Proteases Of Infectious Agents

Author : Ben Dunn
Publisher : Elsevier
Page : 282 pages
File Size : 51,6 Mb
Release : 1999-07-01
Category : Science
ISBN : 0080525741

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Proteases of Infectious Agents by Ben Dunn Pdf

Proteases are enzymes that essentially "eat" protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search. Proteases of Infectious Agents collects reviews from leading experts describing the latest information on the properties of key enzymes from a variety of viruses, fungi, and parasites. Each chapter provides the critical facts needed to initiate a drug discovery effort in that particular area. Includes information on the basic biology and function of proteases Provides global survey of current research efforts in protease inhibitors Illustrates how structure-based drug design targets effective and selective compounds Highlights important diseases that provide economically important targets Describes the role of proteases as important new targets for drug discovery

Author : Satya Prakash Gupta
Publisher : Academic Press
Page : 516 pages
File Size : 43,8 Mb
Release : 2017-07-03
Category : Science
ISBN : 9780128096826

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Viral Proteases and Their Inhibitors by Satya Prakash Gupta Pdf

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases

Author : Mario Campa,Mauro Bendinelli,Herman Friedman
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 55,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461530367

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Pseudomonas aeruginosa as an Opportunistic Pathogen by Mario Campa,Mauro Bendinelli,Herman Friedman Pdf

Assembling the latest research by an international group of contributors, this volume covers the epidemiology, pathogenesis, clinical features, and control measures of this elusive microorganism. It will provide a deeper understanding of the pathogen to physicians and surgeons caring for patients infected, or at risk of becoming infected, with Pseudomonas Aeruginosa.

Author : Stefan Offermanns,W. Rosenthal
Publisher : Springer Science & Business Media
Page : 1515 pages
File Size : 54,5 Mb
Release : 2008-08-14
Category : Medical
ISBN : 9783540389163

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Encyclopedia of Molecular Pharmacology by Stefan Offermanns,W. Rosenthal Pdf

An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Author : Sajal Chakraborti,Naranjan S. Dhalla
Publisher : Springer Science & Business Media
Page : 407 pages
File Size : 45,6 Mb
Release : 2013-12-04
Category : Science
ISBN : 9781461492337

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Proteases in Health and Disease by Sajal Chakraborti,Naranjan S. Dhalla Pdf

In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 44,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Sajal Chakraborti,Tapati Chakraborti,Naranjan S. Dhalla
Publisher : Springer
Page : 513 pages
File Size : 47,7 Mb
Release : 2017-07-13
Category : Medical
ISBN : 9789811031625

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Proteases in Human Diseases by Sajal Chakraborti,Tapati Chakraborti,Naranjan S. Dhalla Pdf

This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

Author : Kenneth Söderhäll,Sadaaki Iwanaga,Gerardo R. Vasta
Publisher : SOS Publications (NJ)
Page : 494 pages
File Size : 43,7 Mb
Release : 1996
Category : Science
ISBN : 0962550590

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New Directions in Invertebrate Immunology by Kenneth Söderhäll,Sadaaki Iwanaga,Gerardo R. Vasta Pdf

The study of defense systems of invertebrates has drawn increasing attention & fascination in recent years. A considerable range of strategies for recognition & defense against potential pathogens & parasites has been found. Although at the cellular level the invertebrate responses appear to rely in common themes such as phagocytosis & encapsulation, the underlying molecular recognition & effector mechanisms can be quite diverse. From the evolutionary standpoint some of these factors have been substantially conserved through the lineages leading to the cherlates. Hematopoietic disorders, cytotoxic reactions, neuropeptide involvement, production of oxygen intermediates, cytokines, proteinase inhibitors, lectins, prophenoloxidase, clotting cascade, immunoglobulin superfamily proteins, complement-related proteins, ciliate pheromones insect cuticle, virus-insect interactions, insect vector immunity & insect-fungal interaction are among the subjects discussed in this outstanding volume. Chapters were written by leading experts on the selected topics.

Author : Anonim
Publisher : Academic Press
Page : 459 pages
File Size : 50,8 Mb
Release : 1991-01-28
Category : Technology & Engineering
ISBN : 0080865968

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Mechanisms of Catalysis by Anonim Pdf

The remarkable expansion of information leading to a deeper understanding of enzymes on the molecular level necessitated the development of this volume which not only introduces new topics to The Enzymes series but presents new information on some covered in Volume I and II of this edition.

Author : Anonim
Publisher : Unknown
Page : 1154 pages
File Size : 49,6 Mb
Release : 2014
Category : Communicable diseases
ISBN : UGA:32108053598408

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Emerging Infectious Diseases by Anonim Pdf

Author : Alasdair M. Gilfillan,Dean Metcalfe
Publisher : Springer Science & Business Media
Page : 312 pages
File Size : 51,5 Mb
Release : 2011-06-28
Category : Medical
ISBN : 9781441995339

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Mast Cell Biology by Alasdair M. Gilfillan,Dean Metcalfe Pdf

The editors of Mast Cell Biology, Drs. Gilfillan and Metcalfe, have enlisted an outstanding group of investigators to discuss the emerging concepts in mast cell biology with respect to development of these cells, their homeostasis, their activation, as well as their roles in maintaining health on the one hand and on the other, their participation in disease.

Author : Iqbal Ahmad,Mohammad Owais,Mohammed Shahid,Farrukh Aqil
Publisher : Springer Science & Business Media
Page : 549 pages
File Size : 40,5 Mb
Release : 2010-08-03
Category : Medical
ISBN : 9783642121739

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Combating Fungal Infections by Iqbal Ahmad,Mohammad Owais,Mohammed Shahid,Farrukh Aqil Pdf

Fungi are eukaryotic microorganisms that are closely related to humans at cellular level. Human fungal pathogens belong to various classes of fungi, mainly zygo- cetes, ascomycetes, basidiomycetes, and deuteromycetes. In recent years, fungal infections have dramatically increased as a result of improved diagnosis, high frequency of catheterization, instrumentation, etc. However, the main cause remains the increasing number of immunosuppressed patients, mostly because of HIV infection and indiscriminate usage of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics and prosthetic devices, and grafts in clinical settings. Presently available means of combating fungal infections are still weak and clumsy compared to control of bacterial infection. The present scenario of antifungal therapy is still based on two classes of antifungal drugs (polyenes and azoles). These drugs are effective in many cases, but display toxicity and limited spectrum of ef?cacy. The recent trend towards emergence of drug-resistant isolates in the clinic is an additional problem. In recent years, a few new antifungal drugs have entered the clinics, but they are expected to undergo same fate as the older antifungal drugs. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. However, it is too early to expect any novel drugs, as the antifungal drug discovery program is in the stage of infancy. Interestingly, several novel antifungal drug targets have been identi?ed and validated.

Author : Jean-Marc Cavaillon,Mervyn Singer
Publisher : John Wiley & Sons
Page : 1818 pages
File Size : 48,7 Mb
Release : 2018-02-20
Category : Medical
ISBN : 9783527338993

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Inflammation, 4 Volume Set by Jean-Marc Cavaillon,Mervyn Singer Pdf

The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.

Author : Sajal Chakraborti,Naranjan S. Dhalla
Publisher : Springer
Page : 671 pages
File Size : 46,9 Mb
Release : 2017-11-15
Category : Medical
ISBN : 9789811061417

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Pathophysiological Aspects of Proteases by Sajal Chakraborti,Naranjan S. Dhalla Pdf

This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research. Proteases represent one of the largest and most diverse families of enzymes known, and we now know that they are involved in every aspect of a given organism’s life functions. Under physiological conditions, proteases are regulated by their endogenous inhibitors. However, when the activity of proteases is not correctly regulated, disease processes such as tumour progression, vascular remodelling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, Alzheimer’s disease and inflammation can result. Many infective microorganisms require proteases for replication or use them as virulence factors, which has facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

Author : David A. Dougan
Publisher : Springer Science & Business Media
Page : 338 pages
File Size : 43,7 Mb
Release : 2013-03-12
Category : Medical
ISBN : 9789400759404

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Regulated Proteolysis in Microorganisms by David A. Dougan Pdf

This book contains an extensive collection of critical reviews, from leading researchers in the field of regulated protein degradation. It covers the role of regulated proteolysis in a range of microorganisms (from Gram positive, Gram negative and pathogenic bacteria to Archaea and the Baker’s yeast Saccharomyces cerevisiae).