Quantitation And Mass Spectrometric Data Of Drugs And Isotopically Labeled Analogs

Author : Ray H. Liu,Dennis V. Canfield,Sheng-Meng Wang
Publisher : CRC Press
Page : 510 pages
File Size : 45,7 Mb
Release : 2009-08-05
Category : Law
ISBN : 142009498X

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Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs by Ray H. Liu,Dennis V. Canfield,Sheng-Meng Wang Pdf

The analysis of drugs and their metabolites in biological media are now expected to routinely achieve ± 20% accuracy in the ng/mL concentration level. Therefore, the availability and the selection of quality ion-pairs designating the analytes and their isotopically labeled analogs (ILAs) are important considerations in achieving the accuracy of quantitation results. Assisting scientists with this process, Quantitation and Mass Spectrometric Data of Drugs and Isotopically Labeled Analogs provides an extremely valuable reference for labs involved in the analysis of therapeutic and abused drugs. Part One of this comprehensive volume illustrates approaches, mechanisms, and challenges pertaining to the use of isotopic analogs as internal standards for drug quantitation. The second section is a systematic compilation of full-scan mass spectra of drugs and their analogs, as parent compounds and as derivatives resulting from various chemical derivatization approaches, commonly encountered in today’s labs. Based on the mass spectra data presented in the second section, Part Three provides corresponding tables of ion-pairs which can potentially be adapted to designate the drugs and their isotopic analogs in the analytical processes. Relative quality of these ion-pairs (cross-contribution to the intensity of these ions by their isotopic analogs) is included in these tables. With more than 1500 full-scan mass spectra and quick access data tables, this text represents the authors’ years of work compiling mass spectra of the many chemical derivatization forms of drugs, their metabolites, and their isotopically labeled counterparts. The unparalleled scope of this compilation makes it a critical one-stop reference for those involved in drug analyses of biological specimens and interpretation of results.

Author : Uttam Garg
Publisher : Springer Nature
Page : 469 pages
File Size : 40,5 Mb
Release : 2023-11-30
Category : Science
ISBN : 9781071635414

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Clinical Applications of Mass Spectrometry in Drug Analysis by Uttam Garg Pdf

This fully updated volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Exploring the versatility and flexibility of mass spectrometry, the book covers the advantages of this technology, which typically include elimination of the need for special reagents such as antibodies, increased sensitivity and specificity, and multi-component analysis enabling the screening of tens to hundreds of compounds in a single assay run. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols, Second Edition serves as a valuable resource for laboratory professionals who are already utilizing mass spectrometry or considering bringing this technology to their labs.

Author : Swapan Chowdhury
Publisher : Elsevier
Page : 354 pages
File Size : 53,9 Mb
Release : 2005-11-04
Category : Science
ISBN : 0080456065

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Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS by Swapan Chowdhury Pdf

As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and development. With chapters written by experts with a wide range of practical experience from the pharmaceutical industry, emphasis is placed on techniques and applications. The book also includes chapters on how to utilize LC-MS instrumentation for current drug metabolism problems. This book is intended for those beginning to use LC-MS for drug metabolism studies as well as for those considered advanced practitioners. * Introduces readers to the practical applications of modern liquid chromatography-mass spectrometry (LC-MS) in a wide range of drug metabolism studies· * Provides a comprehensive description of different forms of metabolites, with detailed discussion on the wide range of methodologies used to identify them * Highlights problems associated with drug quantification and offers practical solutions

Author : Marek Domin,Robert Cody
Publisher : Royal Society of Chemistry
Page : 528 pages
File Size : 53,6 Mb
Release : 2014-11-25
Category : Science
ISBN : 9781849739269

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Ambient Ionization Mass Spectrometry by Marek Domin,Robert Cody Pdf

Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject. Written by acknowledged experts, there are full descriptions on how new ionization techniques work, with an overview of their strengths, weaknesses and applications. This title will bring the reader right up to date, with both applications and theory, and will be suitable as a tutorial text for those starting in the field from a variety of disciplines.

Author : Jehuda Yinon
Publisher : Springer
Page : 248 pages
File Size : 55,6 Mb
Release : 1987-08-31
Category : Law
ISBN : UOM:39015015449047

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Forensic Mass Spectrometry by Jehuda Yinon Pdf

Author : Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Andy Hoofnagle
Publisher : Elsevier
Page : 216 pages
File Size : 48,7 Mb
Release : 2018-06-26
Category : Science
ISBN : 9780128160640

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Principles and Applications of Clinical Mass Spectrometry by Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Andy Hoofnagle Pdf

Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is a concise resource for quick implementation of mass spectrometry methods in clinical laboratory work. Focusing on the practical use of these techniques, the first half of the book covers principles of chromatographic separations, principles and types of mass spectrometers, and sample preparation for analysis; the second half outlines the main applications of this technology within clinical laboratory settings, including determination of small molecules and peptides, as well as pathogen identification. A thorough yet succinct guide to using mass spectrometry technology in the clinical laboratory, Principles and Applications of Clinical Mass Spectrometry: Small Molecules, Peptides, and Pathogens is an essential resource for chemists, pharmaceutical and biotech researchers, certain government agencies, and standardization groups. Provides concrete examples of the main applications of mass spectrometry technology Describes current capabilities of the LC- and MS-based analytical methods Details methods for successful analytical work in the field

Author : Gregory S. Makowski
Publisher : Elsevier
Page : 344 pages
File Size : 54,8 Mb
Release : 2023-10-17
Category : Science
ISBN : 9780443192937

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Advances in Clinical Chemistry by Gregory S. Makowski Pdf

Advances in Clinical Chemistry, Volume 116, the latest release in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science Authored by world renowned clinical laboratory scientists, physicians and research scientists Presents the international benchmark for novel analytical approaches in the clinical laboratory

Author : Mahmud Hossain
Publisher : Springer Nature
Page : 283 pages
File Size : 54,6 Mb
Release : 2020-09-26
Category : Science
ISBN : 9783030534332

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Selected Reaction Monitoring Mass Spectrometry (SRM-MS) in Proteomics by Mahmud Hossain Pdf

Covering a wide-ranging facet of a “gold-standard” targeted mass spectrometry (MS) method for the consistent detection and accurate quantification of preselected proteins in complex biological matrices, Selected Reaction Monitoring Mass Spectrometry (SRM-MS) in Proteomics: A Comprehensive View describes: The knowledge-based development of highly efficient SRM methodology including assay workflow, selection of proteins, peptides, transitions and its validation, and quality assessment Available bioinformatic tools – for both pre-acquisition method development and post-MS acquisition data analysis and data repositories Various relative and absolute quantification techniques SRM-MS’ widespread applications in biomarker development and in clinical studies, as well as in the analysis of various posttranslational modifications (PTMs) Current challenges and contemporary trends to overcome those difficulties In addition, it features the historical development of modern-day mass spectrometry with its vivid applications and also covers basic MS instrumentation, ionization techniques, and various proteomics approaches. Comprehensive discussion, extensive references at the end of each chapter, and the list of review articles in the bibliography offer invaluable resources for advanced readings. Researchers from the undergraduate to postgraduate level and beyond in both academic or industry settings studying and working on mass spectrometry and/or proteomics will benefit from this book.

Author : Mike S. Lee
Publisher : John Wiley & Sons
Page : 1362 pages
File Size : 40,6 Mb
Release : 2012-05-08
Category : Science
ISBN : 9780470536735

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Mass Spectrometry Handbook by Mike S. Lee Pdf

Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.

Author : Robert K. Boyd,Cecilia Basic,Robert A. Bethem
Publisher : John Wiley & Sons
Page : 1179 pages
File Size : 53,8 Mb
Release : 2011-08-24
Category : Science
ISBN : 9781119964391

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Trace Quantitative Analysis by Mass Spectrometry by Robert K. Boyd,Cecilia Basic,Robert A. Bethem Pdf

This book provides a serious introduction to the subject of mass spectrometry, providing the reader with the tools and information to be well prepared to perform such demanding work in a real-life laboratory. This essential tool bridges several subjects and many disciplines including pharmaceutical, environmental and biomedical analysis that are utilizing mass spectrometry: Covers all aspects of the use of mass spectrometry for quantitation purposes Written in textbook style to facilitate understanding of this topic Presents fundamentals and real-world examples in a ‘learning-though-doing’ style

Author : W. George Fong,H. Anson Moye,James N. Seiber,John P. Toth
Publisher : John Wiley & Sons
Page : 389 pages
File Size : 42,6 Mb
Release : 1999-01-29
Category : Science
ISBN : 9780471574002

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Pesticide Residues in Foods by W. George Fong,H. Anson Moye,James N. Seiber,John P. Toth Pdf

Advances in analytical chemistry methodology now allow us to detect the most minute trace amounts of pesticides. As this capacity grows, so does public concern about toxic contamination, resulting in stricter government regulations and a growing demand for even more sensitive, precise, and reliable analysis. Addressing the interplay between regulations and the development of analytical technology, this volume presents the first unified treatment of the regulatory and analytical aspects of pesticide residues. Current regulations, existing and emerging methodologies, state-of-the-art instrumentation, and the basic science of analyzing for pesticides in food and other environmental media are all covered. The book provides step-by-step guidelines to analytical techniques, along with real-world examples from the latest research-showing the reader how to analyze minute traces of pesticides quickly and accurately, using both highly sophisticated and basic, less sensitive techniques. Many safety issues are explored in depth, as are the regulatory aspects of pesticide registration, residue analysis, exposure monitoring, risk assessment, and tolerance enforcement. Timely, authoritative, and practical throughout, Pesticide Residues in Foods is an invaluable reference for analytical chemists and laboratory managers everywhere-in industry, agriculture, environmental sciences, research, and instrument manufacturing-and for anyone with an interest in the broader environmental, agricultural, and consumer-related implications of pesticide use. An invaluable resource for analytical chemists and laboratory managers, Pesticide Residues in Foods provides a complete overview of the theory, practice, and regulatory aspects of pesticide residue analysis today, including: * All regulatory issues, from risk assessment and tolerance to data-quality requirements to laboratory accreditation standards * State-of-the-art methodologies and instrumentation, including high- performance liquid chromatography and mass spectrometry * The application of analytical technology to "green chemistry," such as the reduction of solvents and toxic reagents in the laboratory * Novel solutions to the old problem of keeping the food supply safe from harmful levels of pesticides * Ample examples to help analytical chemists select the most appropriate method for a given residue analysis * Easy-to-use tables and figures throughout the text

Author : Wenkui Li,Jie Zhang,Francis L. S. Tse
Publisher : John Wiley & Sons
Page : 709 pages
File Size : 41,5 Mb
Release : 2013-09-03
Category : Science
ISBN : 9781118671351

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Handbook of LC-MS Bioanalysis by Wenkui Li,Jie Zhang,Francis L. S. Tse Pdf

Consolidates the information LC-MS bioanalytical scientists need to analyze small molecules and macromolecules The field of bioanalysis has advanced rapidly, propelled by new approaches for developing bioanalytical methods, new liquid chromatographic (LC) techniques, and new mass spectrometric (MS) instruments. Moreover, there are a host of guidelines and regulations designed to ensure the quality of bioanalytical results. Presenting the best practices, experimental protocols, and the latest understanding of regulations, this book offers a comprehensive review of LC-MS bioanalysis of small molecules and macromolecules. It not only addresses the needs of bioanalytical scientists working on routine projects, but also explores advanced and emerging technologies such as high-resolution mass spectrometry and dried blood spot microsampling. Handbook of LC-MS Bioanalysis features contributions from an international team of leading bioanalytical scientists. Their contributions reflect a review of the latest findings, practices, and regulations as well as their own firsthand analytical laboratory experience. The book thoroughly examines: Fundamentals of LC-MS bioanalysis in drug discovery, drug development, and therapeutic drug monitoring The current understanding of regulations governing LC-MS bioanalysis Best practices and detailed technical instructions for LC-MS bioanalysis method development, validation, and stability assessment of analyte(s) of interest Experimental guidelines and protocols for quantitative LC-MS bioanalysis of challenging molecules, including pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds With its focus on current bioanalytical practice, Handbook of LC-MS Bioanalysis enables bioanalytical scientists to develop and validate robust LC-MS assay methods, all in compliance with current regulations and standards.

Author : Barry Levine
Publisher : Amer. Assoc. for Clinical Chemistry
Page : 406 pages
File Size : 44,7 Mb
Release : 2003
Category : Law
ISBN : 1890883875

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Principles of Forensic Toxicology by Barry Levine Pdf

Author : Steven H.Y. Wong
Publisher : Routledge
Page : 521 pages
File Size : 41,6 Mb
Release : 2017-09-19
Category : Medical
ISBN : 9781351408479

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Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography by Steven H.Y. Wong Pdf

This important, new reference provides the first , up-to-date, and comprehensive treatmentof the various liquid chromatography (LC) instrumentation for Therapeutic DrugMonitoring (TDM) and toxicology drug assays and reviews the clinical pharmacologyof major classes of drugs and their LC analyses.Written by authoritative contributors who bring many years of personal laboratory/clinical experience to the book, this interdisciplinary work : presents the principlesof TDM, sampling techniques, and various instrumentation topics, including computerinterfacing, mass spectrometry, fluorescence , electrochemical detection, and bloodcollection devices . .. examines six primary classes of drugs, complete with recommendedLC procedures and emphasizing recently introduced drugs and their LC analyses. .. and documents medicolegal guidelines and laboratory management considerations,providing a contemporary assessment of today's laboratory needs.The only practical, current guide available on the subject, Therapeutic Drug Monitoringand Toxicology by Li([uid Chromatography belongs in the personal libraries of clinicaland analytical chemists and biochemists, clinical pharmacologists, clinical toxicologists,clinical pathologists, immunologists, liquid chromatographers, mass spectroscopists, laboratorydirectors, laboratory instrument manufacturers , and medical technologists. Thebook is also vital supplementary reading for advanced undergraduate and graduate-levelclinical chemistry, toxicology, clinical pathology, and liquid chromatography course.

Author : Anonim
Publisher : ScholarlyEditions
Page : 54 pages
File Size : 54,5 Mb
Release : 2012-12-26
Category : Medical
ISBN : 9781481615136

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N-Glycosyl Hydrolases—Advances in Research and Application: 2012 Edition by Anonim Pdf

N-Glycosyl Hydrolases—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about N-Glycosyl Hydrolases in a concise format. The editors have built N-Glycosyl Hydrolases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about N-Glycosyl Hydrolases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of N-Glycosyl Hydrolases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.