Protein Degradation With New Chemical Modalities

Protein Degradation With New Chemical Modalities Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Protein Degradation With New Chemical Modalities book. This book definitely worth reading, it is an incredibly well-written.

Protein Degradation with New Chemical Modalities

Hilmar Weinmann,Craig Crews
Protein Degradation with New Chemical Modalities Book PDF

Author : Hilmar Weinmann,Craig Crews
Publisher : Royal Society of Chemistry
Page : 382 pages
File Size : 41,5 Mb
Release : 2020-10-07
Category : Medical
ISBN : 9781839160776

Get Book

Protein Degradation with New Chemical Modalities by Hilmar Weinmann,Craig Crews Pdf

Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.

Protein Degradation with New Chemical Modalities

Craig Crews,Hilmar Weinmann
Protein Degradation with New Chemical Modalities Book PDF

Author : Craig Crews,Hilmar Weinmann
Publisher : Royal Society of Chemistry
Page : 382 pages
File Size : 54,5 Mb
Release : 2020-10-08
Category : Medical
ISBN : 9781788016865

Get Book

Protein Degradation with New Chemical Modalities by Craig Crews,Hilmar Weinmann Pdf

Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally 'difficult to target' proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.

Targeted Protein Degradation

Anonim
Targeted Protein Degradation Book PDF

Author : Anonim
Publisher : Elsevier
Page : 342 pages
File Size : 40,8 Mb
Release : 2023-02-08
Category : Science
ISBN : 9780323992015

Get Book

Targeted Protein Degradation by Anonim Pdf

Targeted Protein Degradation, Volume 680 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of timely topics, with each. Each written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology serials Updated release includes the latest information on Targeted Protein Degradation

Inducing Targeted Protein Degradation

Philipp Cromm
Inducing Targeted Protein Degradation Book PDF

Author : Philipp Cromm
Publisher : John Wiley & Sons
Page : 389 pages
File Size : 48,7 Mb
Release : 2022-11-15
Category : Medical
ISBN : 9783527836215

Get Book

Inducing Targeted Protein Degradation by Philipp Cromm Pdf

Inducing Targeted Protein Degradation Enables drug developers in academia and industry to expand the range of accessible drug targets through induced protein degradation Since the breakthrough of the PROTAC technology in 2015, targeted protein degradation has revolutionized drug discovery, enabling pharma companies to develop completely novel therapeutics. Inducing Targeted Protein Degradation is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the druggable space. In Inducing Targeted Protein Degradation, readers will find the most recent information on: Cellular mechanisms of targeted protein degradation and current approaches to utilize these mechanisms for drug discovery A comparison of different induced degradation approaches, including PROTAC, molecular glues, LYTACs and ATTECs as well as additional post translational modifications Drug development aspects such as DMPK optimization and criteria for the selection of clinical candidates A discussion of the potential of targeted degradation for expanding the druggable space Inducing Targeted Protein Degradation will serve as a practice-oriented reference on induced protein degradation for drug discovery professionals and for researchers employing chemical biology approaches.

Chemical Linkers in AntibodyDrug Conjugates (ADCs)

Floris van Delft,John M. Lambert
Chemical Linkers in AntibodyDrug Conjugates ADCs Book PDF

Author : Floris van Delft,John M. Lambert
Publisher : Royal Society of Chemistry
Page : 477 pages
File Size : 46,7 Mb
Release : 2021-12-15
Category : Medical
ISBN : 9781839165160

Get Book

Chemical Linkers in AntibodyDrug Conjugates (ADCs) by Floris van Delft,John M. Lambert Pdf

The covalent conjugation of potent cytotoxic agents to monoclonal antibodies, known as antibody-drug conjugates (ADCs) is a powerful approach in the field of targeted treatment of cancer. Clearly, both monoclonal antibody and cytotoxic payload are crucial elements in determining the clinical value of an ADC and have receive ample attention. However, the structural element connecting the two –the chemical linker– also plays an essential role in mode-of-action, efficacy, pharmacokinetics and safety profile of an ADC, but is often underappreciated in considerations of ADC design. Chemical Linkers in Antibody–Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety. Ideal for postgraduate students and active researchers in drug discovery and development, this book provides a comprehensive description of linkers used in ADCs (clinical and late preclinical), insight into key quality attributes of linkers for ADCs, and aids the reader in understanding the role of linker chemistry and designing new ADCs.

Protein–Protein Interaction Regulators

Siddhartha Roy,Haian Fu
Protein Protein Interaction Regulators Book PDF

Author : Siddhartha Roy,Haian Fu
Publisher : Royal Society of Chemistry
Page : 399 pages
File Size : 47,6 Mb
Release : 2020-12-15
Category : Science
ISBN : 9781788011877

Get Book

Protein–Protein Interaction Regulators by Siddhartha Roy,Haian Fu Pdf

New genomic information has revealed the crucial role that protein-protein interactions (PPIs) play in regulating numerous cellular functions. Aberrant forms of these interactions are common in numerous diseases and thus PPIs have emerged as a vast class of critical drug targets. Despite the importance of PPIs in biology, it has been extremely challenging to convert targets into therapeutics and targeting PPIs had long been considered a very difficult task. However, over the past decade the field has advanced with increasing growth in the number of successful PPI regulators. Protein-Protein Interaction Regulators surveys the latest advances in the structural understanding of PPIs as well as recent developments in modulator discovery.

New Tools to Interrogate Endocannabinoid Signalling

Mauro Maccarrone
New Tools to Interrogate Endocannabinoid Signalling Book PDF

Author : Mauro Maccarrone
Publisher : Royal Society of Chemistry
Page : 473 pages
File Size : 51,8 Mb
Release : 2020-11-16
Category : Science
ISBN : 9781788018012

Get Book

New Tools to Interrogate Endocannabinoid Signalling by Mauro Maccarrone Pdf

New Tools to Interrogate Endocannabinoid Signalling comprehensively covers the innovative research into both natural and synthetic compounds. This timely volume will be a valuable resource to pharmaceutical researchers and medicinal chemists working in natural products and endocannabinoid drug discovery in academia and industry.

Drug Repurposing

David Cavalla
Drug Repurposing Book PDF

Author : David Cavalla
Publisher : Royal Society of Chemistry
Page : 351 pages
File Size : 50,9 Mb
Release : 2022-01-31
Category : Medical
ISBN : 9781839163418

Get Book

Drug Repurposing by David Cavalla Pdf

Drug repurposing is the development of existing drugs for new uses: given that 9 in 10 drugs that enter drug development are never marketed and therefore represent wasted effort, it is an attractive as well as inherently more efficient process. Three repurposed drugs can be brought to market for the same cost as one new chemical entity; and they can also be identified more quickly, an important benefit for patients whose diseases are progressing faster than therapeutic innovation. But repurposing also requires a fresh look at configuring pharmaceutical R&D, considering clinical, regulatory and patent issues much earlier than would otherwise be the case; a holistic gedanken experiment almost needs to be undertaken at the very start of any repurposing development. In addition to new ways of thinking, the discovery of repurposing opportunities can take advantage of artificial intelligence techniques to match the perfect new use for an existing drug. And while repurposing of medicines has been in the mind of every doctor since Hypocrates, modern clinical practice will simply have to adapt to new repurposing techniques in an age where the number of known diseases is increasing much faster than the healthcare dollars available.

The Medicinal Chemist's Guide to Solving ADMET Challenges

Patrick Schnider
The Medicinal Chemist s Guide to Solving ADMET Challenges Book PDF

Author : Patrick Schnider
Publisher : Royal Society of Chemistry
Page : 541 pages
File Size : 47,9 Mb
Release : 2021-08-20
Category : Science
ISBN : 9781839160493

Get Book

The Medicinal Chemist's Guide to Solving ADMET Challenges by Patrick Schnider Pdf

The Medicinal Chemist’s Guide to Solving ADMET Challenges summarizes a series of design strategies and tactics that have been successfully employed across pharmaceutical and academic laboratories to solve common ADMET issues. These are exemplified with a curated collection of concrete examples displayed in a highly visual “table-of-contents” style format, allowing readers to rapidly identify the most promising approaches applicable to their own challenges. Each ADMET parameter is introduced in a concise yet comprehensive manner and includes background, relevance and screening strategies. Medicinal chemistry knowledge of how best to modify molecular structure to solve ADMET issues is challenging to retrieve from the literature, public databases and even corporate data warehouses. The Medicinal Chemist’s Guide to Solving ADMET Challenges addresses this gap by presenting state-of-the-art design strategies put together by a global group of experienced medicinal chemists and ADMET experts across academia and the pharmaceutical industry.

Antiviral Discovery for Highly Pathogenic Emerging Viruses

César Muñoz-Fontela,Rafael Delgado
Antiviral Discovery for Highly Pathogenic Emerging Viruses Book PDF

Author : César Muñoz-Fontela,Rafael Delgado
Publisher : Royal Society of Chemistry
Page : 309 pages
File Size : 53,9 Mb
Release : 2021-11-26
Category : Medical
ISBN : 9781839160530

Get Book

Antiviral Discovery for Highly Pathogenic Emerging Viruses by César Muñoz-Fontela,Rafael Delgado Pdf

New antiviral drugs are urgently needed. Recent outbreaks caused by viruses with great epidemiological impact such as Zika, or extraordinary virulence such as Ebola, Nipah, Lassa, Crimean-Congo haemorrhagic fever highlight the current lack of clinically proven vaccines and treatments for these potentially catastrophic agents. Antiviral Discovery for Highly Pathogenic Emerging Viruses comprehensively outlines the state of the art in antiviral drug discovery including identification of targets, screening strategies and the current pipeline of antiviral candidates including regulatory issues. The book also addresses the challenges faced in proceeding from pre-clinical studies to animal models and clinical trials with these highly pathogenic agents. Ideal for drug discovery scientists and medicinal chemists with an interest in antiviral drug discovery and development, this book provides a complete overview of the latest progress in the field, recent advances and the challenges that remain in developing these highly pathogenic agents. Illustrated throughout with case studies this book is a valuable resource in this complex and multidisciplinary field.

The Handbook of Medicinal Chemistry

Simon E Ward,Andrew Davis
The Handbook of Medicinal Chemistry Book PDF

Author : Simon E Ward,Andrew Davis
Publisher : Royal Society of Chemistry
Page : 1051 pages
File Size : 45,7 Mb
Release : 2023-02-03
Category : Medical
ISBN : 9781839165887

Get Book

The Handbook of Medicinal Chemistry by Simon E Ward,Andrew Davis Pdf

Completely revised and updated, the 2nd edition of The Handbook of Medicinal Chemistry draws together contributions from authoritative practitioners to provide a comprehensive overview of the field as well as insight into the latest trends and research. An ideal companion for students in medicinal chemistry, drug discovery and drug development, while also communicating core principles, the book places the discipline within the context of the burgeoning platform of new modalities now available to drug discovery. The book also highlights the role chemistry has to play in wider target validation and translational technologies. This is a carefully curated compilation of writing from global experts using their broad experience of medicinal chemistry, project leadership and drug discovery and development from an industry, academic and charity perspective to provide unparalleled insight into the field.

Phenotypic Drug Discovery

Angelique Augustin,Beverley Isherwood
Phenotypic Drug Discovery Book PDF

Author : Angelique Augustin,Beverley Isherwood
Publisher : Royal Society of Chemistry
Page : 273 pages
File Size : 41,8 Mb
Release : 2020-12-10
Category : Medical
ISBN : 9781788018760

Get Book

Phenotypic Drug Discovery by Angelique Augustin,Beverley Isherwood Pdf

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of novel medical entities. This book aims to equip researchers with a thought-provoking guide to the application and development of contemporary phenotypic drug discovery for clinical success.

Artificial Intelligence in Drug Discovery

Nathan Brown
Artificial Intelligence in Drug Discovery Book PDF

Author : Nathan Brown
Publisher : Royal Society of Chemistry
Page : 425 pages
File Size : 46,9 Mb
Release : 2020-11-04
Category : Computers
ISBN : 9781839160547

Get Book

Artificial Intelligence in Drug Discovery by Nathan Brown Pdf

Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and simulation. Providing a wealth of information from leading experts in the field this book is ideal for students, postgraduates and established researchers in both industry and academia.

Targeted Protein Degradation

Angela M. Cacace,Christopher M. Hickey,Miklós Békés
Targeted Protein Degradation Book PDF

Author : Angela M. Cacace,Christopher M. Hickey,Miklós Békés
Publisher : Humana
Page : 351 pages
File Size : 49,8 Mb
Release : 2021-08-26
Category : Science
ISBN : 1071616641

Get Book

Targeted Protein Degradation by Angela M. Cacace,Christopher M. Hickey,Miklós Békés Pdf

This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteolysis-targeting chimeras (PROTACs) approaches, E3 ligase, E3 ligase-induced ubiquitylation, proteomic approaches, novel degrader molecules, molecular glue, and stabilize binding interaction between a target and E3 ubiquitin ligase. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Targeted Protein Degradation: Methods and Protocols aims to ensure successful results in this emerging field of drug discovery.

Alzheimer's Disease

Thimmaiah Govindaraju
Alzheimer s Disease Book PDF

Author : Thimmaiah Govindaraju
Publisher : Royal Society of Chemistry
Page : 695 pages
File Size : 42,9 Mb
Release : 2022-01-04
Category : Medical
ISBN : 9781839162749

Get Book

Alzheimer's Disease by Thimmaiah Govindaraju Pdf

Alzheimer’s disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition. Due to its multifactorial pathogenesis, current treatments are directed against symptoms and even precise diagnosis remains difficult as the majority of cases are diagnosed symptomatically and usually confirmed only by autopsy. Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities provides a comprehensive overview from aetiology and neurochemistry to diagnosis, evaluation and management of Alzheimer's disease, and latest therapeutic approaches. Intended to provide an introduction to all aspects of the disease and latest developments, this book is ideal for students, postgraduates and researchers in neurochemistry, neurological drug discovery and Alzheimer’s disease.