Prokaryotic And Eukaryotic Heat Shock Proteins In Infectious Disease

Author : A. Graham Pockley,Stuart K. Calderwood,M. Gabriella Santoro
Publisher : Springer Science & Business Media
Page : 314 pages
File Size : 43,6 Mb
Release : 2009-11-10
Category : Medical
ISBN : 9789048129768

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Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease by A. Graham Pockley,Stuart K. Calderwood,M. Gabriella Santoro Pdf

Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease provides the most current review of the literature relating to the role and influence of heat shock (stress) proteins on the establishment, progression and resolution of infectious disease. Written by leaders in the field of heat shock proteins (HSP) and their biological and immunological properties, the contributors provide a fascinating insight into the complex relationship between, and the involvement of prokaryotic and eukaryotic HSP in disease states. It has been known for some considerable time that heat shock proteins from prokaryotic organisms are immunodominant molecules that are intimately involved in the induction of potential protective inflammatory responses, and this aspect of HSP biology is updated herein. In addition to regulating heat shock protein gene expression, the transcription factor HSF1 also appears to play an important role in regulating immune responses to infection. Heat shock proteins are now known to influence infectious disease processes in a number of diverse ways: they are involved in the propagation of prions, the replication and morphogenesis of viruses, and the resistance of parasites to chemotherapy. These proteins also appear to be important mediators of bacteria-host interactions and inflammation, the latter via interactions with cell surface molecules and structures such as Toll-like receptors and lipid rafts. Heat shock proteins can be expressed on the surface of infected cells, and this is likely to provide a target for the innate immune response. Elevated levels of circulating HSP are present in infectious diseases and these proteins might therefore regulate inflammatory responses to pathogenic challenge on a systemic basis. Heat shock proteins are also implicated in the impact of genital tract infections on the reproductive outcome, as well as in the local and systemic consequences of periodontal disease. Fever-range temperatures can induce the expression of heat shock proteins, and the final chapter in the book examines the influence of fever-range hyperthermia on a variety of cells and the organization of plasma membranes. This book is an essential read for graduates and postgraduates in Biology, pro- and eukaryotic Biochemistry, Immunology, Microbiology, Inflammatory and Infectious Disease, and Pathology.

Author : Brian Henderson,A. Graham Pockley
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 49,8 Mb
Release : 2012-11-19
Category : Medical
ISBN : 9789400747401

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Cellular Trafficking of Cell Stress Proteins in Health and Disease by Brian Henderson,A. Graham Pockley Pdf

Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.

Author : Brian Henderson,A. Graham Pockley
Publisher : Springer
Page : 298 pages
File Size : 54,6 Mb
Release : 2012-11-20
Category : Medical
ISBN : 9400747411

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Cellular Trafficking of Cell Stress Proteins in Health and Disease by Brian Henderson,A. Graham Pockley Pdf

Since the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular chaperones from cells. In bacteria, molecular chaperones are involved in the trafficking of other proteins and are themselves released into the external milieu. The increasing appreciation of the role of molecular chaperones and Protein-Folding Catalysts in the interplay between bacteria and the cells of their hosts is now an important area of research for understanding the mechanisms of infectious diseases. This volume brings together experts in the biochemistry, cellular biology, immunology and molecular biology of molecular chaperones and Protein-Folding Catalysts with a focus on the mechanisms of cellular trafficking of these proteins and the role of these variegated trafficking mechanisms in both human and animal health and disease.

Author : Brian Henderson
Publisher : Springer Science & Business Media
Page : 406 pages
File Size : 52,6 Mb
Release : 2013-07-08
Category : Medical
ISBN : 9789400767874

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Moonlighting Cell Stress Proteins in Microbial Infections by Brian Henderson Pdf

Microbial infection is increasingly seen as a problem as we begin to run out of antibiotics. Understanding how microbes cause disease is essential. In recent years it has begun to emerge that bacteria, fungi, protozoa and viruses can use their cell stress proteins to cause infection. This volume brings together the world's leading experts in the study of the microbial and human cell stress proteins that are involved in enabling microorganisms to infect humans and cause serious disease.

Author : David S. Latchman
Publisher : Springer Science & Business Media
Page : 436 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642582592

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Stress Proteins by David S. Latchman Pdf

This work is concerned with a group of proteins which were originally consid ered to be an esoteric phenomenon but which have now been shown to play critical roles both in normal and stressed cells as well as being involved in a variety of human diseases. It is the purpose of this work to give a comprehen sive view of these proteins and their various aspects. After an introductory chapter providing an overview of these proteins, the work is divided into four main sections each of which deals with one important aspect of these proteins. Thus, the first section contains a series of chapters which describe individual stress proteins and their roles in particular biological phenomena. Evidently, the induction of these proteins by elevated tempera ture or other stresses is their defining feature and the second section of this book therefore considers the regulation of stress protein gene expression both by stressful stimuli such as elevated temperature or ischaemia and by non stressful stimuli such as cytokines.

Author : Alexzander A.A. Asea,Naif N. Almasoud,Sunil Krishnan,Punit Kaur
Publisher : Springer
Page : 385 pages
File Size : 42,9 Mb
Release : 2015-07-22
Category : Medical
ISBN : 9783319172118

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Heat Shock Protein-Based Therapies by Alexzander A.A. Asea,Naif N. Almasoud,Sunil Krishnan,Punit Kaur Pdf

The book Heat Shock Protein-Based Therapies provides the most up-to-date review on new heat shock protein-based mechanisms used in the therapy and treatment of various human disorders and diseases, including cancer, muscular atrophy, neurodegenerative disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious diseases (HIV, periodontal disease). Written by leaders in the field of heat shock protein research, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which mechanisms dependent on heat shock proteins are targeted. The chapters also provide answers as to HSP biological significance to the host. This book is a must read for graduate and postgraduates in the field of Drug Development, Biotechnology, Pharmaceutical Industry, Phytomedicine, Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Oncology, Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.

Author : Cedric A. Mims,Nigel J. Dimmock,Anthony A. Nash,John Stephen
Publisher : Academic Press
Page : 414 pages
File Size : 40,5 Mb
Release : 2013-10-22
Category : Health & Fitness
ISBN : 9780080571911

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Mims' Pathogenesis of Infectious Disease by Cedric A. Mims,Nigel J. Dimmock,Anthony A. Nash,John Stephen Pdf

The newly revised edition of this work provides an up-to-date description of the mechanisms of infection and disease production in a clear and logical manner. Dealing in an integrated manner with all microorganisms, the factors common to all infectious diseases are set out. Molecular biology, pathology, and immunology are brought together to explain how an infectious agent causes disease, and how the body reacts to it. Attachment to and entry of microorganisms Events occurring immediately after entry The encounter of the microbe with the phagocytic cell The spread of microbes through the body The immune response to infection Microbial strategies in relation to the immune response Mechanisms of cell and tissue damage Recovery from infection Failure to eliminate the microbe Host and microbial factors influencing susceptibility Vaccines

Author : Cedric A. Mims,Anthony A. Nash,John Stephen
Publisher : Gulf Professional Publishing
Page : 492 pages
File Size : 41,6 Mb
Release : 2001
Category : Medical
ISBN : 0124982654

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Mims' Pathogenesis of Infectious Disease by Cedric A. Mims,Anthony A. Nash,John Stephen Pdf

This textbook provides a comprehensive description of the mechanisms of microbial infection and the pathogenesis of infectious disease. This edition presents an up-to-date picture of the global burden of infectious diseases.

Author : Sonia Longhi
Publisher : Nova Publishers
Page : 180 pages
File Size : 45,9 Mb
Release : 2007
Category : Measles virus
ISBN : 1600216293

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Measles Virus Nucleoprotein by Sonia Longhi Pdf

Measles virus possesses a non segmented, single stranded, negative sense RNA genome that is encapsidated by the nucleoprotein to form a helical nucleocapsid. This ribonucleoproteic complex is the substrate for both transcription and replication. The RNA-dependent RNA polymerase binds to the nucleocapsid template via its co-factor, the phosphoprotein. This book focuses on the main structural information available on the nucleoprotein, showing that it consists of a structured core (NCORE) and of an intrinsically disordered C-terminal domain (NTAIL). The functional implications of the disordered nature of NTAIL are discussed in light of the ability of disordered regions to establish interactions with multiple partners, thus leading to multiple biological effects. Indeed, beyond the phosphoprotein, NTAIL also interacts with cellular partners, including the major heat shock protein, hsp72, the interferon regulator factor 3, IRF3, and a yet unidentified cellular receptor referred to as NR. This book consists of two chapters devoted to the general functions of the nucleoprotein in transcription and replication and to a detailed overview of its structural properties, and of three chapters focused on the functional relevance of the interaction between NTAIL and its various intracellular and extracellular partners.

Author : Brian Henderson,A. Graham Pockley
Publisher : Cambridge University Press
Page : 366 pages
File Size : 47,9 Mb
Release : 2005-07-18
Category : Science
ISBN : 9781139444019

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Molecular Chaperones and Cell Signalling by Brian Henderson,A. Graham Pockley Pdf

This book reviews understanding of the biological roles of extracellular molecular chaperones. It provides an overview of the structure and function of molecular chaperones, their role in the cellular response to stress and their disposition within the cell. It also questions the basic paradigm of molecular chaperone biology - that these proteins are first and foremost protein-folding molecules. Paradigms of protein secretion are reviewed and the evolving concept of proteins (such as molecular chaperones) as multi-functional molecules for which the term 'moonlighting proteins' has been introduced is discussed. The role of exogenous molecular chaperones as cell regulators is examined and the physiological and pathophysiological role that molecular chaperones play is described. In the final section, the potential therapeutic use of molecular chaperones is described and the final chapter asks the question - what does the future hold for the extracellular biology of molecular chaperones?

Author : Declan C. Schroeder,Jim L. Van Etten,Ian M. Jones,Janusz Tadeusz Paweska,Zhengli Shi,Ahmed Sayed Abdel-Moneim
Publisher : Frontiers Media SA
Page : 427 pages
File Size : 43,5 Mb
Release : 2021-02-24
Category : Science
ISBN : 9782889665068

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Host And Pathogen Mechanisms Underpinning Viral Ecology And Emerging Infections by Declan C. Schroeder,Jim L. Van Etten,Ian M. Jones,Janusz Tadeusz Paweska,Zhengli Shi,Ahmed Sayed Abdel-Moneim Pdf

Author : Bruno Maresca,Susan Lindquist
Publisher : Springer Science & Business Media
Page : 308 pages
File Size : 53,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642766794

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Heat Shock by Bruno Maresca,Susan Lindquist Pdf

During the last years the heat shock response has been stu- died as a model system to analyze control mechanisms regula- ting the synthesis of heat shock proteins providing impor- tant general insight into the regulation of gene expression. But the major revelation, which has sparked interest from all quarters of biology, is the discovery that heat shock proteins play major roles in an extraordinary variety of normal cellular processes. They are the focus of investiga- tions in many areas of cell biology, including protein traf- ficking, signal transduction, DNS replication, transcrip- tion, protein synthesis, and in the assembly of di- verse protein structures. These aspects are thoroughly trea- ted in the book, as are the implications in immunology, in- fec- tious diseases, chronic degeneration, hyperthermia, and can- cer research.

Author : Willem van Eden
Publisher : Birkhäuser
Page : 287 pages
File Size : 54,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783034880282

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Heat Shock Proteins and Inflammation by Willem van Eden Pdf

Heat shock proteins (HSP) have received ample interest by immunologists over recent years. Initially they were found to be dominantly immunogenic microbial antigens. The connection with inflammation was established when it was uncovered that T cells specific for these antigens have a crucial role in the induction and regulation of experimental arthritis. Since then, the raised presence of immunity to HSPs in virtually all conditions of inflammation, including autoimmune diseases, transplant rejection and atherosclerosis, has emphasised the critical significance of immunity to HSPs in inflammatory diseases.

Author : Alexzander A. A. Asea,Punit Kaur
Publisher : Springer
Page : 398 pages
File Size : 45,8 Mb
Release : 2018-03-21
Category : Science
ISBN : 9783319733777

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Heat Shock Proteins in Veterinary Medicine and Sciences by Alexzander A. A. Asea,Punit Kaur Pdf

This books provides up-to-date reviews on current advances of the role of HSP in veterinary medicine and research. Key basic and clinical research laboratories from major universities, veterinary hospitals and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into sections on HSP in the following aspects of Veterinary Medicine, including, I - Domestic Animals, II - Poultry, III - Aquatic and IV - Parasites. The book is a must read for heat shock protein researchers in general and specifically those involved in clinical and research in veterinary medicine.

Author : Matthias Gaestel
Publisher : Springer Science & Business Media
Page : 442 pages
File Size : 45,9 Mb
Release : 2006-01-18
Category : Science
ISBN : 9783540297178

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Molecular Chaperones in Health and Disease by Matthias Gaestel Pdf

Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.