Prospects For Chemoprevention Of Colorectal Neoplasia

Author : Andrew T. Chan,Elmar Detering
Publisher : Springer Science & Business Media
Page : 186 pages
File Size : 55,5 Mb
Release : 2012-08-15
Category : Medical
ISBN : 9783642303319

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Prospects for Chemoprevention of Colorectal Neoplasia by Andrew T. Chan,Elmar Detering Pdf

The prevention of colorectal cancer is a subject of increasing medical importance, and there have been a number of promising recent developments. This book examines in detail important aspects of the current status and future prospects for chemoprevention of colorectal tumors. Research into the mechanisms that lead from early colorectal adenoma to colorectal cancer is discussed. The role and modes of action of available drugs such as celecoxib and sulindac are described, and recent data from aspirin trials are analyzed. In addition, the possible impact of nutritional agents with anti-inflammatory properties is considered, and strategies applicable in those with a high level of genetic risk are evaluated. An important feature of the book is its holistic perspective, making it relevant for gastroenterologists, internists, general practitioners, oncologists, colorectal and gastroenterological surgeons, and public health practitioners.

Author : Gary Kelloff,Charles W. Boone
Publisher : Unknown
Page : 216 pages
File Size : 52,6 Mb
Release : 1997
Category : Biochemical markers
ISBN : UCSC:32106012913627

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Prospects for Chemoprevention in Cohorts with Cancer Risk Markers by Gary Kelloff,Charles W. Boone Pdf

Author : Daniel W. Nixon
Publisher : CRC Press
Page : 160 pages
File Size : 53,7 Mb
Release : 1994-11-08
Category : Medical
ISBN : 0849368502

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Chemoprevention of Cancer by Daniel W. Nixon Pdf

Chemoprevention of Cancer guides you through the exciting new field of cancer chemoprevention. It covers epidemiology, known chemopreventive compounds, development of new chemopreventive agents, specific examples of preventive agents and their mechanisms of action, and current prevention clinical trials.

Author : Gary J. Kelloff,Ernest T. Hawk,Caroline C. Sigman
Publisher : Springer Science & Business Media
Page : 543 pages
File Size : 52,8 Mb
Release : 2008-08-17
Category : Medical
ISBN : 9781592597680

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Cancer Chemoprevention by Gary J. Kelloff,Ernest T. Hawk,Caroline C. Sigman Pdf

Despite significant advances in cancer treatment and measures of neoplastic progression, drug effect (or early detection, overall cancer incidence has increased, pharmacodynamic markers), and markers that measure cancer-associated morbidity is considerable, and overall prognosis as well as predict responses to specific therapy. cancer survival has remained relatively flat over the past All these biomarkers have the potential to greatly augment several decades (1,2). However, new technology the development of successful chemoprevention therapies, allowing exploration of signal transduction pathways, but two specific types of biomarkers will have the most identification of cancer-associated genes, and imaging of immediate impact on successful chemopreventive drug tissue architecture and molecular and cellular function is development—those that measure the risk of developing increasing our understanding of carcinogenesis and cancer invasive life-threatening disease, and those whose mo- progression. This knowledge is moving the focus of cancer lation can “reasonably predict” clinical benefit and, therapeutics, including cancer preventive treatments, to therefore, serve as surrogate endpoints for later-occurring drugs that take advantage of cellular control mechanisms clinical disease. Thus far, the biomarker that best measures to selectively suppress cancer progression. these two phenomena is intraepithelial neoplasia (IEN) Carcinogenesis is now visualized as a multifocal, because it is a near obligate precursor to cancer.

Author : Rosalind A. Eeles,Christine D. Berg,Jeffrey S. Tobias
Publisher : John Wiley & Sons
Page : 453 pages
File Size : 40,5 Mb
Release : 2018-11-13
Category : Medical
ISBN : 9781118990872

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Cancer Prevention and Screening by Rosalind A. Eeles,Christine D. Berg,Jeffrey S. Tobias Pdf

Winner of the Council Chair's Choice Award at the 2019 British Medical Association Awards. Cancer Prevention and Screening offers physicians and all clinical healthcare professionals a comprehensive, useful source of the latest information on cancer screening and prevention with both a global and a multidisciplinary perspective. Includes background information on epidemiology, cancer prevention, and cancer screening, for quick reference Offers the latest information for clinical application of the most recent techniques in prevention and screening of all major and many lesser cancer types Emphasises the importance of multidisciplinary teamwork in cancer screening Highlights frequent dilemmas and difficulties encountered during cancer screening Provides clear-cut clinical strategies for optimal patient education, communication, and compliance with cancer prevention techniques

Author : Kevin M. Haigis, Ph.D.
Publisher : Springer Science & Business Media
Page : 316 pages
File Size : 46,8 Mb
Release : 2013-10-02
Category : Medical
ISBN : 9781461484127

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Molecular Pathogenesis of Colorectal Cancer by Kevin M. Haigis, Ph.D. Pdf

Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.

Author : Hans-Olov Adami,David Hunter,Dimitrios Trichopoulos
Publisher : Oxford University Press
Page : 784 pages
File Size : 40,9 Mb
Release : 2008-02-27
Category : Medical
ISBN : 9780199718634

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Textbook of Cancer Epidemiology by Hans-Olov Adami,David Hunter,Dimitrios Trichopoulos Pdf

This superb text gives a concise, systematic account of what is currently known about the epidemiology and primary prevention for most forms of human cancer. Part 1 provides an introduction to basic concepts in epidemiology, a description of the global burden of cancer, definitions and characterizations of the various measures used, and approaches used to reveal genetic determinants of cancer risk and integrate biologic markers in the epidemiogic research process. Part 2 contains chapters of uniform structure on over 20 types of cancer, providing clinical and pathological outlines, descriptive epidemiology, and a comprehensive account of risk factors and their etiological importance. Specific sections address somatic and germ cell mutations that play a role in the occurrence of particular forms of cancer.

Author : Jindong Chen
Publisher : BoD – Books on Demand
Page : 130 pages
File Size : 55,5 Mb
Release : 2018-05-16
Category : Medical
ISBN : 9781789231007

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Colorectal Cancer by Jindong Chen Pdf

With international experts sharing their experience and knowledge on these different aspects in the management of colorectal cancer, this book has this opportunity to offer all physicians treating colorectal cancer, as well as researchers, updated information concerning the biology, diagnosis, screening, and treatment of colorectal carcinoma. This book provides a detailed evaluation of diagnostic modalities, in-depth analysis of screening for colorectal cancer, recent advances in treatment, and principles and trends in the management of colorectal cancer. This updated knowledge will be an interesting and informative read for any clinician involved in the management of patients with colorectal cancer. In addition, readers such as related physicians, researchers, and colorectal cancer patients are potential beneficiaries of this book.

Author : H.-J. Senn,Alberto Costa,Craig Jordan
Publisher : Springer Science & Business Media
Page : 183 pages
File Size : 44,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642599453

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Chemoprevention of Cancer by H.-J. Senn,Alberto Costa,Craig Jordan Pdf

Pharmacologic interventions to prevent the evolution of human cancers are still in its infancy, although a good number o- mostly controlled - clinical studies have been performed in the past two decades. However, regarding the partially stagnating therapeutic results of major epithelial cancer types such as breast-, lung-, colon- and ENT-cancer types, the problem of in terference with the evolution of disease at a preclinical level is an intriguing one, and the field seems to develop into one of the fastest growing domaines of modern oncology. This process is fa cilitated by the developments of molecular on co-genetics and the gowing existence of family cancer units, allowing to better identi fy and inform respective high risk groups, thus enabling re searchers and clinicians to more realistically target their chemo preventive efforts to the true populations at risk. On this changing background, the newly formed International Society of Cancer Chemoprevention (ISCaC) together with the Swiss Cancer League and the Interdisciplinary Oncology Center of St. Gallen/Switzerland organized an international Symposium in September 1997, inviting basic researchers, epidemiologists and clinical oncologists of related disciplines to discuss pertinent issues of experimental and clinical chemo- and bio-prevention in a scientific workshop.

Author : Gabriel Kune
Publisher : Springer Science & Business Media
Page : 408 pages
File Size : 43,8 Mb
Release : 1996-05-31
Category : Medical
ISBN : 0792340590

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Causes and Control of Colorectal Cancer by Gabriel Kune Pdf

Causes and Control of Colorectal Cancer: A Model for Cancer Prevention is a ground- breaking monograph which takes a global, multidisciplinary approach to the causes, carcinogenesis and control of colorectal cancer. Over 1000 key studies were analyzed on colorectal cancer cause, carcinogenesis, primary prevention, early detection using modern screening techniques, and surveillance after tumor excision. All major research results are included up to the date of publication. The key chapters include those on morphology, molecular biology and evolution of tumors, etiology chapters on heredity, diet, alcohol, smoking, physical activity, life stress and others, while major chapters in the area of colorectal cancer control are on primary prevention, early detection by screening and surveillance, and post-tumor excision surveillance. Important recommendations on primary prevention, screening and surveillance of colorectal tumors are made in keeping with the most current research data. Causes and Control of Colorectal Cancer: A Model for Cancer Prevention takes colorectal cancer control into the 21st century, and suggests this to be the first cancer in which control will be largely achieved within the next generation, as a result of the unprecedented multidisciplinary research into causation, primary prevention, screening and surveillance over the past 30 years. The book also serves as a model for the control of other common malignancies, particularly cancers of the breast and prostate, the causes and prevention of which are less well understood.

Author : Eduardo L. Franco,Thomas E. Rohan
Publisher : Springer Science & Business Media
Page : 430 pages
File Size : 45,9 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9780387216058

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Cancer Precursors by Eduardo L. Franco,Thomas E. Rohan Pdf

Cancer Precursors is a groundbreaking, multidisciplinary text containing a comprehensive overview of methodological issues associated with the study of pre-cancerous conditions, as well as reviews of the contributions of descriptive, analytical, and molecular epidemiological research to knowledge about cancer precursors at specific anatomical locations. The research focuses on the early natural history of cancers, by helping to define the etiology of precursor lesions, improving the means of detecting them either directly or via testing of surrogate biomarkers, and by elucidating the role of remote causes leading to the early onset of such lesions.

Author : Naohiro Tomita
Publisher : Springer Nature
Page : 143 pages
File Size : 47,5 Mb
Release : 2020-08-24
Category : Medical
ISBN : 9789811568916

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Lynch Syndrome by Naohiro Tomita Pdf

This book offers a comprehensive review of Lynch Syndrome (LS), addressing both the basic and clinical aspects of this condition. Due to the recent advances in our understanding of the genetic mechanism of LS, and to new screening methods, including universal screening and/or multi-gene panel analysis, the standard treatment strategy for patients and family members of LS have been steadily improving. In this book, experts describe the disease’s manifestations, discuss state-of-the-art diagnosis and management options, and offer a cutting-edge overview of the genetic and epigenetic basis of the syndrome. Providing essential insights into this new phase in the management of LS, this book is a valuable resource not only for colorectal surgeons, but also for general gastrointestinal clinicians, gynecologists, oncologists and all basic researchers with an interest in LS.

Author : Summya Rashid
Publisher : Springer
Page : 173 pages
File Size : 48,9 Mb
Release : 2017-07-05
Category : Medical
ISBN : 9789811025792

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Cancer and Chemoprevention: An Overview by Summya Rashid Pdf

This book focuses on the most recent, relevant, comprehensive and significant advances in cancer and chemo prevention. It broadly discusses cancer, its hallmarks and classification, molecular mechanisms of outbreak, contributing factors, role of oxidative stress, inflammatory mediators and evading apoptosis, which leads to the progression of disease. Though modern medicine has left us with no option to treat this deadly disease due to drawbacks associated with conventional treatment – like its non-targeted nature, drug resistance, varied organ toxicities and unaffordability – chemoprevention offers a viable therapeutic window. Given chemoprevention’s importance in the present scenario, the book highlights various chemo preventive strategies currently used in the management of cancer; a selection of novel chemo preventive agents used at clinics and in the pre-clinical stage; hurdles to effective chemoprevention; future prospects and the road ahead. It offers a valuable guide for all graduate students and researchers seeking information on cancer and chemoprevention in general, irrespective of the specific type/pathways involved in its onset.

Author : Institute of Medicine,National Cancer Policy Forum
Publisher : National Academies Press
Page : 128 pages
File Size : 50,9 Mb
Release : 2008-12-01
Category : Medical
ISBN : 9780309178303

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Implementing Colorectal Cancer Screening by Institute of Medicine,National Cancer Policy Forum Pdf

The IOM's National Cancer Policy Board estimated in 2003 that even modest efforts to implement known tactics for cancer prevention and early detection could result in up to a 29 percent drop in cancer deaths in about 20 years. The IOM's National Cancer Policy Forum, which succeeded the Board after it was disbanded in 2005, continued the Board's work to outline ways to increase screening in the U.S. On February 25 and 26, 2008, the Forum convened a workshop to discuss screening for colorectal cancer. Colorectal cancer screening remains low, despite strong evidence that screening prevents deaths. With the aim to make recommended colorectal cancer screening more widespread, the workshop discussed steps to be taken at the clinic, community, and health system levels. Workshop speakers, representing a broad spectrum of leaders in the field, identified major barriers to increased screening and described strategies to overcome these obstacles. This workshop summary highlights the information presented, as well as the subsequent discussion about actions needed to increase colorectal screening and, ultimately, to prevent more colorectal cancer deaths.

Author : Leonard B. Saltz
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 41,9 Mb
Release : 2007-11-07
Category : Medical
ISBN : 9781597452151

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Colorectal Cancer by Leonard B. Saltz Pdf

Management options for patients with colorectal cancer have undergone d- matic changes over the past decade. Whereas at the start of 1996 only one drug, 5-Fluorouracil, was available for the treatment of this disease, a mere 10 yr later, six drugs are licensed for use in colorectal cancer, and others are in the late phases of clinical development. Likewise, surgical and ablative options, as well as an array of supportive medications, have shown substantial progress and undergone a dramatic proliferation over the past decade. With the increased number of therapeutic options from which to choose, the clinician is better able to offer effective therapy to the patient with colorectal cancer. The clinician is challenged, however, to keep up with the rapidly changing landscape and the rapidly emerging data that shape the options for treatment today and tom- row. In this text, leaders in the management of colorectal cancer review the current literature that has led us to where we are today. Critical evaluations of the data are offered, and evidence-based recommendations are made.