184 pages
File Size : 47,7 Mb
Release : 1999-09-28
Category : Medical
ISBN : 3211833110

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Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products by A. Akhila,G. Adam,K. Rani,J. Schmidt,B. Schneider Pdf

The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Author : A. D. Kinghorn,H. Falk,J. Kobayashi
Publisher : Springer
Page : 588 pages
File Size : 51,8 Mb
Release : 2014-11-17
Category : Science
ISBN : 9783319052755

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Progress in the Chemistry of Organic Natural Products 100 by A. D. Kinghorn,H. Falk,J. Kobayashi Pdf

The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. It is therefore not really surprising to find out that the list of contributing authors, who were awarded a Nobel Prize, is quite long: Kurt Alder, Derek H.R. Barton, George Wells Beadle, Dorothy Crowfoot-Hodgkin, Otto Diels, Hans von Euler-Chelpin, Paul Karrer, Luis Federico Leloir, Linus Pauling, Vladimir Prelog, with Walter Norman Haworth and Adolf F.J. Butenandt serving as members of the editorial board. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Author : A. Douglas Kinghorn,Heinz Falk,Junichi Kobayashi
Publisher : Springer Science & Business Media
Page : 254 pages
File Size : 53,7 Mb
Release : 2011-08-12
Category : Science
ISBN : 3709107482

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Progress in the Chemistry of Organic Natural Products Vol. 94 by A. Douglas Kinghorn,Heinz Falk,Junichi Kobayashi Pdf

The three reviews cover the advances in the chemistry and biology of withanolides over the last 16 years, review the chemistry and biology of the rocaglamide-type derivatives and related compounds, with emphasis on their structural diversity, biosynthesis, pharmacological significance and total synthesis, and summarize the extensive chemistry and biology studies on a natural product, which have resulted in a novel therapy approved worldwide.