Proteins At Solid Liquid Interfaces

Author : Philippe Déjardin
Publisher : Springer Science & Business Media
Page : 341 pages
File Size : 43,6 Mb
Release : 2006-09-28
Category : Science
ISBN : 9783540326588

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Proteins at Solid-Liquid Interfaces by Philippe Déjardin Pdf

This book opens with a description of fundamental aspects of protein adsorption to surfaces, a phenomenon that plays a key role in biotechnological applications, especially at solid-liquid interfaces. Presented here are methods for studying adsorption kinetics and conformational changes such as optical waveguide lightmode spectroscopy (OWLS). Also described are sensitive bench techniques for measuring the orientation and structure of proteins at solid-liquid interfaces, including total internal reflection ellipsometry (TIRE), dual polarisation interferometry (DPI) and time of flight - secondary ion mass spectrometry (TOF–SIMS). A model study of fibronectin at polymer surfaces is included, as are studies using microporous membranes and textiles with immobilized enzymes for large-scale applications. Biocompatibility, anti-fouling properties and surface modification to modulate the adsorption and activity of biomolecules are among the other topics addressed in this invaluable book.

Author : D. Möbius,R. Miller
Publisher : Elsevier
Page : 497 pages
File Size : 41,6 Mb
Release : 1998-04-24
Category : Science
ISBN : 0080540007

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Proteins at Liquid Interfaces by D. Möbius,R. Miller Pdf

The interfacial behaviour of surfactants and proteins, and their mixtures, is of importance in a wide range of areas such as food technology, detergency, cosmetics, coating processes, biomedicine, pharmacy and biotechnology. Methods such as surface and interfacial tension measurements and interfacial dilation and shear rheology characterise the relationships between these interfacial properties and the complex behaviour of foams and emulsions is established. Recently-developed experimental techniques, such as FRAP which enable the measurement of molecular mobility in adsorption layers, are covered in this volume. The development of theories to describe the thermodynamic surface state or the exchange of matter for proteins and protein/surfactant mixtures is also described. Features of this book: • Reflects the state-of-the-art research and application of protein interfacial layers rather than a snapshot of only some recent developments. • Emphasis is placed on experimental details as well as recent theoretical developments. • New experimental techniques applied to protein interfacial layers are described, such as FRAP or ADSA, or rheological methods to determine the mechanical behaviour of protein-modified interfaces. • A large number of practical applications, ranging from emulsions relevant in food technology for medical problems such as lung surfactants, to the characterisation of foams intrinsic to beer and champagne production. The book will be of interest to research and university institutes dedicated to interfacial studies in chemistry, biology, pharmacy, medicine and food engineering. Industrial departments for research and technology in food industry, pharmacy, medicine and brewery research will also find this volume of value.

Author : Jinjiang Li,Mary E. Krause,Raymond Tu
Publisher : Springer Nature
Page : 338 pages
File Size : 41,7 Mb
Release : 2021-02-12
Category : Medical
ISBN : 9783030571771

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Protein Instability at Interfaces During Drug Product Development by Jinjiang Li,Mary E. Krause,Raymond Tu Pdf

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.

Author : Ajit Sadana
Publisher : Elsevier
Page : 346 pages
File Size : 44,9 Mb
Release : 1997-11-27
Category : Science
ISBN : 0080528147

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Bioseparations of Proteins by Ajit Sadana Pdf

This book covers the fundamentals of protein inactivation during bioseparation and the effect on protein processing. Bioseparation of Proteins is unique because it provides a background of the bioseparation processes, and it is the first book available to emphasize the influence of the different bioseparation processes on protein inactivation. Bioseparation of Proteins covers the extent, mechanisms of, and control of protein inactivation during these processes along with the subsequent and essential validation of these processes. The book focuses on the avoidance of protein (biologicalproduct) inactivation at each step in a bioprocess. It compares protein inactivation exhibited during the different bioseparation processes by different workers and provides a valuable framework for workers in different areas interested in bioseparations. Topics include separation and detection methods; estimates of protein inactivation and an analysis of this problem for different separation processes; strategies for avoiding inactivation; the molecular basis of surface activity and protein adsorption,process monitoring, and product validation techniques; and the economics of various bioseparation processes and quality control procedures. Key Features * Protein inactivation and other aspects of biological stability are critical to an effective bioseparation process; This book is a detailed and critical review of the available literature in an area that is essential to the effectiveness, validation, and economics of bioseparation processes for drugs and other biological products; Conveniently assembled under one cover, the survey of the literature and resulting perspective will greatly assist engineers and chemists in designingand improving their own processes; Key features of the text include: * detailed data on biological stability under various bioseparation conditions * extensive case studies from the literature on separation processes, validation, and economics * simplified analysis of protein refolding and inactivation mechanisms * consideration of adsorption theories and the effect of heterogeneity * coverage of both classical and novel bioseparation techniques, including chromatographic procedures

Author : Jonathan P. Blitz,Vladimir M. Gun'ko
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 40,6 Mb
Release : 2006-09-09
Category : Science
ISBN : 9781402047411

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Surface Chemistry in Biomedical and Environmental Science by Jonathan P. Blitz,Vladimir M. Gun'ko Pdf

This volume holds a special niche in describing the current state of the art in the fundamentals and applications of a variety of nanomaterials. A common theme throughout much of this volume involves adsorption and interfacial behavior of nanomaterials. The book provides a useful mixture of reviews and primary research from leading laboratories and offers a unique blend of East European and Western contributors.

Author : Marie Wahlgren
Publisher : Unknown
Page : 214 pages
File Size : 49,8 Mb
Release : 1992
Category : Proteins
ISBN : UOM:39015042136880

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Adsorption of Proteins and Interactions with Surfactants at the Solid/liquid Interface by Marie Wahlgren Pdf

Author : David A. Puleo,Rena Bizios
Publisher : Springer Science & Business Media
Page : 438 pages
File Size : 54,5 Mb
Release : 2009-06-26
Category : Technology & Engineering
ISBN : 9780387981611

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Biological Interactions on Materials Surfaces by David A. Puleo,Rena Bizios Pdf

Success or failure of biomaterials, whether tissue engineered constructs, joint and dental implants, vascular grafts, or heart valves, depends on molecular-level events that determine subsequent responses of cells and tissues. This book presents the latest developments and state-of-the-art knowledge regarding protein, cell, and tissue interactions with both conventional and nanophase materials. Insight into these biomaterial surface interactions will play a critical role in further developments in fields such as tissue engineering, regenerative medicine, and biocompatibility of implanted materials and devices. With chapters written by leaders in their respective fields, this compendium will be the authoritative source of information for scientists, engineers, and medical researchers seeking not only to understand but also to control tissue-biomaterial interactions.

Author : Adam Baszkin,Willem Norde
Publisher : CRC Press
Page : 856 pages
File Size : 43,5 Mb
Release : 1999-11-22
Category : Science
ISBN : 0824775813

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Physical Chemistry of Biological Interfaces by Adam Baszkin,Willem Norde Pdf

An introduction to the most important fundamental concepts of physicochemical interface science and a description of experimental techniques and applications of surface science in relation to biological systems. It explores artificial assemblies of lipids, proteins and polysaccharides that perform novel functions that living systems cannot duplicate.

Author : P. Somasundaran
Publisher : CRC Press
Page : 842 pages
File Size : 47,6 Mb
Release : 2014-05-08
Category : Science
ISBN : 9781482299625

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Encyclopedia of Surface and Colloid Science, 2004 Update Supplement by P. Somasundaran Pdf

Appending the Encyclopedia of Surface and Colloid Science by 42 entries as well as 3800 new citations, 1012 equations, and 485 illustrations and chemical structures, this important supplement summarizes a constellation of new theoretical and experimental findings related to chemical characterization, mechanisms, interfacial behavior, methods and mo

Author : K.S. Birdi
Publisher : Springer Science & Business Media
Page : 330 pages
File Size : 53,8 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781489925251

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Lipid and Biopolymer Monolayers at Liquid Interfaces by K.S. Birdi Pdf

During the past few decades, much research has been reported on the formation of insoluble monomolecular films of lipids and biopolymers (synthetic polymers and proteins) on the surface of water or at the oil-water interface. This interest arises from the fact that monomolecular film studies have been found to provide much useful information on a molecular scale, information that is useful for understanding many industrial and biological phenomena in chemical, agricultural, pharmaceutical, medical, and food science applications. For instance, information obtained from lipid monolayer studies has been useful in determining the forces that are known to stabilize emulsions and biological cell membranes. The current texts on surface chemistry generally devote a single chapter to the characteristics of spread monolayers of lipids and biopolymers on liquids, and a researcher may have to review several hundred references to determine the procedures needed to investigate or analyze a particular phenomenon. Furthermore, there is an urgent need at this stage for a text that discusses the state of the art regarding the surface pheqomena exhibited by lipids and biopolymers, as they are relevant to a wide variety of surface and interfacial processes.

Author : G. Hancock,R.G. Compton
Publisher : Elsevier
Page : 713 pages
File Size : 46,8 Mb
Release : 1999-05-07
Category : Science
ISBN : 0080527345

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Applications of Kinetic Modelling by G. Hancock,R.G. Compton Pdf

Volume 37 is concerned with the use and role of modelling in chemical kinetics and seeks to show the interplay of theory or simulation with experiment in a diversity of physico-chemical areas in which kinetics measurements provide significant physical insight. Areas of application covered within the volume include electro- and interfacial chemistry, physiology, biochemistry, solid state chemistry and chemical engineering. A leading contributor to this general area has been Professor W. John Albery, FRS, to whom the contributors and editors dedicate this book.

Author : John Brash
Publisher : CRC Press
Page : 538 pages
File Size : 52,5 Mb
Release : 1996-08-16
Category : Science
ISBN : 0824796519

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Interfacial Phenomena and Bioproducts by John Brash Pdf

Presents a synopsis of the theoretical principles and practical experience concerning the interfacial behaviour of bioproducts. The volume offers an interdisciplinary approach to the subject that highlights the importance of interfacial phenomena in bioprocessing systems, and the tools used to study and interpret the phenomena. It contains coverage ranging from fundamentals of bioproduct and solid surface structure to the interactions of multicomponent mixtures in heterogeneous.

Author : P. Somasundaran
Publisher : CRC Press
Page : 962 pages
File Size : 46,9 Mb
Release : 2006
Category : Colloids
ISBN : 0849396077

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Encyclopedia of Surface and Colloid Science by P. Somasundaran Pdf

Author : Arthur T. Hubbard
Publisher : CRC Press
Page : 1580 pages
File Size : 52,8 Mb
Release : 2002-07-18
Category : Science
ISBN : 0824707575

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Encyclopedia of Surface and Colloid Science - by Arthur T. Hubbard Pdf

This comprehensive reference collects fundamental theories and recent research from a wide range of fields including biology, biochemistry, physics, applied mathematics, and computer, materials, surface, and colloid science-providing key references, tools, and analytical techniques for practical applications in industrial, agricultural, and forensic processes, as well as in the production of natural and synthetic compounds such as foods, minerals, paints, proteins, pharmaceuticals, polymers, and soaps.

Author : David D. Weis
Publisher : John Wiley & Sons
Page : 422 pages
File Size : 41,6 Mb
Release : 2016-03-21
Category : Science
ISBN : 9781118616499

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Hydrogen Exchange Mass Spectrometry of Proteins by David D. Weis Pdf

Hydrogen exchange mass spectrometry is widely recognized for its ability to probe the structure and dynamics of proteins. The application of this technique is becoming widespread due to its versatility for providing structural information about challenging biological macromolecules such as antibodies, flexible proteins and glycoproteins. Although the technique has been around for 25 years, this is the first definitive book devoted entirely to the topic. Hydrogen Exchange Mass Spectrometry of Proteins: Fundamentals, Methods and Applications brings into one comprehensive volume the theory, instrumentation and applications of Hydrogen Exchange Mass Spectrometry (HX-MS) - a technique relevant to bioanalytical chemistry, protein science and pharmaceuticals. The book provides a solid foundation in the basics of the technique and data interpretation to inform readers of current research in the method, and provides illustrative examples of its use in bio- and pharmaceutical chemistry and biophysics In-depth chapters on the fundamental theory of hydrogen exchange, and tutorial chapters on measurement and data analysis provide the essential background for those ready to adopt HX-MS. Expert users may advance their current understanding through chapters on methods including membrane protein analysis, alternative proteases, millisecond hydrogen exchange, top-down mass spectrometry, histidine exchange and method validation. All readers can explore the diversity of HX-MS applications in areas such as ligand binding, membrane proteins, drug discovery, therapeutic protein formulation, biocomparability, and intrinsically disordered proteins.