Prokaryotic Systems Biology

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Prokaryotic Systems Biology

Nevan J. Krogan, PhD,Mohan Babu, PhD
Prokaryotic Systems Biology Book PDF

Author : Nevan J. Krogan, PhD,Mohan Babu, PhD
Publisher : Springer
Page : 319 pages
File Size : 49,7 Mb
Release : 2015-11-30
Category : Science
ISBN : 9783319236032

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Prokaryotic Systems Biology by Nevan J. Krogan, PhD,Mohan Babu, PhD Pdf

This book focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species. The first part of the volume consists of nine chapters, focusing on biochemical and genetics and genomics approaches including yeast two hybrid, metagenomics, affinity purification in combination with mass spectrometry, chromatin-immunoprecipitation coupled with sequencing, large-scale synthetic genetic screens, and quantitative-based mass spectrometry strategies for mapping the bacterial physical, functional, substrate, and regulatory interaction networks needed for interpreting biological networks, inferring gene function, enzyme discovery, and identifying new drug targets. The second part comprises five chapters, covering the network of participants for protein folding and complex enzyme maturation. It also covers the structural approaches required to understand bacterial intramembrane proteolysis and the structure and function of bacterial proteins involved in surface polysaccharides, outer membrane, and envelope assembly. This volume concludes with a focus on computational and comparative genomics approaches, especially network-based methods for predicting physical or functional interactions, and integrative analytical approaches for generating more reliable information on bacterial gene function. This book provides foundational knowledge in the understanding of prokaryotic systems biology by illuminating how bacterial genes f unction within the framework of global cellular processes. The book will enable the microbiology community to create substantive resources for addressing many pending unanswered questions, and facilitate the development of new technologies that can be applied to other bacterial species lacking experimental data. ​ ​

Prokaryotic Gene Expression

Simon Baumberg
Prokaryotic Gene Expression Book PDF

Author : Simon Baumberg
Publisher : OUP Oxford
Page : 350 pages
File Size : 49,7 Mb
Release : 1999-05-27
Category : Science
ISBN : 9780191565571

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Prokaryotic Gene Expression by Simon Baumberg Pdf

Prokaryotic gene expression is not only of theoretical interest but also of highly practical significance. It has implications for other biological problems, such as developmental biology and cancer, brings insights into genetic engineering and expression systems, and has consequences for important aspects of applied research. For example, the molecular basis of bacterial pathogenicity has implications for new antibiotics and in crop development. Prokaryotic Gene Expression is a major review of the subject, providing up-to-date coverage as well as numerous insights by the prestigious authors. Topics covered include operons; protein recognition of sequence specific DNA- and RNA-binding sites; promoters; sigma factors, and variant tRNA polymerases; repressors and activators; post-transcriptional control and attenuation; ribonuclease activity, mRNA stability, and translational repression; prokaryotic DNA topology, topoisomerases, and gene expression; regulatory networks, regulatory cascades and signal transduction; phosphotransfer reactions; switch systems, transcriptional and translational modulation, methylation, and recombination mechanisms; pathogenicity, toxin regulation and virulence determinants; sporulation and genetic regulation of antibiotic production; origins of regulatory molecules, selective pressures and evolution of prokaryotic regulatory mechanisms systems. Over 1100 references to the primary literature are cited. Prokaryotic Gene Expression is a comprehensive and authoritative review of current knowledge and research in the area. It is essential reading for postgraduates and researchers in the field. Advanced undergraduates in biochemistry, molecular biology, and microbiology will also find this book useful.

Biology of the Prokaryotes

Joseph W. Lengeler,Gerhart Drews,Hans G. Schlegel
Biology of the Prokaryotes Book PDF

Author : Joseph W. Lengeler,Gerhart Drews,Hans G. Schlegel
Publisher : Wiley-Blackwell
Page : 998 pages
File Size : 48,8 Mb
Release : 1999-02-03
Category : Science
ISBN : 0632053577

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Biology of the Prokaryotes by Joseph W. Lengeler,Gerhart Drews,Hans G. Schlegel Pdf

Designed as an upper-level textbook and a reference for researchers, this important book concentrates on central concepts of the bacterial lifestyle. Taking a refreshingly new approach, it present an integrated view of the prokaryotic cell as an organism and as a member of an interacting population. Beginning with a description of cellular structures, the text proceeds through metabolic pathways and metabolic reactions to the genes and regulatory mechanisms. At a higher level of complexity, a discussion of cell differentiation processes is followed by a description of the diversity of prokaryotes and their role in the biosphere. A closing section deals with man and microbes (ie, applied microbiology). The first text to adopt an integrated view of the prokaryotic cell as an organism and as a member of a population. Vividly illustrates the diversity of the prokaryotic world - nearly all the metabolic diversity in living organisms is found in microbes. New developments in applied microbiology highlighted. Extensive linking between related topics allows easy navigation through the book. Essential definitions and conclusions highlighted. Supplementary information in boxes.

Systems Biology

Mohamed Al-Rubeai,Martin Fussenegger
Systems Biology Book PDF

Author : Mohamed Al-Rubeai,Martin Fussenegger
Publisher : Springer Science & Business Media
Page : 426 pages
File Size : 43,7 Mb
Release : 2007-05-15
Category : Science
ISBN : 9781402052521

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Systems Biology by Mohamed Al-Rubeai,Martin Fussenegger Pdf

This book is a comprehensive guide to the revolutionary area of systems biology and its application in cell culture engineering. It is designed to offer a state-of-the-art review with in depth assessments and perspectives of post-genomic biology through understanding the molecular and cellular basis of integrated biological systems. The chapters describe the necessary methodologies for performing systems biology research.

DNA Repair Protocols

Pat Vaughan
DNA Repair Protocols Book PDF

Author : Pat Vaughan
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 40,6 Mb
Release : 2008-02-02
Category : Science
ISBN : 9781592590681

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DNA Repair Protocols by Pat Vaughan Pdf

When setting out to decide on the content of DNA Repair Protocols: Prokaryotic Systems, I was conscious of the need to portray the vast array of pathways and enzymatic activities that are part of the discipline of DNA repair. In addition to the classical DNA repair activities, I wanted to convey the significant interest that has been generated in recent years in the use of the proteins and repair systems as research tools, much like the use of restriction enzymes over the last few decades. Therefore, in addition to chapters deta- ing protocols for investigating specific repair activities, I have included s- eral chapters in this book on the applied use of DNA repair proteins and systems. The many years of research on bacterial DNA repair systems have allowed us to really understand the majority of DNA repair pathways in bac- rial cells. Building on this knowledge, research has lead to major advances in understanding mammalian DNA repair and uncovered its links to human d- ease, such as DNA mismatch repair and colon cancer, nucleotide excision repair and xeroderma pigmentosum, DNA helicase function in Bloom’s s- drome, and so on. Such have been the advances that Science magazine iden- fied the collective DNA repair systems as its “Molecule of the Year” in 1994.

Annual Plant Reviews, Plant Systems Biology

Gloria Coruzzi,Rodrigo Gutiérrez
Annual Plant Reviews Plant Systems Biology Book PDF

Author : Gloria Coruzzi,Rodrigo Gutiérrez
Publisher : John Wiley & Sons
Page : 376 pages
File Size : 52,9 Mb
Release : 2009-05-06
Category : Science
ISBN : 1444312235

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Annual Plant Reviews, Plant Systems Biology by Gloria Coruzzi,Rodrigo Gutiérrez Pdf

Plant Systems Biology is an excellent new addition to theincreasingly well-known and respected Annual Plant Reviews.Split into two parts, this title offers the reader: A fundamental conceptual framework for Systems Biologyincluding Network Theory The progress achieved for diverse model organisms: Prokaryotes, C. elegans and Arabidopsis The diverse sources of “omic” information necessaryfor a systems understanding of plants Insights into the software tools developed for systemsbiology Interesting case studies regarding applications includingnitrogen-use, flowering-time and root development Ecological and evolutionary considerations regarding livingsystems This volume captures the cutting edge of systems biologyresearch and aims to be an introductory material for undergraduateand graduate students as well as plant and agricultural scientists,molecular biologists, geneticists and microbiologists. It alsoserves as a foundation in the biological aspects of the field forinterested computer scientists. Libraries in all universities andresearch establishments where biological and agricultural sciencesare studied and taught and integrated with Computer Sciences shouldhave copies of this important volume on their shelves.

Prokaryotic Cytoskeletons

Jan Löwe,Linda A. Amos
Prokaryotic Cytoskeletons Book PDF

Author : Jan Löwe,Linda A. Amos
Publisher : Springer
Page : 450 pages
File Size : 41,6 Mb
Release : 2017-05-11
Category : Science
ISBN : 9783319530475

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Prokaryotic Cytoskeletons by Jan Löwe,Linda A. Amos Pdf

This book describes the structures and functions of active protein filaments, found in bacteria and archaea, and now known to perform crucial roles in cell division and intra-cellular motility, as well as being essential for controlling cell shape and growth. These roles are possible because the cytoskeletal and cytomotive filaments provide long range order from small subunits. Studies of these filaments are therefore of central importance to understanding prokaryotic cell biology. The wide variation in subunit and polymer structure and its relationship with the range of functions also provide important insights into cell evolution, including the emergence of eukaryotic cells. Individual chapters, written by leading researchers, review the great advances made in the past 20-25 years, and still ongoing, to discover the architectures, dynamics and roles of filaments found in relevant model organisms. Others describe one of the families of dynamic filaments found in many species. The most common types of filament are deeply related to eukaryotic cytoskeletal proteins, notably actin and tubulin that polymerise and depolymerise under the control of nucleotide hydrolysis. Related systems are found to perform a variety of roles, depending on the organisms. Surprisingly, prokaryotes all lack the molecular motors associated with eukaryotic F-actin and microtubules. Archaea, but not bacteria, also have active filaments related to the eukaryotic ESCRT system. Non-dynamic fibres, including intermediate filament-like structures, are known to occur in some bacteria.. Details of known filament structures are discussed and related to what has been established about their molecular mechanisms, including current controversies. The final chapter covers the use of some of these dynamic filaments in Systems Biology research. The level of information in all chapters is suitable both for active researchers and for advanced students in courses involving bacterial or archaeal physiology, molecular microbiology, structural cell biology, molecular motility or evolution. Chapter 3 of this book is open access under a CC BY 4.0 license.

Concepts of Biology

Samantha Fowler,Rebecca Roush,James Wise
Concepts of Biology Book PDF

Author : Samantha Fowler,Rebecca Roush,James Wise
Publisher : Unknown
Page : 618 pages
File Size : 52,7 Mb
Release : 2018-01-07
Category : Science
ISBN : 9888407457

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Concepts of Biology by Samantha Fowler,Rebecca Roush,James Wise Pdf

Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.

Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Methods for Prokaryotic and Eukaryotic Systems

Anonim
Chemical Tools for Imaging Manipulating and Tracking Biological Systems Diverse Methods for Prokaryotic and Eukaryotic Systems Book PDF

Author : Anonim
Publisher : Academic Press
Page : 360 pages
File Size : 49,5 Mb
Release : 2020-05-14
Category : Science
ISBN : 9780128201480

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Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Methods for Prokaryotic and Eukaryotic Systems by Anonim Pdf

Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Methods for Prokaryotic and Eukaryotic Systems, Volume 638, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sample chapters from this new release include In vitro characterization of the colibactin-activating peptidase ClbP enables development of a fluorogenic activity probe, Using FDAA probes to study cell division in Bacillus subtilis, Chemoenzymatic synthesis of UDP-sugars, Chemical tools for selective activity profiling of bacterial penicillin-binding proteins, Chemical Probes Reveal and Extraseptal Mode of Cross-linking in Staphylococcus Aureus, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on retinoid signaling pathways

The Prokaryotes

Stanley Falkow,Eugene Rosenberg,Karl-Heinz Schleifer,Erko Stackebrandt
The Prokaryotes Book PDF

Author : Stanley Falkow,Eugene Rosenberg,Karl-Heinz Schleifer,Erko Stackebrandt
Publisher : Springer Science & Business Media
Page : 1157 pages
File Size : 47,7 Mb
Release : 2006-07-13
Category : Science
ISBN : 9780387254920

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The Prokaryotes by Stanley Falkow,Eugene Rosenberg,Karl-Heinz Schleifer,Erko Stackebrandt Pdf

The revised Third Edition of The Prokaryotes, acclaimed as a classic reference in the field, offers new and updated articles by experts from around the world on taxa of relevance to medicine, ecology and industry. Entries combine phylogenetic and systematic data with insights into genetics, physiology and application. Existing entries have been revised to incorporate rapid progress and technological innovation. The new edition improves on the lucid presentation, logical layout and abundance of illustrations that readers rely on, adding color illustration throughout. Expanded to seven volumes in its print form, the new edition adds a new, searchable online version.

The Pangenome

Hervé Tettelin,Duccio Medini
The Pangenome Book PDF

Author : Hervé Tettelin,Duccio Medini
Publisher : Springer Nature
Page : 311 pages
File Size : 40,5 Mb
Release : 2020-04-30
Category : Science
ISBN : 9783030382810

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The Pangenome by Hervé Tettelin,Duccio Medini Pdf

This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.

Structural and Functional Relationships in Prokaryotes

Larry L. Barton
Structural and Functional Relationships in Prokaryotes Book PDF

Author : Larry L. Barton
Publisher : Springer Science & Business Media
Page : 833 pages
File Size : 41,5 Mb
Release : 2005-11-24
Category : Science
ISBN : 9780387271255

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Structural and Functional Relationships in Prokaryotes by Larry L. Barton Pdf

For several decades, bacteria have served as model systems to describe the life p- cesses of growth and metabolism. In addition, it is well recognized that prokaryotes have contributed greatly to the many advances in the areas of ecology, evolution, and biotechnology. This understanding of microorganisms is based on studies of members from both theBacteria andArchaea domains. With each issue of the various scienti?c publications, new characteristics of prokaryotic cells are being reported and it is - portant to place these insights in the context of the appropriate physiological processes. Structural and Functional Relationships in Prokaryotes describes the fundamental physiological processes for members of the Archaea and Bacteria domains. The - ganization of the book re?ects the emphasis that I have used in my 30 years of teaching a course of bacterial physiology. The philosophy used in the preparation of this book is to focus on the fundamental features of prokaryotic physiology and to use these features as the basis for comparative physiology. Even though diverse phenotypes have evolved from myriad genetic possibilities, these prokaryotes display considerable functional similarity and support the premise that there is a unity of physiology in the prokaryotes. The variations observed in the chemical structures and biochemical p- cesses are important in contributing to the persistence of microbial strains in a speci?c environment.

Systems and Computational Biology

Ning-Sun Yang
Systems and Computational Biology Book PDF

Author : Ning-Sun Yang
Publisher : BoD – Books on Demand
Page : 346 pages
File Size : 45,5 Mb
Release : 2011-09-15
Category : Computers
ISBN : 9789533072807

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Systems and Computational Biology by Ning-Sun Yang Pdf

Whereas some "microarray" or "bioinformatics" scientists among us may have been criticized as doing "cataloging research", the majority of us believe that we are sincerely exploring new scientific and technological systems to benefit human health, human food and animal feed production, and environmental protections. Indeed, we are humbled by the complexity, extent and beauty of cross-talks in various biological systems; on the other hand, we are becoming more educated and are able to start addressing honestly and skillfully the various important issues concerning translational medicine, global agriculture, and the environment. The two volumes of this book presents a series of high-quality research or review articles in a timely fashion to this emerging research field of our scientific community.

The Science and Applications of Synthetic and Systems Biology

Institute of Medicine,Board on Global Health,Forum on Microbial Threats
The Science and Applications of Synthetic and Systems Biology Book PDF

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 570 pages
File Size : 47,9 Mb
Release : 2011-12-30
Category : Science
ISBN : 9780309219396

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The Science and Applications of Synthetic and Systems Biology by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

Biology for AP ® Courses

Julianne Zedalis,John Eggebrecht
Biology for AP Courses Book PDF

Author : Julianne Zedalis,John Eggebrecht
Publisher : Unknown
Page : 1923 pages
File Size : 55,9 Mb
Release : 2017-10-16
Category : Biology
ISBN : 1947172409

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Biology for AP ® Courses by Julianne Zedalis,John Eggebrecht Pdf

Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences.