Pseudomonas Aeruginosa The Superbug

Author : Silpi Basak,Sanchari Das
Publisher : Cambridge Scholars Publishing
Page : 130 pages
File Size : 43,7 Mb
Release : 2022-07-12
Category : Medical
ISBN : 9781527584143

Get Book

Pseudomonas aeruginosa, the Superbug by Silpi Basak,Sanchari Das Pdf

Pseudomonas aeruginosa is one of the most commonly isolated bacterial species in clinical microbiology laboratories and it causes infections in hospitalized patients with strains resistant to many antimicrobials. In addition, it can form a biofilm especially in cystic fibrosis patients and patients with medical devices. Extracellular polymeric substances (EPS) or extracellular matrixes in biofilm prevent access of antimicrobial agents, disinfectants, and host-produced immune responses. Antimicrobial resistance in Pseudomonas aeruginosa is multifactorial and can be due to mutation, transfer of genes by plasmids, or transposons, among other causes. Production of β-lactamases causes resistance to β-lactam drugs including Carbapenems. Against this background of emergence of antibiotic resistance, this book studies different types of β-lactamases routinely produced by Pseudomonas aeruginosa strains in clinical microbiology laboratories. It shows that, although molecular methods like Polymerase Chain Reaction (PCR) are the gold standard for detection of different types of β-lactamases, they are very costly and require expertise.

Author : Theerthankar Das
Publisher : Unknown
Page : 0 pages
File Size : 47,9 Mb
Release : 2021
Category : Electronic
ISBN : 1839686499

Get Book

Pseudomonas Aeruginosa by Theerthankar Das Pdf

Emerging antibiotic resistance of bacteria is driving us to catastrophic failure of the healthcare system. Pseudomonas aeruginosa is one such pathogen that is responsible for causing nosocomial infections, urinary tract infections, cystic fibrosis, otitis media, and infections of wounds and burns. P. aeruginosa is a critical pathogen as defined by the World Health Organization (WHO) due to its intrinsic and adaptive competence to defy antibiotics and persist as a superbug. This book covers a wide array of subjects relevant to bacterial biofilms specifically focusing on P. aeruginosa and associated infections. It provides readers with a clear and comprehensive overview of biofilm formation and associated detrimental impacts. In addition, this book also examines topics related to biosynthesis virulence factors by P. aeruginosa to facilitate biofilm formation, antibiotic resistance mechanisms, and infections.

Author : Dinesh Sriramulu
Publisher : BoD – Books on Demand
Page : 124 pages
File Size : 51,6 Mb
Release : 2019-10-02
Category : Science
ISBN : 9781789238150

Get Book

Pseudomonas Aeruginosa by Dinesh Sriramulu Pdf

Pseudomonas aeruginosa, though unfamiliar as an aggressive invader, has gained importance in the scientific community due to its association with cystic fibrosis (CF) and its ability to construct biofilms resilient to host defense. The chronic nature of CF allows this bacterium to colonize, adapt, and evolve at its own pace, thereby causing further complications in CF patients. With its huge genetic repertoire and plasticity of the genome, P. aeruginosa has been able to alter its contents by way of deletions, insertions, inversions, and so on. Therefore scientists and researchers are eager to study this bacterium in diverse and unusual niches. Written by experts from around the world, this book describes and discusses the various mechanisms of adaptation and evolution displayed by P. aeruginosa.

Author : Theerthankar Das
Publisher : Unknown
Page : 0 pages
File Size : 55,9 Mb
Release : 2021-09
Category : Electronic
ISBN : 1839686472

Get Book

Pseudomonas Aeruginosa by Theerthankar Das Pdf

Author : Stephanie Watson
Publisher : The Rosen Publishing Group, Inc
Page : 66 pages
File Size : 41,8 Mb
Release : 2010-01-15
Category : Juvenile Nonfiction
ISBN : 9781435835856

Get Book

Superbugs by Stephanie Watson Pdf

Provides information on the increase of drug-resistant germs called "superbugs" and different viewpoints on how to deal with the issue.

Author : Steffanie Strathdee,Thomas Patterson
Publisher : Hachette Books
Page : 346 pages
File Size : 41,9 Mb
Release : 2019-02-26
Category : Science
ISBN : 9780316418072

Get Book

The Perfect Predator by Steffanie Strathdee,Thomas Patterson Pdf

An electrifying memoir of one woman's extraordinary effort to save her husband's life-and the discovery of a forgotten cure that has the potential to save millions more. "A memoir that reads like a thriller." -New York Times Book Review "A fascinating and terrifying peek into the devastating outcomes of antibiotic misuse-and what happens when standard health care falls short." -Scientific American Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world. Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure. A nail-biting medical mystery, The Perfect Predator is a story of love and survival against all odds, and the (re)discovery of a powerful new weapon in the global superbug crisis.

Author : OECD.
Publisher : Org. for Economic Cooperation & Development
Page : 224 pages
File Size : 53,6 Mb
Release : 2019-01-21
Category : Electronic
ISBN : 9264307583

Get Book

OECD Health Policy Studies Stemming the Superbug Tide by OECD. Pdf

Antimicrobial resistance (AMR) is a large and growing problem with the potential for enormous health and economic consequences, globally. As such, AMR has become a central issue at the top of the public health agenda of OECD countries and beyond. In this

Author : Alain Filloux,Juan-Luis Ramos
Publisher : Springer Nature
Page : 452 pages
File Size : 55,8 Mb
Release : 2022-10-18
Category : Science
ISBN : 9783031084911

Get Book

Pseudomonas aeruginosa by Alain Filloux,Juan-Luis Ramos Pdf

This book covers the wide set of well-regulated virulence factors and defense mechanisms of Pseudomonas aeruginosa focusing on stress responses and the evolution of this opportunistic human pathogen. Pseudomonas aeruginosa is responsible for one out of ten hospital infections. Additionally, this Gram-negative bacterium is accountable for persistent infections in immunocompromised individuals and the leading cause of chronic lung infections in cystic fibrosis patients. This book provides insight on the metabolic versatility of Pseudomonas aeruginosa and its mechanisms for biofilm formation that make this organism highly efficient in causing infections. The book invites the readers to learn more about the intrinsic ability of Pseudomonas aeruginosa to resist a wide variety of antimicrobial agents due to the concerted action of multidrug efflux pumps, antibiotic-degrading enzymes, and the low permeability of bacterial cellular envelopes. Particular focus is put on the evolutionary role of different types of protein-secretion systems in pathogenesis, flagella and their role in chemotaxis and surface sensing, and host-pathogen interactions. This book is a useful introduction to the field for junior scientists interested in the biology and pathogenesis of Pseudomonas aeruginosa. It is also an interesting read for advanced scientists and medical specialists working within this field, providing a broader view of the topic beyond their specific area of specialization.

Author : Michael Robert Withington Brown
Publisher : John Wiley & Sons
Page : 360 pages
File Size : 49,7 Mb
Release : 1975
Category : Medical
ISBN : UOM:39015000311871

Get Book

Resistance of Pseudomonas Aeruginosa by Michael Robert Withington Brown Pdf

Author : L. D. Sabath
Publisher : Unknown
Page : 280 pages
File Size : 46,8 Mb
Release : 1980
Category : Nosocomial infections
ISBN : NWU:35558002456628

Get Book

Pseudomonas Aeruginosa by L. D. Sabath Pdf

Author : William Hall
Publisher : Harvard University Press
Page : 236 pages
File Size : 49,7 Mb
Release : 2018-04-09
Category : Medical
ISBN : 9780674985070

Get Book

Superbugs by William Hall Pdf

Antibiotics are powerful drugs that can prevent and treat infections, but they are becoming less effective as a result of drug resistance. Resistance develops because the bacteria that antibiotics target can evolve ways to defend themselves against these drugs. When antibiotics fail, there is very little else to prevent an infection from spreading. Unnecessary use of antibiotics in both humans and animals accelerates the evolution of drug-resistant bacteria, with potentially catastrophic personal and global consequences. Our best defenses against infectious disease could cease to work, surgical procedures would become deadly, and we might return to a world where even small cuts are life-threatening. The problem of drug resistance already kills over one million people across the world every year and has huge economic costs. Without action, this problem will become significantly worse. Following from their work on the Review on Antimicrobial Resistance, William Hall, Anthony McDonnell, and Jim O’Neill outline the major systematic failures that have led to this growing crisis. They also provide a set of solutions to tackle these global issues that governments, industry, and public health specialists can adopt. In addition to personal behavioral modifications, such as better handwashing regimens, Superbugs argues for mounting an offense against this threat through agricultural policy changes, an industrial research stimulus, and other broad-scale economic and social incentives.

Author : Beningo M. Penha Escudeiro
Publisher : Nova Science Publishers
Page : 256 pages
File Size : 47,8 Mb
Release : 2012
Category : Pseudomonas aeruginosa
ISBN : 1622572300

Get Book

Pseudomonas Aeruginosa by Beningo M. Penha Escudeiro Pdf

Author : Beningo M. Penha Escudeiro,Eduardo C. Baracho Marques
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 48,9 Mb
Release : 2012
Category : Pseudomonas aeruginosa infections
ISBN : 1622571983

Get Book

Pseudomonas Aeruginosa by Beningo M. Penha Escudeiro,Eduardo C. Baracho Marques Pdf

Pseudomonas aeruginosa is a unique pathogen with a characteristic hospital epidemiology resulting in colonisation and major infectious complications. Institutions of infection control policies including guidelines on surveillance, infection control interventions and environmental decontamination are important preventive measures. In this book, the authors present current research on the symptoms of infection, antibiotic resistance and treatment of pseudomonas aeruginosa. Topics discussed include the mechanisms of antimicrobial resistance and antimicrobial treatment options; chronic pseudomonas aeruginosa infection in cystic fibrosis; and biofilm-forming ability and antimicrobial resistance of pseudomonas aeruginosa isolates of veterinary origin.

Author : Connie R. Mahon,Donald C. Lehman,George Manuselis
Publisher : Saunders
Page : 1080 pages
File Size : 52,9 Mb
Release : 2011
Category : Medical
ISBN : 1416061657

Get Book

Textbook of Diagnostic Microbiology by Connie R. Mahon,Donald C. Lehman,George Manuselis Pdf

Providing a solid introduction to the essentials of diagnostic microbiology, this accessible, full-color text helps you develop the problem-solving skills necessary for success in the clinical setting. A reader-friendly, "building block" approach to microbiology moves progressively from basic concepts to advanced understanding, guiding you through the systematic identification of etiologic agents of infectious diseases. Building block approach encourages recall of previously learned information, enhancing your critical and problem solving skills. Case in Point feature introduces case studies at the beginning of each chapter. Issues to Consider encourages you to analyze and comprehend the case in point. Key Terms provide a list of the most important and relevant terms in each chapter. Objectives give a measurable outcome to achieve by completing the material. Points to Remember summarize and help clearly identify key concepts covered in each chapter. Learning assessment questions evaluate how well you have mastered the material. New content addresses bone and joint infections, genital tract infections, and nosocomial infections. Significantly updated chapter includes current information on molecular biology and highlights content on multidrug resistant bacteria. Reorganized chapters accent the most relevant information about viruses and parasites that are also transmissible to humans. Case studies on the Evolve site let you apply the information that you learn to realistic scenarios encountered in the laboratory.

Author : Douglas L. Mayers,Jack D. Sobel,Marc Ouellette,Keith S. Kaye,Dror Marchaim
Publisher : Springer
Page : 773 pages
File Size : 55,5 Mb
Release : 2017-06-19
Category : Medical
ISBN : 9783319467184

Get Book

Antimicrobial Drug Resistance by Douglas L. Mayers,Jack D. Sobel,Marc Ouellette,Keith S. Kaye,Dror Marchaim Pdf

The two volumes included in Antimicrobial Drug Resistance, Second Edition is an updated, comprehensive and multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. This newly revised compendium reviews the most current research and development on drug resistance while still providing the information in the accessible format of the first edition. The first volume, Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant organisms, the approach to dealing with the drug resistance problem must include the research of different aspects of the mechanisms of bacterial resistance and the dissemination of resistance genes as well as research utilizing new genomic information. These approaches will permit the design of novel strategies to develop new antibiotics and preserve the effectiveness of those currently available. The second volume, Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious diseases physician requires input from the clinical microbiologist, antimicrobial stewardship personnel, and infection control specialist to make informed choices for the effective management of various strains of drug-resistant pathogens in individual patients. This 2-volume set is an important reference for students in microbiology, infectious diseases physicians, medical students, basic scientists, drug development researchers, microbiologists, epidemiologists, and public health practitioners.