Progress In The Chemistry Of Organic Natural Products 115

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Yoshinori Asakawa,Ji-Kai Liu,Verena M. Dirsch
Publisher : Springer Nature
Page : 214 pages
File Size : 52,8 Mb
Release : 2021-04-02
Category : Science
ISBN : 9783030648534

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Progress in the Chemistry of Organic Natural Products 115 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Yoshinori Asakawa,Ji-Kai Liu,Verena M. Dirsch Pdf

This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi
Publisher : Springer
Page : 246 pages
File Size : 52,5 Mb
Release : 2017-01-25
Category : Science
ISBN : 9783319456188

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Progress in the Chemistry of Organic Natural Products 104 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi Pdf

The first contribution describes apolar and polar molecular fossils and, in particular biomarkers, along the lines usually followed in organic chemistry textbooks, and points to their bioprecursors when available. Thus, the apolar compounds are divided in linear and branched alkanes followed by alicyclic compounds and aromatic and heterocyclic molecules, and, in particular, the geoporphyrins. The polar molecular fossils contain as functional groups or constituent units ethers, alcohols, phenols, carbonyl groups, flavonoids, quinones, and acids, or are polymers like kerogen, amber, melanin, proteins, or nucleic acids. The final sections discuss the methodology used and the fundamental processes encountered by the biomolecules described, including diagenesis, catagenesis, and metagenesis. The second contribution covers the distribution of phthalides in nature and the findings in the structural diversity, chemical reactivity, biotransformations, syntheses, and bioactivity of natural and semisynthetic phthalides.

Author : Anonim
Publisher : Springer Science & Business Media
Page : 508 pages
File Size : 46,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783709168875

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Progress in the Chemistry of Organic Natural Products by Anonim Pdf

The objective of this ASI was to bring together specialists in several complex variables (many of whom have contributed to complex potential theory) and specialists in potential theory (all of whom have contributed to several complex variables) together with young researchers and graduate students for an interchange of ideas and techniques. Not only was the status of current research presented, but also the relevant background, much of which is not yet available in books. The following topics and interconnections among them were discussed: 1. Real and Complex Potential Theory. Capacity and approximation, basic prop erties of plurisubharmonic functions and methods to manipulate their singularities and study their growth, Green functions, Chebyshev-type quadratures, electrostatic fields and potentials, propagation of smallness. 2. Complex Dynamics. Review of complex dynamics in one variable, Julia sets, Fatou sets, background in several variables, Henon maps, ergodicity, use of potential theory and multifunctions. 3. Banach Algebras and Infinite Dimensional Holomorphy. Analytic multi functions, spectral theory, analytic functions on a Banach space, semigroups of holomor phic isometries, Pick interpolation on uniform algebras and Von Neumann inequalities for operators on a Hilbert space. The basic notion of complex potential theory is that of a plurisubharmonic function.

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Yoshinori Asakawa,Ji-Kai Liu,Verena M. Dirsch
Publisher : Springer
Page : 0 pages
File Size : 42,8 Mb
Release : 2022-10-28
Category : Science
ISBN : 303080562X

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Progress in the Chemistry of Organic Natural Products 116 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Yoshinori Asakawa,Ji-Kai Liu,Verena M. Dirsch Pdf

This volume describes several highly diverse subjects: Chapter 1 explores marine biodiscovery of the North-eastern Atlantic off the coast of Ireland as a model for best practice in research. The second chapter investigates Brazilian Chemical Ecology and examples of insect-plant communication studies that are mediated by natural products demonstrate the beautiful interconnectedness of species in a biome. Our third chapter comprises the advances in the science of the sesquiterpene quinone, perezone, which in 1852 was the first natural product isolated in crystalline form in the New World. The last two chapters are from a Vietnamese group and the first of these follows the phytochemistry, pharmacology, and ethnomedical uses of the genus Xanthium, which produces interesting sulfur and nitrogen containing natural products. Finally, the genus Desmos is discussed, where an overview of its constituent natural products and their in vitro pharmacological potential is described.

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi
Publisher : Springer
Page : 252 pages
File Size : 53,6 Mb
Release : 2016-07-05
Category : Science
ISBN : 9783319331720

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Progress in the Chemistry of Organic Natural Products 102 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi Pdf

The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its “reverse-pharmacology” focus. The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.

Author : A. Douglas Kinghorn,Heinz Falk,Junichi Kobayashi
Publisher : Unknown
Page : 260 pages
File Size : 43,6 Mb
Release : 2014-08-31
Category : Electronic
ISBN : 3319049011

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Progress in the Chemistry of Organic Natural Products 99 by A. Douglas Kinghorn,Heinz Falk,Junichi Kobayashi Pdf

Author : A Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu
Publisher : Springer Nature
Page : 247 pages
File Size : 45,8 Mb
Release : 2021-04-16
Category : Science
ISBN : 9783030530280

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Progress in the Chemistry of Organic Natural Products 113 by A Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu Pdf

In this book, chemical studies are described mainly from literature reports appearing since 2000, inclusive of investigations performed by the present authors, on the diversity in secondary metabolites of Ligularia growing in the Hengduan Mountains area of China, focusing on eremophilane sesquiterpenoids and other metabolites. More than 100 Ligularia species and their related genera in the plant family Senecioneae plants (Cremanthodium, Cacalia, Senecio, and others) grow in East Asia. For many years, researchers have studied the chemical constituents of these plants, and terpenoids, flavonoids, steroids, alkaloids, and aromatic compounds have been isolated. Among these, in particular, numerous sesquiterpenoids were reported. Within this book terpenoids and aromatic compounds (total 1049), both previously unknown and known, are presented. Finally, genetic studies and synthesis investigations are briefly reviewed.

Author : Anonim
Publisher : Unknown
Page : 295 pages
File Size : 46,5 Mb
Release : 1981
Category : Electronic
ISBN : OCLC:39554219

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Progress in the Chemistry of Organic Natural Products by Anonim Pdf

Author : A. Douglas Kinghorn,Heinz Falk,Junichi Kobayashi
Publisher : Springer Science & Business Media
Page : 269 pages
File Size : 42,6 Mb
Release : 2011-08-12
Category : Science
ISBN : 9783709107485

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Progress in the Chemistry of Organic Natural Products Vol. 94 by A. Douglas Kinghorn,Heinz Falk,Junichi Kobayashi Pdf

The three reviews cover the advances in the chemistry and biology of withanolides over the last 16 years, review the chemistry and biology of the rocaglamide-type derivatives and related compounds, with emphasis on their structural diversity, biosynthesis, pharmacological significance and total synthesis, and summarize the extensive chemistry and biology studies on a natural product, which have resulted in a novel therapy approved worldwide.

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu
Publisher : Springer Nature
Page : 158 pages
File Size : 53,5 Mb
Release : 2020-02-29
Category : Science
ISBN : 9783030378653

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Progress in the Chemistry of Organic Natural Products 111 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu Pdf

The first chapter in volume 111 summarizes research on the sesterterpenoids, which are known as a relatively small group of natural products. However, they express a variety of simple to complicated chemical structures. This chapter focuses on the chemical structures of sesterterpenoids and how their structures are synthesized in Nature. The second chapter is devoted to marine-derived fungi, which play an important role in the search for structurally unique secondary metabolites, some of which show promising pharmacological activities that make them useful leads for drug discovery. Marine natural product research in China in general has made enormous progress in the last two decades as described in this chapter on fungal metabolites. This contribution covers 613 new natural products reported from 2001 to 2017 from marine-derived fungi obtained from algae, sponges, corals, and other marine organisms from Chinese waters.

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Yoshinori Asakawa,Ji-Kai Liu,Verena M. Dirsch
Publisher : Springer Nature
Page : 183 pages
File Size : 47,9 Mb
Release : 2022-04-13
Category : Science
ISBN : 9783030920302

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Progress in the Chemistry of Organic Natural Products 118 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Yoshinori Asakawa,Ji-Kai Liu,Verena M. Dirsch Pdf

This volume consists of four chapters that cover a structurally diverse range of naturally occurring compounds. Chapter 1 delves into the chemistry of pyrogallols and their oxidized products, the hydroxy-o-quinones, including their role in cycloaddition reactions in the chemical synthesis of several fungal metabolites. Chapter 2 provides an in-depth description of the constituents of agarwood essential oil and smoke samples that are used in the perfumery industry, with an emphasis on the sesquiterpenoid and chromones constituents so far known. Chapter 3 discusses the defensive chemical ecology of two North American newt species that both produce tetrodotoxin, a well-known neurotoxin that causes paralysis and death in metazoans by disrupting electrical signals in the nerves and muscles. Chapter 4 discusses the limonoids and triterpenoids from the genus Walsura of the plant family Meliaceae, of which a number of species are utilized in several southeastern Asian countries in systems of folk medicine.

Author : H. Grisebach,G. W. Kirby
Publisher : Unknown
Page : 128 pages
File Size : 44,8 Mb
Release : 1978
Category : Electronic
ISBN : OCLC:797256870

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Fortschritte Der Chemie Organischer Naturstoffe by H. Grisebach,G. W. Kirby Pdf

Author : Anonim
Publisher : Elsevier
Page : 4266 pages
File Size : 43,9 Mb
Release : 2020-07-22
Category : Science
ISBN : 9780081026915

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Comprehensive Natural Products III by Anonim Pdf

Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu
Publisher : Springer
Page : 271 pages
File Size : 52,8 Mb
Release : 2020-10-29
Category : Science
ISBN : 3030146340

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Progress in the Chemistry of Organic Natural Products 110 by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi,Yoshinori Asakawa,Ji-Kai Liu Pdf

The book summarizes important aspects of cheminformatics that are relevant for natural product research. It highlights cheminformatics tools that help to match natural products with their respective biological targets or off-targets, and discusses the potential and limitations of this approach.

Author : Anonim
Publisher : Springer Science & Business Media
Page : 626 pages
File Size : 55,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783709168967

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Fortschritte der Chemie organischer Naturstoffe/Progress in the Chemistry of Organic Natural Products by Anonim Pdf

Contents: Y. Asakawa: Chemical Constituents of the Bryophytes. The volumes of this classic series, now referred to simply as "Zechmeister” after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series’ inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.